EuRBPDB

Description

Ensembl ID: ENSG00000163946 (Gene tree)
Gene ID: 23272
Gene Symbol: TASOR
Alias: se89-1|RAP140|KIAA1105|TASOR1|C3orf63|FAM208A
Full Name: transcription activation suppressor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 63,111 bases
Position: chr3:56,620,132-56,683,242
Accession: 30314
RBP type: non-canonical RBP
Summary: (Transcription Activation Suppressor) is a Protein Coding gene. An important paralog of this gene is TASOR2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000431842	FAM208A-202	7119	XM_006713078	ENSP00000399410	1233 (aa)	XP_006713141	Q9UK61
ENST00000461863	FAM208A-204	576	-	-	- (aa)	-	-
ENST00000487036	FAM208A-208	590	-	-	- (aa)	-	-
ENST00000485156	FAM208A-207	926	-	-	- (aa)	-	-
ENST00000355628	FAM208A-201	5239	XM_005264999	ENSP00000347845	1609 (aa)	XP_011531854	Q9UK61
ENST00000478052	FAM208A-206	299	-	-	- (aa)	-	-
ENST00000493960	FAM208A-209	5600	XM_017006030	ENSP00000417509	1512 (aa)	-	Q9UK61
ENST00000459993	FAM208A-203	5099	-	-	- (aa)	-	-
ENST00000477406	FAM208A-205	435	-	-	- (aa)	-	-
ENST00000614531	FAM208A-210	3441	-	ENSP00000483340	1035 (aa)	-	A0A087X0F1

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163946	Blood Cells	2.34783259152148E-6	17903294
ENSG00000163946	Hip	1.43945137588219E-7	17903296
ENSG00000163946	Hip	3.79930985925236E-6	17903296
ENSG00000163946	Hip	2.36629405068913E-6	17903296
ENSG00000163946	Hip	1.50131822188546E-7	17903296
ENSG00000163946	Hip	1.24603206437999E-7	17903296
ENSG00000163946	Hip	2.40803087818491E-8	17903296
ENSG00000163946	Hip	1.2784073643726E-8	17903296
ENSG00000163946	Platelet Function Tests	5.1171692E-007	-
ENSG00000163946	Platelet Function Tests	5.6888263E-007	-
ENSG00000163946	Resistin	6.3000000E-005	-
ENSG00000163946	Cryptorchidism	9.2200000E-005	-
ENSG00000163946	Attention	8E-6	26174813
ENSG00000163946	Attention Deficit Disorder with Hyperactivity	8E-6	26174813
ENSG00000163946	Body Height	4E-22	25282103
ENSG00000163946	Body Height	5E-13	20881960
ENSG00000163946	Body Height	8E-8	21998595

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163946	rs9835332	3	56633654	C	Height	20881960	[NR] unit decrease	0.026	EFO_0004339
ENSG00000163946	rs9835332	3	56633654	C	Height	25282103	[0.022-0.034] unit decrease	0.028	EFO_0004339
ENSG00000163946	rs4681994	3	56681335	?	General cognitive ability	29844566	z-score increase	4.864	EFO_0004337
ENSG00000163946	rs6445804	3	56630824	?	Eczema	30595370			HP_0000964
ENSG00000163946	rs6762851	3	56652301	?	Fat-free mass	30593698	[0.12-0.26] unit decrease	0.19057	EFO_0004995
ENSG00000163946	rs9845655	3	56667300	T	Diastolic blood pressure	27841878	unit increase	0.161	EFO_0006336
ENSG00000163946	rs9845655	3	56667300	T	Systolic blood pressure	27841878	unit increase	0.215	EFO_0006335
ENSG00000163946	rs6762851	3	56652301	?	Fat-free mass	30593698	[0.1-0.19] unit decrease	0.1488	EFO_0004995

Protein-Protein Interaction (PPI)

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163946	TASOR	100	81.143	ENSMUSG00000040651	Fam208a	99	84.192	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000792	heterochromatin	28581500.	IDA	Component
GO:0003682	chromatin binding	29211708.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	26022416.28581500.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0045814	negative regulation of gene expression, epigenetic	26022416.28581500.29211708.	IDA	Process
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	29211708.	IMP	Process
GO:0090309	positive regulation of methylation-dependent chromatin silencing	28581500.29211708.	IDA	Process
GO:0097355	protein localization to heterochromatin	28581500.	IDA	Process