EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000163950 (Gene tree)
Gene ID: 7884
Gene Symbol: SLBP
Alias: HBP
Full Name: stem-loop binding protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 19,895 bases
Position: chr4:1,692,800-1,712,694
Accession: 10904
RBP type: canonical RBP
Summary: This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000426891	SLBP_RNA_bind	PF15247.6	7e-29	1	1
ENSP00000418658	SLBP_RNA_bind	PF15247.6	7.3e-29	1	1
ENSP00000406322	SLBP_RNA_bind	PF15247.6	1.4e-28	1	1
ENSP00000417686	SLBP_RNA_bind	PF15247.6	1.9e-28	1	1
ENSP00000316490	SLBP_RNA_bind	PF15247.6	2e-28	1	1
ENSP00000417359	SLBP_RNA_bind	PF15247.6	9.1e-16	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11238936	Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing.	Mol Cell Biol	2001 Mar	Dominski Z	-
12192062	3' end processing of Drosophila melanogaster histone pre-mRNAs: requirement for phosphorylated Drosophila stem-loop binding protein and coevolution of the histone pre-mRNA processing system.	Mol Cell Biol	2002 Sep	Dominski Z	-
11105754	Specificities of Caenorhabditis elegans and human hairpin binding proteins for the first nucleotide in the histone mRNA hairpin loop.	RNA	2000 Nov	Michel F	-
25002523	Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation.	Proc Natl Acad Sci U S A	2014 Jul 22	Zhang J	doi: 10.1073/pnas.1406381111
11871662	NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein.	RNA	2002 Jan	DeJong ES	-
16164992	Expression of metazoan replication-dependent histone genes.	Biochimie	2005 Sep-Oct	Jaeger S	-
25379382	Contribution of protein phosphorylation to binding-induced folding of the SLBP-histone mRNA complex probed by phosphorus-31 NMR.	FEBS Open Bio	2014 Oct 16	Thapar R	doi: 10.1016/j.fob.2014.10.002
23941746	Replication stress-induced alternative mRNA splicing alters properties of the histone RNA-binding protein HBP/SLBP: a key factor in the control of histone gene expression.	Biosci Rep	2013 Sep 6	Rattray AM	doi: 10.1042/BSR20130074.
26123393	CSP41b, a protein identified via FOX hunting using Eutrema salsugineum cDNAs, improves heat and salinity stress tolerance in transgenic Arabidopsis thaliana.	Biochem Biophys Res Commun	2015 Aug 14	Ariga H	doi: 10.1016/j.bbrc.2015.06.151
30655309	UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.	RNA	2019 Apr	Kim YK	doi: 10.1261/rna.070136.118
23329046	Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex.	Science	2013 Jan 18	Tan D	doi: 10.1126/science.1228705.
10710426	Positive and negative mutant selection in the human histone hairpin-binding protein using the yeast three-hybrid system.	Nucleic Acids Res	2000 Apr 1	Martin F	-
22439849	Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization.	Biochemistry	2012 Apr 17	Zhang M	doi: 10.1021/bi2018255
9049306	The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.	EMBO J	1997 Feb 17	Martin F	-
8957003	The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing.	Genes Dev	1996 Dec 1	Wang ZF	-
15546920	The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells.	J Cell Sci	2004 Dec 1	Zhao X	-
15358832	SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP.	Nucleic Acids Res	2004 Sep 9	Whitfield ML	-
14706861	Critical residues for RNA discrimination of the histone hairpin binding protein (HBP) investigated by the yeast three-hybrid system.	FEBS Lett	2004 Jan 2	Jaeger S	-
22907757	The prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination.	Mol Cell Biol	2012 Nov	Krishnan N	doi: 10.1128/MCB.00382-12
26377992	A multiprotein occupancy map of the mRNP on the 3' end of histone mRNAs.	RNA	2015 Nov	Brooks L 3rd	doi: 10.1261/rna.053389.115
25992900	Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.	Biomolecules	2015 May 18	Thapar R	doi: 10.3390/biom5020974.
23142872	Systematic reconstruction of RNA functional motifs with high-throughput microfluidics.	Nat Methods	2012 Dec	Martin L	doi: 10.1038/nmeth.2225
17998288	Early evolution of histone mRNA 3' end processing.	RNA	2008 Jan	Davila Lopez M	-
12727197	Read-through histone transcripts containing 3' adenylate tails are zygotically expressed in Xenopus embryos and undergo processing to mature transcripts when introduced into oocyte nuclei.	Biochem Biophys Res Commun	2003 May 16	Masi T	-
11606722	T7 phage display: a novel genetic selection system for cloning RNA-binding proteins from cDNA libraries.	Proc Natl Acad Sci U S A	2001 Nov 6	Danner S	-
15611298	Nuclear export of metazoan replication-dependent histone mRNAs is dependent on RNA length and is mediated by TAP.	RNA	2005 Jan	Erkmann JA	-
14675449	CSP41a, a multifunctional RNA-binding protein, initiates mRNA turnover in tobacco chloroplasts.	Plant J	2003 Dec	Bollenbach TJ	-
19759367	Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice.	Biol Reprod	2010 Jan	Yang Q	doi: 10.1095/biolreprod.109.076588
22467188	An oocyte-preferential histone mRNA stem-loop-binding protein like is expressed in several mammalian species.	Mol Reprod Dev	2012 Jun	Thelie A	doi: 10.1002/mrd.22040
25940597	Chromatin remodelling and histone m RNA accumulation in bovine germinal vesicle oocytes.	Mol Reprod Dev	2015 Jun	Labrecque R	doi: 10.1002/mrd.22494
29483154	Transcription elongation rate affects nascent histone pre-mRNA folding and 3' end processing.	Genes Dev	2018 Feb 1	Saldi T	doi: 10.1101/gad.310896.117
9642171	The U7 snRNP and the hairpin binding protein: Key players in histone mRNA metabolism.	Semin Cell Dev Biol	1997 Dec	Muller B	-
7899087	The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein.	Nucleic Acids Res	1995 Feb 25	Williams AS	-
11865041	The Caenorhabditis elegans histone hairpin-binding protein is required for core histone gene expression and is essential for embryonic and postembryonic cell division.	J Cell Sci	2002 Feb 15	Pettitt J	-
11214174	The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs.	RNA	2001 Jan	Battle DJ	-
15451662	Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP.	J Mol Biol	2004 Oct 15	Cheng Y	-
14536070	A 3' exonuclease that specifically interacts with the 3' end of histone mRNA.	Mol Cell	2003 Aug	Dominski Z	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000483348	SLBP-204	1030	-	ENSP00000426891	225 (aa)	-	H0YAE8
ENST00000318386	SLBP-201	1635	-	ENSP00000316490	277 (aa)	-	F8W8D3
ENST00000488267	SLBP-205	987	-	ENSP00000418658	235 (aa)	-	E7EUV9
ENST00000480936	SLBP-203	558	-	ENSP00000417359	186 (aa)	-	H7C4H8
ENST00000489418	SLBP-206	1977	-	ENSP00000417686	270 (aa)	-	Q14493
ENST00000429429	SLBP-202	1623	-	ENSP00000406322	231 (aa)	-	Q14493

Gene Model

Click here to download ENSG00000163950's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000163950	Hip	6E-10	25673412
ENSG00000163950	Body Mass Index	6E-10	25673412
ENSG00000163950	Body Height	2E-11	20881960
ENSG00000163950	Cartilage	1E-6	27701424
ENSG00000163950	Hip	8E-7	25673412
ENSG00000163950	Body Mass Index	8E-7	25673412

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000163950	rs2247341	4	1699590	A	Height	20881960	[NR] unit increase	0.025	EFO_0004339
ENSG00000163950	rs2236995	4	1702815	T	Hip minimal joint space width	27701424	[0.029-0.069] unit increase	0.049	EFO_0007873
ENSG00000163950	rs2247341	4	1699590	A	Hip circumference adjusted for BMI	25673412	[0.015-0.03] unit increase	0.0226	EFO_0008039
ENSG00000163950	rs2247341	4	1699590	A	Hip circumference adjusted for BMI	25673412	[0.014-0.033] unit increase	0.0235	EFO_0008039
ENSG00000163950	rs2592831	4	1709677	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000163950	rs11732213	4	1702517	T	Osteoarthritis of the hip or knee	30664745	[1.04-1.08]	1.06	EFO_1000786\|EFO_0004616

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000163950's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000163950	SLBP	80	53.659	ENSAPOG00000004953	slbp	73	58.173	Acanthochromis_polyacanthus
ENSG00000163950	SLBP	92	93.088	ENSAMEG00000016915	SLBP	100	93.088	Ailuropoda_melanoleuca
ENSG00000163950	SLBP	80	59.606	ENSACIG00000022308	slbp	92	53.909	Amphilophus_citrinellus
ENSG00000163950	SLBP	80	54.268	ENSAOCG00000024545	slbp	73	58.173	Amphiprion_ocellaris
ENSG00000163950	SLBP	84	54.128	ENSAPEG00000017629	slbp	91	50.579	Amphiprion_percula
ENSG00000163950	SLBP	91	48.746	ENSATEG00000016358	slbp	97	48.913	Anabas_testudineus
ENSG00000163950	SLBP	92	71.818	ENSAPLG00000015989	-	100	76.364	Anas_platyrhynchos
ENSG00000163950	SLBP	100	97.403	ENSANAG00000034769	SLBP	100	97.403	Aotus_nancymaae
ENSG00000163950	SLBP	80	56.522	ENSACLG00000007036	-	90	48.413	Astatotilapia_calliptera
ENSG00000163950	SLBP	81	61.463	ENSAMXG00000014527	slbp	90	58.607	Astyanax_mexicanus
ENSG00000163950	SLBP	100	84.727	ENSBTAG00000001328	SLBP	100	84.727	Bos_taurus
ENSG00000163950	SLBP	100	94.946	ENSCJAG00000001790	SLBP	100	94.946	Callithrix_jacchus
ENSG00000163950	SLBP	100	85.091	ENSCAFG00000015016	SLBP	100	86.545	Canis_familiaris
ENSG00000163950	SLBP	100	85.091	ENSCAFG00020012334	SLBP	100	86.545	Canis_lupus_dingo
ENSG00000163950	SLBP	100	84.364	ENSCHIG00000019364	SLBP	100	84.364	Capra_hircus
ENSG00000163950	SLBP	100	94.372	ENSTSYG00000000376	SLBP	100	94.372	Carlito_syrichta
ENSG00000163950	SLBP	78	85.083	ENSCAPG00000016340	SLBP	100	86.188	Cavia_aperea
ENSG00000163950	SLBP	100	82.079	ENSCPOG00000000031	SLBP	100	82.796	Cavia_porcellus
ENSG00000163950	SLBP	100	68.936	ENSCCAG00000026134	SLBP	87	98.000	Cebus_capucinus
ENSG00000163950	SLBP	100	99.259	ENSCATG00000029173	SLBP	100	99.259	Cercocebus_atys
ENSG00000163950	SLBP	100	84.000	ENSCLAG00000008157	SLBP	100	84.727	Chinchilla_lanigera
ENSG00000163950	SLBP	100	83.273	ENSCSAG00000015628	SLBP	100	83.273	Chlorocebus_sabaeus
ENSG00000163950	SLBP	92	74.771	ENSCPBG00000000746	SLBP	100	68.551	Chrysemys_picta_bellii
ENSG00000163950	SLBP	91	99.052	ENSCANG00000041008	SLBP	100	99.052	Colobus_angolensis_palliatus
ENSG00000163950	SLBP	100	85.818	ENSCGRG00001009760	-	100	86.545	Cricetulus_griseus_chok1gshd
ENSG00000163950	SLBP	100	82.909	ENSCGRG00001012991	-	100	83.636	Cricetulus_griseus_chok1gshd
ENSG00000163950	SLBP	100	85.818	ENSCGRG00000004506	Slbp	100	86.545	Cricetulus_griseus_crigri
ENSG00000163950	SLBP	80	59.748	ENSCSEG00000020337	-	90	52.209	Cynoglossus_semilaevis
ENSG00000163950	SLBP	89	49.624	ENSCVAG00000019592	-	94	48.649	Cyprinodon_variegatus
ENSG00000163950	SLBP	73	64.368	ENSDARG00000100558	slbp	64	63.580	Danio_rerio
ENSG00000163950	SLBP	100	78.445	ENSDNOG00000047539	SLBP	100	78.445	Dasypus_novemcinctus
ENSG00000163950	SLBP	91	89.815	ENSDORG00000003028	Slbp	100	89.815	Dipodomys_ordii
ENSG00000163950	SLBP	68	93.590	ENSETEG00000004641	SLBP	99	79.079	Echinops_telfairi
ENSG00000163950	SLBP	81	90.104	ENSEASG00005022714	SLBP	100	90.104	Equus_asinus_asinus
ENSG00000163950	SLBP	83	86.996	ENSECAG00000011689	SLBP	73	86.996	Equus_caballus
ENSG00000163950	SLBP	89	53.363	ENSELUG00000012854	slbp	97	50.730	Esox_lucius
ENSG00000163950	SLBP	100	90.678	ENSFCAG00000000169	SLBP	100	90.678	Felis_catus
ENSG00000163950	SLBP	100	67.616	ENSFALG00000010003	-	100	67.616	Ficedula_albicollis
ENSG00000163950	SLBP	61	56.338	ENSFALG00000009994	-	62	59.091	Ficedula_albicollis
ENSG00000163950	SLBP	92	89.401	ENSFDAG00000007592	SLBP	99	88.189	Fukomys_damarensis
ENSG00000163950	SLBP	87	50.189	ENSFHEG00000007497	slbp	96	48.462	Fundulus_heteroclitus
ENSG00000163950	SLBP	63	72.667	ENSGMOG00000015352	slbp	96	72.667	Gadus_morhua
ENSG00000163950	SLBP	100	65.836	ENSGALG00000015712	SLBP	100	67.972	Gallus_gallus
ENSG00000163950	SLBP	81	54.673	ENSGAFG00000019577	slbp	89	52.459	Gambusia_affinis
ENSG00000163950	SLBP	84	54.950	ENSGACG00000019596	slbp	98	50.000	Gasterosteus_aculeatus
ENSG00000163950	SLBP	86	64.082	ENSGAGG00000012096	SLBP	98	66.531	Gopherus_agassizii
ENSG00000163950	SLBP	100	100.000	ENSGGOG00000003167	SLBP	100	100.000	Gorilla_gorilla
ENSG00000163950	SLBP	80	56.190	ENSHBUG00000003338	-	90	48.413	Haplochromis_burtoni
ENSG00000163950	SLBP	99	73.932	ENSHGLG00000008313	-	100	73.455	Heterocephalus_glaber_female
ENSG00000163950	SLBP	92	76.959	ENSHGLG00000010461	-	96	78.138	Heterocephalus_glaber_female
ENSG00000163950	SLBP	100	85.417	ENSHGLG00000005955	-	100	85.417	Heterocephalus_glaber_female
ENSG00000163950	SLBP	92	79.263	ENSHGLG00100014906	-	96	78.138	Heterocephalus_glaber_male
ENSG00000163950	SLBP	100	85.455	ENSHGLG00100014018	-	100	87.619	Heterocephalus_glaber_male
ENSG00000163950	SLBP	99	74.786	ENSHGLG00100010510	-	100	74.182	Heterocephalus_glaber_male
ENSG00000163950	SLBP	80	53.205	ENSHCOG00000013425	slbp	76	55.869	Hippocampus_comes
ENSG00000163950	SLBP	81	59.868	ENSIPUG00000016780	slbp	72	66.138	Ictalurus_punctatus
ENSG00000163950	SLBP	100	88.000	ENSSTOG00000003262	SLBP	100	88.000	Ictidomys_tridecemlineatus
ENSG00000163950	SLBP	100	83.088	ENSJJAG00000002394	-	100	85.455	Jaculus_jaculus
ENSG00000163950	SLBP	100	85.818	ENSJJAG00000020549	-	100	86.545	Jaculus_jaculus
ENSG00000163950	SLBP	81	54.419	ENSKMAG00000008187	slbp	89	51.587	Kryptolebias_marmoratus
ENSG00000163950	SLBP	87	54.626	ENSLBEG00000024709	slbp	93	48.302	Labrus_bergylta
ENSG00000163950	SLBP	90	60.465	ENSLACG00000014623	SLBP	91	56.078	Latimeria_chalumnae
ENSG00000163950	SLBP	88	57.014	ENSLOCG00000011027	slbp	89	53.358	Lepisosteus_oculatus
ENSG00000163950	SLBP	68	95.541	ENSLAFG00000012933	SLBP	100	80.658	Loxodonta_africana
ENSG00000163950	SLBP	96	99.537	ENSMFAG00000030130	SLBP	95	99.539	Macaca_fascicularis
ENSG00000163950	SLBP	96	99.078	ENSMMUG00000032303	SLBP	96	99.611	Macaca_mulatta
ENSG00000163950	SLBP	100	81.227	ENSMNEG00000008082	SLBP	100	81.227	Macaca_nemestrina
ENSG00000163950	SLBP	92	99.528	ENSMLEG00000024639	SLBP	92	94.737	Mandrillus_leucophaeus
ENSG00000163950	SLBP	88	47.805	ENSMAMG00000001046	-	87	48.077	Mastacembelus_armatus
ENSG00000163950	SLBP	80	56.190	ENSMZEG00005017261	-	90	48.413	Maylandia_zebra
ENSG00000163950	SLBP	91	72.811	ENSMGAG00000013085	SLBP	100	75.576	Meleagris_gallopavo
ENSG00000163950	SLBP	100	86.182	ENSMAUG00000009490	Slbp	100	86.909	Mesocricetus_auratus
ENSG00000163950	SLBP	100	95.238	ENSMICG00000014244	SLBP	100	95.238	Microcebus_murinus
ENSG00000163950	SLBP	100	85.091	ENSMOCG00000015826	Slbp	99	89.573	Microtus_ochrogaster
ENSG00000163950	SLBP	84	57.711	ENSMMOG00000010181	slbp	93	52.586	Mola_mola
ENSG00000163950	SLBP	92	82.488	ENSMODG00000004304	SLBP	100	78.927	Monodelphis_domestica
ENSG00000163950	SLBP	84	53.211	ENSMALG00000013883	-	66	50.195	Monopterus_albus
ENSG00000163950	SLBP	100	86.182	MGP_CAROLIEiJ_G0027117	Slbp	100	86.909	Mus_caroli
ENSG00000163950	SLBP	100	86.545	ENSMUSG00000004642	Slbp	100	87.273	Mus_musculus
ENSG00000163950	SLBP	100	86.545	MGP_PahariEiJ_G0016901	Slbp	100	87.273	Mus_pahari
ENSG00000163950	SLBP	100	86.545	MGP_SPRETEiJ_G0028113	Slbp	100	87.273	Mus_spretus
ENSG00000163950	SLBP	79	91.209	ENSMPUG00000011139	SLBP	97	90.000	Mustela_putorius_furo
ENSG00000163950	SLBP	96	78.509	ENSMLUG00000004425	SLBP	97	82.456	Myotis_lucifugus
ENSG00000163950	SLBP	100	84.364	ENSNGAG00000020799	Slbp	100	85.091	Nannospalax_galili
ENSG00000163950	SLBP	64	67.763	ENSNBRG00000006044	-	85	52.423	Neolamprologus_brichardi
ENSG00000163950	SLBP	100	100.000	ENSNLEG00000000048	SLBP	100	100.000	Nomascus_leucogenys
ENSG00000163950	SLBP	68	89.103	ENSMEUG00000002501	SLBP	100	85.955	Notamacropus_eugenii
ENSG00000163950	SLBP	100	84.000	ENSODEG00000012641	SLBP	100	84.000	Octodon_degus
ENSG00000163950	SLBP	81	56.872	ENSONIG00000017469	-	90	49.206	Oreochromis_niloticus
ENSG00000163950	SLBP	92	81.567	ENSOANG00000014243	SLBP	95	84.332	Ornithorhynchus_anatinus
ENSG00000163950	SLBP	82	54.808	ENSORLG00000024887	-	89	49.791	Oryzias_latipes
ENSG00000163950	SLBP	82	54.808	ENSORLG00020007798	slbp	89	49.372	Oryzias_latipes_hni
ENSG00000163950	SLBP	82	54.808	ENSORLG00015016656	slbp	89	49.372	Oryzias_latipes_hsok
ENSG00000163950	SLBP	82	55.238	ENSOMEG00000010818	slbp	94	49.808	Oryzias_melastigma
ENSG00000163950	SLBP	100	92.593	ENSOGAG00000009750	SLBP	100	92.593	Otolemur_garnettii
ENSG00000163950	SLBP	92	89.862	ENSOARG00000016090	SLBP	100	89.862	Ovis_aries
ENSG00000163950	SLBP	100	99.567	ENSPPAG00000033300	SLBP	100	99.567	Pan_paniscus
ENSG00000163950	SLBP	92	91.705	ENSPPRG00000016897	SLBP	100	88.000	Panthera_pardus
ENSG00000163950	SLBP	81	91.146	ENSPTIG00000015057	SLBP	100	91.146	Panthera_tigris_altaica
ENSG00000163950	SLBP	100	99.567	ENSPTRG00000015832	SLBP	100	99.567	Pan_troglodytes
ENSG00000163950	SLBP	100	99.134	ENSPANG00000004932	SLBP	100	99.134	Papio_anubis
ENSG00000163950	SLBP	89	53.604	ENSPKIG00000006183	slbp	94	49.270	Paramormyrops_kingsleyae
ENSG00000163950	SLBP	85	54.455	ENSPMGG00000017684	-	96	55.155	Periophthalmus_magnuspinnatus
ENSG00000163950	SLBP	100	86.182	ENSPEMG00000018369	Slbp	100	86.909	Peromyscus_maniculatus_bairdii
ENSG00000163950	SLBP	92	84.793	ENSPCIG00000013575	SLBP	86	73.559	Phascolarctos_cinereus
ENSG00000163950	SLBP	81	54.206	ENSPFOG00000000462	slbp	89	52.049	Poecilia_formosa
ENSG00000163950	SLBP	81	54.206	ENSPLAG00000008300	slbp	89	52.049	Poecilia_latipinna
ENSG00000163950	SLBP	81	54.206	ENSPMEG00000020807	slbp	89	52.049	Poecilia_mexicana
ENSG00000163950	SLBP	81	54.206	ENSPREG00000004561	slbp	89	52.049	Poecilia_reticulata
ENSG00000163950	SLBP	100	99.259	ENSPPYG00000014529	SLBP	100	99.259	Pongo_abelii
ENSG00000163950	SLBP	100	95.671	ENSPCOG00000017399	SLBP	100	95.671	Propithecus_coquereli
ENSG00000163950	SLBP	100	79.636	ENSPVAG00000002807	SLBP	100	79.636	Pteropus_vampyrus
ENSG00000163950	SLBP	80	56.190	ENSPNYG00000005451	-	90	48.413	Pundamilia_nyererei
ENSG00000163950	SLBP	81	61.000	ENSPNAG00000018503	slbp	89	57.983	Pygocentrus_nattereri
ENSG00000163950	SLBP	100	86.182	ENSRNOG00000037162	Slbp	100	86.909	Rattus_norvegicus
ENSG00000163950	SLBP	100	99.259	ENSRBIG00000039159	SLBP	100	99.259	Rhinopithecus_bieti
ENSG00000163950	SLBP	96	99.535	ENSRROG00000030081	SLBP	100	99.535	Rhinopithecus_roxellana
ENSG00000163950	SLBP	81	96.791	ENSSBOG00000033897	SLBP	100	96.791	Saimiri_boliviensis_boliviensis
ENSG00000163950	SLBP	92	84.793	ENSSHAG00000013939	SLBP	100	73.064	Sarcophilus_harrisii
ENSG00000163950	SLBP	91	55.273	ENSSFOG00015019429	slbp	98	53.650	Scleropages_formosus
ENSG00000163950	SLBP	84	47.328	ENSSMAG00000016028	-	84	46.241	Scophthalmus_maximus
ENSG00000163950	SLBP	75	58.904	ENSSDUG00000000855	-	74	58.049	Seriola_dumerili
ENSG00000163950	SLBP	72	40.654	ENSSLDG00000007554	-	62	40.887	Seriola_lalandi_dorsalis
ENSG00000163950	SLBP	69	54.815	ENSSLDG00000022893	-	87	54.054	Seriola_lalandi_dorsalis
ENSG00000163950	SLBP	92	67.890	ENSSPUG00000016007	SLBP	96	66.406	Sphenodon_punctatus
ENSG00000163950	SLBP	81	57.143	ENSSPAG00000004021	slbp	88	52.400	Stegastes_partitus
ENSG00000163950	SLBP	100	81.818	ENSSSCG00000008676	SLBP	100	82.545	Sus_scrofa
ENSG00000163950	SLBP	91	71.296	ENSTGUG00000010626	-	100	68.199	Taeniopygia_guttata
ENSG00000163950	SLBP	92	50.000	ENSTRUG00000000688	slbp	97	48.148	Takifugu_rubripes
ENSG00000163950	SLBP	82	48.571	ENSTNIG00000000484	-	96	46.888	Tetraodon_nigroviridis
ENSG00000163950	SLBP	92	67.281	ENSTBEG00000004085	SLBP	99	66.798	Tupaia_belangeri
ENSG00000163950	SLBP	75	83.708	ENSTTRG00000004010	-	100	87.079	Tursiops_truncatus
ENSG00000163950	SLBP	91	90.278	ENSTTRG00000010901	-	100	90.278	Tursiops_truncatus
ENSG00000163950	SLBP	100	86.643	ENSUAMG00000012990	SLBP	100	86.643	Ursus_americanus
ENSG00000163950	SLBP	81	91.667	ENSUMAG00000006119	SLBP	100	91.667	Ursus_maritimus
ENSG00000163950	SLBP	100	84.364	ENSVVUG00000015578	-	100	85.818	Vulpes_vulpes
ENSG00000163950	SLBP	96	56.180	ENSXETG00000003876	slbp	97	58.955	Xenopus_tropicalis
ENSG00000163950	SLBP	80	55.128	ENSXCOG00000008275	slbp	77	58.824	Xiphophorus_couchianus
ENSG00000163950	SLBP	81	54.206	ENSXMAG00000001331	-	88	52.049	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	16912046.	IDA	Function
GO:0005515	protein binding	15829567.16086026.18172165.23329046.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15829567.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	15829567.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	21873635.	IBA	Process
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	-	ISS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008334	histone mRNA metabolic process	-	TAS	Process
GO:0033260	nuclear DNA replication	19155325.	IMP	Process
GO:0044770	cell cycle phase transition	19155325.	IMP	Process
GO:0051028	mRNA transport	21873635.	IBA	Process
GO:0051028	mRNA transport	19155325.	IDA	Process
GO:0071204	histone pre-mRNA 3'end processing complex	21873635.	IBA	Component
GO:0071204	histone pre-mRNA 3'end processing complex	-	ISS	Component
GO:0071207	histone pre-mRNA stem-loop binding	21873635.	IBA	Function
GO:0071207	histone pre-mRNA stem-loop binding	-	ISS	Function
GO:0071208	histone pre-mRNA DCP binding	-	ISS	Function
GO:1990904	ribonucleoprotein complex	10825184.	TAS	Component