EuRBPDB

Description

Ensembl ID: ENSG00000164024 (Gene tree)
Gene ID: 23173
Gene Symbol: METAP1
Alias: KIAA0094|MetAP1A|MAP1A
Full Name: methionyl aminopeptidase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 67,194 bases
Position: chr4:98,995,620-99,062,813
Accession: 15789
RBP type: non-canonical RBP
Summary: (Methionyl Aminopeptidase 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Phototransduction. Gene Ontology (GO) annotations related to this gene include hydrolase activity and metalloexopeptidase activity. An important paralog of this gene is METAP1D.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000506548	METAP1-204	714	-	-	- (aa)	-	-
ENST00000510209	METAP1-208	559	-	-	- (aa)	-	-
ENST00000503247	METAP1-202	653	-	ENSP00000424462	44 (aa)	-	H0Y9L0
ENST00000625963	METAP1-212	147	-	ENSP00000485924	48 (aa)	-	D6RF24
ENST00000510133	METAP1-207	715	-	ENSP00000423071	170 (aa)	-	H0Y955
ENST00000507537	METAP1-205	718	-	ENSP00000427563	48 (aa)	-	D6RF24
ENST00000510107	METAP1-206	770	-	ENSP00000427187	38 (aa)	-	H0YAI3
ENST00000513097	METAP1-209	586	-	-	- (aa)	-	-
ENST00000296411	METAP1-201	2791	XM_011531777	ENSP00000296411	386 (aa)	XP_011530079	P53582
ENST00000514051	METAP1-211	1058	-	ENSP00000422689	116 (aa)	-	H0Y903
ENST00000506238	METAP1-203	553	-	ENSP00000426702	48 (aa)	-	D6RF24
ENST00000513199	METAP1-210	613	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164024	Triglycerides	1.34659463622752E-7	17903299

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164024	rs146788033	4	99019987	A	Alcohol use disorder (total score)	30336701	[NR] z score increase	10.48	EFO_0009458
ENSG00000164024	rs146788033	4	99019987	G	Alcohol use disorder (consumption score)	30336701	[0.032-0.048] unit decrease	0.04	EFO_0007878
ENSG00000164024	rs146788033	4	99019987	G	Alcohol use disorder (dependence and problematic use scores)	30336701	[NR] unit decrease	0.04	EFO_0007835

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000164024	METAP1	99	62.304	FBgn0039219	CG13630	99	62.304	Drosophila_melanogaster
ENSG00000164024	METAP1	100	98.187	ENSMUSG00000005813	Metap1	100	98.187	Mus_musculus
ENSG00000164024	METAP1	94	52.342	YLR244C		90	52.342	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004177	aminopeptidase activity	16386852.	TAS	Function
GO:0005737	cytoplasm	14532271.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006417	regulation of translation	16386852.	TAS	Process
GO:0006508	proteolysis	-	IEA	Process
GO:0008235	metalloexopeptidase activity	16386852.	TAS	Function
GO:0018206	peptidyl-methionine modification	16386852.	TAS	Process
GO:0022400	regulation of rhodopsin mediated signaling pathway	-	TAS	Process
GO:0031365	N-terminal protein amino acid modification	16386852.	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0070006	metalloaminopeptidase activity	-	IEA	Function
GO:0070084	protein initiator methionine removal	-	IEA	Process
GO:0070527	platelet aggregation	23382103.	HMP	Process