EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000164062 (Gene tree)
Gene ID: 327
Gene Symbol: APEH
Alias: D3F15S2|DNF15S2|D3S48E
Full Name: acylaminoacyl-peptide hydrolase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 10,834 bases
Position: chr3:49,673,130-49,683,963
Accession: 586
RBP type: non-canonical RBP
Summary: This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000446089	APEH-204	855	-	ENSP00000410149	58 (aa)	-	F8WBC4
ENST00000491799	APEH-216	733	-	-	- (aa)	-	-
ENST00000442186	APEH-203	924	-	ENSP00000402365	308 (aa)	-	H7C1U0
ENST00000462439	APEH-209	829	-	-	- (aa)	-	-
ENST00000447541	APEH-206	708	-	ENSP00000404353	54 (aa)	-	H7C273
ENST00000449966	APEH-207	825	-	ENSP00000414369	232 (aa)	-	C9JLK2
ENST00000438011	APEH-202	2249	-	ENSP00000415862	737 (aa)	-	C9JIF9
ENST00000296456	APEH-201	3220	XM_005265097	ENSP00000296456	732 (aa)	XP_005265154	P13798
ENST00000482301	APEH-214	1041	-	-	- (aa)	-	-
ENST00000463616	APEH-210	699	-	-	- (aa)	-	-
ENST00000463995	APEH-211	1024	-	-	- (aa)	-	-
ENST00000483715	APEH-215	1055	-	-	- (aa)	-	-
ENST00000457042	APEH-208	853	-	ENSP00000410366	284 (aa)	-	H7C393
ENST00000480772	APEH-213	703	-	-	- (aa)	-	-
ENST00000469362	APEH-212	830	-	ENSP00000438180	47 (aa)	-	H0YFE5
ENST00000447436	APEH-205	963	-	ENSP00000401871	50 (aa)	-	F8WEH5

Gene Model

Click here to download ENSG00000164062's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164062	Colitis, Ulcerative	2E-17	21297633

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164062	rs9822268	3	49682296	A	Ulcerative colitis	21297633	[1.16-1.26]	1.21	EFO_0000729

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164062's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004252	serine-type endopeptidase activity	17241160.	IDA	Function
GO:0004252	serine-type endopeptidase activity	-	TAS	Function
GO:0005515	protein binding	16189514.25416956.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006415	translational termination	-	TAS	Process
GO:0006508	proteolysis	17241160.	IDA	Process
GO:0008242	omega peptidase activity	17241160.	IDA	Function
GO:0031965	nuclear membrane	-	IDA	Component
GO:0042802	identical protein binding	16189514.25416956.	IPI	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0050435	amyloid-beta metabolic process	17241160.	IDA	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21931648	Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review.	PLoS One	2011	Cleynen I	doi: 10.1371/journal.pone.0024106

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	49678913	Silent	NA	Q374Q	0.06
BLCA	chr3	49674378	5'UTR	novel		0.56
BLCA	chr3	49676178	Missense_Mutation	rs761116888	D189N	0.12
BLCA	chr3	49678868	Silent	novel	I359I	0.39
BLCA	chr3	49682706	Missense_Mutation	novel	S618F	0.13
BLCA	chr3	49682707	Silent	novel	S618S	0.13
BLCA	chr3	49683393	3'UTR	rs771898040		0.14
BLCA	chr3	49681218	Missense_Mutation	NA	E473Q	0.48
BLCA	chr3	49676375	Splice_Region	novel		0.14
BRCA	chr3	49675288	Missense_Mutation	novel	N84S	0.09
CESC	chr3	49681788	Missense_Mutation	novel	M502K	0.36
CESC	chr3	49683274	Missense_Mutation	novel	E711Q	0.41
CESC	chr3	49675253	Silent	rs761871519	D72D	0.45
CESC	chr3	49683955	3'UTR	novel		0.53
COAD	chr3	49681903	Silent	NA	S513S	0.26
COAD	chr3	49683238	Missense_Mutation	NA	L699F	0.42
COAD	chr3	49675756	Missense_Mutation	rs767157178	T112M	0.31
COAD	chr3	49681724	Missense_Mutation	NA	G481S	0.27
COAD	chr3	49676962	Missense_Mutation	rs147426925	R313C	0.33
COAD	chr3	49683350	3'UTR	novel		0.49
COAD	chr3	49681169	Silent	NA	E456E	0.36
COAD	chr3	49682846	Silent	rs374746175	C629C	0.41
COAD	chr3	49675253	Silent	rs761871519	D72D	0.16
COAD	chr3	49681886	Splice_Site	NA	X509_splice	0.31
COAD	chr3	49676133	Missense_Mutation	NA	E174K	0.11
COAD	chr3	49681886	Splice_Site	NA	X509_splice	0.12
COAD	chr3	49681892	Frame_Shift_Del	NA	*H511Ifs24**	0.24
COAD	chr3	49676694	Missense_Mutation	rs758011278	N277S	0.09
COAD	chr3	49676446	Silent	rs138376291	C225C	0.06
COAD	chr3	49675935	Silent	rs756326423	A137A	0.29
DLBC	chr3	49681109	Silent	novel	G436G	0.31
ESCA	chr3	49676175	Missense_Mutation	rs374901664	D188N	0.52
ESCA	chr3	49679596	Missense_Mutation	novel	L388V	0.27
ESCA	chr3	49676682	Missense_Mutation	novel	R273L	0.55
GBM	chr3	49676143	Missense_Mutation	novel	F177C	0.11
GBM	chr3	49680622	Missense_Mutation	novel	P431L	0.13
HNSC	chr3	49681892	Frame_Shift_Del	NA	*H511Ifs24**	0.2
HNSC	chr3	49678870	Missense_Mutation	novel	Y360F	0.18
KIRP	chr3	49683256	Missense_Mutation	NA	S705G	0.17
KIRP	chr3	49683951	3'UTR	novel		0.38
KIRP	chr3	49680586	Missense_Mutation	NA	L419P	0.26
LAML	chr3	49676620	Silent	novel	A252A	0.18
LGG	chr3	49683238	Missense_Mutation	novel	L699I	0.09
LIHC	chr3	49683052	Silent	NA	L667L	0.45
LIHC	chr3	49674391	5'UTR	novel		0.7
LIHC	chr3	49682604	Missense_Mutation	NA	M584T	0.18
LIHC	chr3	49681762	Silent	NA	S493S	0.13
LUAD	chr3	49683330	Missense_Mutation	NA	H729Q	0.18
LUSC	chr3	49676198	Silent	NA	K195K	0.63
LUSC	chr3	49682613	Missense_Mutation	NA	S587F	0.37
LUSC	chr3	49682559	Missense_Mutation	novel	Q569L	0.13
LUSC	chr3	49676182	Frame_Shift_Del	novel	*I191Pfs3**	0.1
MESO	chr3	49682855	Missense_Mutation	novel	E632D	0.09
OV	chr3	49682864	In_Frame_Ins	novel	F635_P636insTGPAW	0.18
OV	chr3	49676161	Missense_Mutation	NA	D183V	0.26
OV	chr3	49681228	Missense_Mutation	novel	N476T	0.14
OV	chr3	49681187	Missense_Mutation	novel	H462Q	0.18
PAAD	chr3	49676627	Missense_Mutation	novel	D255N	0.21
PAAD	chr3	49682402	Missense_Mutation	novel	G553D	0.15
PRAD	chr3	49675303	Frame_Shift_Del	NA	*E91Nfs3**	0.3
PRAD	chr3	49683083	Missense_Mutation	rs749450590	R677H	0.31
READ	chr3	49682586	Missense_Mutation	NA	A578V	0.17
READ	chr3	49682674	Silent	rs377618583	C607C	0.34
READ	chr3	49682578	Silent	NA	H575H	0.21
SARC	chr3	49680557	Missense_Mutation	novel	S409R	0.43
SARC	chr3	49676682	Missense_Mutation	novel	R273H	0.09
SKCM	chr3	49676921	Missense_Mutation	NA	S299F	0.35
SKCM	chr3	49676681	Missense_Mutation	rs571736407	R273C	0.44
SKCM	chr3	49682613	Missense_Mutation	NA	S587F	0.55
SKCM	chr3	49683386	3'UTR	rs533443649		0.27
SKCM	chr3	49683419	3'UTR	novel		0.32
SKCM	chr3	49682865	Missense_Mutation	NA	P636S	0.31
SKCM	chr3	49681172	Silent	NA	P457P	0.12
SKCM	chr3	49676938	Missense_Mutation	NA	P305S	0.32
SKCM	chr3	49676668	Silent	NA	F268F	0.35
SKCM	chr3	49675247	Silent	NA	F70F	0.17
SKCM	chr3	49675781	Silent	NA	F120F	0.32
SKCM	chr3	49683105	Missense_Mutation	novel	M684I	0.4
SKCM	chr3	49682925	Missense_Mutation	novel	P656S	0.11
SKCM	chr3	49682926	Missense_Mutation	novel	P656L	0.11
SKCM	chr3	49676053	Splice_Region	novel		0.34
STAD	chr3	49678945	Missense_Mutation	rs145125345	R385Q	0.21
STAD	chr3	49675303	Frame_Shift_Del	NA	*E91Nfs3**	0.17
STAD	chr3	49681886	Splice_Site	NA	X509_splice	0.36
STAD	chr3	49676162	Silent	rs769546586	D183D	0.22
STAD	chr3	49676994	Frame_Shift_Del	novel	*H325Ifs21**	0.34
STAD	chr3	49683387	3'UTR	rs745482805		0.47
STAD	chr3	49682640	Frame_Shift_Ins	novel	*I597Dfs28**	0.06
STAD	chr3	49676963	Missense_Mutation	NA	R313H	0.31
STAD	chr3	49681728	Missense_Mutation	NA	L482P	0.11
STAD	chr3	49681886	Splice_Site	NA	X509_splice	0.18
STAD	chr3	49683382	3'UTR	rs371397519		0.24
STAD	chr3	49677570	Splice_Region	novel		0.19
UCEC	chr3	49675221	Nonsense_Mutation	rs577640330	R62*	0.42
UCEC	chr3	49675262	Silent	novel	S75S	0.18
UCEC	chr3	49676160	Missense_Mutation	novel	D183N	0.24
UCEC	chr3	49682857	Missense_Mutation	novel	A633V	0.5
UCEC	chr3	49676656	Nonsense_Mutation	novel	W264*	0.47
UCEC	chr3	49680584	Silent	novel	D418D	0.44
UCEC	chr3	49682674	Silent	rs377618583	C607C	0.46
UCEC	chr3	49677015	Silent	NA	Q330Q	0.23
UCEC	chr3	49683131	Missense_Mutation	rs758684307	R693Q	0.05
UCEC	chr3	49681776	Missense_Mutation	NA	T498I	0.12
UCEC	chr3	49676506	Silent	novel	S245S	0.44
UCEC	chr3	49683405	3'UTR	novel		0.21
UCEC	chr3	49676613	Missense_Mutation	novel	F250C	0.37
UCEC	chr3	49676943	Silent	novel	R306R	0.22
UCEC	chr3	49681233	Nonsense_Mutation	novel	Q478*	0.37
UCEC	chr3	49680556	Missense_Mutation	novel	S409N	0.31
UCEC	chr3	49676090	Missense_Mutation	novel	E159D	0.29
UCEC	chr3	49675230	Missense_Mutation	rs772175127	R65C	0.5
UCEC	chr3	49681886	Splice_Site	NA	X509_splice	0.56
UCEC	chr3	49676805	Frame_Shift_Del	novel	*K291Sfs17**	0.33
UCEC	chr3	49675222	Missense_Mutation	novel	R62Q	0.23
UCEC	chr3	49675303	Frame_Shift_Del	NA	*E91Nfs3**	0.31
UCEC	chr3	49676677	Silent	novel	G271G	0.06
UCEC	chr3	49675906	Missense_Mutation	rs372455516	R128W	0.06
UCEC	chr3	49678853	Missense_Mutation	rs779678983	E354D	0.31
UCEC	chr3	49675221	Nonsense_Mutation	rs577640330	R62*	0.31
UCEC	chr3	49676963	Missense_Mutation	NA	R313H	0.19
UCEC	chr3	49681758	Missense_Mutation	novel	G492A	0.32
UCEC	chr3	49676121	Missense_Mutation	rs765493835	R170C	0.22
UCEC	chr3	49681886	Splice_Site	NA	X509_splice	0.38
UCEC	chr3	49682419	Missense_Mutation	novel	D559Y	0.37
UCEC	chr3	49675221	Nonsense_Mutation	rs577640330	R62*	0.4
UCEC	chr3	49682357	Missense_Mutation	rs774564457	R538H	0.39
UCEC	chr3	49676963	Missense_Mutation	NA	R313H	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2815	4.5968e-31
CHOL	DEL	0.8056	0.02241
DLBC	DEL	0.1667	0.016959
GBM	DEL	0.078	0.056565
LGG	DEL	0.078	0.00089193
LUAD	DEL	0.3391	0.0021265
PAAD	DEL	0.1848	0.030662
SARC	DEL	0.214	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	AMP	0.12	0.23596
TGCT	DEL	0.1867	0.08422
THYM	DEL	0.0813	0.037527

Survival Analysis

Cancer	P-value	Q-value
STAD	0.049	Kaplan-Meier Survival Analysis
MESO	0.038	Kaplan-Meier Survival Analysis
UCS	0.0047	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.036	Kaplan-Meier Survival Analysis
LAML	0.00029	Kaplan-Meier Survival Analysis
DLBC	0.019	Kaplan-Meier Survival Analysis
CHOL	0.027	Kaplan-Meier Survival Analysis
UVM	0.00053	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742