EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000164070 (Gene tree)
Gene ID: 22824
Gene Symbol: HSPA4L
Alias: APG-1|Osp94|HSPH3
Full Name: heat shock protein family A (Hsp70) member 4 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 58,913 bases
Position: chr4:127,781,821-127,840,733
Accession: 17041
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508776	HSPA4L-204	3020	-	ENSP00000422482	839 (aa)	-	O95757
ENST00000508549	HSPA4L-203	1822	XM_011531745	ENSP00000427305	531 (aa)	XP_011530047	D6RJ96
ENST00000296464	HSPA4L-201	10790	-	ENSP00000296464	839 (aa)	-	O95757
ENST00000515262	HSPA4L-205	648	-	-	- (aa)	-	-
ENST00000505726	HSPA4L-202	2639	-	ENSP00000425645	813 (aa)	-	E9PDE8

Gene Model

Click here to download ENSG00000164070's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164070	Cholesterol, LDL	5.15425798871414E-6	17903299
ENSG00000164070	Lipoproteins, VLDL	8.42420657511944E-5	17903299
ENSG00000164070	Thyrotropin	2.75307362773281E-6	17903292
ENSG00000164070	Osteoporosis	3.58303311491027E-6	17903295

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164070	rs187279821	4	127836228	A	Major depressive disorder	29317602	[0.24-0.6] unit decrease	0.42	EFO_0003761

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164070's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005524	ATP binding	-	ISS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	21231916.	IDA	Component
GO:0006457	protein folding	-	ISS	Process
GO:0006986	response to unfolded protein	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26486082	The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.	Oncotarget	2015 Nov 3	Wang S	doi: 10.18632/oncotarget.5651.
21946539	Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.	Nat Med	2011 Sep 25	Dorard C	doi: 10.1038/nm.2457.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr4	127832885	3'UTR	novel		0.84
BLCA	chr4	127794089	Silent	novel	S40S	0.22
BLCA	chr4	127811514	Missense_Mutation	novel	I486V	0.32
BLCA	chr4	127830777	Nonsense_Mutation	novel	S769*	0.23
BLCA	chr4	127801221	Missense_Mutation	NA	M171I	0.2
BLCA	chr4	127795767	Splice_Site	novel	X56_splice	0.5
BLCA	chr4	127782620	Nonsense_Mutation	novel	E24*	0.34
BLCA	chr4	127805102	Missense_Mutation	novel	E339Q	0.11
BLCA	chr4	127801842	Missense_Mutation	NA	R196T	0.58
BLCA	chr4	127782619	Silent	novel	I23I	0.16
BLCA	chr4	127830689	Missense_Mutation	NA	C740R	0.35
BLCA	chr4	127782635	Missense_Mutation	novel	E29K	0.25
BRCA	chr4	127830766	Silent	NA	V765V	0.36
BRCA	chr4	127803858	Missense_Mutation	rs759610355	S298F	0.29
BRCA	chr4	127805692	Silent	rs577260042	A381A	0.32
BRCA	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.17
BRCA	chr4	127833023	3'UTR	novel		0.06
BRCA	chr4	127832999	3'UTR	novel		0.17
BRCA	chr4	127833119	3'UTR	novel		0.07
CESC	chr4	127805100	Missense_Mutation	rs139697778	I338T	0.67
COAD	chr4	127827391	Silent	NA	L711L	0.35
COAD	chr4	127782636	Missense_Mutation	novel	E29G	0.28
COAD	chr4	127801147	Frame_Shift_Del	novel	*F148Lfs9**	0.25
COAD	chr4	127820470	Frame_Shift_Del	NA	*G575Efs18**	0.36
COAD	chr4	127795819	Nonsense_Mutation	novel	R73*	0.07
COAD	chr4	127794079	Missense_Mutation	rs766607334	A37V	0.24
COAD	chr4	127822859	Silent	rs755149556	L635L	0.36
COAD	chr4	127832701	Missense_Mutation	NA	N783Y	0.15
COAD	chr4	127832907	3'UTR	rs778119980		0.13
COAD	chr4	127808044	Silent	novel	V431V	0.32
COAD	chr4	127803741	Missense_Mutation	NA	N259S	0.24
COAD	chr4	127805158	Missense_Mutation	rs746127288	F357L	0.2
COAD	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.12
COAD	chr4	127827356	Missense_Mutation	NA	K700Q	0.35
COAD	chr4	127795775	Missense_Mutation	rs200226261	T58M	0.37
ESCA	chr4	127805168	Missense_Mutation	novel	D361H	0.44
GBM	chr4	127811573	Silent	rs367749617	G505G	0.55
GBM	chr4	127811536	Frame_Shift_Del	novel	*A493Vfs5**	0.09
GBM	chr4	127801868	Missense_Mutation	novel	H205Y	0.05
HNSC	chr4	127805110	Silent	novel	V341V	0.63
HNSC	chr4	127803747	Missense_Mutation	rs773358656	R261Q	0.24
HNSC	chr4	127820449	Missense_Mutation	novel	D566H	0.37
HNSC	chr4	127822787	Missense_Mutation	novel	D611Y	0.38
HNSC	chr4	127827338	Missense_Mutation	novel	E694Q	0.3
HNSC	chr4	127811542	Missense_Mutation	novel	A495V	0.24
HNSC	chr4	127832772	Missense_Mutation	novel	H806Q	0.16
KIRC	chr4	127804026	Silent	NA	Q308Q	0.32
KIRP	chr4	127805102	Frame_Shift_Del	novel	*I340Efs8**	0.21
LGG	chr4	127832736	Missense_Mutation	NA	E794D	0.19
LGG	chr4	127818407	Missense_Mutation	NA	G554E	0.39
LUAD	chr4	127798711	Splice_Site	novel	X143_splice	0.16
LUAD	chr4	127832780	Missense_Mutation	NA	P809Q	0.06
LUAD	chr4	127811621	Frame_Shift_Ins	novel	*N522Lfs5**	0.25
LUAD	chr4	127811623	Frame_Shift_Ins	novel	*K523Qfs3**	0.25
LUAD	chr4	127798682	Silent	novel	K134K	0.18
LUAD	chr4	127782533	5'UTR	novel		0.23
LUAD	chr4	127801793	Missense_Mutation	NA	A180S	0.44
LUAD	chr4	127830755	Nonsense_Mutation	novel	Q762*	0.26
LUAD	chr4	127820471	Missense_Mutation	novel	K573T	0.17
LUSC	chr4	127820527	Missense_Mutation	novel	L592V	0.29
LUSC	chr4	127803849	Missense_Mutation	NA	L295P	0.22
LUSC	chr4	127803815	Missense_Mutation	NA	L284F	0.34
LUSC	chr4	127804018	Frame_Shift_Del	novel	*E307Wfs8**	0.13
LUSC	chr4	127804088	Splice_Site	NA	X329_splice	0.21
LUSC	chr4	127811611	Missense_Mutation	novel	F518C	0.17
OV	chr4	127794090	Silent	NA	L41L	0.84
OV	chr4	127808073	Missense_Mutation	novel	E441A	0.06
OV	chr4	127830731	Missense_Mutation	rs756784442	A754S	0.27
OV	chr4	127794127	Missense_Mutation	novel	K53R	0.37
PAAD	chr4	127794088	Missense_Mutation	novel	S40L	0.16
PRAD	chr4	127805123	Nonsense_Mutation	NA	R346*	0.29
PRAD	chr4	127811540	Silent	NA	S494S	0.36
PRAD	chr4	127827316	Silent	novel	Q686Q	0.34
READ	chr4	127798661	Missense_Mutation	NA	E127D	0.2
READ	chr4	127795878	Missense_Mutation	NA	Q92H	0.36
READ	chr4	127782591	Missense_Mutation	novel	Y14C	0.39
READ	chr4	127798670	Silent	novel	E130E	0.39
READ	chr4	127833012	3'UTR	novel		0.37
READ	chr4	127805144	Missense_Mutation	NA	Q353K	0.18
SARC	chr4	127832981	3'UTR	novel		0.53
SKCM	chr4	127811612	Silent	NA	F518F	0.38
SKCM	chr4	127822796	Missense_Mutation	novel	E614K	0.16
SKCM	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.31
SKCM	chr4	127801154	Missense_Mutation	NA	T149I	0.3
SKCM	chr4	127823574	Missense_Mutation	rs376346224	G666R	0.4
SKCM	chr4	127823575	Missense_Mutation	novel	G666E	0.39
SKCM	chr4	127811548	Frame_Shift_Ins	novel	*I498Nfs5**	0.07
SKCM	chr4	127811568	Missense_Mutation	NA	E504K	0.15
SKCM	chr4	127830739	Missense_Mutation	novel	N756K	0.15
SKCM	chr4	127801147	Frame_Shift_Del	novel	*F148Lfs9**	0.33
SKCM	chr4	127795887	Silent	NA	P95P	0.62
SKCM	chr4	127804038	Silent	NA	S312S	0.21
SKCM	chr4	127803651	Missense_Mutation	novel	P229L	0.06
SKCM	chr4	127795831	Missense_Mutation	NA	D77N	0.4
SKCM	chr4	127794115	Missense_Mutation	NA	G49E	0.45
SKCM	chr4	127811516	Silent	NA	I486I	0.33
SKCM	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.65
SKCM	chr4	127830653	Missense_Mutation	NA	H728Y	0.37
SKCM	chr4	127805787	Missense_Mutation	NA	G413E	0.5
STAD	chr4	127805691	Missense_Mutation	rs768194196	A381V	0.13
STAD	chr4	127820470	Frame_Shift_Del	NA	*G575Efs18**	0.29
STAD	chr4	127805691	Missense_Mutation	rs768194196	A381V	0.28
STAD	chr4	127803795	Missense_Mutation	NA	M277T	0.22
STAD	chr4	127801795	Silent	rs769513282	A180A	0.22
STAD	chr4	127804015	Missense_Mutation	NA	Q305E	0.36
STAD	chr4	127795779	Silent	rs75776460	N59N	0.14
STAD	chr4	127804068	Silent	NA	K322K	0.32
STAD	chr4	127818398	Missense_Mutation	NA	D551G	0.32
STAD	chr4	127801795	Silent	rs769513282	A180A	0.25
STAD	chr4	127830642	Frame_Shift_Del	novel	*R725Dfs21**	0.38
STAD	chr4	127827335	Missense_Mutation	NA	M693V	0.09
STAD	chr4	127832887	3'UTR	novel		0.14
STAD	chr4	127801916	Missense_Mutation	novel	K221Q	0.3
STAD	chr4	127830796	Silent	NA	S775S	0.22
STAD	chr4	127811462	Silent	NA	F468F	0.37
STAD	chr4	127832800	Missense_Mutation	NA	T816A	0.21
STAD	chr4	127805207	Missense_Mutation	NA	R374G	0.13
STAD	chr4	127818420	Missense_Mutation	NA	K558N	0.08
THCA	chr4	127832898	3'UTR	novel		0.07
UCEC	chr4	127801794	Missense_Mutation	rs137878800	A180V	0.27
UCEC	chr4	127832682	Splice_Site	NA	X777_splice	0.18
UCEC	chr4	127782569	Missense_Mutation	NA	D7Y	0.27
UCEC	chr4	127805158	Missense_Mutation	rs746127288	F357L	0.16
UCEC	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.32
UCEC	chr4	127805198	Missense_Mutation	novel	A371T	0.45
UCEC	chr4	127832920	3'UTR	rs754005316		0.38
UCEC	chr4	127803746	Missense_Mutation	NA	R261W	0.4
UCEC	chr4	127827310	Silent	rs61748160	Y684Y	0.44
UCEC	chr4	127832896	3'UTR	novel		0.38
UCEC	chr4	127832882	3'UTR	novel		0.39
UCEC	chr4	127805793	Missense_Mutation	novel	G415E	0.11
UCEC	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.4
UCEC	chr4	127832697	Missense_Mutation	NA	F781L	0.37
UCEC	chr4	127832849	Missense_Mutation	NA	S832F	0.46
UCEC	chr4	127805146	Missense_Mutation	novel	Q353H	0.26
UCEC	chr4	127801794	Missense_Mutation	rs137878800	A180V	0.29
UCEC	chr4	127823622	Splice_Region	novel	K682delinsRDQ	0.05
UCEC	chr4	127801824	Missense_Mutation	NA	P190Q	0.16
UCEC	chr4	127833044	3'UTR	novel		0.36
UCEC	chr4	127818358	Nonsense_Mutation	novel	Q538*	0.23
UCEC	chr4	127805795	Splice_Site	novel	X415_splice	0.08
UCEC	chr4	127782565	Silent	rs111543768	G5G	0.31
UCEC	chr4	127832944	3'UTR	novel		0.38
UCEC	chr4	127782450	5'UTR	novel		0.19
UCEC	chr4	127795885	Missense_Mutation	novel	P95S	0.27
UCEC	chr4	127820470	Frame_Shift_Del	NA	*G575Efs18**	0.41
UCEC	chr4	127794105	Nonsense_Mutation	rs140639721	R46*	0.29
UCEC	chr4	127823626	Splice_Site	novel	X682_splice	0.38
UCEC	chr4	127805691	Missense_Mutation	rs768194196	A381V	0.38
UCEC	chr4	127805705	Missense_Mutation	NA	A386T	0.3
UCEC	chr4	127832697	Missense_Mutation	NA	F781L	0.45
UCEC	chr4	127782653	Missense_Mutation	NA	T35A	0.2
UCEC	chr4	127820470	Frame_Shift_Del	NA	*G575Efs18**	0.37
UCEC	chr4	127811540	Silent	NA	S494S	0.49
UCEC	chr4	127805124	Missense_Mutation	rs755578805	R346Q	0.34
UCEC	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.18
UCEC	chr4	127801147	Frame_Shift_Del	novel	*F148Lfs9**	0.38
UCEC	chr4	127822864	Silent	novel	G636G	0.41
UCEC	chr4	127823563	Missense_Mutation	novel	L662R	0.38
UCEC	chr4	127832920	3'UTR	rs754005316		0.09
UCEC	chr4	127782615	Missense_Mutation	NA	G22D	0.44
UCEC	chr4	127801859	Missense_Mutation	novel	D202N	0.41
UCEC	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.59
UCEC	chr4	127808034	Missense_Mutation	NA	F428C	0.21
UCEC	chr4	127832697	Missense_Mutation	NA	F781L	0.23
UCEC	chr4	127804010	Splice_Site	novel	X303_splice	0.36
UCEC	chr4	127803768	Missense_Mutation	novel	Q268R	0.34
UCEC	chr4	127820470	Frame_Shift_Del	NA	*G575Efs18**	0.48
UCEC	chr4	127782422	5'UTR	novel		0.26
UCEC	chr4	127801817	Missense_Mutation	NA	L188I	0.38
UCEC	chr4	127803744	Missense_Mutation	NA	S260Y	0.09
UCEC	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.29
UCEC	chr4	127798685	Silent	novel	K135K	0.22
UCEC	chr4	127801229	Missense_Mutation	novel	T174N	0.23
UCEC	chr4	127808103	Missense_Mutation	rs760776765	E451G	0.25
UCEC	chr4	127811505	Missense_Mutation	rs141362649	R483C	0.41
UCEC	chr4	127832943	3'UTR	novel		0.48
UCEC	chr4	127798590	Missense_Mutation	rs766704348	R104W	0.34
UCEC	chr4	127782518	5'UTR	novel		0.23
UCEC	chr4	127820436	Silent	novel	V561V	0.22
UCS	chr4	127820463	Missense_Mutation	novel	Q570H	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1222	2.13e-13
LUAD	DEL	0.2093	0.050802
MESO	DEL	0.3678	0.075661
PRAD	DEL	0.0772	0.0026708

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0025	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
LUSC	0.031	Kaplan-Meier Survival Analysis
PAAD	0.041	Kaplan-Meier Survival Analysis
BLCA	0.00064	Kaplan-Meier Survival Analysis
READ	0.022	Kaplan-Meier Survival Analysis
LAML	0.0051	Kaplan-Meier Survival Analysis
KICH	0.033	Kaplan-Meier Survival Analysis
LIHC	0.0022	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
UVM	0.0074	Kaplan-Meier Survival Analysis
OV	0.034	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742