EuRBPDB

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  • Basic Information
  • Cancer Related Information

  • Description
  • RBDs
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000164087 (Gene tree)
Gene ID
25886
Gene Symbol
POC1A
Alias
DKFZP434C245|WDR51A
Full Name
POC1 centriolar protein A
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
79,458 bases
Position
chr3:52,075,233-52,154,690
Accession
24488
RBP type
canonical RBP
Summary
POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome. [provided by RefSeq, Sep 2012]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000378421eIF2APF08662.113e-1011
ENSP00000296484eIF2APF08662.115.3e-1011
ENSP00000418968eIF2APF08662.117.8e-0911
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000296484POC1A-2011898XM_011533560ENSP00000296484407 (aa)XP_011531862Q8NBT0
ENST00000394970POC1A-2021999XM_011533561ENSP00000378421359 (aa)XP_011531863Q8NBT0
ENST00000474012POC1A-2031760XM_017006104ENSP00000418968369 (aa)XP_016861593Q8NBT0
Gene Model
Click here to download ENSG00000164087's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000164087rs77861329352081736GMacrophage inflammatory protein 1b levels27989323[0.091-0.18] SD units decrease0.1356EFO_0008219
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164087's network
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000164087POC1A9475.000ENSAPOG00000002677POC1A9875.000Acanthochromis_polyacanthus
ENSG00000164087POC1A10094.580ENSAMEG00000009136POC1A9894.763Ailuropoda_melanoleuca
ENSG00000164087POC1A9188.462ENSACIG00000018288poc1a7488.462Amphilophus_citrinellus
ENSG00000164087POC1A9475.000ENSAOCG00000001066POC1A9875.000Amphiprion_ocellaris
ENSG00000164087POC1A9779.599ENSAPEG00000005795poc1a9675.434Amphiprion_percula
ENSG00000164087POC1A9877.750ENSAPLG00000007756POC1A9977.750Anas_platyrhynchos
ENSG00000164087POC1A10096.206ENSANAG00000030897POC1A10096.069Aotus_nancymaae
ENSG00000164087POC1A9776.282ENSACLG00000017869POC1A9873.394Astatotilapia_calliptera
ENSG00000164087POC1A9672.012ENSAMXG00000024703poc1a9772.012Astyanax_mexicanus
ENSG00000164087POC1A10094.309ENSBTAG00000001471POC1A10094.309Bos_taurus
ENSG00000164087POC1A10096.657ENSCJAG00000005972POC1A10096.657Callithrix_jacchus
ENSG00000164087POC1A10087.715ENSCAFG00020022379POC1A10087.715Canis_lupus_dingo
ENSG00000164087POC1A10094.038ENSCHIG00000002571POC1A10093.366Capra_hircus
ENSG00000164087POC1A10095.822ENSTSYG00000008302POC1A10095.822Carlito_syrichta
ENSG00000164087POC1A9180.217ENSCAPG00000016201POC1A8980.217Cavia_aperea
ENSG00000164087POC1A10091.643ENSCPOG00000006740POC1A10091.643Cavia_porcellus
ENSG00000164087POC1A10097.052ENSCCAG00000023380POC1A10097.052Cebus_capucinus
ENSG00000164087POC1A10097.789ENSCATG00000021822POC1A10097.789Cercocebus_atys
ENSG00000164087POC1A9987.151ENSCLAG00000010593POC1A9987.151Chinchilla_lanigera
ENSG00000164087POC1A10098.103ENSCSAG00000013862POC1A10098.103Chlorocebus_sabaeus
ENSG00000164087POC1A7786.716ENSCPBG00000016728POC1A9886.716Chrysemys_picta_bellii
ENSG00000164087POC1A9965.217ENSCSAVG00000008477-9967.069Ciona_savignyi
ENSG00000164087POC1A9998.045ENSCANG00000033064POC1A9998.045Colobus_angolensis_palliatus
ENSG00000164087POC1A10091.643ENSCGRG00001007357Poc1a9991.643Cricetulus_griseus_chok1gshd
ENSG00000164087POC1A9867.036ENSCSEG00000010287POC1A9467.259Cynoglossus_semilaevis
ENSG00000164087POC1A9868.280ENSCVAG00000015594POC1A9778.041Cyprinodon_variegatus
ENSG00000164087POC1A7560.690ENSEBUG00000008246POC1A5560.690Eptatretus_burgeri
ENSG00000164087POC1A8270.946ENSEBUG00000002614POC1A9454.292Eptatretus_burgeri
ENSG00000164087POC1A9463.066ENSEBUG00000008013poc1a8363.066Eptatretus_burgeri
ENSG00000164087POC1A9868.132ENSELUG00000015504poc1a9768.262Esox_lucius
ENSG00000164087POC1A10095.265ENSFCAG00000015704POC1A10095.265Felis_catus
ENSG00000164087POC1A9974.201ENSFALG00000008922POC1A9974.201Ficedula_albicollis
ENSG00000164087POC1A9993.785ENSFDAG00000011606POC1A9993.785Fukomys_damarensis
ENSG00000164087POC1A9867.905ENSFHEG00000015504POC1A9678.041Fundulus_heteroclitus
ENSG00000164087POC1A9979.718ENSGALG00000034572-9979.718Gallus_gallus
ENSG00000164087POC1A9969.779ENSGACG00000007015poc1a9869.779Gasterosteus_aculeatus
ENSG00000164087POC1A9976.923ENSGAGG00000014637POC1A9976.923Gopherus_agassizii
ENSG00000164087POC1A10099.509ENSGGOG00000006652POC1A10099.509Gorilla_gorilla
ENSG00000164087POC1A10093.315ENSHGLG00000013436POC1A10093.315Heterocephalus_glaber_female
ENSG00000164087POC1A10092.141ENSHGLG00100003479POC1A10092.138Heterocephalus_glaber_male
ENSG00000164087POC1A9869.146ENSIPUG00000001227POC1A9675.490Ictalurus_punctatus
ENSG00000164087POC1A10093.593ENSSTOG00000002638POC1A10093.593Ictidomys_tridecemlineatus
ENSG00000164087POC1A10092.683ENSJJAG00000018739Poc1a9894.318Jaculus_jaculus
ENSG00000164087POC1A9672.136ENSLBEG00000016119POC1A9772.136Labrus_bergylta
ENSG00000164087POC1A10069.095ENSLACG00000018788POC1A8879.739Latimeria_chalumnae
ENSG00000164087POC1A9873.243ENSLOCG00000013801poc1a9673.134Lepisosteus_oculatus
ENSG00000164087POC1A9984.615ENSLAFG00000028434POC1A9988.000Loxodonta_africana
ENSG00000164087POC1A10097.561ENSMFAG00000001970POC1A10097.561Macaca_fascicularis
ENSG00000164087POC1A10097.789ENSMMUG00000012485POC1A10097.789Macaca_mulatta
ENSG00000164087POC1A10097.290ENSMNEG00000042811POC1A10097.290Macaca_nemestrina
ENSG00000164087POC1A10097.772ENSMLEG00000039574POC1A10097.772Mandrillus_leucophaeus
ENSG00000164087POC1A9476.596ENSMAMG00000014233POC1A9876.596Mastacembelus_armatus
ENSG00000164087POC1A9776.282ENSMZEG00005013503POC1A9873.394Maylandia_zebra
ENSG00000164087POC1A9882.051ENSMGAG00000001628POC1A9967.562Meleagris_gallopavo
ENSG00000164087POC1A10093.315ENSMAUG00000017403Poc1a9993.315Mesocricetus_auratus
ENSG00000164087POC1A10095.543ENSMICG00000002709POC1A10095.543Microcebus_murinus
ENSG00000164087POC1A9194.495ENSMOCG00000003396Poc1a10093.067Microtus_ochrogaster
ENSG00000164087POC1A9865.414ENSMMOG00000010427poc1a9465.414Mola_mola
ENSG00000164087POC1A8684.790ENSMODG00000011717POC1A9678.049Monodelphis_domestica
ENSG00000164087POC1A9872.853ENSMALG00000009054poc1a9572.853Monopterus_albus
ENSG00000164087POC1A10092.201MGP_CAROLIEiJ_G0032617Poc1a10092.201Mus_caroli
ENSG00000164087POC1A10091.922ENSMUSG00000023345Poc1a10091.922Mus_musculus
ENSG00000164087POC1A10091.643MGP_PahariEiJ_G0015485Poc1a10091.643Mus_pahari
ENSG00000164087POC1A10091.643MGP_SPRETEiJ_G0033763Poc1a10091.643Mus_spretus
ENSG00000164087POC1A10093.496ENSMPUG00000011723POC1A10093.366Mustela_putorius_furo
ENSG00000164087POC1A10092.683ENSMLUG00000015092POC1A9292.118Myotis_lucifugus
ENSG00000164087POC1A10094.038ENSNGAG00000005212Poc1a10093.366Nannospalax_galili
ENSG00000164087POC1A9965.104ENSNBRG00000022135poc1a9875.974Neolamprologus_brichardi
ENSG00000164087POC1A10098.886ENSNLEG00000007084POC1A10098.886Nomascus_leucogenys
ENSG00000164087POC1A91100.000ENSMEUG00000007715-79100.000Notamacropus_eugenii
ENSG00000164087POC1A10090.244ENSOPRG00000008831POC1A9190.323Ochotona_princeps
ENSG00000164087POC1A10091.644ENSODEG00000018290POC1A9991.811Octodon_degus
ENSG00000164087POC1A9775.000ENSONIG00000014378POC1A9872.171Oreochromis_niloticus
ENSG00000164087POC1A10092.683ENSOCUG00000002080POC1A10092.683Oryctolagus_cuniculus
ENSG00000164087POC1A9870.303ENSOMEG00000019834POC1A9870.303Oryzias_melastigma
ENSG00000164087POC1A10087.097ENSOGAG00000032245POC1A10087.073Otolemur_garnettii
ENSG00000164087POC1A10093.767ENSOARG00000006352POC1A10093.120Ovis_aries
ENSG00000164087POC1A100100.000ENSPPAG00000043583POC1A100100.000Pan_paniscus
ENSG00000164087POC1A10095.265ENSPPRG00000003365POC1A10095.265Panthera_pardus
ENSG00000164087POC1A10095.122ENSPTIG00000005388POC1A10095.122Panthera_tigris_altaica
ENSG00000164087POC1A100100.000ENSPTRG00000014989POC1A100100.000Pan_troglodytes
ENSG00000164087POC1A9181.538ENSPSIG00000014809POC1A9281.538Pelodiscus_sinensis
ENSG00000164087POC1A9969.003ENSPMGG00000005356poc1a9968.293Periophthalmus_magnuspinnatus
ENSG00000164087POC1A9193.578ENSPEMG00000024131Poc1a10093.578Peromyscus_maniculatus_bairdii
ENSG00000164087POC1A8776.250ENSPMAG00000000333poc1a9863.239Petromyzon_marinus
ENSG00000164087POC1A9979.178ENSPCIG00000018160POC1A9978.908Phascolarctos_cinereus
ENSG00000164087POC1A10099.017ENSPPYG00000013816POC1A10099.017Pongo_abelii
ENSG00000164087POC1A10089.435ENSPCAG00000002118POC1A10089.435Procavia_capensis
ENSG00000164087POC1A10096.100ENSPCOG00000012625POC1A10096.100Propithecus_coquereli
ENSG00000164087POC1A10072.973ENSPVAG00000012480POC1A10072.973Pteropus_vampyrus
ENSG00000164087POC1A9970.270ENSPNYG00000019517poc1a9870.823Pundamilia_nyererei
ENSG00000164087POC1A9970.229ENSPNAG00000007556POC1A9780.906Pygocentrus_nattereri
ENSG00000164087POC1A10087.027ENSRNOG00000037295Poc1a10087.027Rattus_norvegicus
ENSG00000164087POC1A10098.050ENSRBIG00000031748POC1A10098.050Rhinopithecus_bieti
ENSG00000164087POC1A10098.050ENSRROG00000044472POC1A10098.050Rhinopithecus_roxellana
ENSG00000164087POC1A10097.019ENSSBOG00000027902POC1A10097.019Saimiri_boliviensis_boliviensis
ENSG00000164087POC1A9478.058ENSSMAG00000013505POC1A9674.688Scophthalmus_maximus
ENSG00000164087POC1A9674.688ENSSDUG00000016161POC1A9759.121Seriola_dumerili
ENSG00000164087POC1A9877.907ENSSLDG00000003828POC1A9676.949Seriola_lalandi_dorsalis
ENSG00000164087POC1A9780.645ENSSPUG00000008656POC1A9962.273Sphenodon_punctatus
ENSG00000164087POC1A9760.448ENSSPAG00000020330POC1A9360.448Stegastes_partitus
ENSG00000164087POC1A10094.038ENSSSCG00000011426POC1A10093.366Sus_scrofa
ENSG00000164087POC1A9973.098ENSTGUG00000006036POC1A9973.750Taeniopygia_guttata
ENSG00000164087POC1A9565.169ENSTRUG00000007900POC1A9665.169Takifugu_rubripes
ENSG00000164087POC1A9764.345ENSTNIG00000014818POC1A9756.660Tetraodon_nigroviridis
ENSG00000164087POC1A10090.418ENSTTRG00000016798POC1A10090.418Tursiops_truncatus
ENSG00000164087POC1A10093.767ENSUAMG00000020816POC1A9994.015Ursus_americanus
ENSG00000164087POC1A10093.767ENSUMAG00000021482POC1A10093.767Ursus_maritimus
ENSG00000164087POC1A8775.238ENSXETG00000010813poc1a9862.749Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000922spindle pole23015594.IDAComponent
GO:0003431growth plate cartilage chondrocyte development-IEAProcess
GO:0005515protein binding23015594.25036637.26638075.IPIFunction
GO:0005813centrosome21399614.IDAComponent
GO:0005814centriole20008567.23015594.IDAComponent
GO:0007052mitotic spindle organization-IEAProcess
GO:0007283spermatogenesis-IEAProcess
GO:0010825positive regulation of centrosome duplication-IEAProcess
GO:0036064ciliary basal body20008567.IDAComponent
GO:1905515non-motile cilium assembly-IEAProcess

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr352075902SilentnovelQ403Q0.65
BLCAchr352149876Missense_Mutationrs746676896S72L0.42
BLCAchr352149956SilentnovelV45V0.09
BLCAchr352149849Missense_MutationNAR81Q0.18
BLCAchr352138265Silentrs372379559P239P0.24
BLCAchr352145921Missense_MutationNAI202V0.34eIF2A
BLCAchr352075973Missense_MutationnovelL380V0.42
BRCAchr352075933Missense_MutationNAQ393P0.41
CESCchr352149311Silentrs150866318F118F0.28
CESCchr352147070Missense_MutationnovelV161M0.33eIF2A
CESCchr352147071Silentrs753301992I160I0.37
COADchr352122380Missense_MutationNAL327R0.39
COADchr352145879Missense_Mutationrs139462706V216M0.2eIF2A
COADchr352149901Missense_MutationNAV64I0.13
COADchr352125145Frame_Shift_Delrs770990008E284Sfs*120.2
COADchr352147025Missense_MutationNAS176C0.33eIF2A
COADchr352125173SilentNAA274A0.4
COADchr352145960Missense_MutationnovelF189V0.15eIF2A
COADchr352151069Missense_MutationNAG17D0.28
DLBCchr3521543835'UTRnovel0.2
GBMchr352147071Silentrs753301992I160I0.23
GBMchr352138243Missense_Mutationrs781292462A247T0.19
HNSCchr352075908SilentnovelI401I0.22
HNSCchr352151014Splice_SitenovelX35_splice0.26
HNSCchr352149311Silentrs150866318F118F0.36
KIRPchr352147024Missense_MutationNAS176I0.25eIF2A
LAMLchr352075908SilentnovelI401I0.28
LAMLchr352138288Missense_MutationNAV232M0.43
LGGchr352125148Missense_MutationNAG283R0.29
LGGchr3520758613'UTRnovel0.09
LGGchr3520758713'UTRnovel0.33
LIHCchr352149219Missense_MutationnovelR149L0.33eIF2A
LIHCchr352145879Missense_Mutationrs139462706V216M0.26eIF2A
LUADchr352138208SilentNAL258L0.16
LUADchr352147085Missense_MutationnovelD156Y0.13eIF2A
LUADchr352151093Missense_MutationNAP9L0.11
LUADchr352096571Missense_MutationNAQ375E0.51
LUADchr352149970Missense_MutationNAS41A0.7
LUSCchr352122453Missense_MutationnovelD303H0.31
OVchr352145910Silentrs540200806A205A0.13
OVchr352147063Missense_MutationnovelA163G0.07eIF2A
PAADchr352122447Missense_MutationnovelV305I0.07
PAADchr352147038SilentnovelL171L0.15
PAADchr352151058Missense_MutationnovelA21S0.17
READchr3520758623'UTRrs7489404440.21
SKCMchr352096619SilentnovelL359L0.45
SKCMchr352096620SilentnovelT358T0.43
SKCMchr352096690Missense_MutationNAP335L0.28
SKCMchr3520757633'UTRnovel0.26
SKCMchr352149311Silentrs150866318F118F0.3
SKCMchr352151090Missense_Mutationrs745428642S10L0.31
SKCMchr352096698SilentNAF332F0.17
SKCMchr352151038SilentNAF27F0.23
SKCMchr352149338Silentrs778065985V109V0.2
STADchr352145880Silentrs374642866D215D0.31
STADchr352149310Missense_MutationNAV119M0.34eIF2A
STADchr352151088SilentnovelL11L0.07
STADchr352149933Missense_MutationNAR53H0.07
STADchr3520757033'UTRnovel0.32
STADchr352149348Missense_MutationNAV106A0.16
UCECchr352122461Missense_MutationnovelS300N0.21
UCECchr352138262SilentnovelS240S0.15
UCECchr352075923Missense_MutationNAE396D0.36
UCECchr352122459Missense_MutationnovelN301D0.52
UCECchr352147005Silentrs190747966S182S0.5
UCECchr352149264Missense_Mutationrs763745798R134H0.2eIF2A
UCECchr352122439SilentnovelH307H0.36
UCECchr352147027Missense_MutationnovelS175N0.33eIF2A
UCECchr3520757873'UTRnovel0.33
UCECchr3520756763'UTRnovel0.63
UCECchr352125143Silentrs767223133E284E0.36
UCECchr352147059SilentnovelS164S0.13
UCECchr352075979Missense_MutationNAS378A0.38
UCECchr3520758613'UTRnovel0.2
UCECchr352149939Missense_MutationnovelQ51R0.21
UCECchr352151153Intronnovel0.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.77780.016387
GBMDEL0.08320.056565
LGGDEL0.08190.00089193
LUADDEL0.32950.0021265
PAADDEL0.18480.030662
SARCDEL0.22180.0034746
SKCMDEL0.16620.13887
TGCTAMP0.14670.23596
THYMDEL0.08130.037527

Survival Analysis
CancerP-value Q-value
THYM0.0078

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.023

Kaplan-Meier Survival Analysis

SARC0.037

Kaplan-Meier Survival Analysis

MESO0.00012

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

SKCM0.0032

Kaplan-Meier Survival Analysis

KIRP0.00068

Kaplan-Meier Survival Analysis

COAD0.0021

Kaplan-Meier Survival Analysis

PAAD0.00074

Kaplan-Meier Survival Analysis

PCPG0.034

Kaplan-Meier Survival Analysis

BLCA0.045

Kaplan-Meier Survival Analysis

READ0.043

Kaplan-Meier Survival Analysis

KICH0.0041

Kaplan-Meier Survival Analysis

LIHC0.00014

Kaplan-Meier Survival Analysis

DLBC0.0056

Kaplan-Meier Survival Analysis

LUAD0.0014

Kaplan-Meier Survival Analysis

OV0.032

Kaplan-Meier Survival Analysis


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