EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000164111 (Gene tree)
Gene ID: 308
Gene Symbol: ANXA5
Alias: ENX2|ANX5
Full Name: annexin A5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 29,159 bases
Position: chr4:121,667,955-121,697,113
Accession: 543
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15090652	Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa.	Proc Natl Acad Sci U S A	2004 Apr 27	Rebello G	-
8778191	Species specificity for HBsAg binding protein endonexin II.	J Hepatol	1996 Mar	de Bruin WC	-
15827323	Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer.	Mol Cancer Ther	2005 Apr	Liao X	-
19762561	Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.	Am J Respir Crit Care Med	2009 Dec 1	Lee HS	doi: 10.1164/rccm.200905-0740OC
20798520	Effect of anandamide in Plasmodium Berghei-infected mice.	Cell Physiol Biochem	2010	Bobbala D	doi: 10.1159/000320559
25540384	Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection.	J Virol	2015 Mar	Baquero-Perez B	doi: 10.1128/JVI.03421-14

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000511552	ANXA5-206	1036	-	-	- (aa)	-	-
ENST00000501272	ANXA5-202	1363	-	ENSP00000424106	260 (aa)	-	D6RBL5
ENST00000513523	ANXA5-208	582	-	-	- (aa)	-	-
ENST00000506395	ANXA5-203	1606	-	ENSP00000421421	163 (aa)	-	E9PHT9
ENST00000509648	ANXA5-205	1083	-	-	- (aa)	-	-
ENST00000515017	ANXA5-210	1190	-	ENSP00000424199	220 (aa)	-	D6RBE9
ENST00000513728	ANXA5-209	447	-	ENSP00000427135	35 (aa)	-	D6RCN3
ENST00000515717	ANXA5-211	594	-	-	- (aa)	-	-
ENST00000509016	ANXA5-204	556	-	-	- (aa)	-	-
ENST00000296511	ANXA5-201	1762	-	ENSP00000296511	320 (aa)	-	P08758
ENST00000513428	ANXA5-207	868	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000164111's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164111	Arteries	7.0030000E-005	-
ENSG00000164111	Smoking	5E-7	21685187
ENSG00000164111	Pulmonary Disease, Chronic Obstructive	5E-7	21685187
ENSG00000164111	Diabetes Mellitus, Type 2	9E-6	17554300

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164111	rs55645543	4	121686023	C	Age at smoking initiation in chronic obstructive pulmonary disease	21685187	unit increase	0.228	EFO_0000341\|EFO_0005670

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164111's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0004859	phospholipase inhibitor activity	2967495.	TAS	Function
GO:0005388	calcium-transporting ATPase activity	21873635.	IBA	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005543	phospholipid binding	2967291.	TAS	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005544	calcium-dependent phospholipid binding	2138016.	IDA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007165	signal transduction	16130169.	TAS	Process
GO:0007596	blood coagulation	-	IEA	Process
GO:0008201	heparin binding	21873635.	IBA	Function
GO:0009897	external side of plasma membrane	-	IEA	Component
GO:0010033	response to organic substance	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	21873635.	IBA	Component
GO:0017046	peptide hormone binding	21873635.	IBA	Function
GO:0030195	negative regulation of blood coagulation	21873635.	IBA	Process
GO:0030971	receptor tyrosine kinase binding	21873635.	IBA	Function
GO:0043065	positive regulation of apoptotic process	21873635.	IBA	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043086	negative regulation of catalytic activity	-	IEA	Process
GO:0051260	protein homooligomerization	21873635.	IBA	Process
GO:0051283	negative regulation of sequestering of calcium ion	21873635.	IBA	Process
GO:0051592	response to calcium ion	21873635.	IBA	Process
GO:0060090	molecular adaptor activity	21873635.	IBA	Function
GO:0062023	collagen-containing extracellular matrix	28675934.	HDA	Component
GO:0062023	collagen-containing extracellular matrix	28327460.	HDA	Component
GO:0070062	extracellular exosome	19056867.20458337.21362503.23533145.	HDA	Component
GO:0070588	calcium ion transmembrane transport	-	IEA	Process
GO:0071284	cellular response to lead ion	21873635.	IBA	Process
GO:0072563	endothelial microparticle	-	IEA	Component
GO:0097066	response to thyroid hormone	21873635.	IBA	Process
GO:0097211	cellular response to gonadotropin-releasing hormone	21873635.	IBA	Process
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	-	IEA	Process
GO:1901317	regulation of flagellated sperm motility	21873635.	IBA	Process
GO:1902721	negative regulation of prolactin secretion	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29093625	Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance.	World J Gastroenterol	2017 Oct 21	Sun CB	doi: 10.3748/wjg.v23.i39.7168.
19461527	Expression of annexin a5 is associated with higher tumor stage and poor prognosis in colorectal adenocarcinomas.	J Clin Gastroenterol	2009 Oct	Xue G	doi: 10.1097/MCG.0b013e31819cc731.
25899647	Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer.	Pancreas	2015 Aug	Guillen KP	doi: 10.1097/MPA.0000000000000343.
25080795	[The annexin 5 in serums of pregnant women and patients with particular types of cancer].	Klin Lab Diagn	2014 Apr	Pogosian GG	-
18384219	Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma.	Arch Pathol Lab Med	2008 Apr	Chan CM	doi: 10.1043/1543-2165(2008)132[675:PCONCC]2.0.CO;2.
28497265	Proteomics analysis of pleomorphic adenoma of the human parotid gland.	Eur Arch Otorhinolaryngol	2017 Aug	Mutlu A	doi: 10.1007/s00405-017-4608-6
30197345	Comparative expression of caspases and annexin V in benign and malignant ovarian tumors.	J Cancer Res Ther	2018 Jul-Sep	Hassan HA	doi: 10.4103/0973-1482.187282.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr4	121686355	Silent	novel	V9V	0.14
BLCA	chr4	121686324	Missense_Mutation	rs374862609	D20N	0.11
BLCA	chr4	121669716	Silent	rs750613571	G263G	0.33
BLCA	chr4	121668497	Missense_Mutation	novel	L312V	0.42
BLCA	chr4	121668295	3'UTR	novel		0.6
BLCA	chr4	121677950	Missense_Mutation	novel	A159S	0.25
BLCA	chr4	121670006	Missense_Mutation	NA	S243C	0.14
BRCA	chr4	121672593	Frame_Shift_Ins	NA	*T189Dfs3**	0.13
BRCA	chr4	121668330	3'UTR	novel		0.36
BRCA	chr4	121686367	Silent	novel	L5L	0.43
BRCA	chr4	121668326	3'UTR	novel		0.19
BRCA	chr4	121669701	Silent	NA	T268T	0.14
CESC	chr4	121668383	3'UTR	novel		0.46
CESC	chr4	121684733	Nonsense_Mutation	rs759419433	R45*	0.3
COAD	chr4	121683389	Missense_Mutation	novel	A93V	0.05
COAD	chr4	121678438	Missense_Mutation	rs780076315	R151W	0.43
COAD	chr4	121684717	Missense_Mutation	novel	R50H	0.41
COAD	chr4	121668329	3'UTR	novel		0.49
COAD	chr4	121681738	Silent	novel	V109V	0.06
COAD	chr4	121668330	3'UTR	novel		0.2
COAD	chr4	121670000	Missense_Mutation	rs145513784	R245Q	0.38
ESCA	chr4	121672585	Missense_Mutation	novel	E191D	0.12
ESCA	chr4	121678485	Nonsense_Mutation	novel	S135*	0.26
GBM	chr4	121684732	Missense_Mutation	novel	R45Q	0.21
HNSC	chr4	121684745	Silent	novel	L41L	0.05
KIRC	chr4	121683406	Silent	NA	P87P	0.43
LGG	chr4	121681751	Missense_Mutation	novel	T105K	0.38
LIHC	chr4	121681726	Silent	novel	I113I	0.28
LUAD	chr4	121683420	Missense_Mutation	novel	A83S	0.07
LUAD	chr4	121677950	Missense_Mutation	novel	A159S	0.24
LUAD	chr4	121686309	Silent	NA	R25R	0.29
LUAD	chr4	121686350	Missense_Mutation	novel	D11V	0.21
LUAD	chr4	121668527	Missense_Mutation	NA	G302R	0.11
LUAD	chr4	121686303	Missense_Mutation	novel	A27S	0.37
LUAD	chr4	121684703	Missense_Mutation	NA	A55S	0.24
LUSC	chr4	121668349	3'UTR	novel		0.23
LUSC	chr4	121672576	Silent	novel	F194F	0.38
LUSC	chr4	121669983	Missense_Mutation	NA	L251F	0.3
LUSC	chr4	121669984	Silent	NA	Y250Y	0.29
LUSC	chr4	121696642	Intron	novel		0.91
LUSC	chr4	121672626	Missense_Mutation	novel	A178T	0.51
LUSC	chr4	121668523	Missense_Mutation	NA	D303V	0.81
OV	chr4	121668518	Missense_Mutation	NA	S305T	0.3
OV	chr4	121677899	Missense_Mutation	novel	A176T	0.03
OV	chr4	121671637	Missense_Mutation	NA	D211H	0.12
PAAD	chr4	121678385	Intron	novel		0.13
PCPG	chr4	121669692	Missense_Mutation	novel	R271S	0.33
PRAD	chr4	121678469	Silent	rs202083195	D140D	0.15
READ	chr4	121686309	Missense_Mutation	rs370872365	R25W	0.58
SARC	chr4	121672614	Missense_Mutation	novel	A182T	0.07
SKCM	chr4	121669681	Missense_Mutation	novel	S275F	0.6
SKCM	chr4	121686309	Missense_Mutation	rs370872365	R25W	0.43
SKCM	chr4	121672573	Silent	NA	I195I	0.2
SKCM	chr4	121668476	Missense_Mutation	NA	D319Y	0.37
SKCM	chr4	121683375	Missense_Mutation	novel	H98D	0.28
STAD	chr4	121671596	Silent	rs532847147	T224T	0.33
STAD	chr4	121683381	Missense_Mutation	novel	L96M	0.44
STAD	chr4	121681748	Missense_Mutation	NA	N106S	0.26
STAD	chr4	121677892	Splice_Site	NA	X177_splice	0.35
STAD	chr4	121686293	Missense_Mutation	NA	G30D	0.44
STAD	chr4	121668433	3'UTR	novel		0.19
UCEC	chr4	121678414	Splice_Site	novel	X158_splice	0.68
UCEC	chr4	121668374	3'UTR	novel		0.23
UCEC	chr4	121671625	Missense_Mutation	novel	T215A	0.44
UCEC	chr4	121669724	Nonsense_Mutation	NA	G261*	0.26
UCEC	chr4	121684766	Missense_Mutation	novel	D34Y	0.07
UCEC	chr4	121684732	Missense_Mutation	novel	R45Q	0.26
UCEC	chr4	121669635	Missense_Mutation	novel	K290N	0.27
UCEC	chr4	121683444	Missense_Mutation	novel	G75R	0.25
UCEC	chr4	121668397	3'UTR	novel		0.48
UCEC	chr4	121684732	Missense_Mutation	novel	R45Q	0.21
UCEC	chr4	121669651	Missense_Mutation	novel	R285M	0.05
UCEC	chr4	121696635	Intron	novel		0.17
UCEC	chr4	121683440	Missense_Mutation	NA	K76I	0.35
UCEC	chr4	121686362	Missense_Mutation	novel	G7V	0.12
UCEC	chr4	121683364	Missense_Mutation	novel	K101N	0.36
UCEC	chr4	121672608	Nonsense_Mutation	novel	E184*	0.33
UCEC	chr4	121686297	Missense_Mutation	novel	K29E	0.32
UCEC	chr4	121668329	3'UTR	novel		0.52
UCEC	chr4	121686318	Nonsense_Mutation	novel	E22*	0.52
UCEC	chr4	121681712	Missense_Mutation	NA	T118I	0.07
UCEC	chr4	121668360	3'UTR	novel		0.39
UCEC	chr4	121683440	Missense_Mutation	novel	K76T	0.25
UCEC	chr4	121669693	Missense_Mutation	novel	R271I	0.18
UCEC	chr4	121668467	3'UTR	rs753101907		0.2
UCEC	chr4	121696628	Splice_Region	novel		0.33
UCEC	chr4	121683456	Missense_Mutation	NA	S71P	0.32
UCEC	chr4	121671615	Missense_Mutation	rs759791586	G218E	0.29
UCEC	chr4	121684732	Missense_Mutation	novel	R45Q	0.4
UCEC	chr4	121678448	Silent	rs746976066	G147G	0.23
UCS	chr4	121669668	Missense_Mutation	novel	I279M	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1222	2.13e-13
LUAD	DEL	0.2074	0.050802
MESO	DEL	0.3678	0.075661
PRAD	DEL	0.065	0.0026708

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.037	Kaplan-Meier Survival Analysis
STAD	0.0001	Kaplan-Meier Survival Analysis
MESO	0.004	Kaplan-Meier Survival Analysis
HNSC	0.00087	Kaplan-Meier Survival Analysis
LUSC	0.0098	Kaplan-Meier Survival Analysis
ESCA	0.00089	Kaplan-Meier Survival Analysis
PAAD	0.048	Kaplan-Meier Survival Analysis
BLCA	0.00027	Kaplan-Meier Survival Analysis
CESC	0.0018	Kaplan-Meier Survival Analysis
LAML	0.0085	Kaplan-Meier Survival Analysis
UCEC	0.00089	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
THCA	0.018	Kaplan-Meier Survival Analysis
LUAD	0.039	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742