EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000164113 (Gene tree)
Gene ID: 132612
Gene Symbol: ADAD1
Alias: Tenr
Full Name: adenosine deaminase domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 50,850 bases
Position: chr4:122,378,966-122,429,815
Accession: 30713
RBP type: canonical RBP
Summary: (Adenosine Deaminase Domain Containing 1) is a Protein Coding gene. Diseases associated with ADAD1 include Celiac Disease 1. Gene Ontology (GO) annotations related to this gene include RNA binding and adenosine deaminase activity. An important paralog of this gene is ADARB2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000397254	dsrm	PF00035.26	8.2e-11	1	1
ENSP00000373376	dsrm	PF00035.26	8.5e-11	1	1
ENSP00000373377	dsrm	PF00035.26	8.6e-11	1	1
ENSP00000296513	dsrm	PF00035.26	8.9e-11	1	1
ENSP00000390510	dsrm	PF00035.26	1.2e-08	1	1
ENSP00000373377	A_deamin	PF02137.18	2.9e-89	1	1
ENSP00000296513	A_deamin	PF02137.18	3.1e-89	1	1
ENSP00000373376	A_deamin	PF02137.18	5.3e-79	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
7543294	Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse.	Biol Reprod	1995 Jun	Schumacher JM	-
15649457	Disruption of murine Tenr results in teratospermia and male infertility.	Dev Biol	2005 Feb 1	Connolly CM	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000439307	ADAD1-204	977	-	ENSP00000397254	241 (aa)	-	C9JAT9
ENST00000464160	ADAD1-206	539	-	-	- (aa)	-	-
ENST00000492454	ADAD1-207	772	-	-	- (aa)	-	-
ENST00000446706	ADAD1-205	627	-	ENSP00000390510	156 (aa)	-	C9JGM6
ENST00000296513	ADAD1-201	1961	XM_005262741	ENSP00000296513	576 (aa)	XP_005262798	Q96M93
ENST00000388725	ADAD1-203	1918	-	ENSP00000373377	558 (aa)	-	Q96M93
ENST00000388724	ADAD1-202	1912	XM_005262744	ENSP00000373376	565 (aa)	XP_005262801	Q96M93

Gene Model

Click here to download ENSG00000164113's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164113	Child Development Disorders, Pervasive	5.1359100E-005	-
ENSG00000164113	Colitis, Ulcerative	9E-7	21297633
ENSG00000164113	Autoantibodies	6E-6	21829393
ENSG00000164113	Diabetes Mellitus, Type 1	6E-6	21829393
ENSG00000164113	Hypersensitivity	6E-10	23817571
ENSG00000164113	Inflammatory Bowel Diseases	1E-7	28067908
ENSG00000164113	Crohn Disease	9E-7	28067908
ENSG00000164113	Diabetes Mellitus, Type 1	3E-6	17554300
ENSG00000164113	Hypersensitivity	4E-8	23817569

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000164113	rs17388568	4	122408207	A	Self-reported allergy	23817569	[0.047-0.099] unit increase	0.0727	EFO_0003785
ENSG00000164113	rs17388568	4	122408207	A	Type 1 diabetes	21829393	[NR]	1.1	EFO_0001359
ENSG00000164113	rs17388568	4	122408207	A	Type 1 diabetes	17554300	[1.11-1.42]	1.26	EFO_0001359
ENSG00000164113	rs17388568	4	122408207	A	Ulcerative colitis	21297633	[1.07-1.17]	1.12	EFO_0000729
ENSG00000164113	rs1904522	4	122415763	?	Eczema	30595370			HP_0000964

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164113's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000164113	ADAD1	86	32.186	ENSG00000140955	ADAD2	80	32.186

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000164113	ADAD1	91	50.000	ENSAPOG00000004214	adad1	94	50.000	Acanthochromis_polyacanthus
ENSG00000164113	ADAD1	100	91.234	ENSAMEG00000005920	ADAD1	99	90.815	Ailuropoda_melanoleuca
ENSG00000164113	ADAD1	99	45.819	ENSACIG00000019144	adad1	98	45.819	Amphilophus_citrinellus
ENSG00000164113	ADAD1	90	50.391	ENSAOCG00000012507	adad1	90	50.391	Amphiprion_ocellaris
ENSG00000164113	ADAD1	89	50.593	ENSAPEG00000000903	adad1	95	50.593	Amphiprion_percula
ENSG00000164113	ADAD1	99	47.917	ENSATEG00000006279	adad1	99	47.917	Anabas_testudineus
ENSG00000164113	ADAD1	99	61.101	ENSAPLG00000006694	ADAD1	99	60.585	Anas_platyrhynchos
ENSG00000164113	ADAD1	100	71.231	ENSACAG00000011970	ADAD1	99	71.235	Anolis_carolinensis
ENSG00000164113	ADAD1	100	93.728	ENSANAG00000034045	-	100	93.576	Aotus_nancymaae
ENSG00000164113	ADAD1	100	90.385	ENSANAG00000019704	-	98	87.560	Aotus_nancymaae
ENSG00000164113	ADAD1	59	44.681	ENSACLG00000013974	adad1	99	44.681	Astatotilapia_calliptera
ENSG00000164113	ADAD1	89	48.617	ENSACLG00000013906	adad1	96	48.617	Astatotilapia_calliptera
ENSG00000164113	ADAD1	100	50.355	ENSAMXG00000016301	adad1	98	50.524	Astyanax_mexicanus
ENSG00000164113	ADAD1	100	92.308	ENSBTAG00000046191	ADAD1	99	88.350	Bos_taurus
ENSG00000164113	ADAD1	100	94.803	ENSCJAG00000002796	ADAD1	100	94.792	Callithrix_jacchus
ENSG00000164113	ADAD1	100	92.665	ENSCAFG00000004013	ADAD1	100	92.201	Canis_familiaris
ENSG00000164113	ADAD1	100	92.665	ENSCAFG00020018271	ADAD1	90	92.201	Canis_lupus_dingo
ENSG00000164113	ADAD1	100	91.667	ENSCHIG00000026052	ADAD1	93	91.161	Capra_hircus
ENSG00000164113	ADAD1	100	88.929	ENSTSYG00000008859	ADAD1	100	88.927	Carlito_syrichta
ENSG00000164113	ADAD1	99	85.806	ENSCPOG00000014455	ADAD1	93	80.488	Cavia_porcellus
ENSG00000164113	ADAD1	100	96.057	ENSCCAG00000020664	ADAD1	100	95.833	Cebus_capucinus
ENSG00000164113	ADAD1	100	98.387	ENSCATG00000023127	ADAD1	100	98.387	Cercocebus_atys
ENSG00000164113	ADAD1	100	87.120	ENSCLAG00000004688	ADAD1	93	86.285	Chinchilla_lanigera
ENSG00000164113	ADAD1	100	98.077	ENSCSAG00000003673	ADAD1	100	97.917	Chlorocebus_sabaeus
ENSG00000164113	ADAD1	100	90.385	ENSCHOG00000000966	ADAD1	100	89.965	Choloepus_hoffmanni
ENSG00000164113	ADAD1	100	73.891	ENSCPBG00000024656	ADAD1	93	73.891	Chrysemys_picta_bellii
ENSG00000164113	ADAD1	100	97.917	ENSCANG00000036024	ADAD1	100	97.917	Colobus_angolensis_palliatus
ENSG00000164113	ADAD1	99	90.323	ENSCGRG00001010493	Adad1	93	88.889	Cricetulus_griseus_chok1gshd
ENSG00000164113	ADAD1	99	90.323	ENSCGRG00000008807	Adad1	95	88.889	Cricetulus_griseus_crigri
ENSG00000164113	ADAD1	88	48.089	ENSCSEG00000004516	adad1	89	48.089	Cynoglossus_semilaevis
ENSG00000164113	ADAD1	90	47.843	ENSCVAG00000022422	adad1	93	47.843	Cyprinodon_variegatus
ENSG00000164113	ADAD1	93	50.826	ENSDARG00000089181	adad1	97	50.826	Danio_rerio
ENSG00000164113	ADAD1	100	91.055	ENSDNOG00000014986	ADAD1	93	90.641	Dasypus_novemcinctus
ENSG00000164113	ADAD1	100	88.909	ENSDORG00000015684	Adad1	93	88.215	Dipodomys_ordii
ENSG00000164113	ADAD1	100	88.948	ENSETEG00000005199	ADAD1	100	88.601	Echinops_telfairi
ENSG00000164113	ADAD1	100	91.413	ENSEASG00005018202	ADAD1	96	90.988	Equus_asinus_asinus
ENSG00000164113	ADAD1	99	91.577	ENSECAG00000016639	ADAD1	99	90.972	Equus_caballus
ENSG00000164113	ADAD1	76	90.270	ENSEEUG00000010513	-	66	90.270	Erinaceus_europaeus
ENSG00000164113	ADAD1	99	48.270	ENSELUG00000022167	adad1	99	48.270	Esox_lucius
ENSG00000164113	ADAD1	100	90.698	ENSFCAG00000019180	ADAD1	100	90.295	Felis_catus
ENSG00000164113	ADAD1	99	55.403	ENSFALG00000008219	ADAD1	99	55.403	Ficedula_albicollis
ENSG00000164113	ADAD1	100	82.826	ENSFDAG00000010164	ADAD1	93	82.118	Fukomys_damarensis
ENSG00000164113	ADAD1	100	44.872	ENSFHEG00000020841	adad1	99	45.283	Fundulus_heteroclitus
ENSG00000164113	ADAD1	66	61.538	ENSGMOG00000002821	adad1	82	61.538	Gadus_morhua
ENSG00000164113	ADAD1	60	60.119	ENSGALG00000044995	-	89	60.119	Gallus_gallus
ENSG00000164113	ADAD1	99	45.641	ENSGAFG00000017716	adad1	99	45.641	Gambusia_affinis
ENSG00000164113	ADAD1	88	48.089	ENSGACG00000016712	adad1	100	48.089	Gasterosteus_aculeatus
ENSG00000164113	ADAD1	100	67.273	ENSGAGG00000013883	ADAD1	93	72.638	Gopherus_agassizii
ENSG00000164113	ADAD1	100	100.000	ENSGGOG00000004388	ADAD1	99	99.814	Gorilla_gorilla
ENSG00000164113	ADAD1	89	48.617	ENSHBUG00000020450	adad1	79	48.617	Haplochromis_burtoni
ENSG00000164113	ADAD1	100	83.184	ENSHGLG00000003874	ADAD1	95	83.187	Heterocephalus_glaber_female
ENSG00000164113	ADAD1	100	72.451	ENSHGLG00100000772	ADAD1	100	73.905	Heterocephalus_glaber_male
ENSG00000164113	ADAD1	88	46.000	ENSHCOG00000003944	adad1	96	46.000	Hippocampus_comes
ENSG00000164113	ADAD1	98	48.427	ENSIPUG00000007574	adad1	98	48.427	Ictalurus_punctatus
ENSG00000164113	ADAD1	100	89.088	ENSSTOG00000027523	ADAD1	94	88.542	Ictidomys_tridecemlineatus
ENSG00000164113	ADAD1	100	88.014	ENSJJAG00000022661	Adad1	93	87.500	Jaculus_jaculus
ENSG00000164113	ADAD1	99	45.217	ENSKMAG00000008195	adad1	99	45.217	Kryptolebias_marmoratus
ENSG00000164113	ADAD1	99	45.833	ENSLBEG00000001334	adad1	99	45.833	Labrus_bergylta
ENSG00000164113	ADAD1	100	66.667	ENSLACG00000004540	ADAD1	100	66.667	Latimeria_chalumnae
ENSG00000164113	ADAD1	99	49.310	ENSLOCG00000002873	adad1	99	49.310	Lepisosteus_oculatus
ENSG00000164113	ADAD1	100	91.026	ENSLAFG00000012345	ADAD1	99	90.155	Loxodonta_africana
ENSG00000164113	ADAD1	100	98.438	ENSMFAG00000003813	ADAD1	100	98.438	Macaca_fascicularis
ENSG00000164113	ADAD1	100	98.438	ENSMMUG00000004572	ADAD1	100	98.438	Macaca_mulatta
ENSG00000164113	ADAD1	100	98.438	ENSMNEG00000032586	ADAD1	100	98.438	Macaca_nemestrina
ENSG00000164113	ADAD1	100	98.387	ENSMLEG00000011428	ADAD1	100	98.387	Mandrillus_leucophaeus
ENSG00000164113	ADAD1	89	49.603	ENSMAMG00000015290	adad1	99	49.603	Mastacembelus_armatus
ENSG00000164113	ADAD1	89	48.814	ENSMZEG00005002920	adad1	90	48.814	Maylandia_zebra
ENSG00000164113	ADAD1	88	62.602	ENSMGAG00000010585	ADAD1	99	62.602	Meleagris_gallopavo
ENSG00000164113	ADAD1	100	89.088	ENSMAUG00000018314	Adad1	93	88.715	Mesocricetus_auratus
ENSG00000164113	ADAD1	100	91.577	ENSMICG00000015912	ADAD1	100	91.146	Microcebus_murinus
ENSG00000164113	ADAD1	100	88.372	ENSMOCG00000013223	Adad1	93	88.021	Microtus_ochrogaster
ENSG00000164113	ADAD1	89	48.119	ENSMMOG00000003761	adad1	96	48.337	Mola_mola
ENSG00000164113	ADAD1	100	85.536	ENSMODG00000018918	ADAD1	100	85.121	Monodelphis_domestica
ENSG00000164113	ADAD1	98	46.154	ENSMALG00000015338	adad1	96	46.154	Monopterus_albus
ENSG00000164113	ADAD1	100	89.445	MGP_CAROLIEiJ_G0024944	Adad1	100	89.234	Mus_caroli
ENSG00000164113	ADAD1	100	89.445	ENSMUSG00000027719	Adad1	100	89.234	Mus_musculus
ENSG00000164113	ADAD1	99	89.677	MGP_PahariEiJ_G0026384	Adad1	100	88.139	Mus_pahari
ENSG00000164113	ADAD1	99	90.323	MGP_SPRETEiJ_G0025878	-	83	89.922	Mus_spretus
ENSG00000164113	ADAD1	100	91.592	ENSMPUG00000017394	ADAD1	99	91.161	Mustela_putorius_furo
ENSG00000164113	ADAD1	100	89.172	ENSMLUG00000011788	ADAD1	93	87.197	Myotis_lucifugus
ENSG00000164113	ADAD1	100	87.120	ENSNGAG00000020288	Adad1	93	86.458	Nannospalax_galili
ENSG00000164113	ADAD1	89	48.134	ENSNBRG00000014156	adad1	97	48.723	Neolamprologus_brichardi
ENSG00000164113	ADAD1	100	98.264	ENSNLEG00000009415	ADAD1	100	98.264	Nomascus_leucogenys
ENSG00000164113	ADAD1	100	78.750	ENSMEUG00000009367	-	100	77.509	Notamacropus_eugenii
ENSG00000164113	ADAD1	100	85.256	ENSOPRG00000014155	ADAD1	85	93.182	Ochotona_princeps
ENSG00000164113	ADAD1	96	88.667	ENSODEG00000001197	ADAD1	92	83.363	Octodon_degus
ENSG00000164113	ADAD1	89	48.718	ENSONIG00000001405	adad1	99	48.718	Oreochromis_niloticus
ENSG00000164113	ADAD1	100	78.036	ENSOANG00000015125	ADAD1	99	77.951	Ornithorhynchus_anatinus
ENSG00000164113	ADAD1	100	91.771	ENSOCUG00000012989	ADAD1	100	91.161	Oryctolagus_cuniculus
ENSG00000164113	ADAD1	88	46.573	ENSORLG00015021839	adad1	90	46.573	Oryzias_latipes_hsok
ENSG00000164113	ADAD1	97	43.540	ENSOMEG00000003366	adad1	94	43.540	Oryzias_melastigma
ENSG00000164113	ADAD1	100	92.473	ENSOGAG00000008455	ADAD1	94	92.014	Otolemur_garnettii
ENSG00000164113	ADAD1	100	91.667	ENSOARG00000000116	ADAD1	93	91.319	Ovis_aries
ENSG00000164113	ADAD1	100	99.826	ENSPPAG00000028860	ADAD1	100	99.826	Pan_paniscus
ENSG00000164113	ADAD1	100	90.877	ENSPPRG00000008821	ADAD1	100	90.468	Panthera_pardus
ENSG00000164113	ADAD1	100	91.413	ENSPTIG00000008158	ADAD1	100	90.988	Panthera_tigris_altaica
ENSG00000164113	ADAD1	100	99.823	ENSPTRG00000016417	ADAD1	100	99.823	Pan_troglodytes
ENSG00000164113	ADAD1	100	96.795	ENSPANG00000005749	ADAD1	99	97.417	Papio_anubis
ENSG00000164113	ADAD1	89	51.440	ENSPKIG00000015129	adad1	89	52.224	Paramormyrops_kingsleyae
ENSG00000164113	ADAD1	100	73.801	ENSPSIG00000011531	ADAD1	100	73.801	Pelodiscus_sinensis
ENSG00000164113	ADAD1	90	45.367	ENSPMGG00000008284	adad1	85	45.367	Periophthalmus_magnuspinnatus
ENSG00000164113	ADAD1	100	89.624	ENSPEMG00000013728	Adad1	93	89.236	Peromyscus_maniculatus_bairdii
ENSG00000164113	ADAD1	100	80.255	ENSPCIG00000021928	-	89	82.584	Phascolarctos_cinereus
ENSG00000164113	ADAD1	100	82.321	ENSPCIG00000027949	-	100	83.333	Phascolarctos_cinereus
ENSG00000164113	ADAD1	99	45.812	ENSPFOG00000018333	adad1	99	45.812	Poecilia_formosa
ENSG00000164113	ADAD1	99	45.812	ENSPLAG00000014896	adad1	99	45.812	Poecilia_latipinna
ENSG00000164113	ADAD1	99	45.641	ENSPMEG00000013703	adad1	99	45.641	Poecilia_mexicana
ENSG00000164113	ADAD1	99	45.486	ENSPREG00000006635	adad1	96	49.102	Poecilia_reticulata
ENSG00000164113	ADAD1	100	87.674	ENSPPYG00000015042	ADAD1	100	87.674	Pongo_abelii
ENSG00000164113	ADAD1	100	87.179	ENSPCAG00000014466	ADAD1	85	88.636	Procavia_capensis
ENSG00000164113	ADAD1	100	90.385	ENSPCOG00000000862	ADAD1	100	90.000	Propithecus_coquereli
ENSG00000164113	ADAD1	100	89.103	ENSPVAG00000016465	ADAD1	100	83.333	Pteropus_vampyrus
ENSG00000164113	ADAD1	90	48.617	ENSPNYG00000001453	adad1	98	48.617	Pundamilia_nyererei
ENSG00000164113	ADAD1	100	50.000	ENSPNAG00000027389	adad1	100	50.000	Pygocentrus_nattereri
ENSG00000164113	ADAD1	99	89.677	ENSRNOG00000017246	Adad1	94	88.174	Rattus_norvegicus
ENSG00000164113	ADAD1	100	98.077	ENSRBIG00000027881	ADAD1	100	97.917	Rhinopithecus_bieti
ENSG00000164113	ADAD1	100	98.077	ENSRROG00000039189	ADAD1	100	97.917	Rhinopithecus_roxellana
ENSG00000164113	ADAD1	100	96.057	ENSSBOG00000027476	ADAD1	100	96.057	Saimiri_boliviensis_boliviensis
ENSG00000164113	ADAD1	100	85.536	ENSSHAG00000002892	-	99	85.294	Sarcophilus_harrisii
ENSG00000164113	ADAD1	100	82.166	ENSSHAG00000003938	-	97	81.356	Sarcophilus_harrisii
ENSG00000164113	ADAD1	96	47.756	ENSSFOG00015002386	adad1	98	47.756	Scleropages_formosus
ENSG00000164113	ADAD1	99	46.087	ENSSMAG00000008001	adad1	99	46.087	Scophthalmus_maximus
ENSG00000164113	ADAD1	99	46.287	ENSSDUG00000007569	adad1	99	46.459	Seriola_dumerili
ENSG00000164113	ADAD1	90	49.109	ENSSLDG00000021425	adad1	96	49.109	Seriola_lalandi_dorsalis
ENSG00000164113	ADAD1	82	81.538	ENSSARG00000000198	ADAD1	100	81.538	Sorex_araneus
ENSG00000164113	ADAD1	100	72.632	ENSSPUG00000009160	ADAD1	99	73.755	Sphenodon_punctatus
ENSG00000164113	ADAD1	89	47.750	ENSSPAG00000011210	adad1	93	46.718	Stegastes_partitus
ENSG00000164113	ADAD1	100	91.055	ENSSSCG00000009089	ADAD1	95	90.468	Sus_scrofa
ENSG00000164113	ADAD1	88	61.866	ENSTGUG00000001990	ADAD1	99	61.866	Taeniopygia_guttata
ENSG00000164113	ADAD1	89	46.016	ENSTRUG00000008514	adad1	94	46.016	Takifugu_rubripes
ENSG00000164113	ADAD1	88	46.400	ENSTNIG00000013059	adad1	99	46.400	Tetraodon_nigroviridis
ENSG00000164113	ADAD1	51	92.000	ENSTBEG00000003496	-	51	92.000	Tupaia_belangeri
ENSG00000164113	ADAD1	100	88.372	ENSTTRG00000010867	ADAD1	100	87.522	Tursiops_truncatus
ENSG00000164113	ADAD1	100	92.129	ENSUAMG00000022616	-	94	91.681	Ursus_americanus
ENSG00000164113	ADAD1	100	89.744	ENSUAMG00000003383	-	89	90.857	Ursus_americanus
ENSG00000164113	ADAD1	100	91.950	ENSUMAG00000004507	ADAD1	94	91.508	Ursus_maritimus
ENSG00000164113	ADAD1	100	90.385	ENSVPAG00000010532	ADAD1	100	88.562	Vicugna_pacos
ENSG00000164113	ADAD1	100	92.665	ENSVVUG00000013576	ADAD1	92	92.201	Vulpes_vulpes
ENSG00000164113	ADAD1	67	32.546	ENSXETG00000030929	-	82	32.546	Xenopus_tropicalis
ENSG00000164113	ADAD1	100	51.342	ENSXETG00000001593	adad1	100	54.360	Xenopus_tropicalis
ENSG00000164113	ADAD1	99	44.674	ENSXCOG00000015038	adad1	96	49.102	Xiphophorus_couchianus
ENSG00000164113	ADAD1	99	45.470	ENSXMAG00000001973	adad1	99	45.470	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003725	double-stranded RNA binding	21873635.	IBA	Function
GO:0003726	double-stranded RNA adenosine deaminase activity	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006382	adenosine to inosine editing	21873635.	IBA	Process
GO:0006396	RNA processing	21873635.	IBA	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007286	spermatid development	-	IEA	Process
GO:0008251	tRNA-specific adenosine deaminase activity	21873635.	IBA	Function