EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000164134 (Gene tree)
Gene ID: 80155
Gene Symbol: NAA15
Alias: TBDN100|NATH|FLJ13340|NARG1
Full Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 118,579 bases
Position: chr4:139,301,455-139,420,033
Accession: 30782
RBP type: non-canonical RBP
Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30559462	Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation.	Nat Struct Mol Biol	2019 Jan	Knorr AG	doi: 10.1038/s41594-018-0165-y

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000398947	NAA15-202	6072	XM_005263236	ENSP00000381920	865 (aa)	XP_005263293	A0A0B4J1W3
ENST00000496716	NAA15-207	677	-	-	- (aa)	-	-
ENST00000468029	NAA15-203	530	-	-	- (aa)	-	-
ENST00000515576	NAA15-208	2456	-	ENSP00000421839	98 (aa)	-	D6RAP7
ENST00000296543	NAA15-201	6222	-	ENSP00000296543	866 (aa)	-	Q9BXJ9
ENST00000480277	NAA15-204	852	-	-	- (aa)	-	-
ENST00000485905	NAA15-206	558	-	-	- (aa)	-	-
ENST00000482087	NAA15-205	550	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000164134's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164134	monocyte chemoattractant protein 1 (66-77)	2.5140000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164134's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000164134	NAA15	100	98.497	ENSMUSG00000063273	Naa15	100	100.000	Mus_musculus
ENSG00000164134	NAA15	80	31.048	YDL040C	NAT1	85	30.984	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001525	angiogenesis	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004596	peptide alpha-N-acetyltransferase activity	21873635.	IBA	Function
GO:0005515	protein binding	12145306.15496142.16507339.24407287.25489052.	IPI	Function
GO:0005634	nucleus	12140756.12145306.	IDA	Component
GO:0005667	transcription factor complex	12145306.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	12140756.15496142.19480662.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006474	N-terminal protein amino acid acetylation	15496142.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016407	acetyltransferase activity	15496142.	IDA	Function
GO:0017196	N-terminal peptidyl-methionine acetylation	21873635.	IBA	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0031415	NatA complex	21873635.	IBA	Component
GO:0031415	NatA complex	15496142.	IDA	Component
GO:0043022	ribosome binding	19480662.	IDA	Function
GO:0043022	ribosome binding	15496142.	IDA	Function
GO:0043066	negative regulation of apoptotic process	19480662.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	12145306.	IDA	Process
GO:0050821	protein stabilization	19480662.	IMP	Process