EuRBPDB

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  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000164362 (Gene tree)
Gene ID
7015
Gene Symbol
TERT
Alias
TRT|TP2|TCS1|hEST2|EST2
Full Name
telomerase reverse transcriptase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
41,923 bases
Position
chr5:1,253,147-1,295,069
Accession
11730
RBP type
canonical RBP
Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000309572RVT_1PF00078.276.4e-1211
ENSP00000334346Telomerase_RBDPF12009.83.9e-4111
ENSP00000309572Telomerase_RBDPF12009.84.5e-4111

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23236287Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.PLoS Genet2012Ding Ddoi: 10.1371/journal.pgen.1003065
9443919Reconstitution of human telomerase activity in vitro.Curr Biol1998 Jan 29Beattie TL-
15731105Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA.J Biol Chem2005 Apr 29O'Connor CM-
26365799Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532.Structure2015 Oct 6Bryan Cdoi: 10.1016/j.str.2015.08.006
11809815Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit.Mol Cell Biol2002 FebMoriarty TJ-
11581271 domain of telomerase reverse transcriptase.J Biol Chem2001 Dec 7Bosoy D-
11238925Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions.Mol Cell Biol2001 MarBachand F-
11158287RNA binding domain of telomerase reverse transcriptase.Mol Cell Biol2001 FebLai CK-
25216780Eimeria tenella: 14-3-3 protein interacts with telomerase.Parasitol Res2014 OctZhao Ndoi: 10.1007/s00436-014-4108-1
24055314A motif in the vertebrate telomerase N-terminal linker of TERT contributes to RNA binding and telomerase activity and processivity.Structure2013 Oct 8Harkisheimer Mdoi: 10.1016/j.str.2013.08.013
23760279A conserved motif in Tetrahymena thermophila telomerase reverse transcriptase is proximal to the RNA template and is essential for boundary definition.J Biol Chem2013 Jul 26Akiyama BMdoi: 10.1074/jbc.M113.452425
28990474Telomerase Reverse Transcriptase Gene from Greasyback Shrimp Metapenaeus ensis: Isolation, Genomic Organization and Expression Pattern Analysis.Zoolog Sci2017 OctLiang Cdoi: 10.2108/zs160130.
29880812HuR regulates telomerase activity through TERC methylation.Nat Commun2018 Jun 7Tang Hdoi: 10.1038/s41467-018-04617-7.
30951520A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.PLoS Biol2019 Apr 5Hernandez-Sanchez Wdoi: 10.1371/journal.pbio.3000204
27259814Short Telomere Length and Ischemic Heart Disease: Observational and Genetic Studies in 290 022 Individuals.Clin Chem2016 AugScheller Madrid Adoi: 10.1373/clinchem.2016.258566
10613354Telomere-related components are coordinately synthesized during human T-lymphocyte activation.Leuk Res1999 DecKosciolek BA-
12897134Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans.Mol Cell Biol2003 AugMason DX-
17322903Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein.Nature2007 Mar 22Stone MD-
20713447Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants.Mol Cell Biol2010 OctBerman AJdoi: 10.1128/MCB.00827-10
12594176TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability.FASEB J2003 AprZhang P-
12007281Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.Pathobiology2001Matsutani N-
11518036Infection of synoviocytes with HTLV-I induces telomerase activity.Rheumatol Int2001 JulTsumuki H-
15371596A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.Proc Natl Acad Sci U S A2004 Oct 12Lin J-
18500353Triple-helix structure in telomerase RNA contributes to catalysis.Nat Struct Mol Biol2008 JunQiao Fdoi: 10.1038/nsmb.1420
18358808Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.Cell2008 Mar 21Venteicher ASdoi: 10.1016/j.cell.2008.01.019.
18039659Structure and function of the smallest vertebrate telomerase RNA from teleost fish.J Biol Chem2008 Jan 25Xie M-
21264070Telomere biology in cardiovascular disease - role of insulin sensitivity in diabetic hearts.Exp Clin Cardiol2010 WinterMakino N-
20357774Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA.Nat Struct Mol Biol2010 AprMitchell Mdoi: 10.1038/nsmb.1777
26286192Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles.Nucleic Acids Res2015 Sep 30Lee JHdoi: 10.1093/nar/gkv844
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000334602TERT-2023210-ENSP000003343461069 (aa)-O14746
ENST00000460137TERT-2032992-ENSP00000425003795 (aa)-O14746
ENST00000310581TERT-2014018-ENSP000003095721132 (aa)-O14746
ENST00000484238TERT-2042422--- (aa)--
ENST00000522877TERT-206408--- (aa)--
ENST00000503656TERT-205406--- (aa)--
Gene Model
Click here to download ENSG00000164362's gene model file
Pathways
Pathway IDPathway NameSource
hsa05165Human papillomavirus infectionKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05225Hepatocellular carcinomaKEGG
hsa05226Gastric cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000164362Pancreatic Neoplasms1.046E-0622523087
ENSG00000164362Glioma4.2800000E-009-
ENSG00000164362Glioma2.1630000E-008-
ENSG00000164362Lung Neoplasms4.2400000E-027-
ENSG00000164362Adenocarcinoma of lung2.6750000E-025-
ENSG00000164362Lung Diseases, Interstitial7.5983770E-014-
ENSG00000164362Lung Diseases, Interstitial8.9298720E-007-
ENSG00000164362Erythrocyte Indices1E-828017375
ENSG00000164362Leukemia, Lymphocytic, Chronic, B-Cell6E-826956414
ENSG00000164362Lung Diseases, Interstitial2E-1923583980
ENSG00000164362Glioma4E-1419578367
ENSG00000164362Melanoma7E-1228212542
ENSG00000164362Pancreatic Carcinoma2E-827579533
ENSG00000164362Breast Neoplasms3E-1427117709
ENSG00000164362Glioma4E-2026424050
ENSG00000164362Breast Neoplasms3E-1427117709
ENSG00000164362Breast Neoplasms5E-1223535733
ENSG00000164362Adenocarcinoma of lung2E-3127501781
ENSG00000164362Triple Negative Breast Neoplasms1E-724325915
ENSG00000164362Lung Neoplasms1E-2721725308
ENSG00000164362Lung Neoplasms4E-2723143601
ENSG00000164362Pancreatic Carcinoma1E-1325086665
ENSG00000164362Erythrocyte Count3E-628017375
ENSG00000164362Glioma1E-1421531791
ENSG00000164362Prostatic Neoplasms3E-2421743467
ENSG00000164362Ovarian Neoplasms9E-925581431
ENSG00000164362Breast Neoplasms3E-827117709
ENSG00000164362Idiopathic Pulmonary Fibrosis3E-818835860
ENSG00000164362Adenocarcinoma of lung3E-1120871597
ENSG00000164362Breast Neoplasms2E-1028171663
ENSG00000164362Breast Neoplasms5E-628171663
ENSG00000164362Breast Neoplasms2E-627117709
ENSG00000164362Glioma1E-1524908248
ENSG00000164362Thyroid Neoplasms3E-728195142
ENSG00000164362Glioma8E-726424050
ENSG00000164362Erythrocyte Count2E-1128017375
ENSG00000164362Adenocarcinoma of lung2E-1027197191
ENSG00000164362Breast Neoplasms2E-1027197191
ENSG00000164362Carcinoma, Non-Small-Cell Lung2E-1027197191
ENSG00000164362Lung Neoplasms2E-1027197191
ENSG00000164362Ovarian Neoplasms2E-1027197191
ENSG00000164362Prostatic Neoplasms2E-1027197191
ENSG00000164362Colorectal Neoplasms2E-1027197191
ENSG00000164362Carcinoma, Endometrioid2E-1027197191
ENSG00000164362Testicular Neoplasms5E-2423666240
ENSG00000164362Telomere4E-624465473
ENSG00000164362Prostatic Neoplasms3E-1125939597
ENSG00000164362Adenocarcinoma of lung3E-4022797724
ENSG00000164362Breast Neoplasms1E-827117709
ENSG00000164362Adenocarcinoma of lung2E-1019836008
ENSG00000164362Breast Neoplasms7E-923535729
ENSG00000164362Glioma7E-921827660
ENSG00000164362Adenocarcinoma of lung1E-827393504
ENSG00000164362Leukemia, Lymphocytic, Chronic, B-Cell6E-1028165464
ENSG00000164362Lung Neoplasms3E-927393504
ENSG00000164362Breast Neoplasms1E-1022037553
ENSG00000164362Breast Neoplasms8E-2827117709
ENSG00000164362Glioma2E-1719578367
ENSG00000164362Glioma4E-922886559
ENSG00000164362Glioblastoma6E-2426424050
ENSG00000164362Testicular Neoplasms8E-1520543847
ENSG00000164362Erythrocyte Count3E-820139978
ENSG00000164362Adenocarcinoma of lung2E-2220700438
ENSG00000164362Testicular Neoplasms1E-2320543847
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000164362rs1006969051279675TBreast Cancer in BRCA1 mutation carriers29058716[1.14-1.23]1.18EFO_0000305
ENSG00000164362rs1006969051279675TBreast cancer (estrogen-receptor negative)29058716[1.15-1.21]1.18EFO_1000650
ENSG00000164362rs770552651285859ATelomere length29151059[0.051-0.129] unit increase0.09EFO_0004505
ENSG00000164362rs273610051286401AMean corpuscular hemoglobin27863252[0.036-0.05] unit increase0.04294034EFO_0004527
ENSG00000164362rs444958351284020TRed blood cell count27863252[0.032-0.047] unit increase0.03983159EFO_0004305
ENSG00000164362rs444958351284020TMean corpuscular volume27863252[0.04-0.055] unit decrease0.04728492EFO_0004526
ENSG00000164362rs285367751287079AMean corpuscular volume27863252[0.028-0.042] unit increase0.03507309EFO_0004526
ENSG00000164362rs1006969051279675CNon-glioblastoma glioma29743610[1.15-1.40]1.27EFO_0005543
ENSG00000164362rs1006969051279675TNon-glioblastoma glioma29743610[1.17-1.46]1.31EFO_0005543
ENSG00000164362rs1006969051279675TGlioblastoma29743610[1.52-1.78]1.64EFO_0005543
ENSG00000164362rs1006969051279675TGlioblastoma29743610[1.45-1.76]1.6EFO_0005543
ENSG00000164362rs1006969051279675TGlioma29743610[1.39-1.60]1.49EFO_0005543
ENSG00000164362rs1006969051279675TGlioma29743610[1.34-1.57]1.45EFO_0005543
ENSG00000164362rs273609851293971CPancreatic cancer29422604[1.14-1.27]1.1904762EFO_0002618
ENSG00000164362rs273609851293971CPancreatic cancer25086665[1.18-1.32]1.25EFO_0002618
ENSG00000164362rs273610051286401GRed blood cell count20139978[0.043-0.091] unit increase0.067EFO_0004305
ENSG00000164362rs273610051286401AMean corpuscular volume28017375[0.0016-0.004] unit increase0.0028EFO_0004526
ENSG00000164362rs273610051286401?Mean corpuscular volume28017375EFO_0004526
ENSG00000164362rs273610051286401?Mean corpuscular hemoglobin28017375EFO_0004527
ENSG00000164362rs1006969051279675TThyroid cancer281951421.12-1.291.2EFO_0002892
ENSG00000164362rs224265251279913?Breast cancer27117709[1.16-1.28] (BRCA1 carriers)1.22EFO_0000305
ENSG00000164362rs772615951282204?Breast cancer27117709[1.02-1.11] (BRCA1 carriers)1.07EFO_0000305
ENSG00000164362rs285367751287079CLung cancer27393504[1.1810-1.3911]1.2818EFO_0001071
ENSG00000164362rs772521851282299ACancer (pleiotropy)27197191EFO_0001071|EFO_1000650|EFO_0005842|EFO_1001515|EFO_0001663|EFO_1001516|EFO_0000305|EFO_0001075|EFO_0000571|EFO_0000708
ENSG00000164362rs285367751287079CLung adenocarcinoma27393504[1.23-1.53]1.37EFO_0000571
ENSG00000164362rs224265251279913?Breast cancer (estrogen-receptor negative)27117709[1.13-1.23]1.18EFO_1000650
ENSG00000164362rs772615951282204?Breast cancer (estrogen-receptor negative)27117709[1.05-1.13]1.09EFO_1000650
ENSG00000164362rs1006969051279675TBreast cancer (estrogen-receptor negative)28171663[1.20-1.41]1.3EFO_1000650
ENSG00000164362rs1006969051279675TBreast cancer28171663[1.07-1.19]1.13EFO_0000305
ENSG00000164362rs13999688051284538AChronic lymphocytic leukemia26956414[1.18-1.42]1.29EFO_0000095
ENSG00000164362rs1006969051279675TBreast cancer23535729[1.04-1.09]1.06EFO_0000305
ENSG00000164362rs273610051286401AInterstitial lung disease23583980[1.27-1.49]1.37EFO_0004244
ENSG00000164362rs273610051286401GEGFR mutation-positive lung adenocarcinoma27501781[1.34-1.50]1.42EFO_0000571
ENSG00000164362rs772521851282299GProstate cancer25939597[1.10-1.19]1.15EFO_0001663
ENSG00000164362rs1006969051279675TNon-glioblastoma glioma26424050[1.15-1.37]1.25EFO_0000326
ENSG00000164362rs1006969051279675TGlioma26424050[1.30-1.50]1.4EFO_0000326
ENSG00000164362rs7270945851283640TGlioblastoma26424050[1.52-1.86]1.68EFO_0000519
ENSG00000164362rs273610051286401GLung cancer23143601[1.30-1.47]1.38EFO_0001071
ENSG00000164362rs1006969051279675TBreast cancer23535733[1.11-1.20]1.15EFO_0000305
ENSG00000164362rs285367751287079CLung adenocarcinoma22797724[1.32-1.50]1.41EFO_0000571
ENSG00000164362rs273610051286401GGlioma22886559[1.19-1.41]1.3EFO_0000326
ENSG00000164362rs273610051286401CTelomere length24465473[NR] unit increase0.0808EFO_0004505
ENSG00000164362rs273610051286401GLung adenocarcinoma19836008[1.08-1.16]1.12EFO_0000571
ENSG00000164362rs273610051286401TTesticular germ cell cancer20543847[1.18-1.50]1.33EFO_0005088
ENSG00000164362rs273610051286401CGlioma (high-grade)24908248[1.28-1.50]1.39EFO_0000326
ENSG00000164362rs273610051286401GGlioma19578367[1.19-1.37]1.27EFO_0000326
ENSG00000164362rs285367651288432AGlioma19578367[1.20-1.32]1.26EFO_0000326
ENSG00000164362rs770552651285859ALung adenocarcinoma28604730[1.20564202-1.293603768]1.2488487EFO_0000571
ENSG00000164362rs770552651285859ALung cancer in never smokers28604730[1.139566941-1.322303439]1.2275395EFO_0006527|EFO_0001071
ENSG00000164362rs1006969051279675TBreast cancer25751625[1.04-1.09]1.06EFO_0000305
ENSG00000164362rs273609951287225AIntrinsic epigenetic age acceleration29374233[0.46-0.81] unit increase0.631GO_0007568
ENSG00000164362rs444958351284020?White blood cell count29403010[0.022-0.041] unit increase novel0.03137EFO_0004308
ENSG00000164362rs444958351284020?Neutrophil count29403010[0.029-0.056] unit increase novel0.04247EFO_0004833
ENSG00000164362rs444958351284020?Red blood cell count29403010[0.039-0.058] unit increase novel0.04855EFO_0004305
ENSG00000164362rs444958351284020?Mean corpuscular volume29403010[0.057-0.076] unit decrease novel0.06654EFO_0004526
ENSG00000164362rs444958351284020?Mean corpuscular hemoglobin29403010[0.05-0.069] unit decrease novel0.05941EFO_0004527
ENSG00000164362rs273610051286401?Platelet count29403010[0.036-0.053] unit decrease novel0.04449EFO_0004309
ENSG00000164362rs497553851280715?Non-albumin protein levels29403010[0.019-0.041] unit decrease novel0.03013EFO_0004568
ENSG00000164362rs770552651285859AMyeloid white cell count27863252[0.027-0.042] unit increase0.03473723EFO_0007988
ENSG00000164362rs773499251280013CNeutrophil percentage of white cells27863252[0.017-0.032] unit increase0.02457254EFO_0007990
ENSG00000164362rs770552651285859AWhite blood cell count27863252[0.026-0.041] unit increase0.03350265EFO_0004308
ENSG00000164362rs1006969051279675TGlioblastoma283464431.53-1.691.61EFO_0000326|EFO_0000519
ENSG00000164362rs1006969051279675TNon-glioblastoma glioma283464431.20-1.341.27EFO_0000326|EFO_0005543
ENSG00000164362rs770552651285859AChronic lymphocytic leukemia28165464[1.12-1.25]1.18EFO_0000095
ENSG00000164362rs770552651285859ANeutrophil count27863252[0.028-0.043] unit increase0.03545307EFO_0004833
ENSG00000164362rs770552651285859APlateletcrit27863252[0.046-0.061] unit increase0.05365946EFO_0007985
ENSG00000164362rs285367751287079APlateletcrit27863252[0.038-0.053] unit decrease0.04567411EFO_0007985
ENSG00000164362rs273610051286401APlatelet count27863252[0.026-0.041] unit decrease0.0335519EFO_0004309
ENSG00000164362rs13999688051284538AMelanoma28212542[1.18-1.34]1.26EFO_0000756
ENSG00000164362rs1006969051279675TEpithelial ovarian cancer28346442[1.04978354993499-1.11161732010102]1.0802581EFO_0001075
ENSG00000164362rs770552651285859AEpithelial ovarian cancer28346442[1.04796689850078-1.10621911687371]1.0766991EFO_0001075
ENSG00000164362rs224265251279913GProstate cancer21743467[1.11-1.19]1.15EFO_0001663
ENSG00000164362rs273610051286401?Glioma21827660EFO_0000326
ENSG00000164362rs1006969051279675TBreast cancer22037553[1.13-1.25]1.18EFO_0000305
ENSG00000164362rs273610051286401GLung adenocarcinoma20700438[1.35-1.57]1.46EFO_0000571
ENSG00000164362rs273610051286401CLung adenocarcinoma20871597[1.19-1.37]1.27EFO_0000571
ENSG00000164362rs273610051286401AIdiopathic pulmonary fibrosis18835860[1.61-2.78]2.11EFO_0000768
ENSG00000164362rs273610051286401?Glioma21531791[NR]1.25EFO_0000326
ENSG00000164362rs273610051286401CLung cancer21725308[1.22-1.33]1.27EFO_0001071
ENSG00000164362rs1006969051279675AEpithelial ovarian cancer25581431[1.10-1.19]1.14Orphanet_398934
ENSG00000164362rs770552651285859AGranulocyte count27863252[0.027-0.042] unit increase0.03445749EFO_0007987
ENSG00000164362rs1006969051279675TSerous invasive ovarian cancer28346442[1.09267833241685-1.16926591871766]1.1303236EFO_1001516
ENSG00000164362rs770552651285859ASerous invasive ovarian cancer28346442[1.07188995128973-1.14277166876843]1.1067635EFO_1001516
ENSG00000164362rs1006969051279675TSerous borderline ovarian cancer28346442[1.16419555293272-1.35214154339342]1.2546542EFO_1001516
ENSG00000164362rs770552651285859ASerous borderline ovarian cancer28346442[1.28830538018993-1.48465482476452]1.3829999EFO_1001516
ENSG00000164362rs1006969051279675THigh-grade serous ovarian cancer28346442[1.09226786405932-1.17112854934655]1.1310111EFO_1001516
ENSG00000164362rs770552651285859AHigh-grade serous ovarian cancer28346442[1.06380317084564-1.13629550714478]1.099452EFO_1001516
ENSG00000164362rs1006969051279675TInvasive epithelial ovarian cancer28346442[1.05501477967445-1.11910451351639]1.0865872EFO_0001075
ENSG00000164362rs770552651285859AInvasive epithelial ovarian cancer28346442[1.06151189081851-1.12208885346329]1.0913801EFO_0001075
ENSG00000164362rs1006969051279675TLow-grade serous and serous borderline ovarian cancer28346442[1.14168685260085-1.29313711208919]1.2150546EFO_1001516
ENSG00000164362rs770552651285859ALow-grade serous and serous borderline ovarian cancer28346442[1.24799798080348-1.40391301421926]1.3236618EFO_1001516
ENSG00000164362rs770552651285859ASum neutrophil eosinophil counts27863252[0.027-0.042] unit increase0.03464376EFO_0004833|EFO_0004842
ENSG00000164362rs1006969051279675TGlioma283464431.39-1.511.45EFO_0000326|EFO_0005543
ENSG00000164362rs770552651285859ASum basophil neutrophil counts27863252[0.028-0.043] unit increase0.03527305EFO_0004833|EFO_0005090
ENSG00000164362rs1006969051279675TUterine fibroids30194396[1.1-1.15]1.12EFO_0000731
ENSG00000164362rs770552651285859?Hypothyroidism30595370EFO_0004705
ENSG00000164362rs285367751287079GBenign prostatic hyperplasia and lower urinary tract symptoms30410027[1.09-1.15]1.12EFO_0008008|EFO_0000284
ENSG00000164362rs1006969051279675TGlioblastoma (age-stratified)30152087[1.57-1.89]1.72EFO_0004847|EFO_0000519
ENSG00000164362rs1006969051279675TGlioblastoma (age-stratified)30152087[1.38-1.66]1.51EFO_0004847|EFO_0000519
ENSG00000164362rs1006969051279675TGlioblastoma (age-stratified)30152087[1.62-1.95]1.78EFO_0004847|EFO_0000519
ENSG00000164362rs1006969051279675TSystolic blood pressure30224653[0.22-0.33] mmHg increase0.2735EFO_0006335
ENSG00000164362rs1006969051279675?Systolic blood pressure30595370EFO_0006335
ENSG00000164362rs770552651285859?White blood cell count30595370EFO_0004308
ENSG00000164362rs770552651285859?Red blood cell count30595370EFO_0004305
ENSG00000164362rs770552651285859?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000164362rs224265251279913GProstate cancer29892016[1.15-1.20]1.17EFO_0001663
ENSG00000164362rs1006969051279675TBreast cancer25751625[1.04-1.09]1.06EFO_0000305
ENSG00000164362rs1006969051279675TBreast cancer29059683[1.04-1.08] (Oncoarray)1.06EFO_0000305
ENSG00000164362rs285367751287079GBenign prostatic hyperplasia and lower urinary tract symptoms (prostate cancer excluded)30410027[1.09-1.14]1.12EFO_0008008|EFO_0000284
ENSG00000164362rs285367751287079GProstate-specific antigen levels30410027unit increase0.029EFO_0004624
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164362's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000164362TERT9936.317ENSAPOG00000020553tert9936.442Acanthochromis_polyacanthus
ENSG00000164362TERT9971.552ENSAMEG00000010578TERT9971.305Ailuropoda_melanoleuca
ENSG00000164362TERT9935.794ENSACIG00000017564tert9935.739Amphilophus_citrinellus
ENSG00000164362TERT9936.014ENSAOCG00000003358tert9935.813Amphiprion_ocellaris
ENSG00000164362TERT9936.087ENSAPEG00000001120tert9935.869Amphiprion_percula
ENSG00000164362TERT9936.733ENSATEG00000005094tert9936.554Anabas_testudineus
ENSG00000164362TERT9445.638ENSAPLG00000004975-10045.914Anas_platyrhynchos
ENSG00000164362TERT8651.222ENSACAG00000001261TERT7751.222Anolis_carolinensis
ENSG00000164362TERT9984.929ENSANAG00000032128TERT9989.024Aotus_nancymaae
ENSG00000164362TERT9936.411ENSACLG00000004349tert9935.708Astatotilapia_calliptera
ENSG00000164362TERT9431.830ENSAMXG00000042832tert9731.757Astyanax_mexicanus
ENSG00000164362TERT10069.895ENSBTAG00000012567TERT10069.983Bos_taurus
ENSG00000164362TERT9984.375ENSCJAG00000048026TERT10084.375Callithrix_jacchus
ENSG00000164362TERT10071.454ENSCAFG00000010739TERT9971.181Canis_familiaris
ENSG00000164362TERT10071.541ENSCAFG00020022919TERT10071.267Canis_lupus_dingo
ENSG00000164362TERT10069.843ENSCHIG00000008229TERT10069.755Capra_hircus
ENSG00000164362TERT9671.689ENSTSYG00000031585TERT9971.507Carlito_syrichta
ENSG00000164362TERT6171.532ENSCAPG00000011326-10071.532Cavia_aperea
ENSG00000164362TERT8976.562ENSCPOG00000015559TERT10062.347Cavia_porcellus
ENSG00000164362TERT10087.102ENSCCAG00000030949TERT10087.652Cebus_capucinus
ENSG00000164362TERT10090.439ENSCATG00000036594TERT10090.439Cercocebus_atys
ENSG00000164362TERT9559.178ENSCLAG00000006143TERT10059.361Chinchilla_lanigera
ENSG00000164362TERT10095.583ENSCSAG00000017381TERT10095.583Chlorocebus_sabaeus
ENSG00000164362TERT8753.499ENSCPBG00000015989TERT7953.499Chrysemys_picta_bellii
ENSG00000164362TERT9495.656ENSCANG00000033831TERT10096.667Colobus_angolensis_palliatus
ENSG00000164362TERT10070.000ENSCGRG00001012546Tert9670.000Cricetulus_griseus_chok1gshd
ENSG00000164362TERT9457.752ENSCGRG00000008286Tert9759.480Cricetulus_griseus_crigri
ENSG00000164362TERT9436.155ENSCSEG00000009702tert9935.872Cynoglossus_semilaevis
ENSG00000164362TERT9937.325ENSCVAG00000016496tert9937.325Cyprinodon_variegatus
ENSG00000164362TERT9937.949ENSDARG00000042637tert8238.616Danio_rerio
ENSG00000164362TERT9967.213ENSDNOG00000031902TERT9964.671Dasypus_novemcinctus
ENSG00000164362TERT5365.568ENSETEG00000016873-9965.568Echinops_telfairi
ENSG00000164362TERT9748.847ENSEBUG00000006378tert8648.847Eptatretus_burgeri
ENSG00000164362TERT10073.905ENSEASG00005018543TERT10073.905Equus_asinus_asinus
ENSG00000164362TERT10075.000ENSECAG00000001347TERT10075.000Equus_caballus
ENSG00000164362TERT9644.949ENSELUG00000015660tert9044.949Esox_lucius
ENSG00000164362TERT10071.152ENSFCAG00000009543TERT10071.004Felis_catus
ENSG00000164362TERT8250.812ENSFALG00000002146TERT7950.812Ficedula_albicollis
ENSG00000164362TERT7369.231ENSFDAG00000018329TERT9369.756Fukomys_damarensis
ENSG00000164362TERT9937.262ENSFHEG00000022605tert9937.175Fundulus_heteroclitus
ENSG00000164362TERT9432.221ENSGMOG00000006640tert10031.722Gadus_morhua
ENSG00000164362TERT9450.052ENSGALG00000013183TERT7753.023Gallus_gallus
ENSG00000164362TERT9737.030ENSGAFG00000018581tert9937.351Gambusia_affinis
ENSG00000164362TERT9937.199ENSGACG00000009277tert9937.199Gasterosteus_aculeatus
ENSG00000164362TERT8057.029ENSGAGG00000022112TERT7556.094Gopherus_agassizii
ENSG00000164362TERT10099.252ENSGGOG00000002607TERT10099.252Gorilla_gorilla
ENSG00000164362TERT9935.559ENSHBUG00000018794tert9935.243Haplochromis_burtoni
ENSG00000164362TERT9934.545ENSHCOG00000006623tert9934.111Hippocampus_comes
ENSG00000164362TERT9939.899ENSIPUG00000022566tert8539.064Ictalurus_punctatus
ENSG00000164362TERT9968.975ENSSTOG00000023072TERT9968.624Ictidomys_tridecemlineatus
ENSG00000164362TERT10058.487ENSJJAG00000015110Tert9564.754Jaculus_jaculus
ENSG00000164362TERT9935.629ENSKMAG00000021731tert9935.459Kryptolebias_marmoratus
ENSG00000164362TERT9936.379ENSLBEG00000023746tert9936.466Labrus_bergylta
ENSG00000164362TERT8041.714ENSLACG00000006927-7045.898Latimeria_chalumnae
ENSG00000164362TERT8843.611ENSLOCG00000003516tert9044.933Lepisosteus_oculatus
ENSG00000164362TERT10069.420ENSLAFG00000013077TERT10069.718Loxodonta_africana
ENSG00000164362TERT10095.936ENSMFAG00000033142TERT10095.936Macaca_fascicularis
ENSG00000164362TERT10095.848ENSMMUG00000010940TERT10095.848Macaca_mulatta
ENSG00000164362TERT10095.848ENSMNEG00000041254TERT10095.848Macaca_nemestrina
ENSG00000164362TERT9936.411ENSMAMG00000006156tert9936.817Mastacembelus_armatus
ENSG00000164362TERT9936.411ENSMZEG00005011297tert9936.011Maylandia_zebra
ENSG00000164362TERT9050.926ENSMGAG00000007076TERT9268.354Meleagris_gallopavo
ENSG00000164362TERT10061.223ENSMAUG00000008230Tert10061.485Mesocricetus_auratus
ENSG00000164362TERT9975.000ENSMICG00000010883TERT10074.557Microcebus_murinus
ENSG00000164362TERT10062.136ENSMOCG00000002105Tert10060.469Microtus_ochrogaster
ENSG00000164362TERT9935.955ENSMMOG00000021036tert9935.880Mola_mola
ENSG00000164362TERT9961.000ENSMODG00000000966TERT9461.000Monodelphis_domestica
ENSG00000164362TERT9935.875ENSMALG00000017588tert9935.584Monopterus_albus
ENSG00000164362TERT10066.500MGP_CAROLIEiJ_G0018705Tert9666.500Mus_caroli
ENSG00000164362TERT10065.000ENSMUSG00000021611Tert10062.391Mus_musculus
ENSG00000164362TERT10065.000MGP_PahariEiJ_G0015786Tert10063.002Mus_pahari
ENSG00000164362TERT10066.500MGP_SPRETEiJ_G0019589Tert10062.653Mus_spretus
ENSG00000164362TERT10070.296ENSMPUG00000008917TERT10070.547Mustela_putorius_furo
ENSG00000164362TERT10075.135ENSMLUG00000012533TERT10069.508Myotis_lucifugus
ENSG00000164362TERT10067.965ENSNGAG00000000359Tert10067.532Nannospalax_galili
ENSG00000164362TERT9936.073ENSNBRG00000020336tert9935.621Neolamprologus_brichardi
ENSG00000164362TERT8691.767ENSNLEG00000011118TERT10092.712Nomascus_leucogenys
ENSG00000164362TERT5958.883ENSMEUG00000001324-6358.883Notamacropus_eugenii
ENSG00000164362TERT9460.779ENSOPRG00000006211-8375.581Ochotona_princeps
ENSG00000164362TERT10061.863ENSODEG00000018274TERT10062.039Octodon_degus
ENSG00000164362TERT8740.583ENSONIG00000015386tert9736.049Oreochromis_niloticus
ENSG00000164362TERT9951.565ENSOANG00000014452TERT9951.436Ornithorhynchus_anatinus
ENSG00000164362TERT9936.372ENSORLG00000013929tert9936.379Oryzias_latipes
ENSG00000164362TERT9937.015ENSORLG00020021044tert9936.797Oryzias_latipes_hni
ENSG00000164362TERT9936.947ENSORLG00015009187tert9936.906Oryzias_latipes_hsok
ENSG00000164362TERT7434.309ENSOMEG00000006967-9335.417Oryzias_melastigma
ENSG00000164362TERT9942.051ENSOMEG00000012908tert9542.051Oryzias_melastigma
ENSG00000164362TERT10073.951ENSOGAG00000026171TERT10073.951Otolemur_garnettii
ENSG00000164362TERT9595.547ENSPPAG00000029560TERT10095.547Pan_paniscus
ENSG00000164362TERT10071.592ENSPPRG00000006427TERT10071.479Panthera_pardus
ENSG00000164362TERT9498.163ENSPTRG00000016696TERT10099.738Pan_troglodytes
ENSG00000164362TERT10094.876ENSPANG00000026074TERT10094.876Papio_anubis
ENSG00000164362TERT8046.465ENSPKIG00000022342tert8343.095Paramormyrops_kingsleyae
ENSG00000164362TERT8254.176ENSPSIG00000012449TERT7854.176Pelodiscus_sinensis
ENSG00000164362TERT9934.504ENSPMGG00000019650tert8638.568Periophthalmus_magnuspinnatus
ENSG00000164362TERT10066.000ENSPEMG00000013643Tert10063.319Peromyscus_maniculatus_bairdii
ENSG00000164362TERT9160.500ENSPCIG00000000234-7760.500Phascolarctos_cinereus
ENSG00000164362TERT9736.601ENSPFOG00000014918tert9736.577Poecilia_formosa
ENSG00000164362TERT9936.498ENSPLAG00000019974tert9936.372Poecilia_latipinna
ENSG00000164362TERT9936.490ENSPMEG00000002745tert9936.364Poecilia_mexicana
ENSG00000164362TERT9936.356ENSPREG00000018408tert9936.080Poecilia_reticulata
ENSG00000164362TERT8996.046ENSPPYG00000015315TERT10096.046Pongo_abelii
ENSG00000164362TERT8588.333ENSPCAG00000010832TERT8088.333Procavia_capensis
ENSG00000164362TERT9472.346ENSPCOG00000024942-9974.181Propithecus_coquereli
ENSG00000164362TERT8587.671ENSPVAG00000000005TERT8687.671Pteropus_vampyrus
ENSG00000164362TERT9935.269ENSPNYG00000000769tert9935.013Pundamilia_nyererei
ENSG00000164362TERT9245.528ENSPNAG00000009996tert9345.528Pygocentrus_nattereri
ENSG00000164362TERT10065.000ENSRNOG00000025327Tert10062.827Rattus_norvegicus
ENSG00000164362TERT10096.071ENSRBIG00000032252TERT10096.071Rhinopithecus_bieti
ENSG00000164362TERT10096.165ENSRROG00000032554TERT10096.165Rhinopithecus_roxellana
ENSG00000164362TERT9486.509ENSSBOG00000030569TERT10086.446Saimiri_boliviensis_boliviensis
ENSG00000164362TERT10060.500ENSSHAG00000015951TERT9660.500Sarcophilus_harrisii
ENSG00000164362TERT9936.916ENSSFOG00015012121tert9935.708Scleropages_formosus
ENSG00000164362TERT9937.282ENSSMAG00000020742tert9937.369Scophthalmus_maximus
ENSG00000164362TERT9937.133ENSSDUG00000001907tert9937.133Seriola_dumerili
ENSG00000164362TERT9937.229ENSSLDG00000008100tert9937.229Seriola_lalandi_dorsalis
ENSG00000164362TERT9946.333ENSSPUG00000004156-9453.706Sphenodon_punctatus
ENSG00000164362TERT9946.465ENSSPAG00000020478tert9546.465Stegastes_partitus
ENSG00000164362TERT10071.804ENSSSCG00000017118TERT10071.491Sus_scrofa
ENSG00000164362TERT8651.395ENSTGUG00000008383-7951.336Taeniopygia_guttata
ENSG00000164362TERT9935.366ENSTRUG00000014198tert9935.212Takifugu_rubripes
ENSG00000164362TERT9934.926ENSTNIG00000001503tert9934.779Tetraodon_nigroviridis
ENSG00000164362TERT9466.667ENSTTRG00000003863TERT10062.610Tursiops_truncatus
ENSG00000164362TERT10072.949ENSUAMG00000013975TERT10073.298Ursus_americanus
ENSG00000164362TERT9968.206ENSVVUG00000022219TERT9968.739Vulpes_vulpes
ENSG00000164362TERT9655.689ENSXETG00000015624tert9555.689Xenopus_tropicalis
ENSG00000164362TERT9935.602ENSXCOG00000001915tert9935.515Xiphophorus_couchianus
ENSG00000164362TERT7640.254ENSXMAG00000016384tert9936.828Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000049tRNA binding21937513.IDAFunction
GO:0000333telomerase catalytic core complex21873635.IBAComponent
GO:0000333telomerase catalytic core complex9398860.9443919.16507993.17940095.18082603.IDAComponent
GO:0000333telomerase catalytic core complex11313459.IMPComponent
GO:0000333telomerase catalytic core complex19701182.IPIComponent
GO:0000723telomere maintenance12135483.TASProcess
GO:0000781chromosome, telomeric region12135483.ICComponent
GO:0000783nuclear telomere cap complex15632080.ICComponent
GO:0000784nuclear chromosome, telomeric region25589350.IDAComponent
GO:0001172transcription, RNA-templated19701182.IDAProcess
GO:0001223transcription coactivator binding19571879.IPIFunction
GO:0003677DNA binding21937513.IDAFunction
GO:0003720telomerase activity9398860.9443919.12135483.16043710.16507993.17940095.18082603.21531765.29695869.IDAFunction
GO:0003720telomerase activity11927518.23474713.23784080.TASFunction
GO:0003721telomerase RNA reverse transcriptase activity21873635.IBAFunction
GO:0003721telomerase RNA reverse transcriptase activity9398860.15632080.17940095.19701182.IDAFunction
GO:0003721telomerase RNA reverse transcriptase activity11313459.IMPFunction
GO:0003721telomerase RNA reverse transcriptase activity14991929.TASFunction
GO:0003723RNA binding16507993.17940095.18082603.19701182.20351177.IPIFunction
GO:0003964RNA-directed DNA polymerase activity21937513.IDAFunction
GO:0003964RNA-directed DNA polymerase activity25569094.TASFunction
GO:0003968RNA-directed 5'-3' RNA polymerase activity19701182.IDAFunction
GO:0005515protein binding12377759.12699629.15044100.15381700.17237767.17940095.18082603.18358808.19179534.19487455.19567472.19571879.19843693.21119197.21829167.21846770.22011238.22226966.24550003.25172512.25589350.IPIFunction
GO:0005634nucleus21829167.24415760.IDAComponent
GO:0005654nucleoplasm19567472.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005697telomerase holoenzyme complex12135483.18082603.29695869.IDAComponent
GO:0005697telomerase holoenzyme complex19701182.IPIComponent
GO:0005697telomerase holoenzyme complex10757788.22527283.TASComponent
GO:0005730nucleolus22226966.IDAComponent
GO:0005730nucleolus26194824.NASComponent
GO:0005829cytosol-IDAComponent
GO:0005886plasma membrane-IEAComponent
GO:0006278RNA-dependent DNA biosynthetic process9398860.IDAProcess
GO:0007004telomere maintenance via telomerase21873635.IBAProcess
GO:0007004telomere maintenance via telomerase9443919.16043710.17940095.19701182.21531765.29695869.IDAProcess
GO:0007004telomere maintenance via telomerase9454332.IMPProcess
GO:0007004telomere maintenance via telomerase2805070.NASProcess
GO:0007004telomere maintenance via telomerase-TASProcess
GO:0007005mitochondrion organization21937513.IDAProcess
GO:0008022protein C-terminus binding11701125.IPIFunction
GO:0010629negative regulation of gene expression11927518.IDAProcess
GO:0016605PML body19567472.IDAComponent
GO:0016607nuclear speck-IDAComponent
GO:0022616DNA strand elongation16043710.IDAProcess
GO:0030177positive regulation of Wnt signaling pathway19571879.IGIProcess
GO:0030422production of siRNA involved in RNA interference19701182.IDAProcess
GO:0031379RNA-directed RNA polymerase complex19701182.IPIComponent
GO:0031647regulation of protein stability24415760.26194824.IDAProcess
GO:0031647regulation of protein stability26194824.IMPProcess
GO:0032092positive regulation of protein binding24415760.IDAProcess
GO:0042162telomeric DNA binding21873635.IBAFunction
GO:0042635positive regulation of hair cycle-ISSProcess
GO:0042645mitochondrial nucleoid21937513.IDAComponent
GO:0042802identical protein binding23474713.IPIFunction
GO:0042803protein homodimerization activity11432839.IDAFunction
GO:0042803protein homodimerization activity23474713.IPIFunction
GO:0043524negative regulation of neuron apoptotic process-IEAProcess
GO:0045766positive regulation of angiogenesis-IEAProcess
GO:0046326positive regulation of glucose import-IEAProcess
GO:0046686response to cadmium ion-IEAProcess
GO:0046872metal ion binding-IEAFunction
GO:0047485protein N-terminus binding11701125.IPIFunction
GO:0051000positive regulation of nitric-oxide synthase activity11927518.IDAProcess
GO:0051087chaperone binding10197982.19751963.IPIFunction
GO:0060253negative regulation of glial cell proliferation-IEAProcess
GO:0070034telomerase RNA binding21873635.IBAFunction
GO:0070034telomerase RNA binding11432839.IDAFunction
GO:0070034telomerase RNA binding16507993.17940095.18082603.19701182.20351177.IPIFunction
GO:0070200establishment of protein localization to telomere25589350.IDAProcess
GO:0071456cellular response to hypoxia11313459.IMPProcess
GO:0071897DNA biosynthetic process9398860.19701182.IDAProcess
GO:0090399replicative senescence9454332.IMPProcess
GO:0098680template-free RNA nucleotidyltransferase19701182.IDAFunction
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IEAProcess
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II25569094.IMPProcess
GO:1903620positive regulation of transdifferentiation-IEAProcess
GO:1903704negative regulation of production of siRNA involved in RNA interference19701182.IDAProcess
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IEAProcess
GO:1904751positive regulation of protein localization to nucleolus24415760.IDAProcess
GO:1904754positive regulation of vascular associated smooth muscle cell migration-IEAProcess
GO:1904837beta-catenin-TCF complex assembly-TASProcess
GO:1990572TERT-RMRP complex19701182.IDAComponent
GO:2000352negative regulation of endothelial cell apoptotic process-IEAProcess
GO:2000648positive regulation of stem cell proliferation-ISSProcess
GO:2000773negative regulation of cellular senescence11927518.IDAProcess
GO:2000773negative regulation of cellular senescence11313459.IMPProcess
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand10449030.IMPProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24633336P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma.Cancer Immunol Immunother2014 MayTerashima Tdoi: 10.1007/s00262-014-1529-8
22842823Therapeutic efficacy of an hTERT promoter-driven oncolytic adenovirus that expresses apoptin in gastric carcinoma.Int J Mol Med2012 OctLiu Ldoi: 10.3892/ijmm.2012.1077
29019414The TERT hypermethylated oncologic region predicts recurrence and survival in pancreatic cancer.Future Oncol2017 OctFaleiro Idoi: 10.2217/fon-2017-0167
11936586Telomerase activity in breast cancer in Western India (Gujarat).Int J Biol Markers2002 Jan-MarShah NG-
28247570Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c-Myc expression.Cancer Med2017 AprWang Xdoi: 10.1002/cam4.999
21193962Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression.Mol Cells2011 JanBeck Sdoi: 10.1007/s10059-011-0008-8
22527847Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer.Int J Clin Oncol2013 JunKang Ydoi: 10.1007/s10147-012-0405-9
15989808[Study on apoptosis of human cervical carcinoma HeLa cells with RNA interference targeting hTERT].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2005 JulZhao Y-
26772886miR-1182 inhibits growth and mediates the chemosensitivity of bladder cancer by targeting hTERT.Biochem Biophys Res Commun2016 Feb 5Zhou Jdoi: 10.1016/j.bbrc.2016.01.014
15138842Immunohistochemical localization of hTERT protein in human tissues.Histochem Cell Biol2004 MayYan P-
18437586Human telomerase reverse transcriptase expression correlates with vascular endothelial growth factor-promoted tumor cell proliferation in prostate cancer.Artif Cells Blood Substit Immobil Biotechnol2008Tang Jdoi: 10.1080/10731190801932074.
21319134Evaluation of serum human telomerase reverse transcriptase as a novel marker for cervical cancer.Int J Biol Markers2011 Jan-MarPorika M-
27072825Shorter telomeres and high telomerase activity correlate with a highly aggressive phenotype in breast cancer cell lines.Tumour Biol2016 SepCeja-Rangel HA-
25584719Association of TERT promoter mutation 1,295,228 C>T with BRAF V600E mutation, older patient age, and distant metastasis in anaplastic thyroid cancer.J Clin Endocrinol Metab2015 AprShi Xdoi: 10.1210/jc.2014-3606
19596972Circulating hTERT DNA in early breast cancer.Anticancer Res2009 JulDivella R-
24154961Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.Acta Neuropathol2013 DecKoelsche Cdoi: 10.1007/s00401-013-1195-5
18584973Immunohistochemical localization of telomerase in myomas and in uterine myometrium.Pathol Res Pract2008Madej Pdoi: 10.1016/j.prp.2008.02.006
16388756[Construction of tumor cell-specific expression vector modulated by human telomerase reserse transcription gene core promoter].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2006 JanLi HM-
21553236Telomerase reverse transcriptase catalytic subunit expression and proliferation index in Wilms tumor.Tumour Biol2011 AugDiniz Gdoi: 10.1007/s13277-011-0178-1
30419422BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.Redox Biol2019 JanZhao Xdoi: 10.1016/j.redox.2018.10.018
20032382Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer.Anticancer Res2009 NovSchjlberg AR-
26061753Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.N Engl J Med2015 Jun 25Eckel-Passow JEdoi: 10.1056/NEJMoa1407279
12218171Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells.Proc Natl Acad Sci U S A2002 Sep 17Hernandez J-
19301721Human telomerase reverse transcriptase (hTERT) expression in borderline ovarian tumors: an immunohistochemical study.J Med Assoc Thai2009 MarTantbirojn P-
18451164Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization.Cancer Res2008 May 1Agarwal Mdoi: 10.1158/0008-5472.CAN-07-5831.
17961306Analysis of hTERT expression in exfoliated cells from patients with bladder transitional cell carcinomas using SYBR green real-time fluorescence quantitative PCR.Ann Clin Biochem2007 NovXie XY-
18276798Multistep regulation of telomerase during differentiation of HL60 cells.J Leukoc Biol2008 MayYamada Odoi: 10.1189/jlb.1207848
25225064Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.Clin Cancer Res2014 Sep 15Nickerson MLdoi: 10.1158/1078-0432.CCR-14-0330.
18204433Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone.Mod Pathol2008 AprHorvai AEdoi: 10.1038/modpathol.3801015
11855854The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells.Exp Cell Res2002 Mar 10Hou M-
17172814hTERT/re-caspase-3 system induce apoptosis in hTERT-positive cancer cells.Cancer Biol Ther2006 NovYang LF-
16830373Circulating hTERT mRNA as a tumor marker in cholangiocarcinoma patients.World J Gastroenterol2006 Jul 14Leelawat K-
18250061[Expression of human telomerase reverse transcriptase in renal cell carcinoma and its clinical significance].Nan Fang Yi Ke Da Xue Xue Bao2008 FebWu P-
24562933Biological differential diagnosis of follicular thyroid tumor and H??rthle cell tumor on the basis of telomere length and hTERT expression.Ann Surg Oncol2014 JulSugishita Ydoi: 10.1245/s10434-014-3552-6
26398300Antitumor effect of COOH-terminal polypeptide of human TERT is associated with the declined expression of hTERT and NF-??B p65 in HeLa cells.Oncol Rep2015 DecWu Xdoi: 10.3892/or.2015.4298
22916267Cell-free circulating plasma hTERT mRNA is a useful marker for prostate cancer diagnosis and is associated with poor prognosis tumor characteristics.PLoS One2012March-Villalba JAdoi: 10.1371/journal.pone.0043470
25159205Prevalence and implications of TERT promoter mutation in uveal and conjunctival melanoma and in benign and premalignant conjunctival melanocytic lesions.Invest Ophthalmol Vis Sci2014 Aug 26Koopmans AEdoi: 10.1167/iovs.14-14901.
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27437772A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study.Oncotarget2016 Sep 6Castelo-Branco Pdoi: 10.18632/oncotarget.10639.
27852061Thyroid transcription factor FOXE1 interacts with ETS factor ELK1 to co-regulate TERT.Oncotarget2016 Dec 27Bullock Mdoi: 10.18632/oncotarget.13288.
27825130Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population.Oncotarget2016 Dec 13Duan Xdoi: 10.18632/oncotarget.13102.
29288666ZEB1 stimulates breast cancer growth by up-regulating hTERT expression.Biochem Biophys Res Commun2018 Jan 22Yu Pdoi: 10.1016/j.bbrc.2017.12.139
28616852Ultrasonographic prediction of highly aggressive telomerase reverse transcriptase (TERT) promoter-mutated papillary thyroid cancer.Endocrine2017 AugKim THdoi: 10.1007/s12020-017-1340-3
29436188Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis.Yonsei Med J2018 MarSong JUdoi: 10.3349/ymj.2018.59.2.211.
27833153TERT promoter Mutation and Its Association with Clinicopathological Features and Prognosis of Papillary Thyroid Cancer: A Meta-analysis.Sci Rep2016 Nov 11Liu Cdoi: 10.1038/srep36990.
28418878The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis.Oncotarget2017 Jun 13Li Hdoi: 10.18632/oncotarget.16309.
28296015Constitutional and functional genetics of human alcohol-related hepatocellular carcinoma.Liver Int2017 NovNahon Pdoi: 10.1111/liv.13419
28754720TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker.Oncologist2017 OctLiu Ldoi: 10.1634/theoncologist.2017-0064
29534075Association between TERT rs2853669 polymorphism and cancer risk: A meta-analysis of 9,157 cases and 11,073 controls.PLoS One2018 Mar 13Liu Zdoi: 10.1371/journal.pone.0191560
30024548The role of TERT promoter mutations in postoperative and preoperative diagnosis and prognosis in thyroid cancer.Medicine (Baltimore)2018 JulJin Adoi: 10.1097/MD.0000000000011548.
29506639Genetic polymorphisms in human telomerase reverse transcriptase (hTERT) gene polymorphisms do not associated with breast cancer in patients in a turkish population: hospital-based case-control study.Cell Mol Biol (Noisy-le-grand)2018 Feb 28Aydin Mdoi: 10.14715/cmb/2018.64.1.3.
29693804Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 SuppressionAsian Pac J Cancer Prev2018 Apr 25Rasouli S-
30088231hTERT promoter methylation status in peripheral blood leukocytes as a molecular marker of head and neck cancer progression.J Appl Genet2018 NovSobecka Adoi: 10.1007/s13353-018-0458-1
29749533EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in nonsmall cell lung cancer cells.Oncol Rep2018 JulLin Cdoi: 10.3892/or.2018.6417
30026550CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.Nat Commun2018 Jul 19Feng Xdoi: 10.1038/s41467-018-05154-z.
29603728Distinct profiles of TERT promoter mutations and telomerase expression in head and neck cancer and cervical carcinoma.Int J Cancer2018 Sep 1Annunziata Cdoi: 10.1002/ijc.31412
30082712NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.Nat Commun2018 Aug 6Ludlow ATdoi: 10.1038/s41467-018-05582-x.
29939218rs401681 and rs402710 confer lung cancer susceptibility by regulating TERT expression instead of CLPTM1L in East Asian populations.Carcinogenesis2018 Oct 8Yang YCdoi: 10.1093/carcin/bgy084.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr51294256SilentNAA210A0.67
BLCAchr51294274Missense_MutationnovelN204K0.11
BLCAchr51293437Silentrs761174773N483N0.2
BLCAchr51268526Missense_Mutationrs755183437R859Q0.1
BRCAchr51260570SilentNAL958L0.2
BRCAchr51268634Splice_SitenovelX823_splice0.14
BRCAchr51282615Missense_MutationnovelC528Y0.17RVT_1
BRCAchr51282616Missense_MutationnovelC528R0.15RVT_1
BRCAchr51266485Missense_MutationNAT878N0.18
BRCAchr51282479SilentnovelL573L0.11
BRCAchr51255341Missense_Mutationrs374968697V1035I0.17
BRCAchr51260515Missense_MutationnovelV977L0.07
CESCchr512537253'UTRnovel0.13
CESCchr51264559Silentrs373952421C896C0.08
CESCchr51293310Splice_Regionnovel0.5
CESCchr512536053'UTRnovel0.15
CESCchr51293324Missense_MutationnovelR521H0.45RVT_1
CESCchr51293929SilentNAT319T0.19
CESCchr51280228Missense_MutationnovelP627H0.22
CESCchr51293333Missense_MutationnovelA518V0.15RVT_1
CESCchr51293838Missense_MutationnovelL350V0.25
CESCchr51293420Missense_MutationnovelR489K0.07RVT_1
COADchr51282479SilentNAL573L0.25
COADchr51278703Missense_MutationnovelR742C0.09
COADchr51278665Silentrs778622091H754H0.32
COADchr51280267Missense_MutationNAP614L0.63
COADchr51293817Missense_MutationNAA357T0.7
COADchr51272230Silentrs747564177H779H0.08
COADchr51280158Missense_MutationnovelR650S0.08
COADchr51293672Missense_MutationNAY405C0.18
ESCAchr51264581Missense_Mutationrs532158398R889Q0.06
ESCAchr51279335Missense_MutationNAR696C0.23
ESCAchr512536243'UTRnovel0.12
GBMchr51260592Missense_Mutationrs755707625R951Q0.29
GBMchr51255338Missense_MutationnovelI1036F0.06
GBMchr51294230Missense_MutationnovelP219L0.32
GBMchr51264456Missense_MutationnovelC931G0.28
GBMchr51255308Missense_MutationnovelI1046V0.26
GBMchr51280187Nonsense_MutationNAG641*0.35
GBMchr512536703'UTRnovel0.33
GBMchr51268538Missense_Mutationrs775014633A855V0.24
GBMchr51268628Missense_MutationnovelY825C0.45
GBMchr51255343Missense_Mutationrs62331332R1034H0.35
GBMchr51268608Missense_MutationnovelP832S0.31
GBMchr51268609SilentnovelI831I0.31
HNSCchr51264514Silentrs768646695D911D0.08
HNSCchr51294629Missense_MutationnovelQ86L0.14
HNSCchr51268537Silentrs769077049A855A0.11
HNSCchr51272255Missense_MutationnovelP771L0.19
HNSCchr51272247Silentrs770066110R774R0.1
HNSCchr51294144Missense_MutationnovelR248W0.27
HNSCchr51264503Missense_Mutationrs202033269G915D0.19
HNSCchr51253818SilentnovelL1103L0.09
HNSCchr512536883'UTRnovel0.44
KIRCchr51294608Missense_MutationNAA93V0.2
KIRCchr51255332Missense_MutationNAD1038N0.12
KIRCchr51282535Missense_MutationNAE555Q0.1RVT_1
KIRCchr51272212SilentNAP785P0.17
KIRPchr51255400Missense_MutationNAC1015F0.27
KIRPchr51268536Missense_MutationNAG856W0.09
KIRPchr51258620Missense_MutationnovelI1004V0.33
KIRPchr51258621Missense_MutationnovelK1003N0.32
KIRPchr51282490Missense_MutationNAK570Q0.29RVT_1
LGGchr51293668SilentnovelG406G0.63
LGGchr51294135Missense_Mutationrs776569822V251I0.47
LIHCchr512950465'UTRNA0.34
LIHCchr51294007SilentnovelR293R0.46
LIHCchr51266514SilentnovelD868D0.4
LIHCchr51278706Missense_Mutationrs150819225V741L0.15
LIHCchr512950465'UTRNA0.33
LUADchr51293401SilentNAI495I0.43
LUADchr51294266Missense_MutationNAV207D0.39
LUADchr51293334Missense_Mutationrs551522837A518S0.22RVT_1
LUADchr51264484Missense_MutationnovelQ921H0.06
LUADchr51294227Missense_MutationnovelG220V0.22
LUADchr51278677SilentNAA750A0.35
LUADchr51264586Silentrs756519152L887L0.12
LUADchr51294399Missense_MutationNAA163T0.17
LUADchr51280251SilentnovelS619S0.1
LUADchr51293404SilentnovelF494F0.14
LUADchr51253734SilentnovelL1131L0.31
LUSCchr51253809SilentNAK1106K0.4
LUSCchr51279308Missense_MutationnovelE705Q0.4
LUSCchr51253787Missense_MutationnovelA1114S0.22
LUSCchr51278767SilentNAI720I0.24
LUSCchr51278664Missense_Mutationrs576633619V755I0.03
LUSCchr51294589Silentrs746607875F99F0.1
LUSCchr51282650Intronnovel0.18
LUSCchr51294604SilentnovelK94K0.3
LUSCchr51254372Missense_MutationNAR1097S0.16
MESOchr51293939Missense_MutationnovelP316L0.34
MESOchr51264586Silentrs756519152L887L0.18
OVchr51264442SilentnovelL935L0.26
OVchr51278745Missense_MutationNAV728I0.2
PAADchr51268561Silentrs770543108G847G0.2
PAADchr51254503Missense_MutationnovelM1054V0.21
PAADchr51282535Missense_MutationnovelE555K0.15RVT_1
PAADchr51253765Missense_MutationnovelP1121Q0.21
PAADchr51294213Missense_MutationnovelG225R0.1
PRADchr51264514Silentrs768646695D911D0.51
READchr51253798Missense_Mutationrs199422306T1110M0.45
READchr51264454Silentrs764925909C931C0.14
SARCchr51293437Silentrs761174773N483N0.32
SARCchr51279329Missense_MutationnovelR698W0.26
SARCchr51253768Missense_MutationnovelN1120S0.28
SARCchr51293494Silentrs186596886F464F0.52
SKCMchr51280267Missense_MutationNAP614L0.42
SKCMchr51282503SilentNAE565E0.21
SKCMchr51260543SilentnovelG967G0.36
SKCMchr51260544Missense_MutationnovelG967E0.35
SKCMchr51255348Silentrs757204201F1032F0.48
SKCMchr51255305SilentNAL1047L0.38
SKCMchr51293954Missense_MutationnovelS311L0.26
SKCMchr51255360Missense_MutationNAN1028K0.12
SKCMchr51271151SilentNAF812F0.1
SKCMchr51272239Silentrs748248614F776F0.25
SKCMchr51278644Silentrs370808390S761S0.32
SKCMchr51253784SilentnovelL1115L0.39
SKCMchr51264433SilentnovelR938R0.5
SKCMchr51293398SilentnovelS496S0.42
SKCMchr51253764Silentrs750020682P1121P0.59
SKCMchr51293320Silentrs770410182R522R0.19
SKCMchr51254380Missense_MutationnovelS1095P0.23
SKCMchr51272206SilentNAR787R0.5
SKCMchr51271182Missense_MutationNAS802N0.32
SKCMchr51282638Intronnovel0.39
SKCMchr51278673Missense_MutationNAH752N0.15
SKCMchr51264463SilentNAF928F0.39
SKCMchr51282632Splice_Regionnovel0.17
SKCMchr51282473SilentnovelF575F0.18
SKCMchr51272239Silentrs748248614F776F0.37
SKCMchr51280326SilentNAK594K0.15
SKCMchr51282723Intronnovel0.38
SKCMchr51260548Missense_MutationNAA966T0.1
SKCMchr51255387SilentNAL1019L0.25
SKCMchr51266485Missense_MutationNAT878I0.27
SKCMchr51278655Missense_MutationNAA758T0.46
SKCMchr51255348Silentrs757204201F1032F0.34
SKCMchr51294258Missense_MutationnovelA210P0.27
SKCMchr51264489Missense_MutationNAV920I0.2
SKCMchr51278719SilentNAQ736Q0.26
STADchr51264558Missense_Mutationrs559028617V897M0.46
STADchr51255294Missense_MutationNAK1050N0.19
STADchr51268522Splice_Regionrs751752830D860D0.31
STADchr51255391Missense_MutationnovelQ1018R0.13
STADchr51294783Frame_Shift_DelnovelS70Pfs*80.33
STADchr51272239Silentrs748248614F776F0.26
STADchr51294161Missense_MutationnovelA242V0.6
STADchr51294100SilentnovelT262T0.18
STADchr51294571SilentnovelD105D0.21
STADchr51272197Silentrs376251639V790V0.16
STADchr51253764Silentrs750020682P1121P0.2
STADchr51294459Missense_MutationnovelR143C0.25
STADchr51282506Silentrs377217777T564T0.42
STADchr51294566Missense_MutationnovelA107D0.27
STADchr51264496Silentrs375200599T917T0.26
THCAchr51253790Frame_Shift_DelnovelT1113Lfs*620.14
THCAchr51293477Missense_MutationNAR470H0.5RVT_1
THCAchr51280176Silentrs148582238T644T0.06
UCECchr51280161Missense_MutationnovelK649N0.3
UCECchr51293923SilentnovelC321C0.28
UCECchr51264475Silentrs367672336A924A0.37
UCECchr51272239Silentrs748248614F776F0.42
UCECchr51282731Intronnovel0.33
UCECchr51260530Missense_Mutationrs773537902R972C0.45
UCECchr51293908SilentnovelA326A0.22
UCECchr51255363Missense_MutationNAK1027N0.26
UCECchr51264415SilentnovelS944S0.32
UCECchr51272182Splice_Regionnovel0.25
UCECchr51280218SilentnovelL630L0.24
UCECchr51293759Missense_MutationNAP376L0.29
UCECchr51282458SilentnovelV580V0.43
UCECchr512536333'UTRnovel0.19
UCECchr51293519Missense_MutationnovelS456N0.19
UCECchr51294010SilentnovelT292T0.27
UCECchr51254446SilentnovelL1073L0.2
UCECchr51282608SilentNAP530P0.3
UCECchr51260513SilentnovelV977V0.38
UCECchr51280172Missense_Mutationrs147521473R646C0.45
UCECchr51264415SilentnovelS944S0.45
UCECchr51280302Silentrs773873942S602S0.24
UCECchr51266531Missense_MutationnovelL863F0.35
UCECchr51268608Missense_MutationnovelP832S0.26
UCECchr51293569Missense_MutationNAE439D0.39
UCECchr51293953SilentNAS311S0.27
UCECchr51271152Missense_MutationnovelF812S0.15
UCECchr51272239Silentrs748248614F776F0.37
UCECchr51280255Missense_Mutationrs746434205T618M0.16
UCECchr51282542Silentrs143789839Y552Y0.37
UCECchr51264451SilentnovelG932G0.21
UCECchr51280244Missense_MutationnovelR622C0.42
UCECchr51293342Missense_MutationnovelR515Q0.27RVT_1
UCECchr51279342Silentrs371759577F693F0.5
UCECchr512536823'UTRnovel0.24
UCECchr51293972Missense_Mutationrs750129321A305V0.49
UCECchr51253750Missense_MutationnovelD1126A0.44
UCECchr51278703Missense_MutationnovelR742C0.37
UCECchr51280171Missense_MutationnovelR646H0.12
UCECchr51260558Silentrs542440625R962R0.24
UCECchr51264474Missense_MutationNAH925Y0.3
UCECchr51282644Intronnovel0.27
UCECchr51264514Silentrs768646695D911D0.47
UCECchr51278750Missense_Mutationrs149566858T726M0.29
UCECchr51280177Missense_Mutationrs201927653T644M0.28
UCECchr51282458SilentnovelV580V0.19
UCECchr51293869Silentrs768003291E339E0.4
UCECchr51264514Silentrs768646695D911D0.36
UCECchr51282500SilentnovelT566T0.44
UCECchr51254455Frame_Shift_DelnovelV1070Cfs*130.39
UCECchr512536733'UTRnovel0.46
UCECchr51268609SilentnovelI831I0.45
UCECchr51280310Missense_MutationnovelE600K0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.71111.7994e-08
BLCAAMP0.46817.3103e-07
BRCAAMP0.31670.12333
CESCAMP0.45082.0057e-06
HNSCAMP0.40046.6095e-05
KIRPDEL0.02430.09673
LGGDEL0.07410.0003285
LIHCAMP0.40811.099e-10
LUADAMP0.58335.5544e-28
LUSCAMP0.71863.3442e-18
OVAMP0.49223.6333e-11
SARCAMP0.37351.4189e-05
SARCDEL0.10120.054392
SKCMAMP0.26162.9004e-13
SKCMDEL0.12810.011094
STADAMP0.24260.0018322
TGCTDEL0.56670.098913
THCADEL0.0040.23456
UCECAMP0.14474.6983e-05

Survival Analysis
CancerP-value Q-value
THYM0.021

Kaplan-Meier Survival Analysis

KIRC0.00011

Kaplan-Meier Survival Analysis

SARC0.00011

Kaplan-Meier Survival Analysis

MESO0.0016

Kaplan-Meier Survival Analysis

ACC0.0019

Kaplan-Meier Survival Analysis

HNSC0.0023

Kaplan-Meier Survival Analysis

PRAD0.0038

Kaplan-Meier Survival Analysis

LUSC0.046

Kaplan-Meier Survival Analysis

ESCA0.019

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

COAD0.047

Kaplan-Meier Survival Analysis

CESC0.049

Kaplan-Meier Survival Analysis

GBM0.026

Kaplan-Meier Survival Analysis

LGG0.00029

Kaplan-Meier Survival Analysis

LUAD0.035

Kaplan-Meier Survival Analysis

UVM0.0019

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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