EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000164548 (Gene tree)
Gene ID: 29896
Gene Symbol: TRA2A
Alias: htra-2-alpha|tra2a|AWMS1
Full Name: transformer 2 alpha homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 27,262 bases
Position: chr7:23,504,780-23,532,041
Accession: 16645
RBP type: canonical RBP
Summary: This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000376290	RRM_1	PF00076.22	2.7e-19	1	1
ENSP00000441116	RRM_1	PF00076.22	2.7e-19	1	1
ENSP00000480822	RRM_1	PF00076.22	2.7e-19	1	1
ENSP00000297071	RRM_1	PF00076.22	6e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12766328	Cell differentiation of gonadotropin-releasing hormone neurons and alternative RNA splicing of the gonadotropin-releasing hormone transcript.	Neuroendocrinology	2003 Apr	Choe Y	-
16249178	Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript.	J Biol Chem	2006 Jan 6	Park E	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000392502	TRA2A-202	2229	-	ENSP00000376290	180 (aa)	-	Q13595
ENST00000474586	TRA2A-204	868	-	-	- (aa)	-	-
ENST00000448549	TRA2A-203	582	-	ENSP00000413898	63 (aa)	-	F8WEH2
ENST00000538367	TRA2A-211	2142	XM_005249725	ENSP00000441116	181 (aa)	XP_005249782	Q13595
ENST00000482395	TRA2A-206	661	-	-	- (aa)	-	-
ENST00000497730	TRA2A-210	455	-	-	- (aa)	-	-
ENST00000494255	TRA2A-209	1653	-	-	- (aa)	-	-
ENST00000486934	TRA2A-207	417	-	-	- (aa)	-	-
ENST00000621813	TRA2A-212	1931	XM_017012090	ENSP00000480822	181 (aa)	XP_016867579	Q13595
ENST00000490942	TRA2A-208	862	-	-	- (aa)	-	-
ENST00000475970	TRA2A-205	394	-	-	- (aa)	-	-
ENST00000297071	TRA2A-201	1845	XM_011515331	ENSP00000297071	282 (aa)	-	Q13595

Gene Model

Click here to download ENSG00000164548's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000164548	Iron	5.8930000E-004	19880490
ENSG00000164548	Platelet Function Tests	6.0800000E-006	-
ENSG00000164548	Platelet Function Tests	5.3100000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164548's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000164548	TRA2A	52	32.990	ENSG00000114503	NCBP2	70	32.990
ENSG00000164548	TRA2A	87	71.795	ENSG00000136527	TRA2B	70	73.973
ENSG00000164548	TRA2A	51	34.426	ENSG00000179950	PUF60	59	34.426
ENSG00000164548	TRA2A	60	31.068	ENSG00000162374	ELAVL4	62	35.821
ENSG00000164548	TRA2A	56	31.132	ENSG00000135486	HNRNPA1	61	32.292

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000164548	TRA2A	84	83.553	ENSAPOG00000017425	tra2a	90	75.277	Acanthochromis_polyacanthus
ENSG00000164548	TRA2A	99	97.253	ENSAMEG00000003501	TRA2A	84	97.786	Ailuropoda_melanoleuca
ENSG00000164548	TRA2A	84	86.842	ENSACIG00000001333	tra2a	79	87.500	Amphilophus_citrinellus
ENSG00000164548	TRA2A	90	76.015	ENSAOCG00000015445	tra2a	90	76.015	Amphiprion_ocellaris
ENSG00000164548	TRA2A	84	84.211	ENSAPEG00000018557	tra2a	90	76.015	Amphiprion_percula
ENSG00000164548	TRA2A	90	77.491	ENSATEG00000000671	tra2a	90	77.491	Anabas_testudineus
ENSG00000164548	TRA2A	98	93.820	ENSAPLG00000013689	TRA2A	100	94.052	Anas_platyrhynchos
ENSG00000164548	TRA2A	100	96.175	ENSACAG00000013502	TRA2A	100	95.423	Anolis_carolinensis
ENSG00000164548	TRA2A	94	100.000	ENSANAG00000035184	TRA2A	100	79.787	Aotus_nancymaae
ENSG00000164548	TRA2A	90	78.967	ENSACLG00000024845	tra2a	90	78.967	Astatotilapia_calliptera
ENSG00000164548	TRA2A	87	90.000	ENSAMXG00000005553	tra2a	100	76.190	Astyanax_mexicanus
ENSG00000164548	TRA2A	100	99.645	ENSBTAG00000012622	TRA2A	100	99.645	Bos_taurus
ENSG00000164548	TRA2A	94	98.106	ENSCJAG00000045802	-	100	98.106	Callithrix_jacchus
ENSG00000164548	TRA2A	100	100.000	ENSCJAG00000001509	-	100	100.000	Callithrix_jacchus
ENSG00000164548	TRA2A	99	99.642	ENSCAFG00000002788	TRA2A	100	99.642	Canis_familiaris
ENSG00000164548	TRA2A	100	98.343	ENSCAFG00020002745	TRA2A	95	98.819	Canis_lupus_dingo
ENSG00000164548	TRA2A	100	100.000	ENSTSYG00000000388	TRA2A	100	100.000	Carlito_syrichta
ENSG00000164548	TRA2A	86	86.364	ENSCAPG00000017377	TRA2A	87	86.722	Cavia_aperea
ENSG00000164548	TRA2A	100	100.000	ENSCPOG00000010739	TRA2A	100	100.000	Cavia_porcellus
ENSG00000164548	TRA2A	100	100.000	ENSCCAG00000019576	TRA2A	100	100.000	Cebus_capucinus
ENSG00000164548	TRA2A	100	100.000	ENSCATG00000041219	TRA2A	100	100.000	Cercocebus_atys
ENSG00000164548	TRA2A	100	100.000	ENSCLAG00000007917	TRA2A	100	100.000	Chinchilla_lanigera
ENSG00000164548	TRA2A	99	100.000	ENSCSAG00000014051	TRA2A	99	100.000	Chlorocebus_sabaeus
ENSG00000164548	TRA2A	100	100.000	ENSCHOG00000001130	TRA2A	100	99.645	Choloepus_hoffmanni
ENSG00000164548	TRA2A	100	97.238	ENSCPBG00000022466	TRA2A	100	96.479	Chrysemys_picta_bellii
ENSG00000164548	TRA2A	100	100.000	ENSCANG00000031292	TRA2A	100	100.000	Colobus_angolensis_palliatus
ENSG00000164548	TRA2A	100	98.907	ENSCGRG00001019980	Tra2a	100	98.592	Cricetulus_griseus_chok1gshd
ENSG00000164548	TRA2A	100	98.907	ENSCGRG00000006087	Tra2a	100	98.529	Cricetulus_griseus_crigri
ENSG00000164548	TRA2A	90	71.062	ENSCSEG00000012193	tra2a	90	71.795	Cynoglossus_semilaevis
ENSG00000164548	TRA2A	83	77.515	ENSDARG00000007863	tra2a	90	76.471	Danio_rerio
ENSG00000164548	TRA2A	100	100.000	ENSDNOG00000039446	TRA2A	100	99.645	Dasypus_novemcinctus
ENSG00000164548	TRA2A	100	100.000	ENSDORG00000009361	Tra2a	100	99.291	Dipodomys_ordii
ENSG00000164548	TRA2A	100	98.370	ENSETEG00000007250	TRA2A	100	82.230	Echinops_telfairi
ENSG00000164548	TRA2A	100	99.645	ENSEASG00005022002	TRA2A	100	99.645	Equus_asinus_asinus
ENSG00000164548	TRA2A	100	99.645	ENSECAG00000011508	TRA2A	100	99.645	Equus_caballus
ENSG00000164548	TRA2A	100	98.936	ENSEEUG00000015674	TRA2A	100	98.936	Erinaceus_europaeus
ENSG00000164548	TRA2A	76	74.576	ENSELUG00000005846	tra2a	91	69.360	Esox_lucius
ENSG00000164548	TRA2A	100	99.645	ENSFCAG00000005361	TRA2A	100	99.645	Felis_catus
ENSG00000164548	TRA2A	100	93.923	ENSFALG00000009605	TRA2A	100	94.815	Ficedula_albicollis
ENSG00000164548	TRA2A	100	99.451	ENSFDAG00000004949	TRA2A	100	99.293	Fukomys_damarensis
ENSG00000164548	TRA2A	80	82.237	ENSGMOG00000013740	tra2a	91	69.675	Gadus_morhua
ENSG00000164548	TRA2A	100	94.366	ENSGALG00000010973	TRA2A	100	94.366	Gallus_gallus
ENSG00000164548	TRA2A	84	83.439	ENSGACG00000006878	tra2a	89	75.581	Gasterosteus_aculeatus
ENSG00000164548	TRA2A	100	96.133	ENSGAGG00000005793	TRA2A	100	95.775	Gopherus_agassizii
ENSG00000164548	TRA2A	100	100.000	ENSGGOG00000009053	TRA2A	100	100.000	Gorilla_gorilla
ENSG00000164548	TRA2A	90	79.705	ENSHBUG00000018234	tra2a	90	79.705	Haplochromis_burtoni
ENSG00000164548	TRA2A	100	100.000	ENSHGLG00000012168	TRA2A	100	100.000	Heterocephalus_glaber_female
ENSG00000164548	TRA2A	100	100.000	ENSHGLG00100014577	TRA2A	100	100.000	Heterocephalus_glaber_male
ENSG00000164548	TRA2A	62	61.979	ENSHCOG00000006320	tra2a	95	62.304	Hippocampus_comes
ENSG00000164548	TRA2A	100	64.921	ENSHCOG00000006314	tra2a	80	63.804	Hippocampus_comes
ENSG00000164548	TRA2A	61	78.182	ENSHCOG00000018058	-	99	76.786	Hippocampus_comes
ENSG00000164548	TRA2A	100	100.000	ENSSTOG00000012073	TRA2A	100	100.000	Ictidomys_tridecemlineatus
ENSG00000164548	TRA2A	100	100.000	ENSJJAG00000022787	Tra2a	100	99.291	Jaculus_jaculus
ENSG00000164548	TRA2A	84	77.457	ENSLBEG00000005297	tra2a	88	75.479	Labrus_bergylta
ENSG00000164548	TRA2A	90	88.189	ENSLACG00000014765	TRA2A	90	88.189	Latimeria_chalumnae
ENSG00000164548	TRA2A	63	85.841	ENSLOCG00000009558	-	58	79.769	Lepisosteus_oculatus
ENSG00000164548	TRA2A	90	77.491	ENSLOCG00000011615	-	90	77.491	Lepisosteus_oculatus
ENSG00000164548	TRA2A	100	99.647	ENSLAFG00000006598	TRA2A	100	99.647	Loxodonta_africana
ENSG00000164548	TRA2A	100	100.000	ENSMFAG00000043211	TRA2A	100	100.000	Macaca_fascicularis
ENSG00000164548	TRA2A	100	100.000	ENSMMUG00000006286	TRA2A	100	100.000	Macaca_mulatta
ENSG00000164548	TRA2A	100	100.000	ENSMNEG00000040670	TRA2A	100	100.000	Macaca_nemestrina
ENSG00000164548	TRA2A	100	100.000	ENSMLEG00000032154	TRA2A	100	100.000	Mandrillus_leucophaeus
ENSG00000164548	TRA2A	76	80.687	ENSMAMG00000008575	tra2a	90	81.034	Mastacembelus_armatus
ENSG00000164548	TRA2A	90	78.967	ENSMZEG00005009142	tra2a	90	78.967	Maylandia_zebra
ENSG00000164548	TRA2A	100	93.923	ENSMGAG00000010514	TRA2A	100	94.118	Meleagris_gallopavo
ENSG00000164548	TRA2A	100	100.000	ENSMICG00000043639	-	100	100.000	Microcebus_murinus
ENSG00000164548	TRA2A	100	83.978	ENSMICG00000036849	-	88	76.680	Microcebus_murinus
ENSG00000164548	TRA2A	90	91.358	ENSMOCG00000010249	-	63	90.419	Microtus_ochrogaster
ENSG00000164548	TRA2A	71	82.587	ENSMOCG00000006467	-	97	81.592	Microtus_ochrogaster
ENSG00000164548	TRA2A	87	82.166	ENSMMOG00000020174	tra2a	83	79.583	Mola_mola
ENSG00000164548	TRA2A	100	98.895	ENSMODG00000000807	TRA2A	100	98.227	Monodelphis_domestica
ENSG00000164548	TRA2A	85	77.308	ENSMALG00000020875	tra2a	90	76.277	Monopterus_albus
ENSG00000164548	TRA2A	100	98.907	ENSMUSG00000029817	Tra2a	100	98.592	Mus_musculus
ENSG00000164548	TRA2A	100	98.907	MGP_PahariEiJ_G0022115	Tra2a	100	98.239	Mus_pahari
ENSG00000164548	TRA2A	100	98.907	MGP_SPRETEiJ_G0029368	Tra2a	100	98.592	Mus_spretus
ENSG00000164548	TRA2A	100	99.448	ENSMPUG00000013480	TRA2A	100	99.291	Mustela_putorius_furo
ENSG00000164548	TRA2A	100	98.587	ENSMLUG00000013972	TRA2A	100	98.587	Myotis_lucifugus
ENSG00000164548	TRA2A	100	99.448	ENSNGAG00000023805	Tra2a	100	98.582	Nannospalax_galili
ENSG00000164548	TRA2A	84	89.542	ENSNBRG00000005992	tra2a	73	90.850	Neolamprologus_brichardi
ENSG00000164548	TRA2A	100	71.111	ENSNLEG00000029659	-	88	76.316	Nomascus_leucogenys
ENSG00000164548	TRA2A	100	100.000	ENSNLEG00000014794	TRA2A	100	100.000	Nomascus_leucogenys
ENSG00000164548	TRA2A	100	98.901	ENSMEUG00000001202	TRA2A	100	97.880	Notamacropus_eugenii
ENSG00000164548	TRA2A	100	99.448	ENSOPRG00000007606	TRA2A	100	98.582	Ochotona_princeps
ENSG00000164548	TRA2A	100	100.000	ENSODEG00000008335	TRA2A	100	100.000	Octodon_degus
ENSG00000164548	TRA2A	90	78.832	ENSONIG00000004503	tra2a	90	78.832	Oreochromis_niloticus
ENSG00000164548	TRA2A	89	88.760	ENSOANG00000014202	TRA2A	90	87.984	Ornithorhynchus_anatinus
ENSG00000164548	TRA2A	100	100.000	ENSOCUG00000024139	TRA2A	100	99.645	Oryctolagus_cuniculus
ENSG00000164548	TRA2A	84	75.658	ENSORLG00000022191	tra2a	60	74.251	Oryzias_latipes
ENSG00000164548	TRA2A	84	75.000	ENSORLG00020003490	tra2a	60	73.653	Oryzias_latipes_hni
ENSG00000164548	TRA2A	84	74.342	ENSORLG00015015485	tra2a	60	73.054	Oryzias_latipes_hsok
ENSG00000164548	TRA2A	84	73.026	ENSOMEG00000017864	tra2a	60	71.856	Oryzias_melastigma
ENSG00000164548	TRA2A	100	100.000	ENSOGAG00000009733	TRA2A	99	97.143	Otolemur_garnettii
ENSG00000164548	TRA2A	100	97.283	ENSOARG00000002323	-	100	90.175	Ovis_aries
ENSG00000164548	TRA2A	100	98.582	ENSOARG00000013147	TRA2A	100	98.582	Ovis_aries
ENSG00000164548	TRA2A	99	100.000	ENSPPAG00000034382	TRA2A	99	100.000	Pan_paniscus
ENSG00000164548	TRA2A	100	99.645	ENSPPRG00000015216	TRA2A	100	99.645	Panthera_pardus
ENSG00000164548	TRA2A	100	99.645	ENSPTIG00000021114	TRA2A	100	99.645	Panthera_tigris_altaica
ENSG00000164548	TRA2A	100	100.000	ENSPTRG00000046098	-	100	100.000	Pan_troglodytes
ENSG00000164548	TRA2A	100	100.000	ENSPTRG00000018988	TRA2A	100	100.000	Pan_troglodytes
ENSG00000164548	TRA2A	100	100.000	ENSPANG00000014541	TRA2A	100	100.000	Papio_anubis
ENSG00000164548	TRA2A	90	76.384	ENSPKIG00000012298	tra2a	90	75.646	Paramormyrops_kingsleyae
ENSG00000164548	TRA2A	100	95.580	ENSPSIG00000014993	TRA2A	90	94.378	Pelodiscus_sinensis
ENSG00000164548	TRA2A	100	99.451	ENSPEMG00000008564	-	100	98.940	Peromyscus_maniculatus_bairdii
ENSG00000164548	TRA2A	90	69.939	ENSPMAG00000007947	tra2a	59	69.697	Petromyzon_marinus
ENSG00000164548	TRA2A	100	99.448	ENSPCIG00000007917	TRA2A	100	98.227	Phascolarctos_cinereus
ENSG00000164548	TRA2A	100	100.000	ENSPPYG00000017728	TRA2A	100	100.000	Pongo_abelii
ENSG00000164548	TRA2A	99	98.929	ENSPCAG00000004148	TRA2A	100	98.929	Procavia_capensis
ENSG00000164548	TRA2A	100	85.816	ENSPCOG00000020465	TRA2A	100	85.816	Propithecus_coquereli
ENSG00000164548	TRA2A	100	99.293	ENSPVAG00000011298	TRA2A	100	99.293	Pteropus_vampyrus
ENSG00000164548	TRA2A	84	87.821	ENSPNYG00000020134	tra2a	76	87.821	Pundamilia_nyererei
ENSG00000164548	TRA2A	90	73.432	ENSPNAG00000000482	tra2a	90	71.218	Pygocentrus_nattereri
ENSG00000164548	TRA2A	100	98.907	ENSRNOG00000009156	Tra2a	100	98.592	Rattus_norvegicus
ENSG00000164548	TRA2A	62	100.000	ENSRBIG00000036805	TRA2A	66	100.000	Rhinopithecus_bieti
ENSG00000164548	TRA2A	100	100.000	ENSRROG00000030758	TRA2A	100	100.000	Rhinopithecus_roxellana
ENSG00000164548	TRA2A	100	100.000	ENSSBOG00000031562	TRA2A	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000164548	TRA2A	100	99.448	ENSSHAG00000005727	TRA2A	88	95.600	Sarcophilus_harrisii
ENSG00000164548	TRA2A	90	80.237	ENSSFOG00015014004	tra2a	90	74.908	Scleropages_formosus
ENSG00000164548	TRA2A	86	81.410	ENSSMAG00000014242	tra2a	90	73.432	Scophthalmus_maximus
ENSG00000164548	TRA2A	90	83.594	ENSSDUG00000005610	tra2a	89	83.594	Seriola_dumerili
ENSG00000164548	TRA2A	84	87.500	ENSSLDG00000025577	tra2a	81	88.158	Seriola_lalandi_dorsalis
ENSG00000164548	TRA2A	100	78.014	ENSSARG00000012900	TRA2A	100	78.014	Sorex_araneus
ENSG00000164548	TRA2A	100	97.283	ENSSPUG00000006143	TRA2A	100	96.516	Sphenodon_punctatus
ENSG00000164548	TRA2A	90	78.967	ENSSPAG00000004184	tra2a	90	78.967	Stegastes_partitus
ENSG00000164548	TRA2A	100	99.645	ENSSSCG00000015387	TRA2A	100	99.645	Sus_scrofa
ENSG00000164548	TRA2A	86	89.032	ENSTGUG00000002795	TRA2A	62	89.222	Taeniopygia_guttata
ENSG00000164548	TRA2A	100	83.333	ENSTBEG00000013773	TRA2A	100	83.333	Tupaia_belangeri
ENSG00000164548	TRA2A	100	99.291	ENSTTRG00000008922	TRA2A	100	99.291	Tursiops_truncatus
ENSG00000164548	TRA2A	100	98.352	ENSUMAG00000001181	TRA2A	94	98.352	Ursus_maritimus
ENSG00000164548	TRA2A	100	85.461	ENSVPAG00000001829	TRA2A	100	85.461	Vicugna_pacos
ENSG00000164548	TRA2A	100	99.645	ENSVVUG00000001045	TRA2A	100	99.645	Vulpes_vulpes
ENSG00000164548	TRA2A	90	83.270	ENSXETG00000007397	tra2a	90	83.270	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	9546399.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9546399.	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0048026	positive regulation of mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component