EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000164896 (Gene tree)
Gene ID: 10922
Gene Symbol: FASTK
Alias: FAST
Full Name: Fas activated serine/threonine kinase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,291 bases
Position: chr7:151,076,593-151,080,883
Accession: 24676
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000324817	RAP	PF08373.10	1.1e-06	1	1
ENSP00000418516	RAP	PF08373.10	1.5e-06	1	1
ENSP00000297532	RAP	PF08373.10	1.6e-06	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26370583	FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.	RNA	2015 Nov	Popow J	doi: 10.1261/rna.052365.115
29036396	The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.	Nucleic Acids Res	2017 Nov 2	Jourdain AA	doi: 10.1093/nar/gkx772.
30322967	The Mitochondrial Isoform of FASTK Modulates Nonopsonic Phagocytosis of Bacteria by Macrophages via Regulation of Respiratory Complex I.	J Immunol	2018 Nov 15	Garcia Del Rio A	doi: 10.4049/jimmunol.1701075

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460980	FASTK-204	1521	-	-	- (aa)	-	-
ENST00000478477	FASTK-210	826	-	-	- (aa)	-	-
ENST00000483953	FASTK-214	1178	-	-	- (aa)	-	-
ENST00000467237	FASTK-208	3011	-	-	- (aa)	-	-
ENST00000482571	FASTK-212	1764	XM_017011704	ENSP00000418516	522 (aa)	XP_016867193	Q14296
ENST00000465272	FASTK-206	457	-	-	- (aa)	-	-
ENST00000540185	FASTK-217	1609	XM_011515761	ENSP00000444498	465 (aa)	XP_011514063	G3V1R6
ENST00000482806	FASTK-213	1826	-	-	- (aa)	-	-
ENST00000489884	FASTK-215	1751	-	-	- (aa)	-	-
ENST00000466855	FASTK-207	1894	-	-	- (aa)	-	-
ENST00000461979	FASTK-205	720	-	-	- (aa)	-	-
ENST00000459800	FASTK-203	449	-	-	- (aa)	-	-
ENST00000469237	FASTK-209	1904	-	-	- (aa)	-	-
ENST00000496663	FASTK-216	818	-	-	- (aa)	-	-
ENST00000353841	FASTK-202	1402	XM_011515763	ENSP00000324817	408 (aa)	XP_011514065	Q14296
ENST00000478883	FASTK-211	706	-	-	- (aa)	-	-
ENST00000297532	FASTK-201	1827	XM_005249932	ENSP00000297532	549 (aa)	XP_005249989	Q14296

Gene Model

Click here to download ENSG00000164896's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000164896's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000164896	FASTK	100	95.263	ENSAMEG00000013695	FASTK	100	93.989	Ailuropoda_melanoleuca
ENSG00000164896	FASTK	86	44.565	ENSACIG00000003041	fastk	93	44.565	Amphilophus_citrinellus
ENSG00000164896	FASTK	65	47.212	ENSACAG00000005313	-	99	47.212	Anolis_carolinensis
ENSG00000164896	FASTK	100	95.833	ENSANAG00000028784	FASTK	100	95.833	Aotus_nancymaae
ENSG00000164896	FASTK	82	47.619	ENSACLG00000016505	fastk	58	47.619	Astatotilapia_calliptera
ENSG00000164896	FASTK	100	91.053	ENSBTAG00000011228	FASTK	100	90.727	Bos_taurus
ENSG00000164896	FASTK	100	97.059	ENSCJAG00000020307	FASTK	100	97.059	Callithrix_jacchus
ENSG00000164896	FASTK	100	95.263	ENSCAFG00000004739	FASTK	100	93.989	Canis_familiaris
ENSG00000164896	FASTK	100	95.263	ENSCAFG00020006312	FASTK	100	93.989	Canis_lupus_dingo
ENSG00000164896	FASTK	99	94.280	ENSTSYG00000007984	FASTK	99	94.280	Carlito_syrichta
ENSG00000164896	FASTK	100	96.814	ENSCCAG00000013285	FASTK	100	96.814	Cebus_capucinus
ENSG00000164896	FASTK	100	98.947	ENSCATG00000042475	FASTK	100	98.947	Cercocebus_atys
ENSG00000164896	FASTK	95	90.403	ENSCLAG00000004011	FASTK	100	90.403	Chinchilla_lanigera
ENSG00000164896	FASTK	100	98.947	ENSCSAG00000006690	FASTK	100	98.179	Chlorocebus_sabaeus
ENSG00000164896	FASTK	82	56.481	ENSCPBG00000012219	FASTK	51	53.226	Chrysemys_picta_bellii
ENSG00000164896	FASTK	100	98.775	ENSCANG00000040479	FASTK	100	98.775	Colobus_angolensis_palliatus
ENSG00000164896	FASTK	100	89.474	ENSCGRG00001002508	Fastk	100	89.474	Cricetulus_griseus_chok1gshd
ENSG00000164896	FASTK	95	88.676	ENSCGRG00000012561	Fastk	100	88.676	Cricetulus_griseus_crigri
ENSG00000164896	FASTK	74	51.152	ENSCSEG00000014579	fastk	61	46.269	Cynoglossus_semilaevis
ENSG00000164896	FASTK	82	50.190	ENSDARG00000077075	fastk	51	50.382	Danio_rerio
ENSG00000164896	FASTK	100	92.714	ENSDNOG00000032359	FASTK	100	92.714	Dasypus_novemcinctus
ENSG00000164896	FASTK	100	89.071	ENSDORG00000006552	Fastk	100	89.071	Dipodomys_ordii
ENSG00000164896	FASTK	78	49.275	ENSEBUG00000004770	fastk	50	49.275	Eptatretus_burgeri
ENSG00000164896	FASTK	100	96.316	ENSEASG00005002707	FASTK	100	95.082	Equus_asinus_asinus
ENSG00000164896	FASTK	100	96.316	ENSECAG00000014380	FASTK	100	95.082	Equus_caballus
ENSG00000164896	FASTK	82	50.000	ENSELUG00000017385	fastk	90	50.000	Esox_lucius
ENSG00000164896	FASTK	100	95.789	ENSFCAG00000013198	FASTK	100	95.789	Felis_catus
ENSG00000164896	FASTK	91	49.202	ENSFALG00000013118	FASTK	100	47.934	Ficedula_albicollis
ENSG00000164896	FASTK	82	50.602	ENSFHEG00000021968	fastk	79	43.908	Fundulus_heteroclitus
ENSG00000164896	FASTK	90	45.889	ENSGMOG00000009461	fastk	95	44.928	Gadus_morhua
ENSG00000164896	FASTK	74	58.333	ENSGALG00000033058	FASTK	52	54.839	Gallus_gallus
ENSG00000164896	FASTK	90	46.400	ENSGACG00000001499	fastk	99	43.789	Gasterosteus_aculeatus
ENSG00000164896	FASTK	74	57.870	ENSGAGG00000016922	FASTK	52	54.435	Gopherus_agassizii
ENSG00000164896	FASTK	100	99.818	ENSGGOG00000016906	FASTK	100	99.818	Gorilla_gorilla
ENSG00000164896	FASTK	82	47.619	ENSHBUG00000009697	fastk	54	47.619	Haplochromis_burtoni
ENSG00000164896	FASTK	97	64.750	ENSHGLG00000003297	FASTK	100	64.750	Heterocephalus_glaber_female
ENSG00000164896	FASTK	100	64.144	ENSHGLG00100015402	FASTK	100	64.144	Heterocephalus_glaber_male
ENSG00000164896	FASTK	78	53.125	ENSHCOG00000013053	fastk	51	50.000	Hippocampus_comes
ENSG00000164896	FASTK	75	54.839	ENSIPUG00000002527	FASTK	50	51.406	Ictalurus_punctatus
ENSG00000164896	FASTK	100	97.105	ENSSTOG00000016075	FASTK	100	97.105	Ictidomys_tridecemlineatus
ENSG00000164896	FASTK	100	88.537	ENSJJAG00000016554	Fastk	100	88.537	Jaculus_jaculus
ENSG00000164896	FASTK	78	49.221	ENSLACG00000010865	FASTK	100	49.216	Latimeria_chalumnae
ENSG00000164896	FASTK	82	47.619	ENSLOCG00000010214	fastk	51	47.619	Lepisosteus_oculatus
ENSG00000164896	FASTK	100	91.621	ENSLAFG00000008796	FASTK	100	91.621	Loxodonta_africana
ENSG00000164896	FASTK	100	99.020	ENSMFAG00000041547	FASTK	100	99.020	Macaca_fascicularis
ENSG00000164896	FASTK	100	98.947	ENSMMUG00000020459	FASTK	100	98.947	Macaca_mulatta
ENSG00000164896	FASTK	100	99.020	ENSMNEG00000008431	FASTK	100	99.020	Macaca_nemestrina
ENSG00000164896	FASTK	95	98.273	ENSMLEG00000029888	FASTK	100	98.273	Mandrillus_leucophaeus
ENSG00000164896	FASTK	82	47.619	ENSMZEG00005019400	fastk	58	47.619	Maylandia_zebra
ENSG00000164896	FASTK	100	88.684	ENSMAUG00000015620	Fastk	100	88.684	Mesocricetus_auratus
ENSG00000164896	FASTK	100	95.833	ENSMICG00000004757	FASTK	100	95.833	Microcebus_murinus
ENSG00000164896	FASTK	94	88.544	ENSMOCG00000020800	Fastk	100	88.544	Microtus_ochrogaster
ENSG00000164896	FASTK	74	46.774	ENSMMOG00000018047	fastk	56	46.774	Mola_mola
ENSG00000164896	FASTK	83	45.022	ENSMALG00000000220	fastk	86	42.740	Monopterus_albus
ENSG00000164896	FASTK	100	89.461	MGP_CAROLIEiJ_G0027012	Fastk	100	90.000	Mus_caroli
ENSG00000164896	FASTK	100	89.461	ENSMUSG00000028959	Fastk	100	90.000	Mus_musculus
ENSG00000164896	FASTK	100	90.000	MGP_PahariEiJ_G0021785	Fastk	100	90.000	Mus_pahari
ENSG00000164896	FASTK	100	89.737	MGP_SPRETEiJ_G0028008	Fastk	100	89.737	Mus_spretus
ENSG00000164896	FASTK	100	93.684	ENSMPUG00000008727	FASTK	100	92.714	Mustela_putorius_furo
ENSG00000164896	FASTK	100	91.842	ENSMLUG00000014730	FASTK	100	90.710	Myotis_lucifugus
ENSG00000164896	FASTK	100	92.157	ENSNGAG00000010690	Fastk	100	92.157	Nannospalax_galili
ENSG00000164896	FASTK	82	47.619	ENSNBRG00000017186	fastk	54	47.619	Neolamprologus_brichardi
ENSG00000164896	FASTK	100	99.020	ENSNLEG00000004192	FASTK	100	99.020	Nomascus_leucogenys
ENSG00000164896	FASTK	77	94.161	ENSOPRG00000003885	FASTK	68	94.161	Ochotona_princeps
ENSG00000164896	FASTK	100	88.725	ENSODEG00000015168	FASTK	100	88.725	Octodon_degus
ENSG00000164896	FASTK	90	46.702	ENSONIG00000014035	fastk	100	43.066	Oreochromis_niloticus
ENSG00000164896	FASTK	100	95.789	ENSOCUG00000023964	FASTK	100	94.353	Oryctolagus_cuniculus
ENSG00000164896	FASTK	75	55.046	ENSORLG00000023667	fastk	51	48.299	Oryzias_latipes
ENSG00000164896	FASTK	84	47.782	ENSORLG00020018249	fastk	50	47.945	Oryzias_latipes_hni
ENSG00000164896	FASTK	77	53.879	ENSORLG00015016956	fastk	50	50.951	Oryzias_latipes_hsok
ENSG00000164896	FASTK	82	48.913	ENSOMEG00000022058	fastk	51	48.913	Oryzias_melastigma
ENSG00000164896	FASTK	100	96.316	ENSOGAG00000001782	FASTK	100	94.536	Otolemur_garnettii
ENSG00000164896	FASTK	100	99.636	ENSPPAG00000042376	FASTK	100	99.636	Pan_paniscus
ENSG00000164896	FASTK	100	96.053	ENSPPRG00000003158	FASTK	100	96.053	Panthera_pardus
ENSG00000164896	FASTK	93	96.053	ENSPTIG00000012926	FASTK	100	94.175	Panthera_tigris_altaica
ENSG00000164896	FASTK	100	99.818	ENSPTRG00000019874	FASTK	100	99.818	Pan_troglodytes
ENSG00000164896	FASTK	100	99.020	ENSPANG00000015942	FASTK	100	99.020	Papio_anubis
ENSG00000164896	FASTK	82	47.703	ENSPKIG00000008408	fastk	52	47.872	Paramormyrops_kingsleyae
ENSG00000164896	FASTK	81	40.889	ENSPMGG00000003684	fastk	84	41.204	Periophthalmus_magnuspinnatus
ENSG00000164896	FASTK	100	89.211	ENSPEMG00000012621	Fastk	100	89.211	Peromyscus_maniculatus_bairdii
ENSG00000164896	FASTK	90	42.359	ENSPMAG00000009209	fastk	100	41.087	Petromyzon_marinus
ENSG00000164896	FASTK	78	50.800	ENSPFOG00000010879	fastk	52	51.004	Poecilia_formosa
ENSG00000164896	FASTK	81	50.382	ENSPLAG00000016993	fastk	53	48.421	Poecilia_latipinna
ENSG00000164896	FASTK	79	50.800	ENSPMEG00000009803	fastk	51	51.004	Poecilia_mexicana
ENSG00000164896	FASTK	79	50.800	ENSPREG00000001443	fastk	51	51.004	Poecilia_reticulata
ENSG00000164896	FASTK	100	99.271	ENSPPYG00000018185	FASTK	100	99.271	Pongo_abelii
ENSG00000164896	FASTK	100	93.684	ENSPCAG00000007566	FASTK	100	92.350	Procavia_capensis
ENSG00000164896	FASTK	100	96.053	ENSPCOG00000028719	FASTK	100	96.053	Propithecus_coquereli
ENSG00000164896	FASTK	91	94.921	ENSPVAG00000007095	FASTK	88	95.238	Pteropus_vampyrus
ENSG00000164896	FASTK	82	47.619	ENSPNYG00000004170	fastk	58	47.619	Pundamilia_nyererei
ENSG00000164896	FASTK	100	98.421	ENSRBIG00000030083	FASTK	100	98.421	Rhinopithecus_bieti
ENSG00000164896	FASTK	100	98.421	ENSRROG00000042586	FASTK	100	98.421	Rhinopithecus_roxellana
ENSG00000164896	FASTK	93	96.579	ENSSBOG00000033161	FASTK	100	95.146	Saimiri_boliviensis_boliviensis
ENSG00000164896	FASTK	82	45.397	ENSSFOG00015019472	fastk	59	45.397	Scleropages_formosus
ENSG00000164896	FASTK	76	53.670	ENSSDUG00000006952	fastk	52	51.406	Seriola_dumerili
ENSG00000164896	FASTK	92	41.505	ENSSPUG00000006560	FASTK	67	56.522	Sphenodon_punctatus
ENSG00000164896	FASTK	82	48.387	ENSSPAG00000020341	fastk	85	44.098	Stegastes_partitus
ENSG00000164896	FASTK	100	91.842	ENSSSCG00000024184	FASTK	100	91.439	Sus_scrofa
ENSG00000164896	FASTK	82	47.260	ENSTRUG00000023502	fastk	52	46.552	Takifugu_rubripes
ENSG00000164896	FASTK	93	44.560	ENSTNIG00000003067	fastk	99	49.383	Tetraodon_nigroviridis
ENSG00000164896	FASTK	100	91.579	ENSTTRG00000000853	FASTK	100	91.075	Tursiops_truncatus
ENSG00000164896	FASTK	100	95.789	ENSUAMG00000022753	FASTK	100	95.789	Ursus_americanus
ENSG00000164896	FASTK	95	94.818	ENSUMAG00000016282	FASTK	97	94.818	Ursus_maritimus
ENSG00000164896	FASTK	71	92.617	ENSVPAG00000006535	FASTK	75	92.617	Vicugna_pacos
ENSG00000164896	FASTK	100	95.343	ENSVVUG00000008400	FASTK	100	95.343	Vulpes_vulpes
ENSG00000164896	FASTK	75	49.518	ENSXCOG00000000382	fastk	78	49.838	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004674	protein serine/threonine kinase activity	7544399.	IDA	Function
GO:0005515	protein binding	7544399.15110758.25416956.25910212.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0006468	protein phosphorylation	7544399.	IDA	Process
GO:0033867	Fas-activated serine/threonine kinase activity	-	IEA	Function
GO:0043484	regulation of RNA splicing	17135269.	IDA	Process
GO:0043484	regulation of RNA splicing	17592127.	IMP	Process
GO:0097190	apoptotic signaling pathway	7544399.	TAS	Process