EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165055 (Gene tree)
Gene ID: 55798
Gene Symbol: METTL2B
Alias: METL|FLJ11350|METTL2
Full Name: methyltransferase like 2B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 29,874 bases
Position: chr7:128,476,729-128,506,602
Accession: 18272
RBP type: canonical RBP
Summary: This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262432	Methyltransf_31	PF13847.6	3.3e-09	1	1
ENSP00000418402	Methyltransf_31	PF13847.6	3.4e-09	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000419443	METTL2B-202	411	-	ENSP00000405144	106 (aa)	-	H7C2C8
ENST00000482555	METTL2B-206	1590	-	-	- (aa)	-	-
ENST00000497665	METTL2B-207	977	-	ENSP00000417616	76 (aa)	-	F8WAS9
ENST00000480046	METTL2B-204	5743	-	ENSP00000418402	313 (aa)	-	Q6P1Q9
ENST00000481392	METTL2B-205	564	-	ENSP00000418989	150 (aa)	-	H7C552
ENST00000262432	METTL2B-201	2182	-	ENSP00000262432	378 (aa)	-	Q6P1Q9
ENST00000473488	METTL2B-203	465	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000165055's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165055	rs112426857	7	128504708	?	Yeast infection	28928442	[0.017-0.043] unit increase	0.0298	EFO_0008412
ENSG00000165055	rs143319329	7	128499405	C	Interleukin-1-beta levels	27989323	[0.14-0.42] SD units decrease	0.2801	EFO_0004812

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165055's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000165055	METTL2B	100	98.722	ENSG00000087995	METTL2A	100	98.722

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165055	METTL2B	99	66.990	ENSAPOG00000019825	mettl2a	94	64.021	Acanthochromis_polyacanthus
ENSG00000165055	METTL2B	100	87.599	ENSAMEG00000004032	-	100	87.599	Ailuropoda_melanoleuca
ENSG00000165055	METTL2B	99	62.258	ENSACIG00000009574	mettl2a	90	62.534	Amphilophus_citrinellus
ENSG00000165055	METTL2B	99	66.343	ENSAOCG00000012765	mettl2a	89	65.470	Amphiprion_ocellaris
ENSG00000165055	METTL2B	99	66.343	ENSAPEG00000003799	mettl2a	89	65.470	Amphiprion_percula
ENSG00000165055	METTL2B	99	65.696	ENSATEG00000000903	mettl2a	91	66.295	Anabas_testudineus
ENSG00000165055	METTL2B	97	68.167	ENSAPLG00000005374	-	91	68.129	Anas_platyrhynchos
ENSG00000165055	METTL2B	96	62.783	ENSACAG00000016823	-	95	63.361	Anolis_carolinensis
ENSG00000165055	METTL2B	96	65.449	ENSACLG00000001776	mettl2a	96	64.706	Astatotilapia_calliptera
ENSG00000165055	METTL2B	97	67.123	ENSAMXG00000015090	mettl2a	86	65.922	Astyanax_mexicanus
ENSG00000165055	METTL2B	99	85.256	ENSBTAG00000009458	METTL2A	99	85.224	Bos_taurus
ENSG00000165055	METTL2B	100	95.860	ENSCJAG00000033545	-	100	95.860	Callithrix_jacchus
ENSG00000165055	METTL2B	89	85.294	ENSCAFG00000013365	-	73	87.622	Canis_familiaris
ENSG00000165055	METTL2B	100	88.654	ENSCAFG00020026820	-	100	88.654	Canis_lupus_dingo
ENSG00000165055	METTL2B	98	81.494	ENSTSYG00000002783	-	99	81.494	Carlito_syrichta
ENSG00000165055	METTL2B	99	84.615	ENSCPOG00000003808	-	100	82.850	Cavia_porcellus
ENSG00000165055	METTL2B	100	97.134	ENSCATG00000007364	-	100	97.134	Cercocebus_atys
ENSG00000165055	METTL2B	100	83.113	ENSCLAG00000004955	-	97	83.113	Chinchilla_lanigera
ENSG00000165055	METTL2B	100	96.570	ENSCSAG00000003846	-	100	96.570	Chlorocebus_sabaeus
ENSG00000165055	METTL2B	98	67.895	ENSCPBG00000012298	-	97	68.605	Chrysemys_picta_bellii
ENSG00000165055	METTL2B	100	96.178	ENSCANG00000027777	-	100	96.178	Colobus_angolensis_palliatus
ENSG00000165055	METTL2B	100	80.475	ENSCGRG00001023089	Mettl2	98	80.475	Cricetulus_griseus_chok1gshd
ENSG00000165055	METTL2B	99	80.769	ENSCGRG00000003381	Mettl2	95	81.579	Cricetulus_griseus_crigri
ENSG00000165055	METTL2B	97	66.007	ENSCSEG00000016579	mettl2a	87	66.573	Cynoglossus_semilaevis
ENSG00000165055	METTL2B	97	66.667	ENSCVAG00000012179	mettl2a	91	66.011	Cyprinodon_variegatus
ENSG00000165055	METTL2B	97	66.885	ENSDARG00000008105	mettl2a	91	66.944	Danio_rerio
ENSG00000165055	METTL2B	99	85.577	ENSDNOG00000043251	-	100	84.433	Dasypus_novemcinctus
ENSG00000165055	METTL2B	84	83.333	ENSDORG00000028245	Mettl2	99	83.333	Dipodomys_ordii
ENSG00000165055	METTL2B	98	89.577	ENSEASG00005010594	-	97	87.968	Equus_asinus_asinus
ENSG00000165055	METTL2B	98	89.577	ENSECAG00000018804	-	97	87.968	Equus_caballus
ENSG00000165055	METTL2B	97	65.574	ENSELUG00000017635	mettl2a	89	65.826	Esox_lucius
ENSG00000165055	METTL2B	100	89.172	ENSFCAG00000010931	-	100	89.172	Felis_catus
ENSG00000165055	METTL2B	97	68.987	ENSFALG00000008097	-	97	68.588	Ficedula_albicollis
ENSG00000165055	METTL2B	99	83.121	ENSFDAG00000014414	-	99	83.121	Fukomys_damarensis
ENSG00000165055	METTL2B	97	64.744	ENSFHEG00000013086	mettl2a	89	64.384	Fundulus_heteroclitus
ENSG00000165055	METTL2B	97	64.356	ENSGMOG00000000193	mettl2a	96	63.977	Gadus_morhua
ENSG00000165055	METTL2B	98	66.981	ENSGALG00000000396	METTL2A	98	66.048	Gallus_gallus
ENSG00000165055	METTL2B	97	65.359	ENSGACG00000009023	mettl2a	93	66.282	Gasterosteus_aculeatus
ENSG00000165055	METTL2B	99	68.536	ENSGAGG00000000748	-	99	68.358	Gopherus_agassizii
ENSG00000165055	METTL2B	96	65.781	ENSHBUG00000023834	mettl2a	91	65.537	Haplochromis_burtoni
ENSG00000165055	METTL2B	97	66.007	ENSHCOG00000005928	mettl2a	91	66.387	Hippocampus_comes
ENSG00000165055	METTL2B	98	63.441	ENSIPUG00000024192	mettl2a	93	63.441	Ictalurus_punctatus
ENSG00000165055	METTL2B	100	86.316	ENSSTOG00000010289	-	100	86.316	Ictidomys_tridecemlineatus
ENSG00000165055	METTL2B	99	82.637	ENSJJAG00000017179	Mettl2	100	81.217	Jaculus_jaculus
ENSG00000165055	METTL2B	97	66.667	ENSKMAG00000020718	mettl2a	93	65.027	Kryptolebias_marmoratus
ENSG00000165055	METTL2B	97	69.132	ENSLOCG00000011314	mettl2a	92	67.308	Lepisosteus_oculatus
ENSG00000165055	METTL2B	98	85.993	ENSLAFG00000011224	-	97	86.351	Loxodonta_africana
ENSG00000165055	METTL2B	100	97.134	ENSMFAG00000007048	METTL2A	100	97.134	Macaca_fascicularis
ENSG00000165055	METTL2B	100	97.134	ENSMMUG00000009802	METTL2A	100	97.134	Macaca_mulatta
ENSG00000165055	METTL2B	100	96.815	ENSMLEG00000037621	-	100	96.815	Mandrillus_leucophaeus
ENSG00000165055	METTL2B	97	67.987	ENSMAMG00000022236	mettl2a	88	67.978	Mastacembelus_armatus
ENSG00000165055	METTL2B	96	65.449	ENSMZEG00005022838	mettl2a	91	65.254	Maylandia_zebra
ENSG00000165055	METTL2B	97	66.987	ENSMGAG00000001245	-	99	65.730	Meleagris_gallopavo
ENSG00000165055	METTL2B	100	81.217	ENSMAUG00000008120	Mettl2	98	81.217	Mesocricetus_auratus
ENSG00000165055	METTL2B	100	90.735	ENSMICG00000044781	-	100	90.735	Microcebus_murinus
ENSG00000165055	METTL2B	99	79.947	ENSMOCG00000017424	Mettl2	97	79.947	Microtus_ochrogaster
ENSG00000165055	METTL2B	100	76.178	ENSMODG00000010257	-	100	76.178	Monodelphis_domestica
ENSG00000165055	METTL2B	97	65.347	ENSMALG00000007761	mettl2a	89	66.011	Monopterus_albus
ENSG00000165055	METTL2B	100	78.100	MGP_CAROLIEiJ_G0017298	Mettl2	95	78.100	Mus_caroli
ENSG00000165055	METTL2B	100	79.420	ENSMUSG00000020691	Mettl2	95	79.420	Mus_musculus
ENSG00000165055	METTL2B	100	79.420	MGP_SPRETEiJ_G0018141	Mettl2	95	79.420	Mus_spretus
ENSG00000165055	METTL2B	99	86.495	ENSMLUG00000011972	-	99	84.392	Myotis_lucifugus
ENSG00000165055	METTL2B	96	65.563	ENSNBRG00000019764	mettl2a	91	65.352	Neolamprologus_brichardi
ENSG00000165055	METTL2B	99	97.749	ENSNLEG00000007529	-	100	97.749	Nomascus_leucogenys
ENSG00000165055	METTL2B	99	82.803	ENSODEG00000008990	-	100	82.803	Octodon_degus
ENSG00000165055	METTL2B	98	79.545	ENSODEG00000000055	-	99	79.545	Octodon_degus
ENSG00000165055	METTL2B	96	65.781	ENSONIG00000000977	mettl2a	91	65.254	Oreochromis_niloticus
ENSG00000165055	METTL2B	99	69.872	ENSOANG00000000934	-	97	66.667	Ornithorhynchus_anatinus
ENSG00000165055	METTL2B	96	80.663	ENSOCUG00000011591	-	96	80.663	Oryctolagus_cuniculus
ENSG00000165055	METTL2B	97	66.007	ENSORLG00000003321	mettl2a	91	65.449	Oryzias_latipes
ENSG00000165055	METTL2B	97	66.667	ENSORLG00020009352	mettl2a	91	66.011	Oryzias_latipes_hni
ENSG00000165055	METTL2B	97	66.337	ENSORLG00015002215	mettl2a	98	65.730	Oryzias_latipes_hsok
ENSG00000165055	METTL2B	97	66.118	ENSOMEG00000022489	-	94	65.143	Oryzias_melastigma
ENSG00000165055	METTL2B	99	89.423	ENSOGAG00000014790	-	100	88.127	Otolemur_garnettii
ENSG00000165055	METTL2B	99	83.377	ENSOARG00000012110	-	94	83.377	Ovis_aries
ENSG00000165055	METTL2B	99	88.141	ENSPPRG00000004162	-	99	88.141	Panthera_pardus
ENSG00000165055	METTL2B	99	88.387	ENSPTIG00000013790	-	98	88.350	Panthera_tigris_altaica
ENSG00000165055	METTL2B	100	98.722	ENSPTRG00000019664	-	100	98.722	Pan_troglodytes
ENSG00000165055	METTL2B	100	97.444	ENSPTRG00000009504	METTL2A	100	97.444	Pan_troglodytes
ENSG00000165055	METTL2B	100	96.815	ENSPANG00000021128	-	100	96.815	Papio_anubis
ENSG00000165055	METTL2B	97	68.690	ENSPSIG00000011888	-	97	68.605	Pelodiscus_sinensis
ENSG00000165055	METTL2B	97	64.630	ENSPMGG00000002653	mettl2a	92	63.660	Periophthalmus_magnuspinnatus
ENSG00000165055	METTL2B	99	81.290	ENSPEMG00000011277	Mettl2	98	81.167	Peromyscus_maniculatus_bairdii
ENSG00000165055	METTL2B	96	56.913	ENSPMAG00000007098	mettl2a	91	56.164	Petromyzon_marinus
ENSG00000165055	METTL2B	97	68.092	ENSPFOG00000009811	mettl2a	92	67.507	Poecilia_formosa
ENSG00000165055	METTL2B	97	66.447	ENSPLAG00000022249	mettl2a	92	67.227	Poecilia_latipinna
ENSG00000165055	METTL2B	97	68.092	ENSPMEG00000002599	mettl2a	92	67.227	Poecilia_mexicana
ENSG00000165055	METTL2B	100	97.361	ENSPPYG00000008952	-	100	97.361	Pongo_abelii
ENSG00000165055	METTL2B	100	89.776	ENSPCOG00000022425	-	100	89.776	Propithecus_coquereli
ENSG00000165055	METTL2B	100	87.335	ENSPVAG00000005571	-	100	87.335	Pteropus_vampyrus
ENSG00000165055	METTL2B	96	65.781	ENSPNYG00000011885	mettl2a	90	65.537	Pundamilia_nyererei
ENSG00000165055	METTL2B	93	79.944	ENSRNOG00000006131	Mettl2b	100	79.944	Rattus_norvegicus
ENSG00000165055	METTL2B	100	97.134	ENSRBIG00000033312	-	100	97.134	Rhinopithecus_bieti
ENSG00000165055	METTL2B	100	97.134	ENSRROG00000033706	-	100	97.134	Rhinopithecus_roxellana
ENSG00000165055	METTL2B	99	76.825	ENSSHAG00000002924	-	100	75.131	Sarcophilus_harrisii
ENSG00000165055	METTL2B	97	65.347	ENSSFOG00015023376	mettl2a	89	65.027	Scleropages_formosus
ENSG00000165055	METTL2B	96	65.116	ENSSMAG00000009808	mettl2a	91	63.488	Scophthalmus_maximus
ENSG00000165055	METTL2B	98	66.667	ENSSDUG00000022754	mettl2a	94	66.574	Seriola_dumerili
ENSG00000165055	METTL2B	98	66.993	ENSSLDG00000002078	mettl2a	90	66.852	Seriola_lalandi_dorsalis
ENSG00000165055	METTL2B	97	71.885	ENSSPUG00000009791	-	85	71.858	Sphenodon_punctatus
ENSG00000165055	METTL2B	98	66.340	ENSSPAG00000015837	mettl2a	89	65.833	Stegastes_partitus
ENSG00000165055	METTL2B	99	86.817	ENSSSCG00000033421	-	99	86.817	Sus_scrofa
ENSG00000165055	METTL2B	97	67.101	ENSTGUG00000003112	-	99	67.160	Taeniopygia_guttata
ENSG00000165055	METTL2B	98	64.286	ENSTRUG00000016340	mettl2a	91	64.266	Takifugu_rubripes
ENSG00000165055	METTL2B	97	66.557	ENSTNIG00000011723	mettl2a	90	65.847	Tetraodon_nigroviridis
ENSG00000165055	METTL2B	100	87.599	ENSTTRG00000012619	-	100	87.599	Tursiops_truncatus
ENSG00000165055	METTL2B	89	88.235	ENSUAMG00000022066	-	76	81.267	Ursus_americanus
ENSG00000165055	METTL2B	82	91.057	ENSUMAG00000016063	-	99	92.857	Ursus_maritimus
ENSG00000165055	METTL2B	88	85.075	ENSVPAG00000010383	-	56	91.597	Vicugna_pacos
ENSG00000165055	METTL2B	99	89.711	ENSVVUG00000005506	-	80	88.624	Vulpes_vulpes
ENSG00000165055	METTL2B	97	62.829	ENSXETG00000007856	mettl2b	82	63.056	Xenopus_tropicalis
ENSG00000165055	METTL2B	97	66.776	ENSXMAG00000008640	mettl2a	88	64.247	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0016427	tRNA (cytosine) methyltransferase activity	21518805.	IMP	Function
GO:0030488	tRNA methylation	21518805.	IMP	Process
GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	21873635.	IBA	Function