EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165271 (Gene tree)
Gene ID: 65083
Gene Symbol: NOL6
Alias: bA311H10.1|Nrap|FLJ21959|MGC14896|MGC14921|MGC20838|UTP22
Full Name: nucleolar protein 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,591 bases
Position: chr9:33,461,353-33,473,943
Accession: 19910
RBP type: canonical RBP
Summary: The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000313978	Nrap	PF03813.14	8.7e-43	1	1
ENSP00000368784	Nrap	PF03813.14	1.1e-42	1	1
ENSP00000297990	Nrap	PF03813.14	1.4e-42	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496319	NOL6-206	759	-	-	- (aa)	-	-
ENST00000464829	NOL6-205	1829	-	-	- (aa)	-	-
ENST00000297990	NOL6-201	4741	XM_017015044	ENSP00000297990	1146 (aa)	XP_016870533	Q9H6R4
ENST00000353159	NOL6-202	3411	-	ENSP00000313978	699 (aa)	-	Q9H6R4
ENST00000379471	NOL6-204	3843	-	ENSP00000368784	1008 (aa)	-	A0A0A0MRW6
ENST00000379470	NOL6-203	2190	-	ENSP00000368783	200 (aa)	-	A0A0C4DFX0

Gene Model

Click here to download ENSG00000165271's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165271's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165271	NOL6	99	51.724	ENSAPOG00000002135	nol6	96	54.405	Acanthochromis_polyacanthus
ENSG00000165271	NOL6	100	94.500	ENSAMEG00000007364	NOL6	99	91.449	Ailuropoda_melanoleuca
ENSG00000165271	NOL6	99	53.731	ENSACIG00000018888	nol6	99	53.676	Amphilophus_citrinellus
ENSG00000165271	NOL6	97	54.073	ENSAOCG00000002591	NOL6	99	54.407	Amphiprion_ocellaris
ENSG00000165271	NOL6	99	52.853	ENSAOCG00000006894	nol6	99	52.853	Amphiprion_ocellaris
ENSG00000165271	NOL6	99	51.741	ENSAPEG00000017733	nol6	99	54.463	Amphiprion_percula
ENSG00000165271	NOL6	94	54.727	ENSATEG00000003713	nol6	96	54.967	Anabas_testudineus
ENSG00000165271	NOL6	100	60.891	ENSAPLG00000003837	NOL6	100	62.140	Anas_platyrhynchos
ENSG00000165271	NOL6	100	60.396	ENSACAG00000012749	-	99	61.633	Anolis_carolinensis
ENSG00000165271	NOL6	100	95.565	ENSANAG00000019320	NOL6	100	95.565	Aotus_nancymaae
ENSG00000165271	NOL6	99	54.187	ENSACLG00000006141	nol6	99	53.644	Astatotilapia_calliptera
ENSG00000165271	NOL6	100	52.475	ENSAMXG00000007881	nol6	97	53.176	Astyanax_mexicanus
ENSG00000165271	NOL6	100	91.000	ENSBTAG00000003323	NOL6	100	89.791	Bos_taurus
ENSG00000165271	NOL6	100	96.500	ENSCJAG00000008222	NOL6	100	95.327	Callithrix_jacchus
ENSG00000165271	NOL6	100	95.000	ENSCAFG00000001869	NOL6	100	91.361	Canis_familiaris
ENSG00000165271	NOL6	100	95.000	ENSCAFG00020015767	NOL6	99	90.398	Canis_lupus_dingo
ENSG00000165271	NOL6	100	91.500	ENSCHIG00000011813	NOL6	100	89.442	Capra_hircus
ENSG00000165271	NOL6	100	92.000	ENSTSYG00000008125	NOL6	100	90.750	Carlito_syrichta
ENSG00000165271	NOL6	100	91.000	ENSCAPG00000011587	NOL6	100	82.478	Cavia_aperea
ENSG00000165271	NOL6	100	91.000	ENSCPOG00000012282	NOL6	100	87.871	Cavia_porcellus
ENSG00000165271	NOL6	100	95.000	ENSCCAG00000022349	NOL6	100	94.852	Cebus_capucinus
ENSG00000165271	NOL6	100	99.000	ENSCATG00000031690	NOL6	100	98.000	Cercocebus_atys
ENSG00000165271	NOL6	100	90.000	ENSCLAG00000002096	NOL6	99	89.694	Chinchilla_lanigera
ENSG00000165271	NOL6	100	99.000	ENSCSAG00000009990	NOL6	100	96.422	Chlorocebus_sabaeus
ENSG00000165271	NOL6	100	64.532	ENSCPBG00000005864	NOL6	97	65.385	Chrysemys_picta_bellii
ENSG00000165271	NOL6	100	35.577	ENSCSAVG00000003332	-	100	38.031	Ciona_savignyi
ENSG00000165271	NOL6	100	98.500	ENSCANG00000017993	NOL6	100	98.000	Colobus_angolensis_palliatus
ENSG00000165271	NOL6	100	90.500	ENSCGRG00001020245	Nol6	100	89.442	Cricetulus_griseus_chok1gshd
ENSG00000165271	NOL6	100	90.500	ENSCGRG00000014588	Nol6	99	90.759	Cricetulus_griseus_crigri
ENSG00000165271	NOL6	99	55.500	ENSCVAG00000019497	nol6	99	54.925	Cyprinodon_variegatus
ENSG00000165271	NOL6	100	53.960	ENSDARG00000059711	nol6	98	53.451	Danio_rerio
ENSG00000165271	NOL6	100	82.290	ENSDNOG00000003382	NOL6	99	82.071	Dasypus_novemcinctus
ENSG00000165271	NOL6	100	89.015	ENSDORG00000006018	Nol6	100	89.015	Dipodomys_ordii
ENSG00000165271	NOL6	95	33.867	FBgn0261286	Mat89Ba	90	33.867	Drosophila_melanogaster
ENSG00000165271	NOL6	100	87.500	ENSETEG00000003875	NOL6	90	86.991	Echinops_telfairi
ENSG00000165271	NOL6	89	38.742	ENSEBUG00000005711	nol6	94	38.653	Eptatretus_burgeri
ENSG00000165271	NOL6	100	91.590	ENSEASG00005004206	NOL6	100	91.449	Equus_asinus_asinus
ENSG00000165271	NOL6	100	91.896	ENSECAG00000007914	NOL6	100	91.536	Equus_caballus
ENSG00000165271	NOL6	100	85.000	ENSEEUG00000014186	-	50	87.736	Erinaceus_europaeus
ENSG00000165271	NOL6	100	53.465	ENSELUG00000017818	nol6	99	53.893	Esox_lucius
ENSG00000165271	NOL6	100	92.000	ENSFCAG00000006677	NOL6	100	90.489	Felis_catus
ENSG00000165271	NOL6	100	62.189	ENSFALG00000009997	NOL6	100	62.448	Ficedula_albicollis
ENSG00000165271	NOL6	100	89.500	ENSFDAG00000009930	NOL6	100	88.656	Fukomys_damarensis
ENSG00000165271	NOL6	99	53.731	ENSFHEG00000007788	nol6	99	53.684	Fundulus_heteroclitus
ENSG00000165271	NOL6	99	53.000	ENSGMOG00000000637	nol6	99	53.743	Gadus_morhua
ENSG00000165271	NOL6	100	63.682	ENSGALG00000030730	NOL6	99	62.401	Gallus_gallus
ENSG00000165271	NOL6	99	55.000	ENSGAFG00000009378	nol6	99	54.137	Gambusia_affinis
ENSG00000165271	NOL6	98	53.826	ENSGACG00000010296	nol6	99	53.826	Gasterosteus_aculeatus
ENSG00000165271	NOL6	100	64.039	ENSGAGG00000019996	NOL6	99	64.311	Gopherus_agassizii
ENSG00000165271	NOL6	100	99.500	ENSGGOG00000003997	NOL6	100	99.040	Gorilla_gorilla
ENSG00000165271	NOL6	99	54.187	ENSHBUG00000010058	nol6	99	53.731	Haplochromis_burtoni
ENSG00000165271	NOL6	100	92.000	ENSHGLG00000009478	NOL6	99	89.005	Heterocephalus_glaber_female
ENSG00000165271	NOL6	100	92.000	ENSHGLG00100014962	NOL6	99	89.005	Heterocephalus_glaber_male
ENSG00000165271	NOL6	96	52.119	ENSHCOG00000020017	nol6	99	52.119	Hippocampus_comes
ENSG00000165271	NOL6	100	52.970	ENSIPUG00000018266	nol6	99	53.751	Ictalurus_punctatus
ENSG00000165271	NOL6	100	88.500	ENSSTOG00000015854	NOL6	99	88.482	Ictidomys_tridecemlineatus
ENSG00000165271	NOL6	100	91.000	ENSJJAG00000024225	Nol6	99	86.620	Jaculus_jaculus
ENSG00000165271	NOL6	99	55.721	ENSKMAG00000004749	nol6	99	55.117	Kryptolebias_marmoratus
ENSG00000165271	NOL6	99	54.229	ENSLBEG00000006902	nol6	98	52.271	Labrus_bergylta
ENSG00000165271	NOL6	75	52.294	ENSLACG00000006368	NOL6	99	52.347	Latimeria_chalumnae
ENSG00000165271	NOL6	100	55.224	ENSLOCG00000004991	nol6	100	50.799	Lepisosteus_oculatus
ENSG00000165271	NOL6	100	90.500	ENSLAFG00000004990	NOL6	99	88.482	Loxodonta_africana
ENSG00000165271	NOL6	100	98.500	ENSMFAG00000040117	NOL6	100	98.000	Macaca_fascicularis
ENSG00000165271	NOL6	100	99.000	ENSMMUG00000000389	NOL6	100	98.000	Macaca_mulatta
ENSG00000165271	NOL6	100	99.000	ENSMNEG00000040252	NOL6	100	98.000	Macaca_nemestrina
ENSG00000165271	NOL6	100	98.500	ENSMLEG00000043468	NOL6	100	98.000	Mandrillus_leucophaeus
ENSG00000165271	NOL6	100	54.412	ENSMAMG00000011484	nol6	97	54.973	Mastacembelus_armatus
ENSG00000165271	NOL6	99	54.187	ENSMZEG00005014058	nol6	99	53.644	Maylandia_zebra
ENSG00000165271	NOL6	90	56.346	ENSMGAG00000016978	NOL6	100	55.394	Meleagris_gallopavo
ENSG00000165271	NOL6	76	87.500	ENSMAUG00000010790	Nol6	100	88.268	Mesocricetus_auratus
ENSG00000165271	NOL6	100	92.845	ENSMICG00000012157	NOL6	100	92.845	Microcebus_murinus
ENSG00000165271	NOL6	100	91.500	ENSMOCG00000010981	Nol6	99	88.482	Microtus_ochrogaster
ENSG00000165271	NOL6	99	51.980	ENSMMOG00000005625	nol6	96	54.859	Mola_mola
ENSG00000165271	NOL6	100	73.500	ENSMODG00000003802	NOL6	98	72.188	Monodelphis_domestica
ENSG00000165271	NOL6	99	54.229	ENSMALG00000009130	nol6	98	54.303	Monopterus_albus
ENSG00000165271	NOL6	100	88.500	MGP_CAROLIEiJ_G0025907	Nol6	100	85.079	Mus_caroli
ENSG00000165271	NOL6	100	89.000	ENSMUSG00000028430	Nol6	99	85.253	Mus_musculus
ENSG00000165271	NOL6	100	89.000	MGP_PahariEiJ_G0024030	Nol6	99	85.120	Mus_pahari
ENSG00000165271	NOL6	100	89.500	MGP_SPRETEiJ_G0026855	Nol6	99	85.253	Mus_spretus
ENSG00000165271	NOL6	100	92.000	ENSMPUG00000003922	NOL6	99	86.771	Mustela_putorius_furo
ENSG00000165271	NOL6	100	90.500	ENSMLUG00000003230	NOL6	99	90.191	Myotis_lucifugus
ENSG00000165271	NOL6	100	91.000	ENSNGAG00000017803	Nol6	99	89.529	Nannospalax_galili
ENSG00000165271	NOL6	99	54.187	ENSNBRG00000001435	nol6	99	53.316	Neolamprologus_brichardi
ENSG00000165271	NOL6	100	98.500	ENSNLEG00000005056	NOL6	100	94.123	Nomascus_leucogenys
ENSG00000165271	NOL6	97	74.000	ENSMEUG00000004232	NOL6	100	69.523	Notamacropus_eugenii
ENSG00000165271	NOL6	100	88.500	ENSOPRG00000016817	NOL6	100	86.082	Ochotona_princeps
ENSG00000165271	NOL6	100	91.000	ENSODEG00000015856	NOL6	99	87.892	Octodon_degus
ENSG00000165271	NOL6	99	53.521	ENSONIG00000015951	nol6	99	53.521	Oreochromis_niloticus
ENSG00000165271	NOL6	95	55.721	ENSOANG00000010217	-	100	52.000	Ornithorhynchus_anatinus
ENSG00000165271	NOL6	100	90.500	ENSOCUG00000026918	NOL6	99	89.180	Oryctolagus_cuniculus
ENSG00000165271	NOL6	99	53.234	ENSORLG00000010159	nol6	99	54.513	Oryzias_latipes
ENSG00000165271	NOL6	99	53.234	ENSORLG00015023273	nol6	98	54.334	Oryzias_latipes_hsok
ENSG00000165271	NOL6	99	53.731	ENSOMEG00000006877	nol6	99	54.181	Oryzias_melastigma
ENSG00000165271	NOL6	100	91.449	ENSOGAG00000014354	NOL6	100	91.449	Otolemur_garnettii
ENSG00000165271	NOL6	100	92.500	ENSOARG00000009424	NOL6	99	89.410	Ovis_aries
ENSG00000165271	NOL6	100	99.901	ENSPPAG00000040840	NOL6	100	99.901	Pan_paniscus
ENSG00000165271	NOL6	100	93.000	ENSPPRG00000003583	NOL6	100	90.314	Panthera_pardus
ENSG00000165271	NOL6	100	93.000	ENSPTIG00000002752	NOL6	100	90.227	Panthera_tigris_altaica
ENSG00000165271	NOL6	100	100.000	ENSPTRG00000020861	NOL6	100	99.651	Pan_troglodytes
ENSG00000165271	NOL6	100	99.000	ENSPANG00000025310	NOL6	100	98.000	Papio_anubis
ENSG00000165271	NOL6	100	54.455	ENSPKIG00000011418	nol6	98	53.648	Paramormyrops_kingsleyae
ENSG00000165271	NOL6	97	72.000	ENSPSIG00000014763	NOL6	99	61.934	Pelodiscus_sinensis
ENSG00000165271	NOL6	99	51.961	ENSPMGG00000015119	nol6	99	52.320	Periophthalmus_magnuspinnatus
ENSG00000165271	NOL6	100	89.000	ENSPEMG00000011998	Nol6	99	88.394	Peromyscus_maniculatus_bairdii
ENSG00000165271	NOL6	100	75.500	ENSPCIG00000029061	NOL6	100	72.227	Phascolarctos_cinereus
ENSG00000165271	NOL6	99	55.500	ENSPFOG00000003825	nol6	99	54.665	Poecilia_formosa
ENSG00000165271	NOL6	99	55.500	ENSPLAG00000001410	nol6	99	54.754	Poecilia_latipinna
ENSG00000165271	NOL6	99	55.500	ENSPMEG00000021561	nol6	99	54.489	Poecilia_mexicana
ENSG00000165271	NOL6	99	55.000	ENSPREG00000004807	nol6	99	54.577	Poecilia_reticulata
ENSG00000165271	NOL6	100	98.500	ENSPPYG00000019133	NOL6	100	97.302	Pongo_abelii
ENSG00000165271	NOL6	100	92.845	ENSPCOG00000019262	NOL6	100	92.845	Propithecus_coquereli
ENSG00000165271	NOL6	100	90.500	ENSPVAG00000011487	NOL6	100	87.784	Pteropus_vampyrus
ENSG00000165271	NOL6	99	54.187	ENSPNYG00000020726	nol6	99	53.404	Pundamilia_nyererei
ENSG00000165271	NOL6	96	67.742	ENSPNAG00000028102	nol6	99	51.972	Pygocentrus_nattereri
ENSG00000165271	NOL6	100	91.000	ENSRNOG00000010409	Nol6	100	87.021	Rattus_norvegicus
ENSG00000165271	NOL6	100	97.282	ENSRBIG00000016646	NOL6	100	97.282	Rhinopithecus_bieti
ENSG00000165271	NOL6	100	97.500	ENSRROG00000039046	NOL6	100	97.425	Rhinopithecus_roxellana
ENSG00000165271	NOL6	100	96.037	ENSSBOG00000029525	NOL6	100	96.006	Saimiri_boliviensis_boliviensis
ENSG00000165271	NOL6	100	75.000	ENSSHAG00000004050	NOL6	100	71.875	Sarcophilus_harrisii
ENSG00000165271	NOL6	100	52.970	ENSSFOG00015016052	nol6	99	52.331	Scleropages_formosus
ENSG00000165271	NOL6	100	54.902	ENSSMAG00000008757	nol6	99	54.361	Scophthalmus_maximus
ENSG00000165271	NOL6	99	54.229	ENSSDUG00000016772	nol6	98	54.594	Seriola_dumerili
ENSG00000165271	NOL6	99	53.731	ENSSLDG00000017046	nol6	98	54.505	Seriola_lalandi_dorsalis
ENSG00000165271	NOL6	100	89.000	ENSSARG00000010381	NOL6	88	84.923	Sorex_araneus
ENSG00000165271	NOL6	100	62.871	ENSSPUG00000008506	NOL6	99	62.511	Sphenodon_punctatus
ENSG00000165271	NOL6	99	54.192	ENSSPAG00000005542	nol6	99	54.192	Stegastes_partitus
ENSG00000165271	NOL6	100	91.500	ENSSSCG00000010990	NOL6	100	89.878	Sus_scrofa
ENSG00000165271	NOL6	100	61.194	ENSTGUG00000001674	NOL6	100	63.282	Taeniopygia_guttata
ENSG00000165271	NOL6	99	55.721	ENSTRUG00000005694	nol6	97	55.615	Takifugu_rubripes
ENSG00000165271	NOL6	99	53.500	ENSTNIG00000003826	nol6	99	54.230	Tetraodon_nigroviridis
ENSG00000165271	NOL6	100	93.500	ENSTBEG00000003239	NOL6	85	87.188	Tupaia_belangeri
ENSG00000165271	NOL6	100	88.000	ENSTTRG00000010584	NOL6	93	88.889	Tursiops_truncatus
ENSG00000165271	NOL6	100	93.500	ENSUAMG00000025594	NOL6	100	91.536	Ursus_americanus
ENSG00000165271	NOL6	100	93.500	ENSUMAG00000006051	NOL6	100	91.361	Ursus_maritimus
ENSG00000165271	NOL6	100	94.500	ENSVVUG00000021087	NOL6	100	90.410	Vulpes_vulpes
ENSG00000165271	NOL6	100	58.911	ENSXETG00000002153	nol6	99	55.828	Xenopus_tropicalis
ENSG00000165271	NOL6	99	53.961	ENSXMAG00000019408	nol6	99	53.961	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000794	condensed nuclear chromosome	11895476.	ISS	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005730	nucleolus	11895476.	ISS	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0006364	rRNA processing	21873635.	IBA	Process
GO:0006364	rRNA processing	-	ISS	Process
GO:0006364	rRNA processing	-	TAS	Process
GO:0006409	tRNA export from nucleus	21873635.	IBA	Process
GO:0032040	small-subunit processome	21873635.	IBA	Component
GO:0032545	CURI complex	21873635.	IBA	Component
GO:0034456	UTP-C complex	21873635.	IBA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr9	33463334	Frame_Shift_Ins	novel	*C1034Wfs23**	0.19
BLCA	chr9	33463368	Missense_Mutation	rs778774327	R1023H	0.16
BLCA	chr9	33465268	Missense_Mutation	novel	E874K	0.33
BLCA	chr9	33467735	Missense_Mutation	NA	A520T	0.1
BLCA	chr9	33470059	Missense_Mutation	rs767604471	C171R	0.44
BLCA	chr9	33469025	Missense_Mutation	novel	S320L	0.33
BLCA	chr9	33469527	Silent	novel	L233L	0.19
BLCA	chr9	33467714	Missense_Mutation	rs760969123	H527Y	0.2
BLCA	chr9	33468852	Silent	NA	G349G	0.41
BLCA	chr9	33469618	Missense_Mutation	novel	R203H	0.08	Nrap
BLCA	chr9	33468521	Nonsense_Mutation	novel	S398*	0.32
BLCA	chr9	33464907	Silent	NA	L917L	0.32
BLCA	chr9	33463918	Splice_Region	novel	I969I	0.16
BLCA	chr9	33466617	Silent	NA	L681L	0.54
BLCA	chr9	33468071	Missense_Mutation	rs764989402	M461I	0.13
BRCA	chr9	33466349	Missense_Mutation	rs780346321	R723Q	0.38
BRCA	chr9	33464044	Missense_Mutation	NA	S966L	0.38
BRCA	chr9	33464970	Silent	NA	P896P	0.25
BRCA	chr9	33470123	Silent	rs570175286	K149K	0.3
BRCA	chr9	33462164	3'UTR	NA		0.21
BRCA	chr9	33466364	Missense_Mutation	NA	S718F	0.22
BRCA	chr9	33467131	Silent	rs770227751	V619V	0.11
BRCA	chr9	33467242	Silent	NA	F582F	0.22
BRCA	chr9	33469549	Missense_Mutation	NA	S226C	0.16	Nrap
BRCA	chr9	33470042	Missense_Mutation	novel	I176M	0.12
BRCA	chr9	33465110	Intron	novel		0.6
BRCA	chr9	33467509	Missense_Mutation	NA	I537N	0.27
BRCA	chr9	33467830	Missense_Mutation	rs771212659	R488Q	0.33
BRCA	chr9	33469231	Nonsense_Mutation	NA	R280*	0.25	Nrap
CESC	chr9	33469508	Missense_Mutation	rs774045471	R240W	0.24	Nrap
CESC	chr9	33465893	Missense_Mutation	novel	G790A	0.22
CESC	chr9	33465147	Intron	novel		0.29
CESC	chr9	33467429	Missense_Mutation	rs200677942	V564I	0.39
CESC	chr9	33463872	Missense_Mutation	NA	E985K	0.15
CESC	chr9	33465795	Missense_Mutation	NA	A823T	0.41
CESC	chr9	33466918	Silent	NA	L648L	0.26
CESC	chr9	33463046	Missense_Mutation	rs374584991	P1093L	0.33
CESC	chr9	33467250	Missense_Mutation	novel	R580C	0.29
CESC	chr9	33466923	Missense_Mutation	rs752592088	G647C	0.45
COAD	chr9	33462051	3'UTR	rs746783173		0.33
COAD	chr9	33462590	3'UTR	novel		0.16
COAD	chr9	33465759	Missense_Mutation	NA	P835S	0.15
COAD	chr9	33470053	Nonsense_Mutation	rs764376131	R173*	0.27
COAD	chr9	33472028	Missense_Mutation	NA	R118S	0.35
COAD	chr9	33466104	Silent	novel	C777C	0.39
COAD	chr9	33469246	Missense_Mutation	rs753538678	R275C	0.15	Nrap
COAD	chr9	33472351	Missense_Mutation	rs369599517	R39H	0.27
COAD	chr9	33464943	Missense_Mutation	novel	F905L	0.14
COAD	chr9	33467242	Missense_Mutation	novel	F582L	0.33
COAD	chr9	33465325	Missense_Mutation	novel	A855T	0.14
COAD	chr9	33463832	Missense_Mutation	novel	R998M	0.22
COAD	chr9	33466941	Frame_Shift_Del	NA	*L641Wfs8**	0.21
COAD	chr9	33469098	Frame_Shift_Del	NA	*R296Afs23**	0.43	Nrap
COAD	chr9	33466084	Missense_Mutation	rs763014336	T784M	0.27
COAD	chr9	33467219	Missense_Mutation	rs374756474	R590Q	0.31
COAD	chr9	33469305	Missense_Mutation	rs748252465	P255L	0.54	Nrap
COAD	chr9	33463860	Missense_Mutation	rs758465557	M989V	0.18
COAD	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.19
COAD	chr9	33467450	Missense_Mutation	rs115753355	R557W	0.36
COAD	chr9	33472213	Missense_Mutation	rs370047243	R85H	0.48
COAD	chr9	33469330	Missense_Mutation	rs776353162	R247C	0.4	Nrap
COAD	chr9	33465841	Missense_Mutation	novel	K807N	0.18
COAD	chr9	33469246	Missense_Mutation	rs753538678	R275C	0.61	Nrap
COAD	chr9	33466677	Silent	rs771511009	A661A	0.21
COAD	chr9	33472214	Missense_Mutation	rs115808915	R85C	0.21
COAD	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.07
COAD	chr9	33467864	Missense_Mutation	rs144030112	R477C	0.22
COAD	chr9	33462285	3'UTR	novel		0.17
COAD	chr9	33465147	Intron	novel		0.29
COAD	chr9	33462344	3'UTR	novel		0.23
COAD	chr9	33467831	Missense_Mutation	rs139340786	R488W	0.3
COAD	chr9	33469511	Silent	novel	L239L	0.25
COAD	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.22
COAD	chr9	33468971	Missense_Mutation	NA	R338L	0.26
COAD	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.35
COAD	chr9	33464954	Nonsense_Mutation	NA	R902*	0.27
COAD	chr9	33466946	Frame_Shift_Del	NA	*G639Afs10**	0.07
COAD	chr9	33466946	Frame_Shift_Del	NA	*G639Afs10**	0.22
COAD	chr9	33473838	Missense_Mutation	NA	G2E	0.18
COAD	chr9	33463046	Missense_Mutation	rs374584991	P1093L	0.31
ESCA	chr9	33473786	Splice_Region	novel		0.37
ESCA	chr9	33469246	Missense_Mutation	novel	R275S	0.09	Nrap
ESCA	chr9	33462779	Missense_Mutation	rs138187500	R1109Q	0.13
GBM	chr9	33470067	Missense_Mutation	novel	L168R	0.12
GBM	chr9	33466127	Missense_Mutation	NA	T770S	0.33
GBM	chr9	33466607	Missense_Mutation	novel	A685T	0.16
GBM	chr9	33462537	3'UTR	novel		0.36
GBM	chr9	33464046	Silent	novel	P965P	0.51
GBM	chr9	33466649	Missense_Mutation	rs573802066	R671C	0.5
GBM	chr9	33462632	3'UTR	novel		0.09
GBM	chr9	33467196	Missense_Mutation	rs758772676	R598W	0.49
HNSC	chr9	33467111	Splice_Region	novel		0.11
HNSC	chr9	33467450	Missense_Mutation	rs115753355	R557W	0.24
HNSC	chr9	33467451	Silent	novel	L556L	0.26
KIRC	chr9	33469657	Missense_Mutation	NA	Q190L	0.41	Nrap
KIRC	chr9	33470172	Missense_Mutation	NA	L133P	0.28
KIRC	chr9	33473896	5'UTR	novel		0.29
KIRC	chr9	33467193	Nonsense_Mutation	NA	E599*	0.15
KIRC	chr9	33464890	Missense_Mutation	NA	N923T	0.25
KIRP	chr9	33467724	Silent	novel	N523N	0.32
KIRP	chr9	33467707	Missense_Mutation	novel	R529Q	0.51
KIRP	chr9	33473866	5'UTR	novel		0.56
LGG	chr9	33463113	Missense_Mutation	NA	L1071F	0.35
LGG	chr9	33466323	Missense_Mutation	rs776381070	V732M	0.09
LGG	chr9	33467154	Missense_Mutation	rs184298169	R612C	0.4
LGG	chr9	33468873	Splice_Site	novel	X343_splice	0.32
LGG	chr9	33467863	Missense_Mutation	rs779705744	R477H	0.1
LIHC	chr9	33465830	Missense_Mutation	NA	S811N	0.28
LIHC	chr9	33467219	Missense_Mutation	novel	R590P	0.51
LIHC	chr9	33468833	Missense_Mutation	NA	V356L	0.37
LIHC	chr9	33469277	Silent	NA	P264P	0.47
LIHC	chr9	33466417	Silent	NA	P700P	0.43
LUAD	chr9	33470047	Missense_Mutation	novel	D175N	0.46
LUAD	chr9	33462771	Nonsense_Mutation	NA	E1112*	0.33
LUAD	chr9	33473887	5'UTR	rs756109221		0.24
LUAD	chr9	33472117	Nonsense_Mutation	NA	E89*	0.32
LUAD	chr9	33468332	Missense_Mutation	NA	T433S	0.11
LUAD	chr9	33468558	Missense_Mutation	novel	D386Y	0.07
LUAD	chr9	33464894	Missense_Mutation	NA	N922Y	0.53
LUAD	chr9	33462738	Missense_Mutation	novel	L1123V	0.5
LUAD	chr9	33467826	Silent	novel	L489L	0.4
LUAD	chr9	33464124	Silent	novel	A939A	0.19
LUAD	chr9	33465808	Silent	rs753741911	L818L	0.33
LUAD	chr9	33467209	Missense_Mutation	NA	Q593H	0.15
LUSC	chr9	33472406	Missense_Mutation	novel	E21K	0.88
LUSC	chr9	33462688	Silent	novel	A1139A	0.34
LUSC	chr9	33465847	Silent	rs769352791	I805I	0.31
LUSC	chr9	33468552	Missense_Mutation	novel	T388A	0.34
LUSC	chr9	33466678	Missense_Mutation	rs371383324	A661V	0.56
LUSC	chr9	33473840	Translation_Start_Site	novel	M1?	0.38
LUSC	chr9	33462596	3'UTR	novel		0.67
LUSC	chr9	33463408	Missense_Mutation	rs370221885	V1010M	0.58
LUSC	chr9	33470024	Silent	novel	L182L	0.3
MESO	chr9	33462566	3'UTR	novel		0.09
OV	chr9	33468525	Missense_Mutation	novel	S397G	0.13
OV	chr9	33472007	Silent	novel	T125T	0.06
OV	chr9	33468407	Missense_Mutation	novel	F408L	0.34
OV	chr9	33468784	Nonsense_Mutation	novel	Y372*	0.7
OV	chr9	33469265	Silent	novel	L268L	0.16
OV	chr9	33464142	Silent	novel	I933I	0.09
OV	chr9	33464924	Frame_Shift_Ins	novel	*W912Lfs20**	0.05
OV	chr9	33462693	Missense_Mutation	novel	E1138Q	0.07
OV	chr9	33466617	Silent	NA	L681L	0.28
OV	chr9	33466933	Silent	NA	A643A	0.19
OV	chr9	33472243	Missense_Mutation	novel	T75I	0.09
PAAD	chr9	33468071	Missense_Mutation	rs764989402	M461I	0.05
PAAD	chr9	33468870	Splice_Region	novel	G343G	0.04
PRAD	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.28
READ	chr9	33464999	Intron	novel		0.16
READ	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.3
READ	chr9	33463385	Silent	NA	R1017R	0.28
SARC	chr9	33470086	Frame_Shift_Del	novel	*T161Lfs21**	0.29
SKCM	chr9	33466164	Silent	novel	V757V	0.11
SKCM	chr9	33465873	Missense_Mutation	NA	V797L	0.39
SKCM	chr9	33468753	Splice_Region	NA	L382L	0.85
SKCM	chr9	33462660	3'UTR	novel		0.83
SKCM	chr9	33467122	Silent	novel	L622L	0.9
SKCM	chr9	33467426	Missense_Mutation	novel	L565F	0.83
SKCM	chr9	33465045	Intron	novel		0.31
SKCM	chr9	33465812	Missense_Mutation	rs147925131	S817L	0.09
SKCM	chr9	33467708	Nonsense_Mutation	novel	R529*	0.07
SKCM	chr9	33462616	3'UTR	novel		0.24
SKCM	chr9	33463399	Missense_Mutation	rs778777945	R1013C	0.21
SKCM	chr9	33464954	Nonsense_Mutation	NA	R902*	0.26
SKCM	chr9	33466328	Missense_Mutation	NA	A730V	0.23
SKCM	chr9	33466942	Silent	NA	P640P	0.13
SKCM	chr9	33470120	Silent	NA	G150G	0.48
SKCM	chr9	33468148	Splice_Region	novel		0.5
SKCM	chr9	33462687	Nonsense_Mutation	rs554253286	R1140*	0.21
SKCM	chr9	33469504	Missense_Mutation	rs763835275	P241L	0.38	Nrap
SKCM	chr9	33463379	Silent	rs763517037	I1019I	0.34
SKCM	chr9	33466209	Missense_Mutation	novel	E742D	0.21
SKCM	chr9	33463113	Missense_Mutation	NA	L1071F	0.33
SKCM	chr9	33464972	Missense_Mutation	NA	P896S	0.41
SKCM	chr9	33463433	Silent	novel	F1001F	1
SKCM	chr9	33466069	Splice_Site	NA	X788_splice	0.87
SKCM	chr9	33465812	Missense_Mutation	rs147925131	S817L	0.91
SKCM	chr9	33468381	Silent	NA	F416F	0.42
SKCM	chr9	33470072	Silent	NA	Y166Y	0.16
SKCM	chr9	33467233	Silent	NA	S585S	0.23
SKCM	chr9	33468041	Silent	NA	D471D	0.76
SKCM	chr9	33464974	Missense_Mutation	NA	S895F	0.96
SKCM	chr9	33465236	Silent	NA	F884F	1
SKCM	chr9	33469572	Silent	novel	P218P	0.17
SKCM	chr9	33469573	Missense_Mutation	novel	P218L	0.18	Nrap
SKCM	chr9	33470057	Silent	rs370915912	C171C	0.27
SKCM	chr9	33472072	Missense_Mutation	rs200981776	R104W	0.31
STAD	chr9	33464078	Missense_Mutation	rs141680920	R955C	0.19
STAD	chr9	33466163	Nonsense_Mutation	NA	R758*	0.18
STAD	chr9	33469048	Missense_Mutation	NA	Q312H	0.38	Nrap
STAD	chr9	33466697	Missense_Mutation	NA	G655C	0.11
STAD	chr9	33469529	Silent	NA	L233L	0.05
STAD	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.12
STAD	chr9	33472013	Silent	rs759510368	P123P	0.05
STAD	chr9	33469246	Missense_Mutation	rs753538678	R275C	0.31	Nrap
STAD	chr9	33466946	Frame_Shift_Del	NA	*G639Afs10**	0.33
STAD	chr9	33462591	3'UTR	novel		0.42
STAD	chr9	33463914	Nonsense_Mutation	NA	Q971*	0.34
STAD	chr9	33464954	Nonsense_Mutation	NA	R902*	0.34
STAD	chr9	33472256	Missense_Mutation	rs552985217	R71C	0.4
STAD	chr9	33469003	Silent	novel	G327G	0.16
STAD	chr9	33469231	Nonsense_Mutation	NA	R280*	0.18	Nrap
STAD	chr9	33469619	Missense_Mutation	NA	R203C	0.41	Nrap
STAD	chr9	33468039	Missense_Mutation	NA	H472R	0.06
STAD	chr9	33468170	Intron	novel		0.11
STAD	chr9	33465293	Silent	novel	Q865Q	0.25
STAD	chr9	33467249	Missense_Mutation	NA	R580H	0.25
STAD	chr9	33467205	Missense_Mutation	rs558572103	G595R	0.28
STAD	chr9	33469215	Missense_Mutation	NA	A285V	0.16	Nrap
STAD	chr9	33466682	Missense_Mutation	NA	V660I	0.07
STAD	chr9	33465882	Missense_Mutation	NA	R794W	0.36
STAD	chr9	33470128	Missense_Mutation	rs763391581	V148M	0.21
STAD	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.38
STAD	chr9	33462742	Silent	NA	A1121A	0.27
STAD	chr9	33467735	Frame_Shift_Del	novel	*A520Lfs3**	0.39
STAD	chr9	33469282	Missense_Mutation	rs116746143	R263C	0.17	Nrap
STAD	chr9	33466945	Frame_Shift_Ins	novel	*L641Pfs16**	0.27
STAD	chr9	33466937	Missense_Mutation	NA	D642G	0.05
STAD	chr9	33469282	Missense_Mutation	rs116746143	R263C	0.33	Nrap
STAD	chr9	33473791	Nonsense_Mutation	novel	E18*	0.4
STAD	chr9	33469647	Silent	rs138499927	D193D	0.26
STAD	chr9	33466324	Silent	rs759064707	Y731Y	0.42
THCA	chr9	33465114	Intron	novel		0.22
THYM	chr9	33462794	Missense_Mutation	rs116739206	R1104H	0.28
THYM	chr9	33472351	Missense_Mutation	rs369599517	R39H	0.54
UCEC	chr9	33465262	Missense_Mutation	novel	L876V	0.5
UCEC	chr9	33466941	Frame_Shift_Del	NA	*L641Wfs8**	0.43
UCEC	chr9	33465861	Missense_Mutation	rs199616532	R801W	0.33
UCEC	chr9	33462767	Missense_Mutation	NA	L1113R	0.29
UCEC	chr9	33464141	Missense_Mutation	rs749524318	R934C	0.3
UCEC	chr9	33466133	Missense_Mutation	novel	L768M	0.34
UCEC	chr9	33462572	3'UTR	novel		0.41
UCEC	chr9	33464999	Intron	novel		0.44
UCEC	chr9	33461991	3'UTR	novel		0.5
UCEC	chr9	33464884	Missense_Mutation	novel	L925P	0.33
UCEC	chr9	33462760	Missense_Mutation	novel	M1115I	0.09
UCEC	chr9	33463432	Missense_Mutation	novel	R1002W	0.36
UCEC	chr9	33467220	Missense_Mutation	rs141088844	R590W	0.48
UCEC	chr9	33463863	Missense_Mutation	NA	L988I	0.31
UCEC	chr9	33469286	Missense_Mutation	novel	F261L	0.07	Nrap
UCEC	chr9	33462772	Silent	novel	G1111G	0.2
UCEC	chr9	33468420	Splice_Region	rs552138670	P403P	0.36
UCEC	chr9	33462518	3'UTR	novel		0.54
UCEC	chr9	33467231	Missense_Mutation	novel	R586H	0.13
UCEC	chr9	33465297	Missense_Mutation	novel	A864V	0.33
UCEC	chr9	33470104	Missense_Mutation	novel	P156S	0.26
UCEC	chr9	33469003	Silent	novel	G327G	0.29
UCEC	chr9	33472098	Missense_Mutation	novel	V95A	0.3
UCEC	chr9	33466946	Frame_Shift_Del	NA	*G639Afs10**	0.37
UCEC	chr9	33468125	Silent	novel	L443L	0.24
UCEC	chr9	33467816	Missense_Mutation	NA	P493S	0.44
UCEC	chr9	33469314	Missense_Mutation	rs115821579	R252H	0.41	Nrap
UCEC	chr9	33468337	Missense_Mutation	novel	A431V	0.47
UCEC	chr9	33470120	Silent	novel	G150G	0.34
UCEC	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.35
UCEC	chr9	33466649	Missense_Mutation	novel	R671S	0.56
UCEC	chr9	33466350	Missense_Mutation	rs35135082	R723G	0.36
UCEC	chr9	33462721	Silent	NA	V1128V	0.41
UCEC	chr9	33465310	Missense_Mutation	rs757441192	R860W	0.45
UCEC	chr9	33469504	Missense_Mutation	rs763835275	P241L	0.17	Nrap
UCEC	chr9	33472108	Silent	NA	L92L	0.45
UCEC	chr9	33466089	Silent	NA	T782T	0.51
UCEC	chr9	33462063	3'UTR	novel		0.38
UCEC	chr9	33472249	Missense_Mutation	novel	R73L	0.41
UCEC	chr9	33464141	Missense_Mutation	rs749524318	R934C	0.57
UCEC	chr9	33466580	Missense_Mutation	rs759860117	R694C	0.36
UCEC	chr9	33468528	Missense_Mutation	novel	L396I	0.33
UCEC	chr9	33468843	Silent	novel	V352V	0.23
UCEC	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.19
UCEC	chr9	33462635	3'UTR	novel		0.12
UCEC	chr9	33472340	Missense_Mutation	novel	E43K	0.29
UCEC	chr9	33464083	Frame_Shift_Ins	novel	*Q953Pfs27**	0.32
UCEC	chr9	33466946	Frame_Shift_Del	NA	*G639Afs10**	0.41
UCEC	chr9	33469337	Missense_Mutation	NA	K244N	0.44	Nrap
UCEC	chr9	33466946	Frame_Shift_Del	NA	*G639Afs10**	0.34
UCEC	chr9	33466946	Frame_Shift_Del	NA	*G639Afs10**	0.42
UCEC	chr9	33467501	Missense_Mutation	NA	D540N	0.35
UCEC	chr9	33462516	3'UTR	novel		0.17
UCEC	chr9	33466100	Missense_Mutation	novel	A779T	0.49
UCEC	chr9	33468105	Missense_Mutation	novel	S450N	0.2
UCEC	chr9	33469280	Silent	novel	R263R	0.22
UCEC	chr9	33462676	Silent	NA	R1143R	0.3
UCEC	chr9	33464084	Frame_Shift_Del	NA	*Q953Kfs32**	0.36
UCEC	chr9	33466367	Missense_Mutation	novel	R717Q	0.25
UCEC	chr9	33463367	Silent	novel	R1023R	0.41
UCEC	chr9	33462795	Missense_Mutation	rs768991788	R1104C	0.36
UCEC	chr9	33465229	Missense_Mutation	NA	P887S	0.4
UCEC	chr9	33468105	Missense_Mutation	novel	S450N	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0052	0.24147
TGCT	DEL	0.32	7.3329e-05
THCA	DEL	0.0281	0.24038
THYM	DEL	0.0163	0.022012

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.018	Kaplan-Meier Survival Analysis
STAD	0.044	Kaplan-Meier Survival Analysis
SARC	0.0079	Kaplan-Meier Survival Analysis
ACC	0.05	Kaplan-Meier Survival Analysis
SKCM	0.024	Kaplan-Meier Survival Analysis
BRCA	0.041	Kaplan-Meier Survival Analysis
ESCA	0.0054	Kaplan-Meier Survival Analysis
READ	0.039	Kaplan-Meier Survival Analysis
LIHC	0.00014	Kaplan-Meier Survival Analysis
THCA	0.024	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742