EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165280 (Gene tree)
Gene ID: 7415
Gene Symbol: VCP
Alias: IBMPFD|p97|CDC48|TERA
Full Name: valosin containing protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 17,186 bases
Position: chr9:35,056,064-35,073,249
Accession: 12666
RBP type: non-canonical RBP
Summary: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24799714	Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.	Proc Natl Acad Sci U S A	2014 May 20	Rumpf S	doi: 10.1073/pnas.1406898111
23041957	How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other?	Curr Opin Neurol	2012 Dec	Baloh RH	doi: 10.1097/WCO.0b013e32835a269b.
27632209	Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients.	PLoS One	2016 Sep 15	Guven G	doi: 10.1371/journal.pone.0162592
24085347	Amyotrophic lateral sclerosis: an update on recent genetic insights.	J Neurol	2013 Nov	Iguchi Y	doi: 10.1007/s00415-013-7112-y
23618873	The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP.	Genes Dev	2013 May 1	Zhou HL	doi: 10.1101/gad.215681.113
27066560	Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation.	Neurol Genet	2015 Sep 24	Izumi R	doi: 10.1212/NXG.0000000000000023
28837687	The spliceosome-associated protein Mfap1 binds to VCP in Drosophila.	PLoS One	2017 Aug 24	Rode S	doi: 10.1371/journal.pone.0183733
29405028	Next Generation Sequencing and ALS: known genes, different phenotyphes.	Arch Ital Biol	2017 Dec 1	Campopiano R	doi: 10.12871/00039829201742.
31006653	Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis.	J Biol Chem	2019 May 31	Brody MJ	doi: 10.1074/jbc.RA119.007585
17531340	Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress.	Radiother Oncol	2007 Jun	Magagnin MG	-
29704548	Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster.	Neurobiol Dis	2018 Aug	Ristic G	doi: 10.1016/j.nbd.2018.04.013

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000493886	VCP-207	2942	-	-	- (aa)	-	-
ENST00000417448	VCP-202	722	-	ENSP00000399456	115 (aa)	-	C9JUP7
ENST00000358901	VCP-201	4370	-	ENSP00000351777	806 (aa)	-	P55072
ENST00000479300	VCP-205	559	-	-	- (aa)	-	-
ENST00000480327	VCP-206	884	-	-	- (aa)	-	-
ENST00000448530	VCP-203	950	-	ENSP00000392088	160 (aa)	-	C9IZA5
ENST00000466100	VCP-204	508	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000165280's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa05134	Legionellosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165280's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165280	VCP	99	83.188	FBgn0261014	TER94	97	85.190	Drosophila_melanogaster
ENSG00000165280	VCP	100	100.000	ENSMUSG00000028452	Vcp	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000502	proteasome complex	9452483.	IDA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	9452483.10364224.10855792.15161933.15215856.15743842.16186510.16275660.16407162.16449189.16525503.17314412.17525332.17681147.17872946.18654987.18656546.18711132.18775313.19275885.19570996.19818707.19822669.20414249.21135095.21343306.21645854.21822278.21900206.21949850.21988832.22120668.22466964.22795130.22902628.22948820.23042605.23042607.23349634.24089527.24726327.25593058.25814554.26389662.26496610.26712280.26842564.27753622.29804830.29997244.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10855792.26842564.	IDA	Component
GO:0005634	nucleus	16130169.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	27753622.	IDA	Component
GO:0005783	endoplasmic reticulum	15215856.24089527.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	17872946.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005811	lipid droplet	23297223.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	10855792.15215856.	IDA	Component
GO:0005829	cytosol	16186510.	TAS	Component
GO:0006281	DNA repair	16140914.	NAS	Process
GO:0006302	double-strand break repair	10855792.22120668.	IDA	Process
GO:0006457	protein folding	-	TAS	Process
GO:0006734	NADH metabolic process	23498975.	IMP	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	IEA	Process
GO:0006914	autophagy	20104022.25125609.	IMP	Process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	ISS	Process
GO:0006974	cellular response to DNA damage stimulus	16140914.22120668.23042605.	IDA	Process
GO:0008289	lipid binding	-	IEA	Function
GO:0010494	cytoplasmic stress granule	29804830.	IDA	Component
GO:0010498	proteasomal protein catabolic process	26565908.	IMP	Process
GO:0010918	positive regulation of mitochondrial membrane potential	23498975.	IMP	Process
GO:0016236	macroautophagy	21873635.	IBA	Process
GO:0016236	macroautophagy	27753622.	IMP	Process
GO:0016567	protein ubiquitination	22120668.	IDA	Process
GO:0016567	protein ubiquitination	15215856.	NAS	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0016887	ATPase activity	23349634.25125609.25878907.	IMP	Function
GO:0016887	ATPase activity	15215856.	TAS	Function
GO:0018279	protein N-linked glycosylation via asparagine	22607976.	IMP	Process
GO:0019079	viral genome replication	22379090.	IMP	Process
GO:0019903	protein phosphatase binding	10364224.	IPI	Function
GO:0019904	protein domain specific binding	15362974.	IPI	Function
GO:0019985	translesion synthesis	23042605.	IMP	Process
GO:0030433	ubiquitin-dependent ERAD pathway	21873635.	IBA	Process
GO:0030433	ubiquitin-dependent ERAD pathway	17872946.	IDA	Process
GO:0030433	ubiquitin-dependent ERAD pathway	22607976.	IMP	Process
GO:0030433	ubiquitin-dependent ERAD pathway	15215856.	TAS	Process
GO:0030968	endoplasmic reticulum unfolded protein response	15215856.	TAS	Process
GO:0030970	retrograde protein transport, ER to cytosol	21873635.	IBA	Process
GO:0030970	retrograde protein transport, ER to cytosol	15215856.	IDA	Process
GO:0030970	retrograde protein transport, ER to cytosol	25660456.	IMP	Process
GO:0031334	positive regulation of protein complex assembly	18775313.	IDA	Process
GO:0031593	polyubiquitin modification-dependent protein binding	21873635.	IBA	Function
GO:0031593	polyubiquitin modification-dependent protein binding	11483959.	IDA	Function
GO:0031625	ubiquitin protein ligase binding	22590560.	IPI	Function
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	9452483.	IDA	Process
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	21822278.	IMP	Process
GO:0032991	protein-containing complex	21822278.23349634.	IDA	Component
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	21873635.	IBA	Component
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	-	ISS	Component
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	16186510.	TAS	Component
GO:0034214	protein hexamerization	-	IEA	Process
GO:0034605	cellular response to heat	29804830.	IMP	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0035617	stress granule disassembly	29804830.	IMP	Process
GO:0035800	deubiquitinase activator activity	22970133.	IDA	Function
GO:0035861	site of double-strand break	22120668.	IDA	Component
GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	-	IEA	Function
GO:0036503	ERAD pathway	25088257.	IDA	Process
GO:0036503	ERAD pathway	20104022.	IMP	Process
GO:0036513	Derlin-1 retrotranslocation complex	15215856.17872946.	IDA	Component
GO:0042288	MHC class I protein binding	-	IEA	Function
GO:0042802	identical protein binding	20512113.24055316.26712278.26822609.26849035.	IPI	Function
GO:0042981	regulation of apoptotic process	16130169.	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	20104022.	IMP	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	15743842.	NAS	Process
GO:0043231	intracellular membrane-bounded organelle	-	ISS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043531	ADP binding	-	IEA	Function
GO:0044389	ubiquitin-like protein ligase binding	16186510.	IPI	Function
GO:0045184	establishment of protein localization	15215856.	TAS	Process
GO:0045732	positive regulation of protein catabolic process	11483959.18775313.	IDA	Process
GO:0046034	ATP metabolic process	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	16275660.	IDA	Component
GO:0050807	regulation of synapse organization	-	IEA	Process
GO:0051228	mitotic spindle disassembly	21873635.	IBA	Process
GO:0051260	protein homooligomerization	-	IEA	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0061857	endoplasmic reticulum stress-induced pre-emptive quality control	26565908.	IMP	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0070842	aggresome assembly	-	IEA	Process
GO:0070987	error-free translesion synthesis	-	TAS	Process
GO:0071712	ER-associated misfolded protein catabolic process	21873635.	IBA	Process
GO:0071712	ER-associated misfolded protein catabolic process	24089527.	IMP	Process
GO:0072389	flavin adenine dinucleotide catabolic process	23498975.	IMP	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	28689657.	IDA	Process
GO:0097352	autophagosome maturation	21873635.	IBA	Process
GO:0097352	autophagosome maturation	20104022.	IMP	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1903006	positive regulation of protein K63-linked deubiquitination	22970133.	IDA	Process
GO:1903007	positive regulation of Lys63-specific deubiquitinase activity	22970133.	IDA	Process
GO:1903715	regulation of aerobic respiration	23498975.	IMP	Process
GO:1903843	cellular response to arsenite ion	29804830.	IMP	Process
GO:1903862	positive regulation of oxidative phosphorylation	23498975.	IMP	Process
GO:1904288	BAT3 complex binding	21636303.	IPI	Function
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component
GO:1904949	ATPase complex	-	IEA	Component
GO:1990381	ubiquitin-specific protease binding	22590560.22970133.	IPI	Function
GO:1990730	VCP-NSFL1C complex	-	ISS	Component
GO:2000158	positive regulation of ubiquitin-specific protease activity	-	IEA	Process
GO:2001171	positive regulation of ATP biosynthetic process	23498975.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22870330	Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers.	PLoS One	2012	Lagu MN	doi: 10.1371/journal.pone.0042470
22216170	Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma.	PLoS One	2011	Valle CW	doi: 10.1371/journal.pone.0029073
27344168	Valosin-containing protein (VCP) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling.	Mol Cell Biochem	2016 Jul	Fu Q	doi: 10.1007/s11010-016-2746-6
26555175	Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.	Cancer Cell	2015 Nov 9	Anderson DJ	doi: 10.1016/j.ccell.2015.10.002.
23412975	VCP gene variation predicts outcome of advanced non-small-cell lung cancer platinum-based chemotherapy.	Tumour Biol	2013 Apr	Peng J	doi: 10.1007/s13277-012-0631-9
19356220	Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.	Cancer Sci	2009 Jul	Qiu Y	doi: 10.1111/j.1349-7006.2009.01156.x
26720340	Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.	Cell Death Dis	2015 Dec 31	Parzych K	doi: 10.1038/cddis.2015.373.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr9	35059697	Silent	NA	V600V	0.52
BLCA	chr9	35065381	Missense_Mutation	novel	G149A	0.24
BLCA	chr9	35062183	Intron	novel		0.3
BLCA	chr9	35061089	Missense_Mutation	NA	L429F	0.52
BLCA	chr9	35061059	Missense_Mutation	novel	A439S	0.41
BLCA	chr9	35062061	Silent	NA	V341V	0.13
BLCA	chr9	35059071	Missense_Mutation	novel	S718L	0.11
BLCA	chr9	35062091	Silent	novel	L331L	0.21
BRCA	chr9	35068007	Missense_Mutation	novel	K62N	0.08
BRCA	chr9	35067982	Missense_Mutation	rs748091463	V71I	0.11
BRCA	chr9	35059576	Nonsense_Mutation	NA	Q641*	0.22
BRCA	chr9	35065253	Missense_Mutation	NA	E192Q	0.27
BRCA	chr9	35057432	Silent	NA	R753R	0.21
BRCA	chr9	35060333	Missense_Mutation	novel	V559I	0.08
BRCA	chr9	35063025	Missense_Mutation	novel	A255V	0.08
CESC	chr9	35064277	Missense_Mutation	NA	E195D	0.18
CESC	chr9	35056692	3'UTR	rs575822739		0.24
CESC	chr9	35068295	Missense_Mutation	NA	D29H	0.68
CESC	chr9	35056920	3'UTR	rs760593200		0.29
CESC	chr9	35061103	Missense_Mutation	NA	R424H	0.42
CESC	chr9	35062107	Missense_Mutation	novel	S326L	0.19
CESC	chr9	35057464	Missense_Mutation	novel	A743T	0.24
CHOL	chr9	35056807	3'UTR	novel		0.36
COAD	chr9	35066695	Missense_Mutation	novel	A142V	0.12
COAD	chr9	35062234	Missense_Mutation	NA	A310T	0.05
COAD	chr9	35062008	Missense_Mutation	novel	R359Q	0.31
COAD	chr9	35062029	Missense_Mutation	rs747902669	S352N	0.31
COAD	chr9	35062247	Silent	novel	E305E	0.27
COAD	chr9	35059638	Missense_Mutation	novel	I620T	0.21
COAD	chr9	35059584	Missense_Mutation	NA	R638H	0.28
COAD	chr9	35057457	Missense_Mutation	novel	R745H	0.13
COAD	chr9	35066790	Silent	novel	Y110Y	0.09
COAD	chr9	35060501	Missense_Mutation	NA	F503V	0.18
COAD	chr9	35062234	Missense_Mutation	NA	A310T	0.13
COAD	chr9	35057432	Silent	NA	R753R	0.2
COAD	chr9	35061103	Missense_Mutation	NA	R424H	0.37
ESCA	chr9	35062279	Missense_Mutation	novel	K295E	0.39
ESCA	chr9	35067912	Missense_Mutation	novel	V94A	0.11
ESCA	chr9	35060390	Missense_Mutation	rs765061140	I540V	0.15
ESCA	chr9	35067941	Missense_Mutation	novel	M84I	0.32
GBM	chr9	35060524	Missense_Mutation	novel	Y495C	0.14
GBM	chr9	35065380	Splice_Region	novel	G149G	0.09
GBM	chr9	35061682	Missense_Mutation	novel	F363L	0.04
GBM	chr9	35062071	Missense_Mutation	novel	R338K	0.25
GBM	chr9	35057109	3'UTR	novel		0.14
HNSC	chr9	35062345	Missense_Mutation	novel	E273Q	0.07
HNSC	chr9	35059701	Missense_Mutation	novel	R599Q	0.18
HNSC	chr9	35061653	Missense_Mutation	novel	D373V	0.04
HNSC	chr9	35061123	Silent	novel	E417E	0.08
HNSC	chr9	35061625	Silent	novel	Q382Q	0.15
HNSC	chr9	35061053	Missense_Mutation	novel	V441F	0.24
HNSC	chr9	35059090	Missense_Mutation	novel	E712K	0.29
HNSC	chr9	35062173	Intron	novel		0.06
HNSC	chr9	35060332	Missense_Mutation	novel	V559G	0.45
HNSC	chr9	35059575	Missense_Mutation	novel	Q641L	0.51
KIRP	chr9	35066720	Missense_Mutation	novel	Y134N	0.42
LAML	chr9	35057189	Frame_Shift_Del	novel	*S784Vfs88**	0.07
LGG	chr9	35057055	3'UTR	novel		0.08
LGG	chr9	35060876	Silent	novel	V469V	0.06
LGG	chr9	35066790	Silent	novel	Y110Y	0.35
LGG	chr9	35068298	Missense_Mutation	novel	V28L	0.05
LIHC	chr9	35063007	Missense_Mutation	novel	E261V	0.42
LIHC	chr9	35072450	5'UTR	novel		0.41
LIHC	chr9	35068309	Missense_Mutation	novel	N24T	0.45
LIHC	chr9	35068349	Missense_Mutation	NA	D11N	0.37
LUAD	chr9	35063002	Nonsense_Mutation	NA	G263*	0.1
LUAD	chr9	35061057	Silent	NA	A439A	0.12
LUAD	chr9	35068312	Missense_Mutation	novel	P23L	0.16
LUAD	chr9	35065280	Missense_Mutation	NA	H183Y	0.31
LUAD	chr9	35060355	Nonsense_Mutation	NA	W551*	0.35
LUAD	chr9	35059606	Missense_Mutation	NA	P631A	0.16
LUAD	chr9	35061017	Frame_Shift_Del	novel	*R453Gfs4**	0.23
LUAD	chr9	35059560	Missense_Mutation	NA	P646Q	0.48
LUAD	chr9	35057460	Missense_Mutation	novel	R744L	0.33
LUAD	chr9	35059080	Missense_Mutation	NA	T715I	0.12
LUSC	chr9	35066811	Silent	NA	Q103Q	0.07
OV	chr9	35062234	Frame_Shift_Ins	novel	*A310Lfs47**	0.04
OV	chr9	35062236	Frame_Shift_Ins	novel	*I309Sfs28**	0.03
OV	chr9	35059554	Frame_Shift_Del	novel	*P648Lfs31**	0.32
OV	chr9	35060823	Missense_Mutation	novel	R487P	0.23
OV	chr9	35056826	3'UTR	novel		0.6
OV	chr9	35062242	Missense_Mutation	novel	D307A	0.11
OV	chr9	35057473	Missense_Mutation	novel	M740V	0.03
OV	chr9	35067957	Missense_Mutation	NA	D79V	0.44
PCPG	chr9	35060509	Missense_Mutation	novel	P500L	0.29
PRAD	chr9	35056994	3'UTR	novel		0.12
PRAD	chr9	35062995	Missense_Mutation	novel	F265S	0.36
PRAD	chr9	35062996	Missense_Mutation	novel	F265V	0.36
READ	chr9	35065254	Silent	novel	R191R	0.16
READ	chr9	35059167	Missense_Mutation	novel	D686G	0.07
READ	chr9	35066727	Silent	rs760755090	F131F	0.37
SARC	chr9	35060458	Missense_Mutation	novel	Y517C	0.38
SKCM	chr9	35065364	Missense_Mutation	rs121909330	R155C	0.28
SKCM	chr9	35061586	Silent	novel	D395D	0.26
SKCM	chr9	35060449	Missense_Mutation	NA	P520L	0.3
SKCM	chr9	35066721	Silent	rs772069942	V133V	0.33
SKCM	chr9	35057450	Silent	rs770427007	V747V	0.19
SKCM	chr9	35066699	Missense_Mutation	NA	E141K	0.21
SKCM	chr9	35057498	Silent	rs186657793	I731I	0.93
SKCM	chr9	35068292	Missense_Mutation	NA	E30K	0.5
STAD	chr9	35059797	Missense_Mutation	rs201431036	R567H	0.22
STAD	chr9	35065364	Missense_Mutation	rs121909330	R155C	0.11
STAD	chr9	35061059	Missense_Mutation	novel	A439T	0.18
STAD	chr9	35062116	Missense_Mutation	NA	R323H	0.26
STAD	chr9	35059528	Missense_Mutation	novel	L657I	0.5
STAD	chr9	35066772	Silent	NA	V116V	0.16
STAD	chr9	35068347	Frame_Shift_Del	novel	*D11Afs18**	0.36
STAD	chr9	35062115	Silent	NA	R323R	0.46
STAD	chr9	35059797	Missense_Mutation	rs201431036	R567H	0.17
STAD	chr9	35059580	Silent	NA	L639L	0.37
STAD	chr9	35062174	Intron	novel		0.15
THCA	chr9	35061665	Missense_Mutation	novel	I369T	0.12
THCA	chr9	35065312	Missense_Mutation	NA	P172L	0.3
THCA	chr9	35062151	Intron	novel		0.05
THYM	chr9	35059650	Frame_Shift_Del	rs763971546	*N616Mfs63**	0.31
UCEC	chr9	35056920	3'UTR	rs760593200		0.29
UCEC	chr9	35063022	Missense_Mutation	NA	R256Q	0.34
UCEC	chr9	35067946	Missense_Mutation	NA	R83W	0.19
UCEC	chr9	35056604	3'UTR	novel		0.47
UCEC	chr9	35061057	Silent	NA	A439A	0.37
UCEC	chr9	35059190	Missense_Mutation	novel	M678I	0.54
UCEC	chr9	35057177	Silent	novel	S787S	0.37
UCEC	chr9	35060460	Silent	novel	F516F	0.12
UCEC	chr9	35060846	Silent	rs778069672	I479I	0.22
UCEC	chr9	35056534	3'UTR	novel		0.26
UCEC	chr9	35059205	Silent	NA	E673E	0.27
UCEC	chr9	35064183	Missense_Mutation	NA	P227T	0.2
UCEC	chr9	35068315	Missense_Mutation	NA	R22H	0.16
UCEC	chr9	35062179	Intron	novel		0.35
UCEC	chr9	35056667	3'UTR	novel		0.23
UCEC	chr9	35056351	3'UTR	novel		0.3
UCEC	chr9	35057106	3'UTR	novel		0.29
UCEC	chr9	35063075	Silent	novel	P238P	0.21
UCEC	chr9	35056429	3'UTR	novel		0.47
UCEC	chr9	35060845	Missense_Mutation	novel	G480R	0.24
UCEC	chr9	35061686	Missense_Mutation	novel	R362H	0.45
UCEC	chr9	35059088	Missense_Mutation	novel	E712D	0.57
UCEC	chr9	35068320	Silent	novel	K20K	0.09
UCEC	chr9	35059114	Missense_Mutation	NA	E704K	0.26
UCEC	chr9	35060846	Silent	rs778069672	I479I	0.4
UCEC	chr9	35062234	Missense_Mutation	NA	A310T	0.43
UCEC	chr9	35066727	Silent	rs760755090	F131F	0.34
UCEC	chr9	35057377	Missense_Mutation	novel	R772G	0.4
UCEC	chr9	35059135	Silent	novel	L697L	0.08
UCEC	chr9	35067982	Missense_Mutation	rs748091463	V71I	0.1
UCEC	chr9	35061016	Missense_Mutation	novel	R453Q	0.32
UCEC	chr9	35059623	Missense_Mutation	novel	R625L	0.41
UCEC	chr9	35061686	Missense_Mutation	novel	R362H	0.43
UCEC	chr9	35063007	Missense_Mutation	novel	E261A	0.07
UCEC	chr9	35056663	3'UTR	novel		0.16
UCEC	chr9	35057470	Missense_Mutation	rs764036918	R741C	0.23
UCEC	chr9	35064271	Silent	novel	S197S	0.26
UCEC	chr9	35057150	Silent	rs777887584	Y796Y	0.27
UCEC	chr9	35064256	Silent	novel	G202G	0.07
UCEC	chr9	35056651	3'UTR	novel		0.08
UCEC	chr9	35059624	Missense_Mutation	novel	R625W	0.49
UCEC	chr9	35067945	Missense_Mutation	NA	R83Q	0.25
UCEC	chr9	35060364	Silent	rs759745417	L548L	0.11
UCEC	chr9	35063056	Missense_Mutation	novel	G245R	0.18
UCEC	chr9	35067993	Missense_Mutation	novel	A67V	0.2
UCEC	chr9	35059192	Frame_Shift_Del	novel	M678*	0.23
UCEC	chr9	35059634	Silent	rs376510669	G621G	0.09
UCEC	chr9	35067986	Silent	NA	C69C	0.22
UCEC	chr9	35059126	Missense_Mutation	NA	R700C	0.49
UCEC	chr9	35059098	Missense_Mutation	rs746617777	R709Q	0.44
UCEC	chr9	35060427	Silent	novel	L527L	0.57
UCEC	chr9	35062234	Missense_Mutation	NA	A310T	0.39
UCEC	chr9	35057497	Missense_Mutation	rs758602597	R732C	0.34
UCEC	chr9	35059132	Missense_Mutation	novel	A698T	0.3
UCS	chr9	35060829	Missense_Mutation	novel	V485A	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0052	0.24147
STAD	AMP	0.1497	0.00082114
TGCT	DEL	0.3267	7.3329e-05
THCA	DEL	0.0261	0.24038
THYM	DEL	0.0163	0.022012

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.037	Kaplan-Meier Survival Analysis
ACC	0.0025	Kaplan-Meier Survival Analysis
UCS	0.019	Kaplan-Meier Survival Analysis
LAML	0.00081	Kaplan-Meier Survival Analysis
UCEC	0.0031	Kaplan-Meier Survival Analysis
LIHC	0.0026	Kaplan-Meier Survival Analysis
LUAD	0.05	Kaplan-Meier Survival Analysis
UVM	0.0018	Kaplan-Meier Survival Analysis
OV	0.023	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742