EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

PRI

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165392 (Gene tree)
Gene ID: 7486
Gene Symbol: WRN
Alias: RECQL2|RECQ3
Full Name: Werner syndrome RecQ like helicase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 140,508 bases
Position: chr8:31,033,262-31,173,769
Accession: 12791
RBP type: canonical RBP
Summary: This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000298139	HRDC	PF00570.23	1.5e-11	1	1
ENSP00000298139	DEAD	PF00270.29	3.5e-15	1	1
ENSP00000298139	DNA_pol_A_exo1	PF01612.20	1.2e-35	1	1

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000298139	WRN-201	5215	XM_011544639	ENSP00000298139	1432 (aa)	XP_011542941	Q14191
ENST00000520169	WRN-202	629	-	-	- (aa)	-	-
ENST00000521620	WRN-203	3593	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000165392's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165392	Exercise Test	6.31966375083062E-6	17903301
ENSG00000165392	Iron	2.8850000E-004	19880490
ENSG00000165392	Iron	3.1610000E-004	19880490
ENSG00000165392	Iron	9.2310000E-004	19880490
ENSG00000165392	Iron	8.2240000E-004	19880490
ENSG00000165392	Iron	6.7920000E-004	19880490
ENSG00000165392	Waist-Hip Ratio	7.8790000E-005	-
ENSG00000165392	Waist-Hip Ratio	9.2880000E-005	-
ENSG00000165392	Angiotensin-Converting Enzyme Inhibitors	2E-6	28084903
ENSG00000165392	Cough	2E-6	28084903
ENSG00000165392	Immunoglobulins	3E-6	23382691
ENSG00000165392	Longevity	6E-8	25918517
ENSG00000165392	Immunoglobulins	1E-6	23382691
ENSG00000165392	Exercise Test	6E-6	17903301
ENSG00000165392	Immunoglobulins	1E-6	23382691

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165392	rs10954779	8	31162081	T	Intelligence (MTAG)	29326435	[0.011-0.023] unit decrease	0.017427584	EFO_0004337
ENSG00000165392	rs2737339	8	31155954	A	Cognitive performance	30038396	[0.013-0.024] unit decrease	0.0183	EFO_0008354
ENSG00000165392	rs62506104	8	31162492	A	Educational attainment (MTAG)	30038396	[0.006-0.0126] unit decrease	0.0093	EFO_0004784
ENSG00000165392	rs2553268	8	31078840	?	Exercise treadmill test traits	17903301			EFO_0004328
ENSG00000165392	rs11574358	8	31147066	?	Lifespan	25918517	[NR] unit increase	5.584	EFO_0004300
ENSG00000165392	rs117173564	8	31153953	?	Cough in response to angiotensin-converting enzyme inhibitor drugs	28084903	[2.88-12.82]	6.07	EFO_0005325\|HP_0012735
ENSG00000165392	rs2737339	8	31155954	A	Cognitive performance (MTAG)	30038396	[0.013-0.022] unit decrease	0.0177	EFO_0008354
ENSG00000165392	rs16877794	8	31158766	?	General cognitive ability	29844566	z-score increase	5.212	EFO_0004337
ENSG00000165392	rs10954779	8	31162081	T	Intelligence	29942086	z-score decrease	5.93	EFO_0004337
ENSG00000165392	rs41520844	8	31135670	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000165392	rs62506074	8	31048573	T	Educational attainment (years of education)	30038396	[0.0062-0.012] unit increase	0.0091	EFO_0004784
ENSG00000165392	rs62506104	8	31162492	A	Educational attainment (years of education)	30038396	[0.0063-0.0133] unit decrease	0.0098	EFO_0004784
ENSG00000165392	rs1800389	8	31067041	?	Cardiovascular disease	30595370			EFO_0000319

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165392's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165392	WRN	81	69.805	ENSAMEG00000000475	-	100	69.237	Ailuropoda_melanoleuca
ENSG00000165392	WRN	92	55.049	ENSAPLG00000001616	WRN	91	55.348	Anas_platyrhynchos
ENSG00000165392	WRN	94	50.515	ENSACAG00000003109	WRN	99	50.662	Anolis_carolinensis
ENSG00000165392	WRN	100	85.625	ENSANAG00000032806	WRN	99	89.774	Aotus_nancymaae
ENSG00000165392	WRN	94	47.549	ENSAMXG00000010066	wrn	89	46.896	Astyanax_mexicanus
ENSG00000165392	WRN	100	72.292	ENSBTAG00000021592	WRN	100	72.292	Bos_taurus
ENSG00000165392	WRN	58	31.573	WBGene00006944	wrn-1	71	32.449	Caenorhabditis_elegans
ENSG00000165392	WRN	100	88.494	ENSCJAG00000012511	WRN	100	88.773	Callithrix_jacchus
ENSG00000165392	WRN	100	72.207	ENSCAFG00000006410	WRN	99	71.551	Canis_familiaris
ENSG00000165392	WRN	100	73.943	ENSCAFG00020001236	WRN	100	74.030	Canis_lupus_dingo
ENSG00000165392	WRN	100	72.083	ENSCHIG00000014991	WRN	100	72.083	Capra_hircus
ENSG00000165392	WRN	99	78.457	ENSTSYG00000012689	WRN	99	78.596	Carlito_syrichta
ENSG00000165392	WRN	96	55.081	ENSCAPG00000016803	WRN	98	70.882	Cavia_aperea
ENSG00000165392	WRN	99	70.926	ENSCPOG00000002943	WRN	99	70.791	Cavia_porcellus
ENSG00000165392	WRN	100	87.997	ENSCCAG00000023793	WRN	100	88.276	Cebus_capucinus
ENSG00000165392	WRN	100	91.207	ENSCATG00000040557	WRN	100	92.463	Cercocebus_atys
ENSG00000165392	WRN	98	74.501	ENSCLAG00000000817	WRN	100	71.218	Chinchilla_lanigera
ENSG00000165392	WRN	96	93.827	ENSCSAG00000015810	WRN	99	93.966	Chlorocebus_sabaeus
ENSG00000165392	WRN	80	87.151	ENSCHOG00000008966	WRN	81	87.151	Choloepus_hoffmanni
ENSG00000165392	WRN	95	58.974	ENSCPBG00000013421	WRN	90	59.151	Chrysemys_picta_bellii
ENSG00000165392	WRN	64	37.846	ENSCING00000002232	-	79	37.871	Ciona_intestinalis
ENSG00000165392	WRN	100	93.510	ENSCANG00000037137	WRN	100	93.022	Colobus_angolensis_palliatus
ENSG00000165392	WRN	99	71.110	ENSCGRG00001016491	Wrn	100	71.110	Cricetulus_griseus_chok1gshd
ENSG00000165392	WRN	83	69.891	ENSCGRG00000016821	Wrn	100	69.891	Cricetulus_griseus_crigri
ENSG00000165392	WRN	94	47.237	ENSDARG00000098211	wrn	89	46.951	Danio_rerio
ENSG00000165392	WRN	95	71.418	ENSDNOG00000008481	WRN	100	71.489	Dasypus_novemcinctus
ENSG00000165392	WRN	99	71.399	ENSDORG00000002696	Wrn	100	71.360	Dipodomys_ordii
ENSG00000165392	WRN	77	80.676	ENSETEG00000019854	WRN	79	80.676	Echinops_telfairi
ENSG00000165392	WRN	98	70.526	ENSEASG00005016813	WRN	98	80.986	Equus_asinus_asinus
ENSG00000165392	WRN	100	71.968	ENSECAG00000000110	WRN	100	72.035	Equus_caballus
ENSG00000165392	WRN	85	64.789	ENSEEUG00000004926	WRN	95	64.789	Erinaceus_europaeus
ENSG00000165392	WRN	94	47.123	ENSELUG00000017817	wrn	94	53.271	Esox_lucius
ENSG00000165392	WRN	100	73.093	ENSFCAG00000024759	WRN	100	72.935	Felis_catus
ENSG00000165392	WRN	100	73.681	ENSFDAG00000008637	WRN	100	73.342	Fukomys_damarensis
ENSG00000165392	WRN	99	53.664	ENSGALG00000040909	WRN	92	53.664	Gallus_gallus
ENSG00000165392	WRN	99	55.608	ENSGAGG00000022647	WRN	99	55.571	Gopherus_agassizii
ENSG00000165392	WRN	100	96.718	ENSGGOG00000022154	WRN	100	96.718	Gorilla_gorilla
ENSG00000165392	WRN	99	73.989	ENSHGLG00000003638	WRN	100	73.162	Heterocephalus_glaber_female
ENSG00000165392	WRN	94	47.985	ENSIPUG00000002090	wrn	92	47.935	Ictalurus_punctatus
ENSG00000165392	WRN	100	74.797	ENSSTOG00000013599	WRN	100	74.459	Ictidomys_tridecemlineatus
ENSG00000165392	WRN	99	69.714	ENSJJAG00000015655	Wrn	100	69.574	Jaculus_jaculus
ENSG00000165392	WRN	97	49.929	ENSLACG00000001569	-	93	50.071	Latimeria_chalumnae
ENSG00000165392	WRN	95	51.055	ENSLOCG00000010792	wrn	93	50.000	Lepisosteus_oculatus
ENSG00000165392	WRN	99	74.654	ENSLAFG00000004434	WRN	100	74.654	Loxodonta_africana
ENSG00000165392	WRN	99	92.647	ENSMFAG00000043428	WRN	99	93.557	Macaca_fascicularis
ENSG00000165392	WRN	100	92.394	ENSMMUG00000022655	WRN	100	93.301	Macaca_mulatta
ENSG00000165392	WRN	100	93.719	ENSMNEG00000032617	WRN	100	93.999	Macaca_nemestrina
ENSG00000165392	WRN	100	92.184	ENSMLEG00000038296	WRN	100	92.463	Mandrillus_leucophaeus
ENSG00000165392	WRN	94	54.978	ENSMGAG00000004960	WRN	88	54.792	Meleagris_gallopavo
ENSG00000165392	WRN	99	71.179	ENSMAUG00000016235	Wrn	100	71.179	Mesocricetus_auratus
ENSG00000165392	WRN	99	74.478	ENSMICG00000010630	WRN	100	74.983	Microcebus_murinus
ENSG00000165392	WRN	99	70.133	ENSMOCG00000013972	Wrn	100	70.063	Microtus_ochrogaster
ENSG00000165392	WRN	100	55.163	ENSMODG00000018997	WRN	100	55.532	Monodelphis_domestica
ENSG00000165392	WRN	99	69.805	MGP_CAROLIEiJ_G0030961	Wrn	100	69.526	Mus_caroli
ENSG00000165392	WRN	99	70.014	ENSMUSG00000031583	Wrn	100	69.735	Mus_musculus
ENSG00000165392	WRN	99	69.526	MGP_PahariEiJ_G0021430	Wrn	100	69.247	Mus_pahari
ENSG00000165392	WRN	99	70.223	MGP_SPRETEiJ_G0032079	Wrn	100	69.944	Mus_spretus
ENSG00000165392	WRN	100	73.162	ENSMPUG00000010201	WRN	100	73.162	Mustela_putorius_furo
ENSG00000165392	WRN	99	75.785	ENSMLUG00000005863	WRN	99	75.785	Myotis_lucifugus
ENSG00000165392	WRN	99	72.176	ENSNGAG00000018413	Wrn	99	72.176	Nannospalax_galili
ENSG00000165392	WRN	100	96.371	ENSNLEG00000012006	WRN	100	96.371	Nomascus_leucogenys
ENSG00000165392	WRN	73	63.755	ENSMEUG00000008271	-	76	63.478	Notamacropus_eugenii
ENSG00000165392	WRN	89	63.994	ENSOPRG00000001480	WRN	88	63.893	Ochotona_princeps
ENSG00000165392	WRN	99	73.449	ENSODEG00000004076	WRN	100	73.101	Octodon_degus
ENSG00000165392	WRN	89	61.479	ENSOANG00000005952	-	93	61.479	Ornithorhynchus_anatinus
ENSG00000165392	WRN	100	75.554	ENSOCUG00000012620	WRN	90	75.798	Oryctolagus_cuniculus
ENSG00000165392	WRN	97	73.714	ENSOGAG00000009600	WRN	100	73.714	Otolemur_garnettii
ENSG00000165392	WRN	100	72.222	ENSOARG00000000163	WRN	100	72.222	Ovis_aries
ENSG00000165392	WRN	100	96.718	ENSPPAG00000036871	WRN	100	96.718	Pan_paniscus
ENSG00000165392	WRN	100	74.254	ENSPPRG00000010928	WRN	100	74.046	Panthera_pardus
ENSG00000165392	WRN	100	74.046	ENSPTIG00000020609	WRN	100	73.838	Panthera_tigris_altaica
ENSG00000165392	WRN	100	98.394	ENSPTRG00000020145	WRN	100	98.394	Pan_troglodytes
ENSG00000165392	WRN	100	92.817	ENSPANG00000018594	WRN	100	93.445	Papio_anubis
ENSG00000165392	WRN	70	67.262	ENSPKIG00000025497	wrn	93	60.039	Paramormyrops_kingsleyae
ENSG00000165392	WRN	94	57.768	ENSPSIG00000013411	WRN	89	58.284	Pelodiscus_sinensis
ENSG00000165392	WRN	99	69.784	ENSPEMG00000020615	Wrn	99	70.118	Peromyscus_maniculatus_bairdii
ENSG00000165392	WRN	97	55.713	ENSPCIG00000020146	WRN	99	56.407	Phascolarctos_cinereus
ENSG00000165392	WRN	100	96.439	ENSPPYG00000018494	WRN	100	96.439	Pongo_abelii
ENSG00000165392	WRN	88	70.690	ENSPCAG00000013763	WRN	88	70.690	Procavia_capensis
ENSG00000165392	WRN	79	66.824	ENSPCOG00000012938	WRN	98	66.667	Propithecus_coquereli
ENSG00000165392	WRN	96	74.257	ENSPVAG00000012909	WRN	96	74.257	Pteropus_vampyrus
ENSG00000165392	WRN	94	46.998	ENSPNAG00000021848	wrn	88	46.998	Pygocentrus_nattereri
ENSG00000165392	WRN	99	69.225	ENSRNOG00000015440	Wrn	100	69.156	Rattus_norvegicus
ENSG00000165392	WRN	100	90.021	ENSRBIG00000031825	WRN	100	90.902	Rhinopithecus_bieti
ENSG00000165392	WRN	100	93.231	ENSRROG00000045381	WRN	100	93.440	Rhinopithecus_roxellana
ENSG00000165392	WRN	100	88.904	ENSSBOG00000027238	WRN	100	88.555	Saimiri_boliviensis_boliviensis
ENSG00000165392	WRN	99	57.626	ENSSHAG00000005577	WRN	99	57.833	Sarcophilus_harrisii
ENSG00000165392	WRN	95	48.148	ENSSFOG00015006123	wrn	95	47.962	Scleropages_formosus
ENSG00000165392	WRN	74	65.368	ENSSARG00000006157	WRN	87	65.368	Sorex_araneus
ENSG00000165392	WRN	97	76.450	ENSSSCG00000015840	WRN	100	76.450	Sus_scrofa
ENSG00000165392	WRN	72	57.336	ENSTGUG00000001765	WRN	100	57.336	Taeniopygia_guttata
ENSG00000165392	WRN	78	62.372	ENSTBEG00000012702	-	78	62.030	Tupaia_belangeri
ENSG00000165392	WRN	100	70.744	ENSTTRG00000012302	WRN	100	70.151	Tursiops_truncatus
ENSG00000165392	WRN	100	71.221	ENSUAMG00000021324	WRN	100	71.498	Ursus_americanus
ENSG00000165392	WRN	86	71.637	ENSUMAG00000007159	WRN	97	71.961	Ursus_maritimus
ENSG00000165392	WRN	99	71.329	ENSVPAG00000011004	WRN	99	71.329	Vicugna_pacos
ENSG00000165392	WRN	100	72.005	ENSVVUG00000019867	WRN	100	72.091	Vulpes_vulpes
ENSG00000165392	WRN	98	52.572	ENSXETG00000018302	wrn	99	53.834	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	21873635.	IBA	Function
GO:0000287	magnesium ion binding	16622405.	IDA	Function
GO:0000400	four-way junction DNA binding	21873635.	IBA	Function
GO:0000400	four-way junction DNA binding	11735402.	IDA	Function
GO:0000403	Y-form DNA binding	21873635.	IBA	Function
GO:0000403	Y-form DNA binding	11735402.17715146.26420422.	IDA	Function
GO:0000405	bubble DNA binding	21873635.	IBA	Function
GO:0000405	bubble DNA binding	11433031.11735402.	IDA	Function
GO:0000723	telomere maintenance	18212065.	IMP	Process
GO:0000723	telomere maintenance	25801465.	TAS	Process
GO:0000724	double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0000731	DNA synthesis involved in DNA repair	21873635.	IBA	Process
GO:0000731	DNA synthesis involved in DNA repair	17563354.	IDA	Process
GO:0000781	chromosome, telomeric region	21873635.	IBA	Component
GO:0000781	chromosome, telomeric region	15200954.26420422.	IDA	Component
GO:0001302	replicative cell aging	21873635.	IBA	Process
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	9288107.	IDA	Function
GO:0003678	DNA helicase activity	12944467.19734539.26420422.	IDA	Function
GO:0003678	DNA helicase activity	10871376.	IMP	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	9288107.15200954.	IDA	Function
GO:0004386	helicase activity	12181313.	IDA	Function
GO:0004527	exonuclease activity	12944467.	IDA	Function
GO:0004527	exonuclease activity	15200954.	IMP	Function
GO:0005515	protein binding	10373438.10783163.11328876.11427532.11598021.11919194.12181313.12750383.14596914.14657243.14688284.14734561.15735006.15965237.16030011.17498979.17611195.17715146.17961633.18203716.19343720.21639834.24126761.25931448.26496610.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	11420665.12944467.17498979.21639834.25801465.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005657	replication fork	21873635.	IBA	Component
GO:0005657	replication fork	-	ISS	Component
GO:0005662	DNA replication factor A complex	21873635.	IBA	Component
GO:0005694	chromosome	21873635.	IBA	Component
GO:0005730	nucleolus	9618508.11420665.12181313.12944467.15200954.17498979.21639834.25801465.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	17498979.	IDA	Component
GO:0006259	DNA metabolic process	16622405.	IDA	Process
GO:0006260	DNA replication	12882351.	IMP	Process
GO:0006260	DNA replication	-	ISS	Process
GO:0006260	DNA replication	-	TAS	Process
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006284	base-excision repair	21873635.	IBA	Process
GO:0006284	base-excision repair	17611195.	IDA	Process
GO:0006302	double-strand break repair	21639834.	IMP	Process
GO:0006310	DNA recombination	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	18203716.	IDA	Process
GO:0006979	response to oxidative stress	21873635.	IBA	Process
GO:0006979	response to oxidative stress	17611195.	IDA	Process
GO:0007420	brain development	-	IEA	Process
GO:0007568	aging	9288107.	NAS	Process
GO:0007569	cell aging	21873635.	IBA	Process
GO:0007569	cell aging	18212065.	IMP	Process
GO:0008340	determination of adult lifespan	21873635.	IBA	Process
GO:0008408	3'-5' exonuclease activity	21873635.	IBA	Function
GO:0008408	3'-5' exonuclease activity	10783163.10871373.12181313.16622405.	IDA	Function
GO:0009267	cellular response to starvation	21873635.	IBA	Process
GO:0009267	cellular response to starvation	11420665.	IDA	Process
GO:0009378	four-way junction helicase activity	21873635.	IBA	Function
GO:0009378	four-way junction helicase activity	11433031.11735402.	IDA	Function
GO:0010225	response to UV-C	21873635.	IBA	Process
GO:0010225	response to UV-C	17563354.	IDA	Process
GO:0010259	multicellular organism aging	21873635.	IBA	Process
GO:0010259	multicellular organism aging	16673358.	IMP	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0016887	ATPase activity	10373438.10871376.	IDA	Function
GO:0030145	manganese ion binding	21873635.	IBA	Function
GO:0030145	manganese ion binding	16622405.	IDA	Function
GO:0031297	replication fork processing	21873635.	IBA	Process
GO:0031297	replication fork processing	17115688.	IDA	Process
GO:0031297	replication fork processing	12882351.	IMP	Process
GO:0032405	MutLalpha complex binding	17715146.	IDA	Function
GO:0032508	DNA duplex unwinding	21873635.	IBA	Process
GO:0032508	DNA duplex unwinding	11735402.26420422.	IDA	Process
GO:0035861	site of double-strand break	21873635.	IBA	Component
GO:0040009	regulation of growth rate	-	IEA	Process
GO:0042803	protein homodimerization activity	21873635.	IBA	Function
GO:0042803	protein homodimerization activity	10783163.	IDA	Function
GO:0042981	regulation of apoptotic process	21873635.	IBA	Process
GO:0042981	regulation of apoptotic process	9681877.	IGI	Process
GO:0043005	neuron projection	-	IEA	Component
GO:0043138	3'-5' DNA helicase activity	17715146.	IDA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0044806	G-quadruplex DNA unwinding	21873635.	IBA	Process
GO:0044806	G-quadruplex DNA unwinding	11735402.	IDA	Process
GO:0044806	G-quadruplex DNA unwinding	-	ISS	Process
GO:0044877	protein-containing complex binding	21873635.	IBA	Function
GO:0044877	protein-containing complex binding	10783163.	IDA	Function
GO:0051345	positive regulation of hydrolase activity	21873635.	IBA	Process
GO:0051345	positive regulation of hydrolase activity	17611195.	IDA	Process
GO:0051880	G-quadruplex DNA binding	11433031.11735402.	IDA	Function
GO:0061749	forked DNA-dependent helicase activity	21873635.	IBA	Function
GO:0061749	forked DNA-dependent helicase activity	11735402.	IDA	Function
GO:0061820	telomeric D-loop disassembly	21873635.	IBA	Process
GO:0061820	telomeric D-loop disassembly	15200954.19734539.26420422.	IDA	Process
GO:0061820	telomeric D-loop disassembly	22039056.	IGI	Process
GO:0061820	telomeric D-loop disassembly	22039056.	TAS	Process
GO:0061821	telomeric D-loop binding	21873635.	IBA	Function
GO:0061821	telomeric D-loop binding	19734539.26420422.	IDA	Function
GO:0061849	telomeric G-quadruplex DNA binding	19734539.	IC	Function
GO:0070337	3'-flap-structured DNA binding	21873635.	IBA	Function
GO:0070337	3'-flap-structured DNA binding	26420422.	IDA	Function
GO:0071480	cellular response to gamma radiation	21873635.	IBA	Process
GO:0071480	cellular response to gamma radiation	21639834.	IDA	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process
GO:0090656	t-circle formation	27918544.	TAS	Process
GO:0098530	positive regulation of strand invasion	21873635.	IBA	Process
GO:0098530	positive regulation of strand invasion	26420422.	IDA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:1902570	protein localization to nucleolus	11420665.	IDA	Process
GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	21873635.	IBA	Function
GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	19734539.	IDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26959889	Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.	Oncotarget	2016 Mar 22	Shamanna RA	doi: 10.18632/oncotarget.7906.
25468760	Association Between WRN Cys1367Arg (T>C) and Cancer Risk: A Meta-analysis.	Technol Cancer Res Treat	2016 Feb	Wang B	doi: 10.1177/1533034614561359
22390926	Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death.	Biochem Biophys Res Commun	2012 Mar 30	Cheng WH	doi: 10.1016/j.bbrc.2012.02.104
17624410	Role for the Werner syndrome protein in the promotion of tumor cell growth.	Mech Ageing Dev	2007 Jul-Aug	Opresko PL	-
26241669	A Novel WRN Frameshift Mutation Identified by Multiplex Genetic Testing in a Family with Multiple Cases of Cancer.	PLoS One	2015 Aug 4	Yang L	doi: 10.1371/journal.pone.0133020
22037268	Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects.	Acta Med Okayama	2011 Oct	Wang L	-
16723399	Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.	Proc Natl Acad Sci U S A	2006 Jun 6	Agrelo R	-
19487340	The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.	Toxicol Sci	2009 Aug	Liu FJ	doi: 10.1093/toxsci/kfp104
24757718	Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells.	Aging Cell	2014 Apr	Li B	-
19945966	Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM.	Carcinogenesis	2010 Mar	Frank B	doi: 10.1093/carcin/bgp293
21389352	The Werner syndrome protein: linking the replication checkpoint response to genome stability.	Aging (Albany NY)	2011 Mar	Pichierri P	-
19205873	A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.	Breast Cancer Res Treat	2009 Nov	Wang Z	doi: 10.1007/s10549-009-0327-z
22173703	Esophageal cancer risk is associated with polymorphisms of DNA repair genes MSH2 and WRN in Chinese population.	J Thorac Oncol	2012 Feb	Li T	doi: 10.1097/JTO.0b013e31823c487a.
26690424	Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer.	Int J Mol Sci	2015 Dec 10	Zins K	doi: 10.3390/ijms161226192.
15084309	The Werner syndrome protein has separable recombination and survival functions.	DNA Repair (Amst)	2004 May 4	Swanson C	-
22797812	Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells.	Oncol Rep	2012 Oct	Masuda K	doi: 10.3892/or.2012.1912

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	31083736	Missense_Mutation	novel	Y436C	0.39
BLCA	chr8	31167146	Silent	novel	V1369V	0.21
BLCA	chr8	31081193	Missense_Mutation	novel	R389K	0.63
BLCA	chr8	31141528	Silent	novel	L1022L	0.18
BLCA	chr8	31141478	Missense_Mutation	NA	T1006P	0.33
BLCA	chr8	31087762	Intron	novel		0.14
BLCA	chr8	31111791	Silent	NA	V755V	0.28
BLCA	chr8	31167057	Missense_Mutation	rs747312018	P1340S	0.34
BLCA	chr8	31141482	Frame_Shift_Ins	novel	*T1011Gfs17**	0.17
BLCA	chr8	31090900	Missense_Mutation	novel	S596C	0.14
BLCA	chr8	31157523	Silent	NA	V1325V	0.43
BRCA	chr8	31065036	Silent	novel	V159V	0.09
BRCA	chr8	31141585	Silent	rs773664315	C1041C	0.14
BRCA	chr8	31120314	Silent	NA	G840G	0.29
BRCA	chr8	31076197	Missense_Mutation	novel	M250R	0.04
BRCA	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.18
BRCA	chr8	31111786	Missense_Mutation	NA	L754V	0.43
BRCA	chr8	31076264	Silent	NA	F272F	0.46
BRCA	chr8	31100855	Missense_Mutation	rs752650803	T663M	0.6
BRCA	chr8	31058408	5'UTR	novel		0.12
BRCA	chr8	31083764	Missense_Mutation	NA	E445D	0.2
BRCA	chr8	31085231	Missense_Mutation	novel	E472D	0.04
BRCA	chr8	31087819	Missense_Mutation	novel	S492Y	0.09
BRCA	chr8	31111648	Missense_Mutation	NA	S708A	0.29
BRCA	chr8	31096809	Missense_Mutation	NA	S647L	0.34
BRCA	chr8	31124911	Silent	NA	I912I	0.32
BRCA	chr8	31173103	3'UTR	novel		0.06
CESC	chr8	31111796	Missense_Mutation	NA	T757R	0.29
CESC	chr8	31058539	Frame_Shift_Del	novel	*R31Kfs17**	0.24
CESC	chr8	31141693	Frame_Shift_Del	novel	*L1051Ffs48**	0.18
CESC	chr8	31154719	Silent	NA	I1261I	0.18
COAD	chr8	31059228	Missense_Mutation	rs773803207	D58N	0.34
COAD	chr8	31147471	Missense_Mutation	novel	K1189N	0.28
COAD	chr8	31058404	5'UTR	novel		0.31
COAD	chr8	31087874	Missense_Mutation	rs149565907	E510D	0.08
COAD	chr8	31150354	Nonsense_Mutation	NA	E1196*	0.41
COAD	chr8	31167042	Missense_Mutation	NA	I1335V	0.12
COAD	chr8	31065030	Silent	novel	N157N	0.41
COAD	chr8	31157445	Frame_Shift_Del	novel	*D1302Ifs7**	0.24
COAD	chr8	31058414	5'UTR	novel		0.26
COAD	chr8	31116467	Missense_Mutation	rs779140898	A796V	0.2
COAD	chr8	31067139	Missense_Mutation	novel	P204H	0.06	HRDC
COAD	chr8	31120390	Missense_Mutation	rs776463866	V866I	0.31
COAD	chr8	31059186	Missense_Mutation	novel	L44I	0.05
COAD	chr8	31111655	Missense_Mutation	NA	I710T	0.25
COAD	chr8	31065061	Missense_Mutation	novel	K168Q	0.09	HRDC
COAD	chr8	31154707	Silent	rs777616472	Q1257Q	0.08
COAD	chr8	31132462	Missense_Mutation	NA	E975K	0.18
COAD	chr8	31120268	Missense_Mutation	NA	G825A	0.28
COAD	chr8	31087860	In_Frame_Ins	NA	E510dup	0.3
COAD	chr8	31120427	Splice_Region	rs747115098		0.47
COAD	chr8	31080880	Missense_Mutation	NA	L285V	0.2
ESCA	chr8	31064418	Silent	rs374898432	H113H	0.25
ESCA	chr8	31124608	Missense_Mutation	novel	S906T	0.19
ESCA	chr8	31088912	Silent	rs757279675	N533N	0.24
ESCA	chr8	31120350	Silent	novel	I852I	0.11
ESCA	chr8	31064926	Missense_Mutation	novel	G123R	0.49	HRDC
ESCA	chr8	31154727	Missense_Mutation	novel	S1264C	0.39
GBM	chr8	31154688	Missense_Mutation	novel	K1251T	0.45
GBM	chr8	31167106	Missense_Mutation	novel	K1356T	0.05
GBM	chr8	31065032	Missense_Mutation	novel	F158S	0.11	HRDC
HNSC	chr8	31173002	Missense_Mutation	novel	S1400F	0.17
HNSC	chr8	31091844	Missense_Mutation	novel	P615L	0.12
HNSC	chr8	31067143	Silent	novel	L205L	0.67
HNSC	chr8	31120345	Nonsense_Mutation	novel	E851*	0.15
HNSC	chr8	31067115	Frame_Shift_Del	novel	*R196Pfs32**	0.4	HRDC
HNSC	chr8	31100933	Frame_Shift_Del	novel	L690*	0.52
HNSC	chr8	31120326	Missense_Mutation	novel	D844E	0.32
HNSC	chr8	31083720	Missense_Mutation	novel	E431K	0.15
HNSC	chr8	31154711	Missense_Mutation	novel	M1259V	0.06
KIRC	chr8	31081202	Frame_Shift_Ins	novel	*M393Dfs9**	0.06
KIRC	chr8	31081203	Frame_Shift_Ins	novel	*M393Lfs10**	0.06
KIRC	chr8	31120361	Missense_Mutation	NA	G856D	0.26
KIRP	chr8	31081051	Missense_Mutation	rs764559021	V342I	0.23
LAML	chr8	31147417	Missense_Mutation	novel	M1171I	0.3
LGG	chr8	31081248	Silent	rs758386387	Q407Q	0.09
LGG	chr8	31065005	Missense_Mutation	rs61761625	R149H	0.41	HRDC
LGG	chr8	31080886	Missense_Mutation	novel	D287Y	0.26
LGG	chr8	31087784	Missense_Mutation	novel	E480D	0.33
LGG	chr8	31116471	Silent	NA	G797G	0.38
LGG	chr8	31088919	Missense_Mutation	novel	Q536E	0.4
LIHC	chr8	31173361	3'UTR	novel		0.33
LIHC	chr8	31173033	Nonsense_Mutation	NA	W1410*	0.47
LIHC	chr8	31083775	Splice_Site	novel	X449_splice	0.07
LIHC	chr8	31116489	Missense_Mutation	novel	R803S	0.18
LIHC	chr8	31147412	Missense_Mutation	novel	K1170E	0.29
LUAD	chr8	31096825	Silent	NA	L652L	0.32
LUAD	chr8	31120397	Missense_Mutation	NA	W868L	0.12
LUAD	chr8	31173091	Missense_Mutation	NA	L1430V	0.76
LUAD	chr8	31081291	Missense_Mutation	novel	T422S	0.14
LUAD	chr8	31090488	Missense_Mutation	novel	S559L	0.06
LUAD	chr8	31080874	Missense_Mutation	NA	I283F	1
LUAD	chr8	31173088	Missense_Mutation	novel	G1429C	0.19
LUAD	chr8	31167117	Missense_Mutation	novel	D1360H	0.06
LUAD	chr8	31120286	Missense_Mutation	NA	A831V	0.32
LUAD	chr8	31157456	Missense_Mutation	novel	L1303S	0.55
LUAD	chr8	31120319	Missense_Mutation	NA	P842L	0.17
LUAD	chr8	31096770	Missense_Mutation	novel	G634V	0.24
LUAD	chr8	31067164	Silent	NA	Y212Y	0.11
LUAD	chr8	31141749	Missense_Mutation	NA	L1069F	0.2
LUAD	chr8	31064343	Missense_Mutation	NA	L88F	0.25	HRDC
LUAD	chr8	31116517	Missense_Mutation	novel	D813Y	0.67
LUAD	chr8	31141586	Missense_Mutation	NA	A1042P	0.25
LUAD	chr8	31080898	Missense_Mutation	novel	N291Y	0.25
LUAD	chr8	31076193	Missense_Mutation	rs758055295	D249N	0.37
LUAD	chr8	31100856	Silent	rs201982706	T663T	0.52
LUAD	chr8	31081011	Silent	NA	V328V	0.15
LUAD	chr8	31067145	Missense_Mutation	NA	T206I	0.08	HRDC
LUSC	chr8	31058543	Frame_Shift_Del	rs755891046		0.29
LUSC	chr8	31064333	Missense_Mutation	NA	W85L	0.3	HRDC
LUSC	chr8	31111613	Splice_Site	novel	X697_splice	0.31
LUSC	chr8	31116466	Missense_Mutation	novel	A796T	0.27
LUSC	chr8	31058543	Missense_Mutation	NA	K32N	0.61
LUSC	chr8	31157520	Silent	rs370253199	P1324P	0.45
LUSC	chr8	31111696	Missense_Mutation	novel	Q724E	0.13
LUSC	chr8	31157487	Missense_Mutation	NA	Q1313H	0.51
LUSC	chr8	31167107	Silent	NA	K1356K	0.4
LUSC	chr8	31141569	Missense_Mutation	rs773176431	K1036R	0.18
LUSC	chr8	31059211	Missense_Mutation	novel	S52F	0.1
LUSC	chr8	31167117	Missense_Mutation	novel	D1360Y	0.32
LUSC	chr8	31058452	Missense_Mutation	novel	S2I	0.17
LUSC	chr8	31081023	Missense_Mutation	novel	Q332H	0.1
OV	chr8	31085221	Missense_Mutation	NA	E469G	0.16
OV	chr8	31067159	Missense_Mutation	NA	L211V	0.25	HRDC
OV	chr8	31141563	Missense_Mutation	rs200370409	Y1034F	0.25
OV	chr8	31091893	Missense_Mutation	NA	I631M	0.66
OV	chr8	31100931	Silent	novel	G688G	0.05
OV	chr8	31116503	Missense_Mutation	novel	H808L	0.61
OV	chr8	31064292	Missense_Mutation	novel	M71I	0.07	HRDC
PAAD	chr8	31067114	Missense_Mutation	rs375762379	R196C	0.15	HRDC
PRAD	chr8	31157509	Silent	novel	R1321R	0.08
PRAD	chr8	31100898	Silent	rs776209945	G677G	0.29
READ	chr8	31147396	Missense_Mutation	novel	R1164S	0.08
READ	chr8	31141590	Missense_Mutation	novel	L1043P	0.08
READ	chr8	31081039	Missense_Mutation	rs759046519	V338I	0.38
READ	chr8	31083748	Missense_Mutation	NA	S440N	0.28
READ	chr8	31085165	Splice_Site	novel	X451_splice	0.37
READ	chr8	31090499	Nonsense_Mutation	novel	E563*	0.43
SARC	chr8	31157442	Silent	novel	G1298G	0.33
SARC	chr8	31080881	Missense_Mutation	novel	L285R	0.47
SARC	chr8	31087912	Frame_Shift_Ins	novel	D524*	0.12
SARC	chr8	31087913	Frame_Shift_Ins	novel	*D524Vfs13**	0.12
SKCM	chr8	31141582	Silent	NA	I1040I	0.19
SKCM	chr8	31081093	Missense_Mutation	NA	K356E	0.4
SKCM	chr8	31059248	Silent	novel	F64F	0.29
SKCM	chr8	31059233	Silent	novel	A59A	0.61
SKCM	chr8	31116356	Missense_Mutation	NA	S759F	0.24
SKCM	chr8	31090904	Silent	NA	P597P	0.15
SKCM	chr8	31081040	Missense_Mutation	NA	V338G	0.62
SKCM	chr8	31090898	Silent	NA	I595I	0.18
SKCM	chr8	31141519	Silent	NA	S1019S	0.36
SKCM	chr8	31080981	Missense_Mutation	novel	L318F	0.21
SKCM	chr8	31157509	Nonsense_Mutation	NA	R1321*	0.23
SKCM	chr8	31111742	Missense_Mutation	NA	V739A	0.26
SKCM	chr8	31141768	Silent	NA	L1076L	0.44
SKCM	chr8	31157520	Silent	rs370253199	P1324P	0.35
SKCM	chr8	31067070	Missense_Mutation	rs774751582	V181A	0.47	HRDC
SKCM	chr8	31080995	Missense_Mutation	rs369277330	S323L	0.6
SKCM	chr8	31167182	Silent	NA	I1381I	0.4
SKCM	chr8	31090834	Missense_Mutation	novel	G574E	0.39
SKCM	chr8	31141729	Missense_Mutation	NA	L1063F	0.31
SKCM	chr8	31090857	Nonsense_Mutation	rs757808169	Q582*	0.2
SKCM	chr8	31067138	Missense_Mutation	rs199644081	P204S	0.27	HRDC
SKCM	chr8	31090900	Missense_Mutation	novel	S596F	0.46
SKCM	chr8	31157423	Missense_Mutation	NA	S1292F	0.6
SKCM	chr8	31142676	Missense_Mutation	rs746470648	P1095L	0.39
SKCM	chr8	31167172	Missense_Mutation	NA	S1378F	0.29
SKCM	chr8	31100897	Missense_Mutation	NA	G677A	0.29
SKCM	chr8	31058379	5'UTR	novel		0.67
SKCM	chr8	31141427	Splice_Region	novel		0.61
SKCM	chr8	31111760	Missense_Mutation	NA	N745S	0.52
SKCM	chr8	31124963	Missense_Mutation	NA	M930V	0.23
SKCM	chr8	31067109	Missense_Mutation	rs776831463	S194F	0.39	HRDC
SKCM	chr8	31085201	Silent	novel	S462S	0.27
STAD	chr8	31068277	Missense_Mutation	rs62506077	R225Q	0.15	HRDC
STAD	chr8	31081132	Nonsense_Mutation	rs17847577	R369*	0.69
STAD	chr8	31111650	Silent	NA	S708S	0.16
STAD	chr8	31124542	Missense_Mutation	rs771294955	R884H	0.18
STAD	chr8	31120391	Missense_Mutation	NA	V866G	0.15
STAD	chr8	31067146	Silent	NA	T206T	0.64
STAD	chr8	31141594	Silent	rs775952540	T1044T	0.15
STAD	chr8	31120419	Silent	novel	L875L	0.28
STAD	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.26
STAD	chr8	31111624	Missense_Mutation	NA	V700I	0.27
STAD	chr8	31087874	Missense_Mutation	rs149565907	E510D	0.18
STAD	chr8	31091899	Splice_Site	NA	X633_splice	0.28
STAD	chr8	31090872	Missense_Mutation	novel	Y587H	0.1
STAD	chr8	31150360	Missense_Mutation	novel	V1198L	0.21
STAD	chr8	31067146	Silent	NA	T206T	0.08
STAD	chr8	31124557	Missense_Mutation	rs374262282	R889Q	0.23
STAD	chr8	31111765	Missense_Mutation	NA	L747I	0.24
STAD	chr8	31081172	Missense_Mutation	NA	K382T	0.1
STAD	chr8	31141594	Silent	rs775952540	T1044T	0.18
STAD	chr8	31120314	Silent	NA	G840G	0.13
STAD	chr8	31157429	Missense_Mutation	rs146861737	A1294V	0.09
STAD	chr8	31058454	Frame_Shift_Ins	NA	*L6Ifs12**	0.41
STAD	chr8	31100856	Silent	rs201982706	T663T	0.19
TGCT	chr8	31081206	Missense_Mutation	novel	M393I	0.12
THCA	chr8	31173081	Nonsense_Mutation	novel	R1427*	0.08
THCA	chr8	31147437	Missense_Mutation	NA	L1178P	0.4
UCEC	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.31
UCEC	chr8	31150456	Splice_Site	novel	X1229_splice	0.22
UCEC	chr8	31085219	Missense_Mutation	novel	D468E	0.33
UCEC	chr8	31081036	Nonsense_Mutation	NA	E337*	0.32
UCEC	chr8	31058539	Missense_Mutation	NA	R31I	0.3
UCEC	chr8	31173316	3'UTR	novel		0.27
UCEC	chr8	31142629	Silent	rs11574345	S1079S	0.17
UCEC	chr8	31087786	Missense_Mutation	novel	N481S	0.09
UCEC	chr8	31132376	Missense_Mutation	novel	C946Y	0.48
UCEC	chr8	31087874	Missense_Mutation	rs149565907	E510D	0.28
UCEC	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.34
UCEC	chr8	31143570	Nonsense_Mutation	novel	Y1110*	0.38
UCEC	chr8	31120316	Missense_Mutation	rs755249893	A841V	0.36
UCEC	chr8	31081159	Missense_Mutation	NA	V378L	0.2
UCEC	chr8	31080869	Missense_Mutation	novel	V281A	0.43
UCEC	chr8	31058485	Missense_Mutation	NA	R13Q	0.18
UCEC	chr8	31141440	Missense_Mutation	rs370713742	R993H	0.22
UCEC	chr8	31141758	Missense_Mutation	NA	K1072N	0.26
UCEC	chr8	31116449	Missense_Mutation	novel	S790F	0.18
UCEC	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.57
UCEC	chr8	31096790	Missense_Mutation	NA	V641L	0.07
UCEC	chr8	31058403	5'UTR	novel		0.37
UCEC	chr8	31081138	Nonsense_Mutation	novel	E371*	0.46
UCEC	chr8	31116520	Nonsense_Mutation	novel	E814*	0.26
UCEC	chr8	31059187	Frame_Shift_Ins	novel	*F46Lfs11**	0.33
UCEC	chr8	31120405	Missense_Mutation	novel	A871T	0.24
UCEC	chr8	31173011	Missense_Mutation	novel	R1403K	0.36
UCEC	chr8	31081069	Missense_Mutation	novel	D348N	0.33
UCEC	chr8	31083731	Silent	rs374140086	T434T	0.37
UCEC	chr8	31081172	Missense_Mutation	rs541455377	K382R	0.12
UCEC	chr8	31087896	Nonsense_Mutation	novel	E518*	0.39
UCEC	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.31
UCEC	chr8	31111721	Missense_Mutation	rs777084325	R732Q	0.24
UCEC	chr8	31064351	Missense_Mutation	novel	R91I	0.28	HRDC
UCEC	chr8	31124942	Missense_Mutation	novel	Q923K	0.65
UCEC	chr8	31167021	Splice_Site	rs752465293	X1328_splice	0.53
UCEC	chr8	31083731	Silent	rs374140086	T434T	0.47
UCEC	chr8	31087863	Nonsense_Mutation	novel	E507*	0.48
UCEC	chr8	31067172	Frame_Shift_Ins	novel	*D216Lfs13**	0.12	HRDC
UCEC	chr8	31076178	Nonsense_Mutation	NA	E244*	0.3
UCEC	chr8	31088940	Missense_Mutation	novel	Y543H	0.45
UCEC	chr8	31132462	Missense_Mutation	NA	E975K	0.4
UCEC	chr8	31141758	Missense_Mutation	NA	K1072N	0.23
UCEC	chr8	31120365	Silent	rs3087432	R857R	0.33
UCEC	chr8	31147087	Missense_Mutation	novel	S1140P	0.3
UCEC	chr8	31087673	Intron	novel		0.27
UCEC	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.51
UCEC	chr8	31132462	Missense_Mutation	NA	E975K	0.21
UCEC	chr8	31132365	Missense_Mutation	novel	R942S	0.41
UCEC	chr8	31167083	Silent	rs763768734	I1348I	0.36
UCEC	chr8	31120311	Silent	rs779314628	Y839Y	0.38
UCEC	chr8	31087701	Intron	novel		0.17
UCEC	chr8	31067120	Missense_Mutation	novel	S198R	0.3	HRDC
UCEC	chr8	31058513	Missense_Mutation	novel	Q22H	0.5
UCEC	chr8	31173060	Missense_Mutation	novel	K1419N	0.15
UCEC	chr8	31132462	Missense_Mutation	NA	E975K	0.4
UCEC	chr8	31111721	Missense_Mutation	rs777084325	R732Q	0.23
UCEC	chr8	31087664	Intron	novel		0.3
UCEC	chr8	31167160	Missense_Mutation	NA	C1374F	0.3
UCEC	chr8	31065062	Nonsense_Mutation	novel	*K168delinsNEMRYQPDM**	0.07	HRDC
UCEC	chr8	31142674	Silent	novel	V1094V	0.05
UCEC	chr8	31147119	Silent	novel	Q1150Q	0.36
UCEC	chr8	31059228	Missense_Mutation	novel	D58H	0.47
UCEC	chr8	31087905	Nonsense_Mutation	NA	E521*	0.54
UCEC	chr8	31132432	Missense_Mutation	rs769143572	K965E	0.39
UCEC	chr8	31173234	3'UTR	novel		0.21
UCEC	chr8	31100856	Silent	rs201982706	T663T	0.23
UCEC	chr8	31143616	Frame_Shift_Del	rs778872619	*S1128Vfs34**	0.5
UCEC	chr8	31167157	Missense_Mutation	novel	R1373I	0.11
UCEC	chr8	31132373	Missense_Mutation	NA	H945R	0.04
UCEC	chr8	31065063	Missense_Mutation	novel	K168N	0.21	HRDC
UCEC	chr8	31081247	Missense_Mutation	novel	Q407P	0.19
UCEC	chr8	31111753	Missense_Mutation	novel	T743P	0.4
UCEC	chr8	31116468	Silent	novel	A796A	0.2
UCEC	chr8	31100890	Missense_Mutation	rs758232075	E675Q	0.31
UCEC	chr8	31081051	Missense_Mutation	rs764559021	V342I	0.58
UCEC	chr8	31065019	Missense_Mutation	NA	K154E	0.32	HRDC
UCEC	chr8	31116506	Missense_Mutation	NA	R809M	0.28
UCEC	chr8	31058454	Frame_Shift_Ins	NA	*L6Ifs12**	0.42
UCEC	chr8	31096838	Nonsense_Mutation	novel	E657*	0.47
UCEC	chr8	31100869	Missense_Mutation	novel	D668N	0.29
UCEC	chr8	31124557	Missense_Mutation	rs374262282	R889Q	0.33
UCS	chr8	31087664	Intron	novel		0.25
UCS	chr8	31067085	Missense_Mutation	novel	G186V	1	HRDC
UCS	chr8	31132455	Missense_Mutation	novel	I972M	0.2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5319	4.5185e-08
DLBC	DEL	0.1875	0.15679
ESCA	DEL	0.3804	0.060925
PAAD	DEL	0.2174	0.050455
READ	DEL	0.5273	0.20625

Survival Analysis

Cancer	P-value	Q-value
THYM	0.041	Kaplan-Meier Survival Analysis
KIRC	0.016	Kaplan-Meier Survival Analysis
MESO	0.005	Kaplan-Meier Survival Analysis
SKCM	0.019	Kaplan-Meier Survival Analysis
KIRP	0.0053	Kaplan-Meier Survival Analysis
COAD	0.012	Kaplan-Meier Survival Analysis
READ	0.00062	Kaplan-Meier Survival Analysis
LAML	0.00025	Kaplan-Meier Survival Analysis
KICH	0.0049	Kaplan-Meier Survival Analysis
LIHC	0.002	Kaplan-Meier Survival Analysis
LGG	0.00046	Kaplan-Meier Survival Analysis
THCA	0.022	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

PRI

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742