EuRBPDB

Description

Ensembl ID: ENSG00000165494 (Gene tree)
Gene ID: 51585
Gene Symbol: PCF11
Alias: KIAA0824
Full Name: PCF11 cleavage and polyadenylation factor subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,464 bases
Position: chr11:83,156,988-83,187,451
Accession: 30097
RBP type: non-canonical RBP
Summary: The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22564898	A genetic screen for terminator function in yeast identifies a role for a new functional domain in termination factor Nab3.	Nucleic Acids Res	2012 Aug	Loya TJ	doi: 10.1093/nar/gks377
25437538	The evolutionarily conserved Pol II flap loop contributes to proper transcription termination on short yeast genes.	Cell Rep	2014 Nov 6	Pearson E	doi: 10.1016/j.celrep.2014.10.007

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000530304	PCF11-203	2649	-	ENSP00000431567	784 (aa)	-	E9PKN0
ENST00000530660	PCF11-204	3309	-	ENSP00000434540	998 (aa)	-	E9PQ01
ENST00000298281	PCF11-201	7677	-	ENSP00000298281	1555 (aa)	-	O94913
ENST00000530906	PCF11-205	628	-	ENSP00000437076	198 (aa)	-	E9PNY7
ENST00000624931	PCF11-207	1720	-	-	- (aa)	-	-
ENST00000528336	PCF11-202	1041	-	-	- (aa)	-	-
ENST00000533018	PCF11-206	580	-	ENSP00000436806	99 (aa)	-	E9PQF9

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165494	Motor Activity	7E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165494	rs1943345	11	83165228	C	Obesity-related traits	23251661	[NR] %awake time increase	0.03	EFO_0003940

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000993	RNA polymerase II complex binding	21873635.	IBA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005849	mRNA cleavage factor complex	11060040.	NAS	Component
GO:0006369	termination of RNA polymerase II transcription	21873635.	IBA	Process
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0006379	mRNA cleavage	11060040.	NAS	Process
GO:0031124	mRNA 3'-end processing	-	TAS	Process