EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165506 (Gene tree)
Gene ID: 55172
Gene Symbol: DNAAF2
Alias: FLJ10563|KTU|PF13|CILD10|C14orf104
Full Name: dynein axonemal assembly factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 10,057 bases
Position: chr14:49,625,174-49,635,230
Accession: 20188
RBP type: canonical RBP
Summary: This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in this gene have been associated with primary ciliary dyskinesia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000384862	PIH1	PF08190.12	9.2e-58	1	1
ENSP00000298292	PIH1	PF08190.12	1e-57	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000406043	DNAAF2-202	2819	-	ENSP00000384862	789 (aa)	-	Q9NVR5
ENST00000298292	DNAAF2-201	2963	-	ENSP00000298292	837 (aa)	-	Q9NVR5

Gene Model

Click here to download ENSG00000165506's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165506	Carotid Arteries	2E-6	26343869

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165506	rs2985684	14	49634964	?	Carotid intima media thickness	26343869			EFO_0007117

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165506's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165506	DNAAF2	100	65.036	ENSAMEG00000009538	DNAAF2	100	64.678	Ailuropoda_melanoleuca
ENSG00000165506	DNAAF2	100	90.323	ENSANAG00000031647	DNAAF2	100	89.964	Aotus_nancymaae
ENSG00000165506	DNAAF2	100	73.168	ENSBTAG00000004930	DNAAF2	100	72.813	Bos_taurus
ENSG00000165506	DNAAF2	100	89.205	ENSCJAG00000047844	DNAAF2	100	88.849	Callithrix_jacchus
ENSG00000165506	DNAAF2	100	73.168	ENSCAFG00020021981	DNAAF2	100	73.404	Canis_lupus_dingo
ENSG00000165506	DNAAF2	100	73.286	ENSCHIG00000016942	DNAAF2	100	72.931	Capra_hircus
ENSG00000165506	DNAAF2	96	75.969	ENSCPOG00000009147	DNAAF2	97	79.944	Cavia_porcellus
ENSG00000165506	DNAAF2	100	90.203	ENSCCAG00000004405	DNAAF2	100	89.845	Cebus_capucinus
ENSG00000165506	DNAAF2	100	92.189	ENSCATG00000028591	DNAAF2	94	92.189	Cercocebus_atys
ENSG00000165506	DNAAF2	100	68.868	ENSCLAG00000013335	DNAAF2	100	68.047	Chinchilla_lanigera
ENSG00000165506	DNAAF2	100	92.071	ENSCSAG00000015265	DNAAF2	100	92.071	Chlorocebus_sabaeus
ENSG00000165506	DNAAF2	63	84.566	ENSCHOG00000009583	-	63	84.566	Choloepus_hoffmanni
ENSG00000165506	DNAAF2	100	92.729	ENSCANG00000004726	DNAAF2	100	92.729	Colobus_angolensis_palliatus
ENSG00000165506	DNAAF2	100	67.175	ENSCGRG00001013061	-	100	65.972	Cricetulus_griseus_chok1gshd
ENSG00000165506	DNAAF2	100	73.512	ENSDNOG00000046106	DNAAF2	100	72.929	Dasypus_novemcinctus
ENSG00000165506	DNAAF2	83	81.166	ENSDORG00000000300	-	88	81.166	Dipodomys_ordii
ENSG00000165506	DNAAF2	83	73.784	ENSEASG00005007838	DNAAF2	74	77.871	Equus_asinus_asinus
ENSG00000165506	DNAAF2	83	74.663	ENSECAG00000012031	DNAAF2	74	78.431	Equus_caballus
ENSG00000165506	DNAAF2	100	77.381	ENSFCAG00000022138	DNAAF2	100	77.143	Felis_catus
ENSG00000165506	DNAAF2	84	99.228	ENSGGOG00000024797	DNAAF2	100	99.228	Gorilla_gorilla
ENSG00000165506	DNAAF2	100	68.402	ENSHGLG00000010009	DNAAF2	100	67.574	Heterocephalus_glaber_female
ENSG00000165506	DNAAF2	83	89.623	ENSHGLG00100006214	DNAAF2	99	89.623	Heterocephalus_glaber_male
ENSG00000165506	DNAAF2	99	74.163	ENSSTOG00000023987	DNAAF2	90	73.846	Ictidomys_tridecemlineatus
ENSG00000165506	DNAAF2	100	66.508	ENSJJAG00000021409	-	100	66.904	Jaculus_jaculus
ENSG00000165506	DNAAF2	99	36.667	ENSLACG00000015993	DNAAF2	86	52.691	Latimeria_chalumnae
ENSG00000165506	DNAAF2	99	63.892	ENSLAFG00000003422	DNAAF2	99	75.520	Loxodonta_africana
ENSG00000165506	DNAAF2	100	92.491	ENSMFAG00000045239	DNAAF2	100	92.491	Macaca_fascicularis
ENSG00000165506	DNAAF2	100	92.189	ENSMMUG00000008284	DNAAF2	100	92.189	Macaca_mulatta
ENSG00000165506	DNAAF2	100	92.071	ENSMNEG00000034164	DNAAF2	100	92.071	Macaca_nemestrina
ENSG00000165506	DNAAF2	88	95.946	ENSMLEG00000031338	DNAAF2	100	93.827	Mandrillus_leucophaeus
ENSG00000165506	DNAAF2	100	66.902	ENSMAUG00000014305	-	100	65.848	Mesocricetus_auratus
ENSG00000165506	DNAAF2	100	79.834	ENSMICG00000030317	DNAAF2	100	79.597	Microcebus_murinus
ENSG00000165506	DNAAF2	100	65.724	ENSMOCG00000005708	-	100	64.906	Microtus_ochrogaster
ENSG00000165506	DNAAF2	50	39.206	ENSMMOG00000011990	dnaaf2	63	41.408	Mola_mola
ENSG00000165506	DNAAF2	94	69.613	ENSMODG00000011405	-	71	71.271	Monodelphis_domestica
ENSG00000165506	DNAAF2	100	63.872	MGP_CAROLIEiJ_G0017799	-	100	62.850	Mus_caroli
ENSG00000165506	DNAAF2	100	64.379	ENSMUSG00000020973	Dnaaf2	100	63.679	Mus_musculus
ENSG00000165506	DNAAF2	100	65.376	MGP_PahariEiJ_G0029555	-	100	64.460	Mus_pahari
ENSG00000165506	DNAAF2	100	64.650	MGP_SPRETEiJ_G0018644	-	100	64.218	Mus_spretus
ENSG00000165506	DNAAF2	100	70.918	ENSMLUG00000013903	DNAAF2	100	68.854	Myotis_lucifugus
ENSG00000165506	DNAAF2	100	68.246	ENSNGAG00000019379	-	94	82.234	Nannospalax_galili
ENSG00000165506	DNAAF2	100	88.116	ENSNLEG00000011975	DNAAF2	100	87.990	Nomascus_leucogenys
ENSG00000165506	DNAAF2	67	75.291	ENSMEUG00000011224	-	100	75.291	Notamacropus_eugenii
ENSG00000165506	DNAAF2	100	66.272	ENSODEG00000013283	DNAAF2	100	66.942	Octodon_degus
ENSG00000165506	DNAAF2	100	76.157	ENSOGAG00000028257	DNAAF2	100	76.568	Otolemur_garnettii
ENSG00000165506	DNAAF2	88	95.946	ENSOARG00000020603	DNAAF2	100	63.146	Ovis_aries
ENSG00000165506	DNAAF2	100	95.221	ENSPPAG00000042919	DNAAF2	100	95.221	Pan_paniscus
ENSG00000165506	DNAAF2	100	77.024	ENSPPRG00000024751	DNAAF2	100	76.548	Panthera_pardus
ENSG00000165506	DNAAF2	100	98.925	ENSPTRG00000030748	DNAAF2	100	98.925	Pan_troglodytes
ENSG00000165506	DNAAF2	100	93.087	ENSPANG00000000616	DNAAF2	100	93.087	Papio_anubis
ENSG00000165506	DNAAF2	50	47.132	ENSPKIG00000023536	dnaaf2	77	47.132	Paramormyrops_kingsleyae
ENSG00000165506	DNAAF2	51	39.286	ENSPMGG00000014348	-	70	43.516	Periophthalmus_magnuspinnatus
ENSG00000165506	DNAAF2	100	67.062	ENSPEMG00000011084	-	100	66.549	Peromyscus_maniculatus_bairdii
ENSG00000165506	DNAAF2	89	68.169	ENSPCIG00000011887	-	63	70.879	Phascolarctos_cinereus
ENSG00000165506	DNAAF2	100	71.122	ENSPCAG00000001164	DNAAF2	100	71.002	Procavia_capensis
ENSG00000165506	DNAAF2	79	80.032	ENSPCOG00000022293	DNAAF2	100	79.871	Propithecus_coquereli
ENSG00000165506	DNAAF2	100	76.310	ENSPVAG00000013485	DNAAF2	100	76.071	Pteropus_vampyrus
ENSG00000165506	DNAAF2	81	61.760	ENSRNOG00000028155	Dnaaf2	100	60.375	Rattus_norvegicus
ENSG00000165506	DNAAF2	100	92.729	ENSRBIG00000012684	DNAAF2	100	92.610	Rhinopithecus_bieti
ENSG00000165506	DNAAF2	100	91.716	ENSRROG00000031163	DNAAF2	100	91.716	Rhinopithecus_roxellana
ENSG00000165506	DNAAF2	100	89.798	ENSSBOG00000033917	DNAAF2	100	89.561	Saimiri_boliviensis_boliviensis
ENSG00000165506	DNAAF2	100	71.631	ENSSSCG00000005007	DNAAF2	100	71.158	Sus_scrofa
ENSG00000165506	DNAAF2	53	61.412	ENSTBEG00000005387	-	93	62.085	Tupaia_belangeri
ENSG00000165506	DNAAF2	81	87.500	ENSTTRG00000007660	DNAAF2	75	87.500	Tursiops_truncatus
ENSG00000165506	DNAAF2	100	74.350	ENSUAMG00000003534	DNAAF2	100	74.113	Ursus_americanus
ENSG00000165506	DNAAF2	100	73.018	ENSVVUG00000029866	DNAAF2	100	73.286	Vulpes_vulpes
ENSG00000165506	DNAAF2	80	49.861	ENSXETG00000009122	dnaaf2	88	49.861	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	23872636.28041644.29727692.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	19052621.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0060285	cilium-dependent cell motility	21873635.	IBA	Process
GO:0060285	cilium-dependent cell motility	19052621.	IMP	Process
GO:0070286	axonemal dynein complex assembly	21873635.	IBA	Process
GO:0070286	axonemal dynein complex assembly	19052621.	IMP	Process