EuRBPDB

Description

Ensembl ID: ENSG00000165525 (Gene tree)
Gene ID: 9147
Gene Symbol: NEMF
Alias: NY-CO-1|FLJ10051|SDCCAG1
Full Name: nuclear export mediator factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 71,121 bases
Position: chr14:49,782,083-49,853,203
Accession: 10663
RBP type: non-canonical RBP
Summary: This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000556882	NEMF-212	386	-	-	- (aa)	-	-
ENST00000556074	NEMF-209	3047	-	-	- (aa)	-	-
ENST00000557380	NEMF-215	1742	-	-	- (aa)	-	-
ENST00000557193	NEMF-214	737	-	-	- (aa)	-	-
ENST00000556672	NEMF-210	590	-	ENSP00000452174	121 (aa)	-	G3V547
ENST00000556691	NEMF-211	2062	-	-	- (aa)	-	-
ENST00000556925	NEMF-213	3699	-	-	- (aa)	-	-
ENST00000554275	NEMF-204	873	-	-	- (aa)	-	-
ENST00000554162	NEMF-203	492	-	-	- (aa)	-	-
ENST00000554626	NEMF-205	570	-	ENSP00000451740	178 (aa)	-	G3V4D9
ENST00000298310	NEMF-201	6234	XM_017021760	ENSP00000298310	1076 (aa)	XP_016877249	O60524
ENST00000555970	NEMF-208	3029	-	ENSP00000452540	998 (aa)	-	G3V5V3
ENST00000555411	NEMF-206	573	-	-	- (aa)	-	-
ENST00000553696	NEMF-202	552	-	-	- (aa)	-	-
ENST00000555863	NEMF-207	602	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165525	rs74496085	14	49826962	G	Interleukin-9 levels	27989323	[0.18-0.46] SD units decrease	0.3187	EFO_0008192

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165525	NEMF	98	62.810	FBgn0259152	Clbn	68	51.753	Drosophila_melanogaster
ENSG00000165525	NEMF	100	99.174	ENSMUSG00000020982	Nemf	99	99.174	Mus_musculus
ENSG00000165525	NEMF	97	38.655	YPL009C		68	30.194	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	21873635.	IBA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0043023	ribosomal large subunit binding	21873635.	IBA	Function
GO:0051168	nuclear export	16103875.	IMP	Process
GO:0072344	rescue of stalled ribosome	21873635.	IBA	Process
GO:1990112	RQC complex	21873635.	IBA	Component
GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process