EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165630 (Gene tree)
Gene ID: 8559
Gene Symbol: PRPF18
Alias: hPrp18
Full Name: pre-mRNA processing factor 18
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 43,942 bases
Position: chr10:13,586,927-13,630,868
Accession: 17351
RBP type: canonical RBP
Summary: Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000392142	PRP4	PF08799.11	1.8e-13	1	1
ENSP00000367824	PRP4	PF08799.11	2.9e-13	1	1
ENSP00000367835	PRP4	PF08799.11	3.8e-13	1	1
ENSP00000367835	Prp18	PF02840.15	1.8e-62	1	1
ENSP00000392142	Prp18	PF02840.15	1.4e-13	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24486609	Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA.	J Mol Biol	2014 Apr 17	McKay DB	doi: 10.1016/j.jmb.2014.01.006
28919079	Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae.	Cell	2017 Sep 21	Wan R	doi: 10.1016/j.cell.2017.08.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000320054	PRPF18-201	788	-	ENSP00000367824	167 (aa)	-	Q5T9P8
ENST00000378572	PRPF18-202	1717	XM_011519754	ENSP00000367835	342 (aa)	XP_011518056	Q99633
ENST00000417658	PRPF18-203	1062	-	ENSP00000392142	249 (aa)	-	Q5T9P7

Gene Model

Click here to download ENSG00000165630's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165630	Iron	7.1890000E-004	19880490
ENSG00000165630	Platelet Function Tests	1.3994600E-005	-
ENSG00000165630	Alopecia	7E-6	24025145
ENSG00000165630	Cyclophosphamide	7E-6	24025145
ENSG00000165630	Fluorouracil	7E-6	24025145
ENSG00000165630	Epirubicin	7E-6	24025145
ENSG00000165630	Lupus Erythematosus, Systemic	5E-6	24925725
ENSG00000165630	Lupus Nephritis	5E-6	24925725

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165630	rs7089227	10	13625731	G	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU)	24025145	[1.37-2.90]	1.99	GO_1902522\|GO_1902518\|EFO_0005400\|GO_0036275
ENSG00000165630	rs2478118	10	13608032	T	Lupus nephritis in systemic lupus erythematosus	24925725	[1.30-1.99]	1.61	EFO_0002690\|EFO_0005761

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165630's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165630	PRPF18	100	85.673	ENSAPOG00000024177	prpf18	100	85.673	Acanthochromis_polyacanthus
ENSG00000165630	PRPF18	100	99.415	ENSAMEG00000013591	-	100	99.415	Ailuropoda_melanoleuca
ENSG00000165630	PRPF18	100	84.503	ENSACIG00000001186	prpf18	100	84.503	Amphilophus_citrinellus
ENSG00000165630	PRPF18	98	85.672	ENSAOCG00000006572	prpf18	94	83.041	Amphiprion_ocellaris
ENSG00000165630	PRPF18	100	85.965	ENSAPEG00000004564	prpf18	100	85.965	Amphiprion_percula
ENSG00000165630	PRPF18	100	84.503	ENSATEG00000000303	prpf18	100	84.503	Anabas_testudineus
ENSG00000165630	PRPF18	99	91.471	ENSAPLG00000003387	-	99	91.471	Anas_platyrhynchos
ENSG00000165630	PRPF18	100	91.860	ENSACAG00000000818	-	100	91.860	Anolis_carolinensis
ENSG00000165630	PRPF18	100	99.415	ENSANAG00000037445	-	100	99.415	Aotus_nancymaae
ENSG00000165630	PRPF18	100	85.088	ENSACLG00000026296	prpf18	100	85.088	Astatotilapia_calliptera
ENSG00000165630	PRPF18	100	84.286	ENSAMXG00000012848	prpf18	100	84.286	Astyanax_mexicanus
ENSG00000165630	PRPF18	100	99.123	ENSBTAG00000017244	PRPF18	100	99.123	Bos_taurus
ENSG00000165630	PRPF18	98	38.506	WBGene00009320	F32B6.3	97	38.506	Caenorhabditis_elegans
ENSG00000165630	PRPF18	100	99.415	ENSCJAG00000009432	-	100	99.415	Callithrix_jacchus
ENSG00000165630	PRPF18	100	99.415	ENSCAFG00000004735	-	100	99.415	Canis_familiaris
ENSG00000165630	PRPF18	100	99.415	ENSCAFG00020007712	-	100	99.415	Canis_lupus_dingo
ENSG00000165630	PRPF18	100	99.123	ENSCHIG00000000499	-	100	99.123	Capra_hircus
ENSG00000165630	PRPF18	100	99.123	ENSTSYG00000003517	-	100	99.123	Carlito_syrichta
ENSG00000165630	PRPF18	100	100.000	ENSCPOG00000021069	-	100	100.000	Cavia_porcellus
ENSG00000165630	PRPF18	100	99.415	ENSCCAG00000036822	-	100	99.415	Cebus_capucinus
ENSG00000165630	PRPF18	100	88.889	ENSCATG00000016633	-	100	88.889	Cercocebus_atys
ENSG00000165630	PRPF18	100	99.123	ENSCLAG00000011770	-	100	99.123	Chinchilla_lanigera
ENSG00000165630	PRPF18	100	97.436	ENSCSAG00000013109	-	100	97.436	Chlorocebus_sabaeus
ENSG00000165630	PRPF18	100	89.326	ENSCPBG00000003100	-	100	89.888	Chrysemys_picta_bellii
ENSG00000165630	PRPF18	99	54.706	ENSCING00000020481	-	97	54.706	Ciona_intestinalis
ENSG00000165630	PRPF18	99	54.335	ENSCSAVG00000010546	-	99	54.360	Ciona_savignyi
ENSG00000165630	PRPF18	100	99.708	ENSCANG00000034900	-	100	99.708	Colobus_angolensis_palliatus
ENSG00000165630	PRPF18	100	99.415	ENSCGRG00001023665	Prpf18	100	99.415	Cricetulus_griseus_chok1gshd
ENSG00000165630	PRPF18	100	99.415	ENSCGRG00000014690	Prpf18	100	99.415	Cricetulus_griseus_crigri
ENSG00000165630	PRPF18	100	83.041	ENSCSEG00000005536	prpf18	99	83.041	Cynoglossus_semilaevis
ENSG00000165630	PRPF18	100	84.503	ENSCVAG00000012401	prpf18	100	84.503	Cyprinodon_variegatus
ENSG00000165630	PRPF18	100	85.088	ENSDARG00000058306	prpf18	100	85.088	Danio_rerio
ENSG00000165630	PRPF18	100	98.830	ENSDNOG00000035607	-	100	98.830	Dasypus_novemcinctus
ENSG00000165630	PRPF18	100	99.123	ENSDORG00000000858	Prpf18	100	99.123	Dipodomys_ordii
ENSG00000165630	PRPF18	99	51.622	FBgn0027784	Prp18	98	51.327	Drosophila_melanogaster
ENSG00000165630	PRPF18	100	87.719	ENSETEG00000015060	-	100	87.719	Echinops_telfairi
ENSG00000165630	PRPF18	100	66.571	ENSEBUG00000016502	prpf18	99	65.706	Eptatretus_burgeri
ENSG00000165630	PRPF18	100	99.708	ENSEASG00005019373	-	100	99.708	Equus_asinus_asinus
ENSG00000165630	PRPF18	100	99.708	ENSECAG00000006997	PRPF18	100	99.708	Equus_caballus
ENSG00000165630	PRPF18	99	67.273	ENSEEUG00000001171	-	100	62.975	Erinaceus_europaeus
ENSG00000165630	PRPF18	100	82.507	ENSELUG00000022190	prpf18	100	82.507	Esox_lucius
ENSG00000165630	PRPF18	100	99.123	ENSFCAG00000004436	-	100	99.123	Felis_catus
ENSG00000165630	PRPF18	98	91.770	ENSFALG00000001912	-	97	89.231	Ficedula_albicollis
ENSG00000165630	PRPF18	99	64.638	ENSFDAG00000010713	-	97	64.638	Fukomys_damarensis
ENSG00000165630	PRPF18	96	99.375	ENSFDAG00000014026	-	100	99.375	Fukomys_damarensis
ENSG00000165630	PRPF18	80	89.377	ENSFHEG00000020125	prpf18	98	89.513	Fundulus_heteroclitus
ENSG00000165630	PRPF18	99	80.059	ENSGMOG00000012210	prpf18	99	80.059	Gadus_morhua
ENSG00000165630	PRPF18	100	92.398	ENSGALG00000043593	-	100	92.398	Gallus_gallus
ENSG00000165630	PRPF18	100	83.333	ENSGAFG00000006034	prpf18	100	83.333	Gambusia_affinis
ENSG00000165630	PRPF18	100	81.871	ENSGACG00000012232	prpf18	100	81.871	Gasterosteus_aculeatus
ENSG00000165630	PRPF18	100	92.690	ENSGAGG00000016878	-	100	92.690	Gopherus_agassizii
ENSG00000165630	PRPF18	99	98.381	ENSGGOG00000025188	-	96	100.000	Gorilla_gorilla
ENSG00000165630	PRPF18	100	85.088	ENSHBUG00000010264	prpf18	100	85.088	Haplochromis_burtoni
ENSG00000165630	PRPF18	100	99.415	ENSHGLG00000018534	PRPF18	100	99.415	Heterocephalus_glaber_female
ENSG00000165630	PRPF18	96	99.375	ENSHGLG00100012161	-	98	99.688	Heterocephalus_glaber_male
ENSG00000165630	PRPF18	100	84.503	ENSHCOG00000015987	prpf18	100	84.503	Hippocampus_comes
ENSG00000165630	PRPF18	100	81.870	ENSIPUG00000007432	prpf18	100	82.720	Ictalurus_punctatus
ENSG00000165630	PRPF18	100	98.246	ENSSTOG00000008735	-	100	98.246	Ictidomys_tridecemlineatus
ENSG00000165630	PRPF18	100	100.000	ENSJJAG00000024041	-	100	100.000	Jaculus_jaculus
ENSG00000165630	PRPF18	100	72.622	ENSJJAG00000015191	-	100	72.622	Jaculus_jaculus
ENSG00000165630	PRPF18	100	83.333	ENSKMAG00000012124	prpf18	100	83.333	Kryptolebias_marmoratus
ENSG00000165630	PRPF18	99	83.728	ENSLBEG00000028466	prpf18	99	83.728	Labrus_bergylta
ENSG00000165630	PRPF18	100	86.842	ENSLACG00000009885	prpf18	100	86.842	Latimeria_chalumnae
ENSG00000165630	PRPF18	100	90.643	ENSLOCG00000016736	prpf18	100	90.643	Lepisosteus_oculatus
ENSG00000165630	PRPF18	100	100.000	ENSLAFG00000007753	-	100	100.000	Loxodonta_africana
ENSG00000165630	PRPF18	100	100.000	ENSMFAG00000000540	-	100	100.000	Macaca_fascicularis
ENSG00000165630	PRPF18	100	100.000	ENSMMUG00000015071	PRPF18	100	100.000	Macaca_mulatta
ENSG00000165630	PRPF18	100	100.000	ENSMNEG00000024679	-	100	100.000	Macaca_nemestrina
ENSG00000165630	PRPF18	99	97.576	ENSMLEG00000031715	-	100	84.795	Mandrillus_leucophaeus
ENSG00000165630	PRPF18	100	83.626	ENSMAMG00000006610	prpf18	100	83.626	Mastacembelus_armatus
ENSG00000165630	PRPF18	100	85.088	ENSMZEG00005019392	prpf18	100	85.088	Maylandia_zebra
ENSG00000165630	PRPF18	100	92.398	ENSMGAG00000005023	-	100	92.398	Meleagris_gallopavo
ENSG00000165630	PRPF18	100	99.708	ENSMICG00000006572	-	100	99.708	Microcebus_murinus
ENSG00000165630	PRPF18	100	100.000	ENSMOCG00000021468	Prpf18	100	100.000	Microtus_ochrogaster
ENSG00000165630	PRPF18	100	83.333	ENSMMOG00000013012	prpf18	100	83.333	Mola_mola
ENSG00000165630	PRPF18	98	96.708	ENSMODG00000016902	-	92	91.124	Monodelphis_domestica
ENSG00000165630	PRPF18	100	85.673	ENSMODG00000024043	-	100	85.673	Monodelphis_domestica
ENSG00000165630	PRPF18	100	78.286	ENSMALG00000005486	prpf18	100	78.571	Monopterus_albus
ENSG00000165630	PRPF18	100	99.415	MGP_CAROLIEiJ_G0023143	Prpf18	100	100.000	Mus_caroli
ENSG00000165630	PRPF18	100	99.123	ENSMUSG00000039449	Prpf18	100	100.000	Mus_musculus
ENSG00000165630	PRPF18	100	99.708	MGP_PahariEiJ_G0019203	Prpf18	100	100.000	Mus_pahari
ENSG00000165630	PRPF18	100	98.830	MGP_SPRETEiJ_G0024061	Prpf18	100	100.000	Mus_spretus
ENSG00000165630	PRPF18	100	99.123	ENSMPUG00000000938	-	100	99.123	Mustela_putorius_furo
ENSG00000165630	PRPF18	100	99.123	ENSMLUG00000009200	-	100	99.123	Myotis_lucifugus
ENSG00000165630	PRPF18	100	99.415	ENSNGAG00000012500	-	100	99.415	Nannospalax_galili
ENSG00000165630	PRPF18	67	92.174	ENSNGAG00000023550	-	82	92.174	Nannospalax_galili
ENSG00000165630	PRPF18	100	85.088	ENSNBRG00000001778	prpf18	100	85.088	Neolamprologus_brichardi
ENSG00000165630	PRPF18	100	100.000	ENSNLEG00000012186	-	100	100.000	Nomascus_leucogenys
ENSG00000165630	PRPF18	100	65.497	ENSMEUG00000005032	-	100	65.497	Notamacropus_eugenii
ENSG00000165630	PRPF18	99	75.304	ENSOPRG00000002153	-	100	81.509	Ochotona_princeps
ENSG00000165630	PRPF18	100	99.123	ENSODEG00000003770	-	100	99.123	Octodon_degus
ENSG00000165630	PRPF18	98	84.478	ENSONIG00000014854	prpf18	96	84.478	Oreochromis_niloticus
ENSG00000165630	PRPF18	100	94.737	ENSOANG00000015404	-	100	94.737	Ornithorhynchus_anatinus
ENSG00000165630	PRPF18	100	99.708	ENSOCUG00000027756	-	100	95.614	Oryctolagus_cuniculus
ENSG00000165630	PRPF18	100	82.286	ENSORLG00000010293	prpf18	100	82.286	Oryzias_latipes
ENSG00000165630	PRPF18	100	84.503	ENSORLG00020001530	prpf18	100	84.503	Oryzias_latipes_hni
ENSG00000165630	PRPF18	100	84.211	ENSORLG00015013705	prpf18	100	84.211	Oryzias_latipes_hsok
ENSG00000165630	PRPF18	100	85.673	ENSOMEG00000009167	prpf18	100	85.673	Oryzias_melastigma
ENSG00000165630	PRPF18	100	98.830	ENSOGAG00000007294	-	100	98.830	Otolemur_garnettii
ENSG00000165630	PRPF18	100	96.581	ENSOARG00000006243	-	100	96.581	Ovis_aries
ENSG00000165630	PRPF18	100	100.000	ENSPPAG00000041959	-	100	100.000	Pan_paniscus
ENSG00000165630	PRPF18	100	99.123	ENSPPRG00000000107	-	100	99.123	Panthera_pardus
ENSG00000165630	PRPF18	100	98.830	ENSPTIG00000021094	-	100	98.830	Panthera_tigris_altaica
ENSG00000165630	PRPF18	100	100.000	ENSPTRG00000002306	PRPF18	100	100.000	Pan_troglodytes
ENSG00000165630	PRPF18	100	99.708	ENSPANG00000023346	-	100	99.708	Papio_anubis
ENSG00000165630	PRPF18	86	98.113	ENSPKIG00000014128	prpf18	96	82.336	Paramormyrops_kingsleyae
ENSG00000165630	PRPF18	100	92.982	ENSPSIG00000016064	-	100	92.982	Pelodiscus_sinensis
ENSG00000165630	PRPF18	100	78.655	ENSPMGG00000016486	prpf18	100	78.655	Periophthalmus_magnuspinnatus
ENSG00000165630	PRPF18	100	99.708	ENSPEMG00000013704	Prpf18	100	99.708	Peromyscus_maniculatus_bairdii
ENSG00000165630	PRPF18	100	74.277	ENSPMAG00000000204	prpf18	100	74.277	Petromyzon_marinus
ENSG00000165630	PRPF18	98	97.531	ENSPCIG00000012963	-	99	96.835	Phascolarctos_cinereus
ENSG00000165630	PRPF18	100	82.000	ENSPFOG00000017611	prpf18	100	82.000	Poecilia_formosa
ENSG00000165630	PRPF18	100	83.626	ENSPLAG00000000369	prpf18	100	83.626	Poecilia_latipinna
ENSG00000165630	PRPF18	100	83.626	ENSPMEG00000005183	prpf18	100	83.626	Poecilia_mexicana
ENSG00000165630	PRPF18	100	83.041	ENSPREG00000015232	prpf18	100	83.041	Poecilia_reticulata
ENSG00000165630	PRPF18	100	99.708	ENSPPYG00000002101	PRPF18	100	99.708	Pongo_abelii
ENSG00000165630	PRPF18	99	96.364	ENSPCAG00000010833	-	100	80.994	Procavia_capensis
ENSG00000165630	PRPF18	100	92.398	ENSPCOG00000013057	-	100	92.398	Propithecus_coquereli
ENSG00000165630	PRPF18	100	61.404	ENSPVAG00000002947	-	100	61.404	Pteropus_vampyrus
ENSG00000165630	PRPF18	100	85.088	ENSPNYG00000003554	prpf18	100	85.088	Pundamilia_nyererei
ENSG00000165630	PRPF18	100	85.470	ENSPNAG00000023151	prpf18	100	85.470	Pygocentrus_nattereri
ENSG00000165630	PRPF18	100	98.830	ENSRNOG00000018396	Prpf18	100	98.830	Rattus_norvegicus
ENSG00000165630	PRPF18	100	99.415	ENSRBIG00000028028	-	100	99.415	Rhinopithecus_bieti
ENSG00000165630	PRPF18	100	99.708	ENSRROG00000040695	-	100	99.708	Rhinopithecus_roxellana
ENSG00000165630	PRPF18	100	99.415	ENSSBOG00000034482	-	100	99.415	Saimiri_boliviensis_boliviensis
ENSG00000165630	PRPF18	100	96.784	ENSSHAG00000016463	-	100	96.784	Sarcophilus_harrisii
ENSG00000165630	PRPF18	100	77.485	ENSSHAG00000009669	-	100	77.485	Sarcophilus_harrisii
ENSG00000165630	PRPF18	77	44.528	ENSSFOG00015021154	-	89	48.927	Scleropages_formosus
ENSG00000165630	PRPF18	98	81.449	ENSSFOG00015022118	prpf18	100	76.945	Scleropages_formosus
ENSG00000165630	PRPF18	100	83.333	ENSSMAG00000005308	prpf18	100	83.333	Scophthalmus_maximus
ENSG00000165630	PRPF18	100	85.380	ENSSDUG00000015428	prpf18	100	85.380	Seriola_dumerili
ENSG00000165630	PRPF18	100	85.380	ENSSLDG00000023989	prpf18	100	85.380	Seriola_lalandi_dorsalis
ENSG00000165630	PRPF18	99	73.279	ENSSARG00000005307	-	100	69.006	Sorex_araneus
ENSG00000165630	PRPF18	100	92.690	ENSSPUG00000002619	-	100	92.690	Sphenodon_punctatus
ENSG00000165630	PRPF18	100	84.795	ENSSPAG00000019502	prpf18	100	84.795	Stegastes_partitus
ENSG00000165630	PRPF18	100	99.415	ENSSSCG00000026354	-	100	99.415	Sus_scrofa
ENSG00000165630	PRPF18	100	92.398	ENSTGUG00000002286	-	100	92.398	Taeniopygia_guttata
ENSG00000165630	PRPF18	100	82.456	ENSTRUG00000011278	prpf18	100	82.456	Takifugu_rubripes
ENSG00000165630	PRPF18	100	82.164	ENSTNIG00000000911	prpf18	100	82.164	Tetraodon_nigroviridis
ENSG00000165630	PRPF18	79	100.000	ENSTBEG00000013011	-	79	100.000	Tupaia_belangeri
ENSG00000165630	PRPF18	100	99.708	ENSTTRG00000011117	PRPF18	100	99.708	Tursiops_truncatus
ENSG00000165630	PRPF18	95	96.308	ENSUAMG00000001815	-	94	96.308	Ursus_americanus
ENSG00000165630	PRPF18	99	96.364	ENSUMAG00000012329	-	100	94.444	Ursus_maritimus
ENSG00000165630	PRPF18	99	95.758	ENSVPAG00000011486	-	100	93.860	Vicugna_pacos
ENSG00000165630	PRPF18	100	99.415	ENSVVUG00000005453	-	100	99.415	Vulpes_vulpes
ENSG00000165630	PRPF18	100	80.580	ENSXETG00000024057	prpf18	100	80.580	Xenopus_tropicalis
ENSG00000165630	PRPF18	100	82.849	ENSXCOG00000020414	prpf18	100	82.849	Xiphophorus_couchianus
ENSG00000165630	PRPF18	100	83.333	ENSXMAG00000004713	prpf18	91	83.333	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000350	generation of catalytic spliceosome for second transesterification step	21873635.	IBA	Process
GO:0000386	second spliceosomal transesterification activity	21873635.	IBA	Function
GO:0005634	nucleus	9000057.	TAS	Component
GO:0005681	spliceosomal complex	9000057.	TAS	Component
GO:0005682	U5 snRNP	21873635.	IBA	Component
GO:0006397	mRNA processing	9000057.	TAS	Process
GO:0008380	RNA splicing	9000057.	TAS	Process
GO:0016607	nuclear speck	-	IEA	Component
GO:0046540	U4/U6 x U5 tri-snRNP complex	21873635.	IBA	Component
GO:0071021	U2-type post-spliceosomal complex	21873635.	IBA	Component
GO:0071048	nuclear retention of unspliced pre-mRNA at the site of transcription	21873635.	IBA	Process