EuRBPDB

Description

Ensembl ID: ENSG00000165637 (Gene tree)
Gene ID: 7417
Gene Symbol: VDAC2
Alias: N
Full Name: voltage dependent anion channel 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 21,295 bases
Position: chr10:75,210,154-75,231,448
Accession: 12672
RBP type: non-canonical RBP
Summary: This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000468285	VDAC2-208	850	-	-	- (aa)	-	-
ENST00000460044	VDAC2-207	770	-	-	- (aa)	-	-
ENST00000332211	VDAC2-203	1557	-	ENSP00000361686	294 (aa)	-	P45880
ENST00000543351	VDAC2-214	1424	-	ENSP00000443092	294 (aa)	-	P45880
ENST00000498394	VDAC2-213	804	-	-	- (aa)	-	-
ENST00000313132	VDAC2-202	1467	-	ENSP00000361635	309 (aa)	-	P45880
ENST00000481876	VDAC2-212	822	-	-	- (aa)	-	-
ENST00000472137	VDAC2-210	859	-	-	- (aa)	-	-
ENST00000298468	VDAC2-201	931	-	ENSP00000298468	282 (aa)	-	A0A0A0MR02
ENST00000475142	VDAC2-211	819	-	-	- (aa)	-	-
ENST00000447677	VDAC2-206	738	-	ENSP00000401492	204 (aa)	-	Q5JSD1
ENST00000413289	VDAC2-205	457	-	ENSP00000389551	109 (aa)	-	A2A3S1
ENST00000344036	VDAC2-204	681	-	ENSP00000344876	194 (aa)	-	Q5JSD2
ENST00000470745	VDAC2-209	661	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04020	Calcium signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04216	Ferroptosis	KEGG
hsa04217	Necroptosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa04979	Cholesterol metabolism	KEGG
hsa05012	Parkinson disease	KEGG
hsa05016	Huntington disease	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165637	VDAC2	93	43.750	WBGene00019900	vdac-1	98	41.281	Caenorhabditis_elegans
ENSG00000165637	VDAC2	96	74.908	ENSG00000213585	VDAC1	100	74.558	Homo_sapiens
ENSG00000165637	VDAC2	98	97.091	ENSMUSG00000021771	Vdac2	100	97.173	Mus_musculus
ENSG00000165637	VDAC2	96	74.539	ENSMUSG00000020402	Vdac1	100	74.205	Mus_musculus
ENSG00000165637	VDAC2	96	73.852	ENSMUSG00000008892	Vdac3	100	73.852	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	-	IEA	Function
GO:0001669	acrosomal vesicle	23355646.	IDA	Component
GO:0005515	protein binding	15082785.23355646.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005741	mitochondrial outer membrane	21873635.	IBA	Component
GO:0006820	anion transport	8420959.	IDA	Process
GO:0007339	binding of sperm to zona pellucida	23355646.	IMP	Process
GO:0008021	synaptic vesicle	-	IEA	Component
GO:0008308	voltage-gated anion channel activity	21873635.	IBA	Function
GO:0008308	voltage-gated anion channel activity	8420959.	IDA	Function
GO:0015288	porin activity	-	IEA	Function
GO:0015698	inorganic anion transport	-	IEA	Process
GO:0032272	negative regulation of protein polymerization	-	IEA	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0046930	pore complex	-	IEA	Component
GO:0098656	anion transmembrane transport	-	IEA	Process
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	-	IEA	Process