EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165819 (Gene tree)
Gene ID: 56339
Gene Symbol: METTL3
Alias: Spo8|M6A|MT-A70
Full Name: methyltransferase like 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,245 bases
Position: chr14:21,498,131-21,511,375
Accession: 17563
RBP type: canonical RBP
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000298717	MT-A70	PF05063.14	5.7e-60	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31131257	YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma.	Front Oncol	2019 May 3	Bai Y	doi: 10.3389/fonc.2019.00332
28334903	N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.	Nucleic Acids Res	2017 Jun 2	Liu N	doi: 10.1093/nar/gkx141.
29970596	The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1.	RNA	2018 Oct	Kretschmer J	doi: 10.1261/rna.064238.117
31328227	The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.	Nucleic Acids Res	2019 Jul 22	van Tran N	doi: 10.1093/nar/gkz619
25412662	FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.	Cell Res	2014 Dec	Zhao X	doi: 10.1038/cr.2014.151
24407421	Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.	Cell Res	2014 Feb	Ping XL	doi: 10.1038/cr.2014.3
27627798	Structural insights into the molecular mechanism of the m(6)A writer complex.	Elife	2016 Sep 14	Sledz P	doi: 10.7554/eLife.18434.
27281194	Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.	Nature	2016 Jun 23	Wang X	doi: 10.1038/nature18298
29140688	RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome.	J Am Chem Soc	2017 Dec 6	Arguello AE	doi: 10.1021/jacs.7b09213
30107516	Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.	Hum Mol Genet	2018 Nov 15	Zhang F	doi: 10.1093/hmg/ddy292.
30591559	RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation.	Proc Natl Acad Sci U S A	2019 Jan 15	Zhang Y	doi: 10.1073/pnas.1812536116
30865855	METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1/STAT5/C/EBPβ pathway via an m6A-YTHDF2-dependent manner.	FASEB J	2019 Jun	Yao Y	doi: 10.1096/fj.201802644R
30870073	METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.	Autophagy	2019 Aug	Song H	doi: 10.1080/15548627.2019.1586246
31106001	Epitranscriptomic m6A modification in the stem cell field and its effects on cell death and survival.	Am J Cancer Res	2019 Apr 1	Chen J	-
31107151	N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction.	RNA Biol	2019 Aug	Chen J	doi: 10.1080/15476286.2019.1620060
30894375	The Critical Role of RNA m6A Methylation in Cancer.	Cancer Res	2019 Apr 1	Lan Q	doi: 10.1158/0008-5472.CAN-18-2965
30276938	N6 -Methyladenosine-Sensitive RNA-Cleaving Deoxyribozymes.	Angew Chem Int Ed Engl	2018 Nov 12	Sednev MV	doi: 10.1002/anie.201808745
11470232	Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells.	Int J Biochem Cell Biol	2001 Oct	Leach RA	-
25242552	Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.	Nat Chem Biol	2014 Nov	Xu C	doi: 10.1038/nchembio.1654
27072590	Increased N6-methyladenosine in Human Sperm RNA as a Risk Factor for Asthenozoospermia.	Sci Rep	2016 Apr 13	Yang Y	doi: 10.1038/srep24345.
27179969	N (6)-Methyladenosine (m(6)A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification.	Mol Biotechnol	2016 Jul	Wu R	doi: 10.1007/s12033-016-9947-9.
29348140	Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex.	RNA	2018 Apr	Scholler E	doi: 10.1261/rna.064063.117
29716990	The m6A Reader ECT2 Controls Trichome Morphology by Affecting mRNA Stability in Arabidopsis.	Plant Cell	2018 May	Wei LH	doi: 10.1105/tpc.17.00934
29783144	Analogous modified DNA probe and immune competition method-based electrochemical biosensor for RNA modification.	Biosens Bioelectron	2018 Aug 30	Dai T	doi: 10.1016/j.bios.2018.05.018
30364964	N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.	Nucleic Acids Res	2019 Jan 10	Hao H	doi: 10.1093/nar/gky1007.
31080453	A Review in Research Progress Concerning m6A Methylation and Immunoregulation.	Front Immunol	2019 Apr 26	Zhang C	doi: 10.3389/fimmu.2019.00922
31149892	The dynamics of FTO binding and demethylation from the m6A motifs.	RNA Biol	2019 May 31:1-11	Li Y	doi: 10.1080/15476286.2019.1621120

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000538267	METTL3-207	1553	-	-	- (aa)	-	-
ENST00000542054	METTL3-209	975	-	-	- (aa)	-	-
ENST00000539760	METTL3-208	1462	-	ENSP00000440598	336 (aa)	-	H0YFV6
ENST00000396522	METTL3-204	2523	-	-	- (aa)	-	-
ENST00000544248	METTL3-211	1570	-	ENSP00000437692	245 (aa)	-	F5H6D8
ENST00000536201	METTL3-205	1592	-	-	- (aa)	-	-
ENST00000545788	METTL3-214	545	-	-	- (aa)	-	-
ENST00000537163	METTL3-206	2030	-	ENSP00000442407	153 (aa)	-	B4E349
ENST00000543235	METTL3-210	2124	-	ENSP00000445523	258 (aa)	-	B4DTN4
ENST00000377543	METTL3-203	563	-	ENSP00000366766	9 (aa)	-	A0A0G2JH39
ENST00000298717	METTL3-201	2015	XM_006720206	ENSP00000298717	580 (aa)	XP_006720269	Q86U44
ENST00000544500	METTL3-212	1789	-	-	- (aa)	-	-
ENST00000545319	METTL3-213	563	-	-	- (aa)	-	-
ENST00000367606	METTL3-202	802	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000165819's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165819	Uric Acid	3.7073475692404E-5	17903292
ENSG00000165819	Uric Acid	1.19773350512812E-5	17903292
ENSG00000165819	homoharringtonine	9E-7	25628645
ENSG00000165819	Cell Survival	9E-7	25628645

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165819's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165819	METTL3	100	69.388	ENSAPOG00000013527	mettl3	99	69.795	Acanthochromis_polyacanthus
ENSG00000165819	METTL3	100	98.103	ENSAMEG00000006229	METTL3	100	98.103	Ailuropoda_melanoleuca
ENSG00000165819	METTL3	100	69.205	ENSACIG00000019871	mettl3	99	69.205	Amphilophus_citrinellus
ENSG00000165819	METTL3	51	74.161	ENSAOCG00000011395	METTL3	97	74.161	Amphiprion_ocellaris
ENSG00000165819	METTL3	58	53.693	ENSAPEG00000014349	-	70	53.693	Amphiprion_percula
ENSG00000165819	METTL3	100	69.610	ENSAPEG00000006642	mettl3	99	69.779	Amphiprion_percula
ENSG00000165819	METTL3	100	66.722	ENSATEG00000001187	mettl3	99	66.557	Anabas_testudineus
ENSG00000165819	METTL3	100	85.345	ENSACAG00000002851	METTL3	100	86.034	Anolis_carolinensis
ENSG00000165819	METTL3	100	99.483	ENSANAG00000031748	METTL3	100	99.483	Aotus_nancymaae
ENSG00000165819	METTL3	100	67.599	ENSACLG00000009682	mettl3	99	67.763	Astatotilapia_calliptera
ENSG00000165819	METTL3	100	67.270	ENSAMXG00000012824	mettl3	100	67.270	Astyanax_mexicanus
ENSG00000165819	METTL3	100	97.931	ENSBTAG00000015148	METTL3	100	97.931	Bos_taurus
ENSG00000165819	METTL3	100	99.483	ENSCJAG00000008893	METTL3	100	99.483	Callithrix_jacchus
ENSG00000165819	METTL3	100	98.448	ENSCAFG00000005657	METTL3	100	98.448	Canis_familiaris
ENSG00000165819	METTL3	100	98.448	ENSCAFG00020015265	METTL3	100	98.448	Canis_lupus_dingo
ENSG00000165819	METTL3	100	97.586	ENSCHIG00000016723	METTL3	100	97.586	Capra_hircus
ENSG00000165819	METTL3	96	97.508	ENSTSYG00000012483	METTL3	100	98.535	Carlito_syrichta
ENSG00000165819	METTL3	96	95.950	ENSCAPG00000012990	METTL3	95	89.266	Cavia_aperea
ENSG00000165819	METTL3	99	95.062	ENSCPOG00000002545	METTL3	100	93.103	Cavia_porcellus
ENSG00000165819	METTL3	100	99.310	ENSCCAG00000034042	METTL3	100	99.310	Cebus_capucinus
ENSG00000165819	METTL3	100	99.655	ENSCATG00000034766	METTL3	100	99.655	Cercocebus_atys
ENSG00000165819	METTL3	100	96.552	ENSCLAG00000001316	METTL3	100	96.552	Chinchilla_lanigera
ENSG00000165819	METTL3	100	99.483	ENSCSAG00000016468	METTL3	100	99.483	Chlorocebus_sabaeus
ENSG00000165819	METTL3	96	90.031	ENSCHOG00000000717	METTL3	100	93.517	Choloepus_hoffmanni
ENSG00000165819	METTL3	100	86.770	ENSCPBG00000012694	METTL3	100	86.770	Chrysemys_picta_bellii
ENSG00000165819	METTL3	99	50.000	ENSCSAVG00000000919	-	98	50.000	Ciona_savignyi
ENSG00000165819	METTL3	100	99.483	ENSCANG00000039497	METTL3	100	99.483	Colobus_angolensis_palliatus
ENSG00000165819	METTL3	100	97.241	ENSCGRG00001022645	Mettl3	100	97.241	Cricetulus_griseus_chok1gshd
ENSG00000165819	METTL3	100	97.241	ENSCGRG00000009628	Mettl3	100	97.241	Cricetulus_griseus_crigri
ENSG00000165819	METTL3	100	66.890	ENSCSEG00000004439	mettl3	99	67.057	Cynoglossus_semilaevis
ENSG00000165819	METTL3	99	65.837	ENSCVAG00000007436	mettl3	99	66.555	Cyprinodon_variegatus
ENSG00000165819	METTL3	100	68.519	ENSDARG00000012827	mettl3	100	68.519	Danio_rerio
ENSG00000165819	METTL3	100	96.564	ENSDNOG00000045389	METTL3	100	96.564	Dasypus_novemcinctus
ENSG00000165819	METTL3	99	94.239	ENSDORG00000002212	Mettl3	100	91.897	Dipodomys_ordii
ENSG00000165819	METTL3	99	43.925	FBgn0039139	Ime4	98	43.925	Drosophila_melanogaster
ENSG00000165819	METTL3	100	96.897	ENSETEG00000012361	METTL3	100	96.897	Echinops_telfairi
ENSG00000165819	METTL3	95	65.826	ENSEBUG00000012428	mettl3	100	65.826	Eptatretus_burgeri
ENSG00000165819	METTL3	100	98.448	ENSEASG00005011501	METTL3	100	98.448	Equus_asinus_asinus
ENSG00000165819	METTL3	100	98.448	ENSECAG00000013168	METTL3	100	98.448	Equus_caballus
ENSG00000165819	METTL3	100	96.552	ENSEEUG00000007352	METTL3	100	96.552	Erinaceus_europaeus
ENSG00000165819	METTL3	100	66.225	ENSELUG00000024439	mettl3	100	66.013	Esox_lucius
ENSG00000165819	METTL3	98	98.415	ENSFCAG00000013861	METTL3	99	98.415	Felis_catus
ENSG00000165819	METTL3	100	98.448	ENSFDAG00000012057	METTL3	100	98.448	Fukomys_damarensis
ENSG00000165819	METTL3	99	64.532	ENSFHEG00000017186	mettl3	99	65.662	Fundulus_heteroclitus
ENSG00000165819	METTL3	85	85.757	ENSGMOG00000013509	mettl3	83	85.757	Gadus_morhua
ENSG00000165819	METTL3	100	79.483	ENSGALG00000044213	METTL3	100	79.483	Gallus_gallus
ENSG00000165819	METTL3	99	66.385	ENSGAFG00000003802	mettl3	99	66.892	Gambusia_affinis
ENSG00000165819	METTL3	99	68.675	ENSGACG00000019244	mettl3	100	68.675	Gasterosteus_aculeatus
ENSG00000165819	METTL3	100	86.770	ENSGAGG00000023046	METTL3	100	86.770	Gopherus_agassizii
ENSG00000165819	METTL3	100	100.000	ENSGGOG00000005954	METTL3	100	100.000	Gorilla_gorilla
ENSG00000165819	METTL3	90	65.047	ENSHBUG00000019774	mettl3	97	63.934	Haplochromis_burtoni
ENSG00000165819	METTL3	100	98.448	ENSHGLG00000005321	METTL3	100	98.448	Heterocephalus_glaber_female
ENSG00000165819	METTL3	100	98.448	ENSHGLG00100000891	METTL3	100	98.448	Heterocephalus_glaber_male
ENSG00000165819	METTL3	100	64.580	ENSHCOG00000002864	mettl3	100	65.074	Hippocampus_comes
ENSG00000165819	METTL3	100	68.591	ENSIPUG00000000514	METTL3	100	68.143	Ictalurus_punctatus
ENSG00000165819	METTL3	100	97.414	ENSSTOG00000001902	METTL3	100	97.414	Ictidomys_tridecemlineatus
ENSG00000165819	METTL3	98	80.083	ENSJJAG00000021033	-	100	82.243	Jaculus_jaculus
ENSG00000165819	METTL3	100	97.586	ENSJJAG00000019752	-	100	97.586	Jaculus_jaculus
ENSG00000165819	METTL3	99	65.625	ENSKMAG00000019586	mettl3	100	65.296	Kryptolebias_marmoratus
ENSG00000165819	METTL3	100	68.377	ENSLBEG00000020954	mettl3	99	68.543	Labrus_bergylta
ENSG00000165819	METTL3	100	76.441	ENSLACG00000014108	METTL3	100	77.458	Latimeria_chalumnae
ENSG00000165819	METTL3	100	98.448	ENSLAFG00000014139	METTL3	100	98.448	Loxodonta_africana
ENSG00000165819	METTL3	100	99.655	ENSMFAG00000043302	METTL3	100	99.655	Macaca_fascicularis
ENSG00000165819	METTL3	100	99.655	ENSMNEG00000040458	METTL3	100	99.655	Macaca_nemestrina
ENSG00000165819	METTL3	100	99.483	ENSMLEG00000020583	METTL3	100	99.483	Mandrillus_leucophaeus
ENSG00000165819	METTL3	100	69.322	ENSMAMG00000015933	mettl3	99	69.322	Mastacembelus_armatus
ENSG00000165819	METTL3	100	64.967	ENSMZEG00005021232	mettl3	99	65.132	Maylandia_zebra
ENSG00000165819	METTL3	100	97.069	ENSMAUG00000014244	Mettl3	100	97.069	Mesocricetus_auratus
ENSG00000165819	METTL3	100	98.966	ENSMICG00000015037	METTL3	100	98.966	Microcebus_murinus
ENSG00000165819	METTL3	100	97.069	ENSMOCG00000005884	Mettl3	100	97.069	Microtus_ochrogaster
ENSG00000165819	METTL3	100	66.169	ENSMMOG00000012720	mettl3	99	66.998	Mola_mola
ENSG00000165819	METTL3	98	94.894	ENSMODG00000006085	METTL3	93	94.894	Monodelphis_domestica
ENSG00000165819	METTL3	100	67.925	ENSMALG00000001088	mettl3	99	68.205	Monopterus_albus
ENSG00000165819	METTL3	100	97.241	MGP_CAROLIEiJ_G0019240	Mettl3	100	97.241	Mus_caroli
ENSG00000165819	METTL3	100	97.069	ENSMUSG00000022160	Mettl3	100	97.069	Mus_musculus
ENSG00000165819	METTL3	100	97.069	MGP_PahariEiJ_G0030261	Mettl3	100	97.069	Mus_pahari
ENSG00000165819	METTL3	100	96.897	MGP_SPRETEiJ_G0020132	Mettl3	100	96.897	Mus_spretus
ENSG00000165819	METTL3	98	96.842	ENSMPUG00000018464	-	100	96.842	Mustela_putorius_furo
ENSG00000165819	METTL3	100	97.766	ENSMPUG00000000184	-	100	97.766	Mustela_putorius_furo
ENSG00000165819	METTL3	100	96.897	ENSMLUG00000001919	METTL3	100	96.897	Myotis_lucifugus
ENSG00000165819	METTL3	100	97.586	ENSNGAG00000000872	Mettl3	100	97.586	Nannospalax_galili
ENSG00000165819	METTL3	100	67.210	ENSNBRG00000023965	mettl3	99	67.374	Neolamprologus_brichardi
ENSG00000165819	METTL3	100	100.000	ENSNLEG00000014569	METTL3	100	100.000	Nomascus_leucogenys
ENSG00000165819	METTL3	99	79.620	ENSMEUG00000010520	METTL3	99	79.620	Notamacropus_eugenii
ENSG00000165819	METTL3	99	93.416	ENSOPRG00000016187	METTL3	100	90.878	Ochotona_princeps
ENSG00000165819	METTL3	100	97.241	ENSODEG00000001417	METTL3	100	97.241	Octodon_degus
ENSG00000165819	METTL3	100	67.928	ENSONIG00000009328	mettl3	99	68.092	Oreochromis_niloticus
ENSG00000165819	METTL3	100	97.586	ENSOCUG00000000336	METTL3	100	97.586	Oryctolagus_cuniculus
ENSG00000165819	METTL3	99	67.276	ENSORLG00000007194	mettl3	100	67.774	Oryzias_latipes
ENSG00000165819	METTL3	99	67.769	ENSORLG00020008219	mettl3	100	67.774	Oryzias_latipes_hni
ENSG00000165819	METTL3	99	67.442	ENSORLG00015005062	mettl3	100	67.442	Oryzias_latipes_hsok
ENSG00000165819	METTL3	51	83.959	ENSOMEG00000007542	-	100	83.959	Oryzias_melastigma
ENSG00000165819	METTL3	99	66.060	ENSOMEG00000013883	mettl3	96	66.060	Oryzias_melastigma
ENSG00000165819	METTL3	100	98.103	ENSOGAG00000002730	METTL3	100	98.103	Otolemur_garnettii
ENSG00000165819	METTL3	100	97.414	ENSOARG00000019618	METTL3	100	97.414	Ovis_aries
ENSG00000165819	METTL3	100	99.828	ENSPPAG00000039056	METTL3	100	99.828	Pan_paniscus
ENSG00000165819	METTL3	100	97.759	ENSPPRG00000005752	METTL3	100	97.759	Panthera_pardus
ENSG00000165819	METTL3	100	98.276	ENSPTIG00000020811	METTL3	100	98.276	Panthera_tigris_altaica
ENSG00000165819	METTL3	100	100.000	ENSPTRG00000006127	METTL3	100	100.000	Pan_troglodytes
ENSG00000165819	METTL3	100	99.655	ENSPANG00000021788	METTL3	100	99.655	Papio_anubis
ENSG00000165819	METTL3	100	68.771	ENSPKIG00000012961	mettl3	100	69.454	Paramormyrops_kingsleyae
ENSG00000165819	METTL3	94	79.781	ENSPSIG00000006018	METTL3	100	79.781	Pelodiscus_sinensis
ENSG00000165819	METTL3	100	65.074	ENSPMGG00000018703	mettl3	99	65.568	Periophthalmus_magnuspinnatus
ENSG00000165819	METTL3	100	97.414	ENSPEMG00000005043	Mettl3	100	97.414	Peromyscus_maniculatus_bairdii
ENSG00000165819	METTL3	99	64.179	ENSPMAG00000007910	mettl3	99	64.959	Petromyzon_marinus
ENSG00000165819	METTL3	100	94.483	ENSPCIG00000021953	METTL3	100	94.483	Phascolarctos_cinereus
ENSG00000165819	METTL3	99	65.615	ENSPFOG00000012920	mettl3	99	67.230	Poecilia_formosa
ENSG00000165819	METTL3	99	65.615	ENSPLAG00000002616	mettl3	99	67.230	Poecilia_latipinna
ENSG00000165819	METTL3	99	68.151	ENSPMEG00000016475	mettl3	99	68.836	Poecilia_mexicana
ENSG00000165819	METTL3	100	99.828	ENSPPYG00000005599	METTL3	100	99.828	Pongo_abelii
ENSG00000165819	METTL3	100	98.448	ENSPCOG00000024390	METTL3	100	98.448	Propithecus_coquereli
ENSG00000165819	METTL3	100	98.103	ENSPVAG00000000276	METTL3	100	98.103	Pteropus_vampyrus
ENSG00000165819	METTL3	100	67.599	ENSPNYG00000021511	mettl3	99	67.763	Pundamilia_nyererei
ENSG00000165819	METTL3	100	65.615	ENSPNAG00000025734	mettl3	100	65.506	Pygocentrus_nattereri
ENSG00000165819	METTL3	100	96.724	ENSRNOG00000013111	Mettl3	100	96.724	Rattus_norvegicus
ENSG00000165819	METTL3	100	99.483	ENSRBIG00000031923	METTL3	100	99.483	Rhinopithecus_bieti
ENSG00000165819	METTL3	100	99.483	ENSRROG00000029791	METTL3	100	99.483	Rhinopithecus_roxellana
ENSG00000165819	METTL3	100	99.655	ENSSBOG00000030649	METTL3	100	99.655	Saimiri_boliviensis_boliviensis
ENSG00000165819	METTL3	98	94.542	ENSSHAG00000008993	METTL3	93	94.542	Sarcophilus_harrisii
ENSG00000165819	METTL3	100	68.825	ENSSFOG00015022199	mettl3	100	68.484	Scleropages_formosus
ENSG00000165819	METTL3	100	67.053	ENSSMAG00000006289	mettl3	99	67.053	Scophthalmus_maximus
ENSG00000165819	METTL3	100	66.941	ENSSDUG00000006091	mettl3	99	67.270	Seriola_dumerili
ENSG00000165819	METTL3	100	67.105	ENSSLDG00000003215	mettl3	99	67.270	Seriola_lalandi_dorsalis
ENSG00000165819	METTL3	100	96.724	ENSSARG00000005036	METTL3	100	96.724	Sorex_araneus
ENSG00000165819	METTL3	100	68.359	ENSSPAG00000013519	mettl3	99	68.359	Stegastes_partitus
ENSG00000165819	METTL3	100	98.276	ENSSSCG00000024445	METTL3	100	98.276	Sus_scrofa
ENSG00000165819	METTL3	99	66.945	ENSTRUG00000015365	mettl3	100	67.780	Takifugu_rubripes
ENSG00000165819	METTL3	99	68.966	ENSTNIG00000013005	mettl3	100	69.072	Tetraodon_nigroviridis
ENSG00000165819	METTL3	99	95.062	ENSTBEG00000013992	METTL3	100	87.759	Tupaia_belangeri
ENSG00000165819	METTL3	100	98.276	ENSTTRG00000015286	METTL3	100	98.276	Tursiops_truncatus
ENSG00000165819	METTL3	100	98.448	ENSUAMG00000028083	METTL3	100	98.448	Ursus_americanus
ENSG00000165819	METTL3	100	98.448	ENSUMAG00000004959	METTL3	100	98.448	Ursus_maritimus
ENSG00000165819	METTL3	99	88.889	ENSVPAG00000007362	METTL3	100	90.496	Vicugna_pacos
ENSG00000165819	METTL3	100	98.448	ENSVVUG00000009513	METTL3	100	98.448	Vulpes_vulpes
ENSG00000165819	METTL3	100	77.474	ENSXETG00000017182	mettl3	100	77.645	Xenopus_tropicalis
ENSG00000165819	METTL3	99	65.615	ENSXMAG00000023653	mettl3	99	66.113	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	25719671.26321680.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	-	ISS	Process
GO:0001510	RNA methylation	21873635.	IBA	Process
GO:0001510	RNA methylation	9409616.	IMP	Process
GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	24316715.27281194.27373337.27627798.	IDA	Function
GO:0001734	mRNA (N6-adenosine)-methyltransferase activity	9409616.22575960.24284625.28297716.	IMP	Function
GO:0003729	mRNA binding	27281194.27373337.	IDA	Function
GO:0005515	protein binding	24316715.24394384.26496610.27373337.29507755.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9409616.24316715.26458103.29348140.29506078.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006382	adenosine to inosine editing	-	ISS	Process
GO:0006397	mRNA processing	-	ISS	Process
GO:0006402	mRNA catabolic process	-	ISS	Process
GO:0006974	cellular response to DNA damage stimulus	28297716.	IDA	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0007623	circadian rhythm	-	ISS	Process
GO:0008173	RNA methyltransferase activity	25799998.27602518.29348140.29506078.	IDA	Function
GO:0009048	dosage compensation by inactivation of X chromosome	27602518.	IDA	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	-	IEA	Function
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	24407421.	IDA	Component
GO:0019827	stem cell population maintenance	-	ISS	Process
GO:0021861	forebrain radial glial cell differentiation	-	ISS	Process
GO:0031053	primary miRNA processing	25799998.	IDA	Process
GO:0034644	cellular response to UV	28297716.	IDA	Process
GO:0036396	RNA N6-methyladenosine methyltransferase complex	21873635.	IBA	Component
GO:0036396	RNA N6-methyladenosine methyltransferase complex	24316715.24407421.24981863.27602518.27627798.29348140.29506078.29507755.	IDA	Component
GO:0042063	gliogenesis	-	ISS	Process
GO:0045580	regulation of T cell differentiation	-	ISS	Process
GO:0045746	negative regulation of Notch signaling pathway	-	ISS	Process
GO:0046982	protein heterodimerization activity	27373337.	IDA	Function
GO:0046982	protein heterodimerization activity	27281194.	IPI	Function
GO:0051445	regulation of meiotic cell cycle	-	ISS	Process
GO:0061157	mRNA destabilization	-	ISS	Process
GO:0080009	mRNA methylation	24316715.27281194.27373337.27627798.28297716.	IDA	Process
GO:0080009	mRNA methylation	22575960.24284625.25719671.	IMP	Process
GO:0098508	endothelial to hematopoietic transition	-	ISS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	ISS	Process
GO:1903679	positive regulation of cap-independent translational initiation	26593424.	IMP	Process
GO:1904047	S-adenosyl-L-methionine binding	27281194.27373337.	IDA	Function
GO:1990744	primary miRNA methylation	21873635.	IBA	Process
GO:1990744	primary miRNA methylation	25799998.	IDA	Process