EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165821 (Gene tree)
Gene ID: 6297
Gene Symbol: SALL2
Alias: KIAA0360|Hsal2|ZNF795
Full Name: spalt like transcription factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 16,137 bases
Position: chr14:21,521,080-21,537,216
Accession: 10526
RBP type: canonical RBP
Summary: This gene encodes a protein containing multiple zinc finger domains. The encoded protein functions in optical fissure closure during development of the eye in the embryo. Mutations in this gene are associated with ocular coloboma. [provided by RefSeq, Jul 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000440054	zf-C2H2	PF00096.26	1.1e-17	1	4
ENSP00000440054	zf-C2H2	PF00096.26	1.1e-17	2	4
ENSP00000440054	zf-C2H2	PF00096.26	1.1e-17	3	4
ENSP00000440054	zf-C2H2	PF00096.26	1.1e-17	4	4
ENSP00000396773	zf-C2H2	PF00096.26	1.2e-17	1	4
ENSP00000396773	zf-C2H2	PF00096.26	1.2e-17	2	4
ENSP00000396773	zf-C2H2	PF00096.26	1.2e-17	3	4
ENSP00000396773	zf-C2H2	PF00096.26	1.2e-17	4	4
ENSP00000483562	zf-C2H2	PF00096.26	2.9e-17	1	4
ENSP00000483562	zf-C2H2	PF00096.26	2.9e-17	2	4
ENSP00000483562	zf-C2H2	PF00096.26	2.9e-17	3	4
ENSP00000483562	zf-C2H2	PF00096.26	2.9e-17	4	4
ENSP00000440054	zf-met	PF12874.7	1.9e-11	1	2
ENSP00000440054	zf-met	PF12874.7	1.9e-11	2	2
ENSP00000396773	zf-met	PF12874.7	1.9e-11	1	2
ENSP00000396773	zf-met	PF12874.7	1.9e-11	2	2
ENSP00000483562	zf-met	PF12874.7	4.6e-11	1	2
ENSP00000483562	zf-met	PF12874.7	4.6e-11	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000614342	SALL2-207	4942	-	ENSP00000483562	1007 (aa)	-	Q9Y467
ENST00000613414	SALL2-206	1566	-	ENSP00000483202	200 (aa)	-	A0A0B4J2F7
ENST00000546363	SALL2-204	3094	XM_011537064	ENSP00000440054	902 (aa)	XP_011535366	H0YFS7
ENST00000537235	SALL2-202	659	-	ENSP00000438493	191 (aa)	-	F5H433
ENST00000450879	SALL2-201	3178	XM_011537065	ENSP00000396773	906 (aa)	XP_011535367	E7EW59
ENST00000541965	SALL2-203	553	-	ENSP00000439654	99 (aa)	-	F5H1G6
ENST00000611430	SALL2-205	1466	-	ENSP00000484460	198 (aa)	-	A0A087X1T9

Gene Model

Click here to download ENSG00000165821's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165821	Cholesterol, HDL	6.9530000E-005	-
ENSG00000165821	Platelet Function Tests	2.6896700E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165821	rs8016621	14	21534327	?	Tuberculosis	30713548		3.9682539	Orphanet_3389

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165821's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165821	SALL2	100	90.909	ENSAMEG00000006226	SALL2	96	90.415	Ailuropoda_melanoleuca
ENSG00000165821	SALL2	63	60.202	ENSACAG00000000030	SALL2	76	60.371	Anolis_carolinensis
ENSG00000165821	SALL2	100	97.382	ENSANAG00000031405	SALL2	90	96.000	Aotus_nancymaae
ENSG00000165821	SALL2	100	91.099	ENSBTAG00000013249	SALL2	99	90.707	Bos_taurus
ENSG00000165821	SALL2	100	98.990	ENSCJAG00000008855	SALL2	100	97.621	Callithrix_jacchus
ENSG00000165821	SALL2	89	73.864	ENSCAFG00000005676	SALL2	95	73.913	Canis_familiaris
ENSG00000165821	SALL2	88	83.529	ENSCAFG00020015273	SALL2	100	77.044	Canis_lupus_dingo
ENSG00000165821	SALL2	100	90.864	ENSCHIG00000025803	SALL2	100	90.765	Capra_hircus
ENSG00000165821	SALL2	98	95.467	ENSTSYG00000030220	SALL2	99	92.746	Carlito_syrichta
ENSG00000165821	SALL2	100	90.217	ENSCPOG00000040220	SALL2	100	88.142	Cavia_porcellus
ENSG00000165821	SALL2	100	97.324	ENSCCAG00000033278	SALL2	100	97.324	Cebus_capucinus
ENSG00000165821	SALL2	100	100.000	ENSCATG00000045263	SALL2	100	98.811	Cercocebus_atys
ENSG00000165821	SALL2	100	90.099	ENSCLAG00000001400	SALL2	100	88.515	Chinchilla_lanigera
ENSG00000165821	SALL2	100	93.936	ENSCSAG00000016461	SALL2	100	93.936	Chlorocebus_sabaeus
ENSG00000165821	SALL2	85	52.750	ENSCPBG00000012695	SALL2	61	68.007	Chrysemys_picta_bellii
ENSG00000165821	SALL2	100	98.990	ENSCANG00000036872	SALL2	100	98.513	Colobus_angolensis_palliatus
ENSG00000165821	SALL2	100	88.194	ENSCGRG00001000154	Sall2	100	87.698	Cricetulus_griseus_chok1gshd
ENSG00000165821	SALL2	100	88.095	ENSCGRG00000008130	Sall2	100	87.599	Cricetulus_griseus_crigri
ENSG00000165821	SALL2	100	89.529	ENSDNOG00000032317	SALL2	99	90.515	Dasypus_novemcinctus
ENSG00000165821	SALL2	100	88.987	ENSDORG00000030154	Sall2	100	88.594	Dipodomys_ordii
ENSG00000165821	SALL2	100	95.288	ENSEASG00005011556	SALL2	100	93.168	Equus_asinus_asinus
ENSG00000165821	SALL2	94	93.565	ENSECAG00000024449	SALL2	100	93.565	Equus_caballus
ENSG00000165821	SALL2	100	91.601	ENSFCAG00000044786	SALL2	100	91.502	Felis_catus
ENSG00000165821	SALL2	100	91.790	ENSFDAG00000014250	SALL2	100	89.812	Fukomys_damarensis
ENSG00000165821	SALL2	100	100.000	ENSGGOG00000009133	SALL2	100	99.206	Gorilla_gorilla
ENSG00000165821	SALL2	100	92.857	ENSHGLG00000006009	SALL2	100	91.071	Heterocephalus_glaber_female
ENSG00000165821	SALL2	98	92.417	ENSHGLG00100000859	SALL2	99	90.719	Heterocephalus_glaber_male
ENSG00000165821	SALL2	100	93.452	ENSSTOG00000023637	SALL2	100	92.460	Ictidomys_tridecemlineatus
ENSG00000165821	SALL2	100	88.702	ENSJJAG00000000077	Sall2	100	87.711	Jaculus_jaculus
ENSG00000165821	SALL2	100	92.864	ENSLAFG00000032150	SALL2	100	91.774	Loxodonta_africana
ENSG00000165821	SALL2	100	100.000	ENSMFAG00000002687	SALL2	100	98.811	Macaca_fascicularis
ENSG00000165821	SALL2	100	98.236	ENSMMUG00000014997	SALL2	100	98.236	Macaca_mulatta
ENSG00000165821	SALL2	100	100.000	ENSMNEG00000030415	SALL2	100	98.346	Macaca_nemestrina
ENSG00000165821	SALL2	100	100.000	ENSMLEG00000036462	SALL2	100	98.910	Mandrillus_leucophaeus
ENSG00000165821	SALL2	100	88.142	ENSMAUG00000013964	Sall2	100	86.957	Mesocricetus_auratus
ENSG00000165821	SALL2	100	97.980	ENSMICG00000046438	SALL2	100	93.247	Microcebus_murinus
ENSG00000165821	SALL2	100	86.905	ENSMOCG00000003410	Sall2	100	86.111	Microtus_ochrogaster
ENSG00000165821	SALL2	99	79.277	ENSMODG00000006068	SALL2	99	78.495	Monodelphis_domestica
ENSG00000165821	SALL2	100	88.381	MGP_CAROLIEiJ_G0019241	Sall2	100	88.083	Mus_caroli
ENSG00000165821	SALL2	100	90.052	ENSMUSG00000049532	Sall2	100	88.282	Mus_musculus
ENSG00000165821	SALL2	100	88.679	MGP_PahariEiJ_G0030262	Sall2	100	87.885	Mus_pahari
ENSG00000165821	SALL2	100	88.580	MGP_SPRETEiJ_G0020133	Sall2	100	88.282	Mus_spretus
ENSG00000165821	SALL2	100	93.194	ENSMPUG00000000199	SALL2	88	89.922	Mustela_putorius_furo
ENSG00000165821	SALL2	100	91.179	ENSMLUG00000009185	SALL2	99	91.179	Myotis_lucifugus
ENSG00000165821	SALL2	100	90.278	ENSNGAG00000014258	Sall2	100	89.385	Nannospalax_galili
ENSG00000165821	SALL2	100	100.000	ENSNLEG00000014602	SALL2	100	98.611	Nomascus_leucogenys
ENSG00000165821	SALL2	91	79.871	ENSMEUG00000000526	SALL2	100	78.902	Notamacropus_eugenii
ENSG00000165821	SALL2	100	90.387	ENSODEG00000001454	SALL2	100	89.197	Octodon_degus
ENSG00000165821	SALL2	100	88.137	ENSOCUG00000027464	SALL2	100	89.258	Oryctolagus_cuniculus
ENSG00000165821	SALL2	100	97.980	ENSOGAG00000031464	SALL2	100	93.162	Otolemur_garnettii
ENSG00000165821	SALL2	100	90.070	ENSOARG00000019612	SALL2	100	89.970	Ovis_aries
ENSG00000165821	SALL2	100	100.000	ENSPPAG00000038242	SALL2	100	99.503	Pan_paniscus
ENSG00000165821	SALL2	100	92.079	ENSPPRG00000005572	SALL2	100	91.980	Panthera_pardus
ENSG00000165821	SALL2	100	89.296	ENSPTIG00000018399	SALL2	100	89.197	Panthera_tigris_altaica
ENSG00000165821	SALL2	100	100.000	ENSPTRG00000006128	SALL2	100	99.305	Pan_troglodytes
ENSG00000165821	SALL2	100	98.990	ENSPANG00000020006	SALL2	100	98.414	Papio_anubis
ENSG00000165821	SALL2	100	89.911	ENSPEMG00000022293	Sall2	100	88.922	Peromyscus_maniculatus_bairdii
ENSG00000165821	SALL2	100	99.200	ENSPPYG00000005600	SALL2	92	97.799	Pongo_abelii
ENSG00000165821	SALL2	91	91.667	ENSPCAG00000006689	SALL2	89	89.444	Procavia_capensis
ENSG00000165821	SALL2	100	93.843	ENSPCOG00000017266	SALL2	100	93.049	Propithecus_coquereli
ENSG00000165821	SALL2	100	88.107	ENSPVAG00000000277	SALL2	100	87.909	Pteropus_vampyrus
ENSG00000165821	SALL2	100	89.076	ENSRNOG00000013287	Sall2	100	88.282	Rattus_norvegicus
ENSG00000165821	SALL2	87	98.082	ENSRBIG00000009332	SALL2	100	100.000	Rhinopithecus_bieti
ENSG00000165821	SALL2	100	88.999	ENSRROG00000035352	SALL2	95	95.524	Rhinopithecus_roxellana
ENSG00000165821	SALL2	100	97.906	ENSSBOG00000028539	SALL2	100	97.423	Saimiri_boliviensis_boliviensis
ENSG00000165821	SALL2	100	74.872	ENSSHAG00000009219	SALL2	98	76.547	Sarcophilus_harrisii
ENSG00000165821	SALL2	59	68.223	ENSSPUG00000010045	SALL2	58	68.571	Sphenodon_punctatus
ENSG00000165821	SALL2	99	92.000	ENSSSCG00000022705	SALL2	91	92.000	Sus_scrofa
ENSG00000165821	SALL2	100	90.367	ENSTTRG00000012842	SALL2	100	90.169	Tursiops_truncatus
ENSG00000165821	SALL2	91	91.111	ENSUAMG00000028082	SALL2	88	88.406	Ursus_americanus
ENSG00000165821	SALL2	94	93.388	ENSUMAG00000004963	SALL2	100	86.067	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21362508.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21362508.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21362508.	IMP	Function
GO:0001654	eye development	24412933.	IDA	Process
GO:0005515	protein binding	16189514.19131967.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0021915	neural tube development	-	IEA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	21362508.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23029531	The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.	PLoS One	2012	Sung CK	doi: 10.1371/journal.pone.0046486
21362508	DNA-binding and regulatory properties of the transcription factor and putative tumor suppressor p150(Sal2).	Biochim Biophys Acta	2011 Apr-Jun	Gu H	doi: 10.1016/j.bbagrm.2011.02.002

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr14	21523596	Missense_Mutation	rs764828751	R711Q	0.48
BLCA	chr14	21525385	Missense_Mutation	NA	E115K	0.06
BLCA	chr14	21524398	Missense_Mutation	novel	V444L	0.12
BLCA	chr14	21522206	3'UTR	novel		0.21
BLCA	chr14	21523110	Missense_Mutation	NA	S873L	0.44
BLCA	chr14	21523626	Missense_Mutation	novel	T701I	0.41	zf-C2H2
BLCA	chr14	21525599	Silent	novel	F43F	0.42
BLCA	chr14	21524526	Missense_Mutation	NA	Y401C	0.2
BLCA	chr14	21522055	3'UTR	novel		0.24
BLCA	chr14	21523054	Missense_Mutation	novel	E892Q	0.08
BLCA	chr14	21523393	Missense_Mutation	novel	D779N	0.08
BLCA	chr14	21525170	Silent	novel	L186L	0.15
BLCA	chr14	21525417	Missense_Mutation	NA	S104F	0.1
BLCA	chr14	21522961	Nonsense_Mutation	NA	Q923*	0.26
BLCA	chr14	21525423	Missense_Mutation	novel	S102F	0.15
BLCA	chr14	21523681	Missense_Mutation	novel	A683T	0.31
BLCA	chr14	21536912	Nonsense_Mutation	novel	R4*	0.37
BLCA	chr14	21525286	Missense_Mutation	NA	G148R	0.39
BLCA	chr14	21523323	Nonsense_Mutation	novel	S802*	0.4
BRCA	chr14	21524259	Missense_Mutation	novel	L490P	0.19
BRCA	chr14	21524781	Missense_Mutation	NA	S316L	0.29
BRCA	chr14	21523598	Silent	NA	V710V	0.26
BRCA	chr14	21525481	Missense_Mutation	NA	P83A	0.14
BRCA	chr14	21536994	5'UTR	novel		0.25
BRCA	chr14	21523724	Silent	NA	F668F	0.31
BRCA	chr14	21536879	Missense_Mutation	NA	D15H	0.49
BRCA	chr14	21522526	3'UTR	novel		0.62
CESC	chr14	21522133	3'UTR	novel		0.29
CESC	chr14	21525479	Silent	novel	P83P	0.35
CESC	chr14	21523990	Frame_Shift_Ins	novel	*E580Mfs18**	0.04
CESC	chr14	21525412	Frame_Shift_Ins	novel	*V106Kfs42**	0.14
CESC	chr14	21524186	Frame_Shift_Ins	novel	*M514Ifs38**	0.18
CESC	chr14	21525371	Silent	novel	E119E	0.16
CESC	chr14	21524446	Missense_Mutation	novel	P428T	0.47
CESC	chr14	21526100	Intron	NA		0.23
CESC	chr14	21524848	Nonsense_Mutation	rs756676999	R294*	0.39
CESC	chr14	21522681	3'UTR	novel		0.45
CESC	chr14	21523289	Silent	novel	G813G	0.42
COAD	chr14	21523596	Missense_Mutation	rs764828751	R711Q	0.27
COAD	chr14	21525607	Missense_Mutation	rs781310209	A41T	0.35
COAD	chr14	21523597	Missense_Mutation	rs532455614	R711W	0.44
COAD	chr14	21524457	Missense_Mutation	rs538590182	R424H	0.38
COAD	chr14	21525423	Missense_Mutation	NA	S102Y	0.22
COAD	chr14	21524551	Missense_Mutation	NA	R393C	0.24
COAD	chr14	21525524	Silent	novel	G68G	0.27
COAD	chr14	21536896	Missense_Mutation	novel	P9L	0.07
COAD	chr14	21524307	Missense_Mutation	rs764428403	R474H	0.21
COAD	chr14	21537026	5'UTR	novel		0.23
COAD	chr14	21522668	3'UTR	novel		0.3
COAD	chr14	21525607	Missense_Mutation	rs781310209	A41T	0.22
COAD	chr14	21523193	Silent	rs747695995	S845S	0.35
COAD	chr14	21522693	3'UTR	novel		0.34
COAD	chr14	21523059	Missense_Mutation	novel	L890S	0.24
COAD	chr14	21522894	Missense_Mutation	novel	C945Y	0.23
COAD	chr14	21536891	Nonsense_Mutation	NA	Q11*	0.18
COAD	chr14	21524847	Missense_Mutation	rs753189477	R294Q	0.47
COAD	chr14	21525523	Missense_Mutation	NA	Q69K	0.26
COAD	chr14	21536984	5'UTR	novel		0.07
COAD	chr14	21523122	Missense_Mutation	rs375899234	P869L	0.28
COAD	chr14	21536859	Silent	novel	A21A	0.17
COAD	chr14	21524601	Missense_Mutation	rs145077959	R376H	0.23
COAD	chr14	21523628	Missense_Mutation	NA	F700L	0.29	zf-C2H2
COAD	chr14	21523927	Missense_Mutation	rs768526871	R601W	0.34
ESCA	chr14	21525467	Missense_Mutation	novel	N87K	0.21
ESCA	chr14	21525470	Frame_Shift_Del	novel	*P81Qfs2**	0.2
ESCA	chr14	21524847	Missense_Mutation	rs753189477	R294Q	0.12
ESCA	chr14	21536976	5'UTR	novel		0.48
ESCA	chr14	21523542	Missense_Mutation	novel	G729V	0.38
GBM	chr14	21523715	Silent	novel	R671R	0.53
GBM	chr14	21523309	Missense_Mutation	novel	G807R	0.07
GBM	chr14	21525541	Missense_Mutation	novel	M63V	0.06
GBM	chr14	21522755	Silent	novel	T991T	0.04
GBM	chr14	21523412	Frame_Shift_Del	novel	*E773Kfs5**	0.09
GBM	chr14	21524006	Silent	novel	P574P	0.05
GBM	chr14	21524089	Missense_Mutation	novel	R547C	0.28
GBM	chr14	21522651	3'UTR	novel		0.08
HNSC	chr14	21524847	Missense_Mutation	rs753189477	R294Q	0.16
HNSC	chr14	21536946	5'UTR	novel		0.28
HNSC	chr14	21522914	Silent	rs530697143	P938P	0.32
HNSC	chr14	21523587	Missense_Mutation	novel	L714R	0.23
KICH	chr14	21522731	Silent	NA	P999P	0.1
KIRP	chr14	21523498	Missense_Mutation	rs753233714	G744R	0.44
LAML	chr14	21522736	Frame_Shift_Ins	novel	*F998Lfs6**	0.1
LGG	chr14	21523332	Missense_Mutation	novel	R799K	0.3
LGG	chr14	21525395	Silent	novel	T111T	0.08
LIHC	chr14	21522893	Nonsense_Mutation	novel	C945*	0.05
LIHC	chr14	21522967	Missense_Mutation	NA	P921T	0.33
LIHC	chr14	21536963	5'UTR	novel		0.45
LIHC	chr14	21524216	Silent	NA	G504G	0.3
LIHC	chr14	21524783	Silent	novel	A315A	0.35
LUAD	chr14	21524127	Missense_Mutation	rs781290585	S534L	0.05
LUAD	chr14	21523449	Missense_Mutation	rs778734087	E760G	0.49
LUAD	chr14	21524756	Silent	NA	T324T	0.23
LUSC	chr14	21523005	Missense_Mutation	novel	S908N	0.15
LUSC	chr14	21523833	Missense_Mutation	NA	Q632L	0.2
LUSC	chr14	21524657	Silent	NA	L357L	0.34
LUSC	chr14	21522232	3'UTR	novel		0.28
LUSC	chr14	21523426	Missense_Mutation	NA	E768Q	0.27
LUSC	chr14	21522713	Silent	NA	T1005T	0.57
LUSC	chr14	21523854	Nonsense_Mutation	novel	S625*	0.11
LUSC	chr14	21524276	Silent	rs80044000	L484L	0.21
LUSC	chr14	21524145	Missense_Mutation	novel	P528H	0.45
LUSC	chr14	21522861	Missense_Mutation	novel	K956R	0.45
LUSC	chr14	21523086	Missense_Mutation	NA	P881R	0.25
LUSC	chr14	21524847	Missense_Mutation	rs753189477	R294Q	0.45
LUSC	chr14	21524404	Missense_Mutation	novel	D442H	0.26
OV	chr14	21524667	Missense_Mutation	novel	S354N	0.14
OV	chr14	21524669	Silent	novel	G353G	0.12
OV	chr14	21525018	Missense_Mutation	novel	P237L	0.16
OV	chr14	21525019	Missense_Mutation	novel	P237T	0.16
OV	chr14	21523435	Nonsense_Mutation	NA	E765*	0.33
PAAD	chr14	21523454	Silent	rs200356033	P758P	0.16
PAAD	chr14	21523067	Silent	rs199822625	S887S	0.23
PAAD	chr14	21525005	Silent	novel	L241L	0.13
PCPG	chr14	21526093	Intron	novel		0.17
PRAD	chr14	21525106	Missense_Mutation	novel	L208M	0.5
PRAD	chr14	21525606	Missense_Mutation	novel	A41V	0.4
READ	chr14	21525169	Missense_Mutation	rs762195832	R187W	0.19
SARC	chr14	21524551	Missense_Mutation	NA	R393C	0.39
SARC	chr14	21525081	Missense_Mutation	rs201605296	T216M	0.15
SKCM	chr14	21524427	Missense_Mutation	NA	P434L	0.57
SKCM	chr14	21525039	Missense_Mutation	NA	G230E	0.28
SKCM	chr14	21522918	Missense_Mutation	rs755754870	G937E	0.54
SKCM	chr14	21524634	Missense_Mutation	rs756058987	P365L	0.15
SKCM	chr14	21522027	3'UTR	novel		0.3
SKCM	chr14	21525258	Missense_Mutation	NA	T157I	0.48
SKCM	chr14	21522786	Missense_Mutation	NA	S981F	0.27
SKCM	chr14	21523224	Missense_Mutation	NA	S835F	0.13
SKCM	chr14	21524130	Missense_Mutation	novel	G533D	0.11
SKCM	chr14	21524131	Missense_Mutation	novel	G533S	0.1
SKCM	chr14	21524823	Missense_Mutation	NA	P302L	0.38
SKCM	chr14	21536873	Missense_Mutation	NA	E17K	0.4
SKCM	chr14	21524702	Silent	NA	T342T	0.2
SKCM	chr14	21525321	Missense_Mutation	novel	G136E	0.42
SKCM	chr14	21522068	3'UTR	novel		0.4
SKCM	chr14	21524908	Missense_Mutation	NA	F274L	0.09
SKCM	chr14	21525409	Missense_Mutation	NA	P107S	0.13
SKCM	chr14	21524502	Missense_Mutation	NA	R409H	0.45
SKCM	chr14	21523694	Silent	NA	F678F	0.33
SKCM	chr14	21522139	3'UTR	rs768933396		0.62
SKCM	chr14	21523484	Silent	NA	F748F	0.31
SKCM	chr14	21524212	Missense_Mutation	NA	P506S	0.14
SKCM	chr14	21522926	Silent	rs754175930	P934P	0.42
SKCM	chr14	21536881	Missense_Mutation	novel	S14L	0.42
SKCM	chr14	21525321	Missense_Mutation	NA	G136V	0.41
SKCM	chr14	21522825	Missense_Mutation	novel	P968L	0.07
SKCM	chr14	21525497	Silent	rs777600347	A77A	0.34
SKCM	chr14	21523383	Missense_Mutation	novel	S782F	0.33
SKCM	chr14	21525420	Missense_Mutation	novel	G103E	0.42
SKCM	chr14	21523667	Silent	NA	A687A	0.3
SKCM	chr14	21524903	Silent	NA	F275F	0.45
SKCM	chr14	21524871	Missense_Mutation	NA	P286L	0.51
SKCM	chr14	21525221	Silent	NA	P169P	0.37
SKCM	chr14	21522223	3'UTR	novel		0.28
SKCM	chr14	21522179	3'UTR	rs763071984		0.5
SKCM	chr14	21523694	Silent	NA	F678F	0.25
SKCM	chr14	21522068	3'UTR	novel		0.71
SKCM	chr14	21522814	Missense_Mutation	rs201659642	H972Y	0.2
STAD	chr14	21524142	Frame_Shift_Del	rs781465276	*P529Qfs22**	0.52
STAD	chr14	21523891	Nonsense_Mutation	novel	G613*	0.1
STAD	chr14	21525317	Silent	rs746583610	G137G	0.37
STAD	chr14	21525246	Frame_Shift_Del	novel	*P161Lfs12**	0.35
STAD	chr14	21525342	Missense_Mutation	rs774246706	A129V	0.2
STAD	chr14	21524607	Missense_Mutation	rs752690095	K374T	0.36
STAD	chr14	21522802	Missense_Mutation	novel	N976D	0.26
STAD	chr14	21523632	Missense_Mutation	rs373066758	K699R	0.43	zf-C2H2
STAD	chr14	21523304	Silent	NA	A808A	0.16
STAD	chr14	21524942	Silent	NA	S262S	0.11
STAD	chr14	21524151	Frame_Shift_Del	novel	*N526Tfs25**	0.38
STAD	chr14	21524076	Missense_Mutation	novel	S551I	0.46
STAD	chr14	21525312	Frame_Shift_Del	NA	*G139Afs2**	0.16
STAD	chr14	21523930	Missense_Mutation	NA	D600Y	0.2
STAD	chr14	21524113	Missense_Mutation	NA	V539M	0.26
STAD	chr14	21525312	Frame_Shift_Del	NA	*G139Afs2**	0.3
STAD	chr14	21523499	Silent	rs190385056	S743S	0.39
THCA	chr14	21522838	In_Frame_Ins	novel	H963_H964insKE	0.05
THCA	chr14	21522838	In_Frame_Ins	novel	H963_H964insKE	0.05
THCA	chr14	21523907	Silent	novel	V607V	0.44
THCA	chr14	21524186	Missense_Mutation	novel	M514I	0.6
THYM	chr14	21522737	Frame_Shift_Del	novel	*R1000Efs71**	0.38
UCEC	chr14	21523568	Silent	rs766661633	N720N	0.39
UCEC	chr14	21523704	Missense_Mutation	rs781499652	R675H	0.34
UCEC	chr14	21525445	Missense_Mutation	novel	E95K	0.28
UCEC	chr14	21522988	Missense_Mutation	rs768176595	E914K	0.28
UCEC	chr14	21525037	Missense_Mutation	novel	T231A	0.37
UCEC	chr14	21536899	Missense_Mutation	novel	K8R	0.39
UCEC	chr14	21522659	3'UTR	novel		0.38
UCEC	chr14	21524168	Missense_Mutation	NA	K520N	0.34
UCEC	chr14	21524603	Silent	novel	C375C	0.43
UCEC	chr14	21524701	Missense_Mutation	rs759194170	A343T	0.49
UCEC	chr14	21524007	Missense_Mutation	novel	P574H	0.12
UCEC	chr14	21523978	Frame_Shift_Del	NA	*A584Pfs13**	0.2
UCEC	chr14	21526166	Intron	novel		0.44
UCEC	chr14	21522032	3'UTR	novel		0.21
UCEC	chr14	21537038	5'UTR	novel		0.3
UCEC	chr14	21523540	Missense_Mutation	NA	G730R	0.11
UCEC	chr14	21524362	Missense_Mutation	rs760835214	V456M	0.12
UCEC	chr14	21523281	Missense_Mutation	rs781130763	A816V	0.42
UCEC	chr14	21523841	Silent	NA	G629G	0.34
UCEC	chr14	21525416	Silent	novel	S104S	0.09
UCEC	chr14	21523887	Missense_Mutation	NA	A614V	0.34
UCEC	chr14	21522939	Missense_Mutation	novel	Q930R	0.46
UCEC	chr14	21525002	Missense_Mutation	NA	F242L	0.48
UCEC	chr14	21524051	Silent	novel	S559S	0.24
UCEC	chr14	21521934	3'UTR	novel		0.33
UCEC	chr14	21522630	3'UTR	novel		0.11
UCEC	chr14	21522893	Silent	novel	C945C	0.37
UCEC	chr14	21523517	Silent	rs191602308	S737S	0.45
UCEC	chr14	21523891	Nonsense_Mutation	novel	G613*	0.3
UCEC	chr14	21522539	3'UTR	novel		0.33
UCEC	chr14	21522989	Silent	rs201036397	C913C	0.24
UCEC	chr14	21523911	Missense_Mutation	rs376577664	A606V	0.48
UCEC	chr14	21522814	Frame_Shift_Del	novel	*H972Mfs11**	0.42
UCEC	chr14	21523568	Silent	rs766661633	N720N	0.39
UCEC	chr14	21523281	Missense_Mutation	rs781130763	A816V	0.37
UCEC	chr14	21524627	Missense_Mutation	novel	E367D	0.15
UCEC	chr14	21523653	Missense_Mutation	novel	S692F	0.22
UCEC	chr14	21525182	Silent	novel	I182I	0.43
UCEC	chr14	21525569	Missense_Mutation	novel	Q53H	0.59
UCEC	chr14	21521913	3'UTR	novel		0.64
UCEC	chr14	21536850	Splice_Region	NA	N24N	0.36
UCEC	chr14	21523499	Silent	rs190385056	S743S	0.55
UCEC	chr14	21525008	Silent	NA	P240P	0.41
UCEC	chr14	21522688	3'UTR	novel		0.13
UCEC	chr14	21525438	Missense_Mutation	novel	S97N	0.47
UCEC	chr14	21523789	Missense_Mutation	rs746092722	R647S	0.4
UCEC	chr14	21524191	Missense_Mutation	novel	L513F	0.21
UCEC	chr14	21524602	Missense_Mutation	rs767289738	R376C	0.33
UCEC	chr14	21525423	Missense_Mutation	NA	S102Y	0.43
UCEC	chr14	21523948	Nonsense_Mutation	novel	Q594*	0.45
UCEC	chr14	21522083	3'UTR	novel		0.38
UCEC	chr14	21524559	Missense_Mutation	NA	I390T	0.13
UCEC	chr14	21524961	Missense_Mutation	novel	S256Y	0.25
UCEC	chr14	21523911	Missense_Mutation	rs376577664	A606V	0.18
UCEC	chr14	21536896	Missense_Mutation	novel	P9L	0.39
UCEC	chr14	21524930	Silent	novel	G266G	0.08
UCEC	chr14	21522747	Missense_Mutation	rs774406760	G994V	0.19
UCEC	chr14	21522870	Missense_Mutation	NA	A953V	0.45
UCEC	chr14	21525555	Missense_Mutation	novel	T58I	0.36
UCEC	chr14	21524633	Silent	NA	P365P	0.4
UCEC	chr14	21524847	Missense_Mutation	rs753189477	R294Q	0.3
UCEC	chr14	21525347	Silent	novel	V127V	0.42
UCEC	chr14	21522529	3'UTR	novel		0.2
UCEC	chr14	21522988	Missense_Mutation	rs768176595	E914K	0.28
UCEC	chr14	21524583	Missense_Mutation	NA	F382C	0.13
UCEC	chr14	21521963	3'UTR	rs754253368		0.35
UCEC	chr14	21523424	Missense_Mutation	novel	E768D	0.18
UCEC	chr14	21525575	Silent	novel	A51A	0.16
UCEC	chr14	21525154	Missense_Mutation	novel	R192W	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2778	0.056464
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1169	0.0025503
KIRP	DEL	0.1667	0.085174
LUSC	DEL	0.2635	0.0082553
PAAD	DEL	0.087	0.11332

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0039	Kaplan-Meier Survival Analysis
STAD	0.012	Kaplan-Meier Survival Analysis
ACC	0.0037	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
UCEC	0.0016	Kaplan-Meier Survival Analysis
LIHC	0.013	Kaplan-Meier Survival Analysis
DLBC	0.048	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00073	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742