EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165832 (Gene tree)
Gene ID: 142940
Gene Symbol: TRUB1
Alias: PUS4
Full Name: TruB pseudouridine synthase family member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 39,488 bases
Position: chr10:114,938,193-114,977,680
Accession: 16060
RBP type: canonical RBP
Summary: Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000298746	TruB_N	PF01509.18	1.8e-49	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000298746	TRUB1-201	3408	-	ENSP00000298746	349 (aa)	-	Q8WWH5
ENST00000485065	TRUB1-202	584	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000165832's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165832	Platelet Function Tests	2.2465900E-005	-
ENSG00000165832	Attention Deficit Disorder with Hyperactivity	3E-7	27890468
ENSG00000165832	Bipolar Disorder	3E-7	27890468

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165832	rs61869271	10	114971570	?	Tonsillectomy	28928442	[0.022-0.056] unit increase	0.0394	EFO_0007924

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165832's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000165832	TRUB1	58	35.096	ENSG00000167112	TRUB2	62	35.096

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165832	TRUB1	70	68.571	ENSAPOG00000020565	trub1	89	68.293	Acanthochromis_polyacanthus
ENSG00000165832	TRUB1	96	92.899	ENSAMEG00000014931	TRUB1	99	92.593	Ailuropoda_melanoleuca
ENSG00000165832	TRUB1	70	62.602	ENSACIG00000003060	trub1	82	62.602	Amphilophus_citrinellus
ENSG00000165832	TRUB1	70	68.571	ENSAOCG00000017188	trub1	89	68.293	Amphiprion_ocellaris
ENSG00000165832	TRUB1	70	67.886	ENSAPEG00000015209	trub1	89	67.886	Amphiprion_percula
ENSG00000165832	TRUB1	69	68.880	ENSATEG00000023291	trub1	86	68.880	Anabas_testudineus
ENSG00000165832	TRUB1	79	75.636	ENSAPLG00000006808	TRUB1	99	75.636	Anas_platyrhynchos
ENSG00000165832	TRUB1	77	70.896	ENSACAG00000009282	TRUB1	97	70.896	Anolis_carolinensis
ENSG00000165832	TRUB1	96	97.024	ENSANAG00000022870	TRUB1	100	96.011	Aotus_nancymaae
ENSG00000165832	TRUB1	72	67.063	ENSACLG00000000823	trub1	91	67.063	Astatotilapia_calliptera
ENSG00000165832	TRUB1	77	65.926	ENSAMXG00000015845	trub1	90	65.926	Astyanax_mexicanus
ENSG00000165832	TRUB1	98	92.398	ENSBTAG00000012955	TRUB1	99	91.738	Bos_taurus
ENSG00000165832	TRUB1	100	96.296	ENSCJAG00000047815	TRUB1	100	96.296	Callithrix_jacchus
ENSG00000165832	TRUB1	99	92.550	ENSCAFG00000011688	TRUB1	99	92.550	Canis_familiaris
ENSG00000165832	TRUB1	99	92.837	ENSCAFG00020013237	TRUB1	99	92.837	Canis_lupus_dingo
ENSG00000165832	TRUB1	98	92.398	ENSCHIG00000020884	TRUB1	99	92.000	Capra_hircus
ENSG00000165832	TRUB1	100	90.028	ENSTSYG00000000446	TRUB1	100	91.168	Carlito_syrichta
ENSG00000165832	TRUB1	72	83.858	ENSCAPG00000017088	TRUB1	100	83.858	Cavia_aperea
ENSG00000165832	TRUB1	70	85.306	ENSCPOG00000040236	-	100	85.306	Cavia_porcellus
ENSG00000165832	TRUB1	71	79.032	ENSCPOG00000030129	-	86	79.032	Cavia_porcellus
ENSG00000165832	TRUB1	96	96.439	ENSCCAG00000028842	TRUB1	100	95.442	Cebus_capucinus
ENSG00000165832	TRUB1	100	97.429	ENSCATG00000033431	TRUB1	100	97.429	Cercocebus_atys
ENSG00000165832	TRUB1	70	88.980	ENSCLAG00000008664	TRUB1	100	88.980	Chinchilla_lanigera
ENSG00000165832	TRUB1	100	97.714	ENSCSAG00000004891	TRUB1	100	97.714	Chlorocebus_sabaeus
ENSG00000165832	TRUB1	99	77.971	ENSCHOG00000011931	TRUB1	99	77.971	Choloepus_hoffmanni
ENSG00000165832	TRUB1	78	79.044	ENSCPBG00000003051	TRUB1	94	79.044	Chrysemys_picta_bellii
ENSG00000165832	TRUB1	100	97.714	ENSCANG00000029445	TRUB1	100	97.714	Colobus_angolensis_palliatus
ENSG00000165832	TRUB1	72	87.008	ENSCGRG00001016772	-	99	70.774	Cricetulus_griseus_chok1gshd
ENSG00000165832	TRUB1	80	79.286	ENSCGRG00001010322	-	79	79.252	Cricetulus_griseus_chok1gshd
ENSG00000165832	TRUB1	80	88.214	ENSCGRG00000010806	Trub1	99	78.223	Cricetulus_griseus_crigri
ENSG00000165832	TRUB1	73	62.500	ENSCSEG00000011261	trub1	97	56.250	Cynoglossus_semilaevis
ENSG00000165832	TRUB1	74	65.891	ENSCVAG00000008791	trub1	79	65.891	Cyprinodon_variegatus
ENSG00000165832	TRUB1	75	66.920	ENSDARG00000053805	trub1	90	66.920	Danio_rerio
ENSG00000165832	TRUB1	97	86.471	ENSDNOG00000001069	TRUB1	99	85.714	Dasypus_novemcinctus
ENSG00000165832	TRUB1	99	88.825	ENSDORG00000010431	Trub1	99	87.966	Dipodomys_ordii
ENSG00000165832	TRUB1	81	75.980	ENSETEG00000009183	TRUB1	81	76.961	Echinops_telfairi
ENSG00000165832	TRUB1	96	92.857	ENSEASG00005014739	TRUB1	99	92.550	Equus_asinus_asinus
ENSG00000165832	TRUB1	96	92.857	ENSECAG00000007177	TRUB1	99	92.550	Equus_caballus
ENSG00000165832	TRUB1	99	75.978	ENSEEUG00000013993	TRUB1	99	77.374	Erinaceus_europaeus
ENSG00000165832	TRUB1	70	69.388	ENSELUG00000000502	trub1	86	69.388	Esox_lucius
ENSG00000165832	TRUB1	96	93.134	ENSFCAG00000031927	TRUB1	99	92.816	Felis_catus
ENSG00000165832	TRUB1	66	78.355	ENSFALG00000002232	TRUB1	92	76.250	Ficedula_albicollis
ENSG00000165832	TRUB1	70	86.831	ENSFDAG00000008140	TRUB1	99	86.831	Fukomys_damarensis
ENSG00000165832	TRUB1	70	66.531	ENSFHEG00000004016	trub1	84	66.531	Fundulus_heteroclitus
ENSG00000165832	TRUB1	78	75.000	ENSGALG00000009091	TRUB1	97	74.057	Gallus_gallus
ENSG00000165832	TRUB1	70	64.344	ENSGAFG00000009193	trub1	86	64.344	Gambusia_affinis
ENSG00000165832	TRUB1	56	68.205	ENSGACG00000015387	trub1	96	68.205	Gasterosteus_aculeatus
ENSG00000165832	TRUB1	83	77.241	ENSGAGG00000009758	TRUB1	81	77.817	Gopherus_agassizii
ENSG00000165832	TRUB1	100	98.567	ENSGGOG00000004583	TRUB1	100	98.567	Gorilla_gorilla
ENSG00000165832	TRUB1	72	67.063	ENSHBUG00000016787	trub1	91	67.063	Haplochromis_burtoni
ENSG00000165832	TRUB1	99	86.246	ENSHGLG00000015314	TRUB1	99	86.246	Heterocephalus_glaber_female
ENSG00000165832	TRUB1	70	85.306	ENSHGLG00100009183	TRUB1	100	85.306	Heterocephalus_glaber_male
ENSG00000165832	TRUB1	70	68.571	ENSHCOG00000017877	trub1	89	68.571	Hippocampus_comes
ENSG00000165832	TRUB1	80	64.875	ENSIPUG00000017559	trub1	98	64.875	Ictalurus_punctatus
ENSG00000165832	TRUB1	86	94.020	ENSSTOG00000003641	TRUB1	99	88.252	Ictidomys_tridecemlineatus
ENSG00000165832	TRUB1	99	83.954	ENSJJAG00000011800	Trub1	99	83.668	Jaculus_jaculus
ENSG00000165832	TRUB1	75	64.419	ENSKMAG00000006232	trub1	94	64.419	Kryptolebias_marmoratus
ENSG00000165832	TRUB1	76	64.906	ENSLBEG00000026722	trub1	92	64.906	Labrus_bergylta
ENSG00000165832	TRUB1	79	73.551	ENSLACG00000014885	TRUB1	92	73.551	Latimeria_chalumnae
ENSG00000165832	TRUB1	78	70.696	ENSLOCG00000012979	trub1	93	70.696	Lepisosteus_oculatus
ENSG00000165832	TRUB1	100	79.050	ENSLAFG00000015452	TRUB1	100	79.609	Loxodonta_africana
ENSG00000165832	TRUB1	100	97.429	ENSMFAG00000031767	TRUB1	100	97.429	Macaca_fascicularis
ENSG00000165832	TRUB1	100	97.714	ENSMMUG00000001902	TRUB1	100	97.714	Macaca_mulatta
ENSG00000165832	TRUB1	100	93.143	ENSMNEG00000044646	TRUB1	100	93.143	Macaca_nemestrina
ENSG00000165832	TRUB1	100	97.429	ENSMLEG00000042655	TRUB1	100	97.429	Mandrillus_leucophaeus
ENSG00000165832	TRUB1	72	67.063	ENSMZEG00005024095	trub1	91	67.063	Maylandia_zebra
ENSG00000165832	TRUB1	75	75.954	ENSMGAG00000011135	TRUB1	90	75.954	Meleagris_gallopavo
ENSG00000165832	TRUB1	85	84.899	ENSMAUG00000011101	Trub1	99	78.223	Mesocricetus_auratus
ENSG00000165832	TRUB1	99	94.842	ENSMICG00000016324	TRUB1	99	94.842	Microcebus_murinus
ENSG00000165832	TRUB1	93	81.763	ENSMOCG00000017759	Trub1	99	79.083	Microtus_ochrogaster
ENSG00000165832	TRUB1	82	82.517	ENSMODG00000009676	TRUB1	81	80.743	Monodelphis_domestica
ENSG00000165832	TRUB1	99	81.089	MGP_CAROLIEiJ_G0023100	Trub1	99	81.089	Mus_caroli
ENSG00000165832	TRUB1	99	79.943	ENSMUSG00000025086	Trub1	99	79.943	Mus_musculus
ENSG00000165832	TRUB1	99	81.089	MGP_PahariEiJ_G0014588	Trub1	99	81.089	Mus_pahari
ENSG00000165832	TRUB1	99	80.229	MGP_SPRETEiJ_G0024021	Trub1	99	80.229	Mus_spretus
ENSG00000165832	TRUB1	96	94.345	ENSMPUG00000003556	TRUB1	99	93.983	Mustela_putorius_furo
ENSG00000165832	TRUB1	96	87.761	ENSMLUG00000017686	TRUB1	100	86.610	Myotis_lucifugus
ENSG00000165832	TRUB1	99	86.533	ENSNGAG00000018682	Trub1	99	86.533	Nannospalax_galili
ENSG00000165832	TRUB1	70	68.293	ENSNBRG00000023393	trub1	88	68.293	Neolamprologus_brichardi
ENSG00000165832	TRUB1	100	98.281	ENSNLEG00000016345	TRUB1	100	98.281	Nomascus_leucogenys
ENSG00000165832	TRUB1	58	90.050	ENSMEUG00000006603	TRUB1	78	87.204	Notamacropus_eugenii
ENSG00000165832	TRUB1	86	85.050	ENSOPRG00000009371	TRUB1	99	78.917	Ochotona_princeps
ENSG00000165832	TRUB1	99	84.814	ENSODEG00000010854	TRUB1	99	84.814	Octodon_degus
ENSG00000165832	TRUB1	70	67.480	ENSONIG00000007249	trub1	89	67.480	Oreochromis_niloticus
ENSG00000165832	TRUB1	78	79.927	ENSOANG00000001556	TRUB1	96	75.685	Ornithorhynchus_anatinus
ENSG00000165832	TRUB1	99	83.095	ENSOCUG00000009456	TRUB1	99	83.095	Oryctolagus_cuniculus
ENSG00000165832	TRUB1	76	65.152	ENSORLG00000029719	trub1	92	65.152	Oryzias_latipes
ENSG00000165832	TRUB1	76	64.773	ENSORLG00020016767	trub1	91	64.773	Oryzias_latipes_hni
ENSG00000165832	TRUB1	76	64.773	ENSORLG00015014728	trub1	92	64.773	Oryzias_latipes_hsok
ENSG00000165832	TRUB1	74	66.409	ENSOMEG00000014556	trub1	89	66.797	Oryzias_melastigma
ENSG00000165832	TRUB1	99	93.410	ENSOGAG00000015895	TRUB1	99	93.410	Otolemur_garnettii
ENSG00000165832	TRUB1	84	93.377	ENSOARG00000015591	TRUB1	99	86.798	Ovis_aries
ENSG00000165832	TRUB1	100	99.427	ENSPPAG00000043645	TRUB1	100	99.427	Pan_paniscus
ENSG00000165832	TRUB1	96	93.134	ENSPPRG00000007096	TRUB1	99	92.816	Panthera_pardus
ENSG00000165832	TRUB1	96	92.836	ENSPTIG00000006378	TRUB1	99	92.529	Panthera_tigris_altaica
ENSG00000165832	TRUB1	100	99.427	ENSPTRG00000002964	TRUB1	100	99.427	Pan_troglodytes
ENSG00000165832	TRUB1	100	97.429	ENSPANG00000020712	TRUB1	100	97.429	Papio_anubis
ENSG00000165832	TRUB1	78	77.206	ENSPSIG00000012877	TRUB1	93	77.206	Pelodiscus_sinensis
ENSG00000165832	TRUB1	70	66.531	ENSPMGG00000000075	trub1	88	66.531	Periophthalmus_magnuspinnatus
ENSG00000165832	TRUB1	86	85.333	ENSPEMG00000011156	Trub1	99	78.223	Peromyscus_maniculatus_bairdii
ENSG00000165832	TRUB1	82	81.818	ENSPCIG00000009729	TRUB1	79	80.822	Phascolarctos_cinereus
ENSG00000165832	TRUB1	70	66.122	ENSPFOG00000009950	trub1	90	66.122	Poecilia_formosa
ENSG00000165832	TRUB1	70	66.122	ENSPLAG00000013855	trub1	86	66.122	Poecilia_latipinna
ENSG00000165832	TRUB1	70	66.122	ENSPMEG00000009064	trub1	88	66.122	Poecilia_mexicana
ENSG00000165832	TRUB1	70	66.939	ENSPREG00000003343	trub1	88	66.939	Poecilia_reticulata
ENSG00000165832	TRUB1	100	98.567	ENSPPYG00000002676	TRUB1	100	98.567	Pongo_abelii
ENSG00000165832	TRUB1	100	75.284	ENSPCAG00000008427	TRUB1	100	75.852	Procavia_capensis
ENSG00000165832	TRUB1	99	90.258	ENSPCOG00000024360	TRUB1	99	90.258	Propithecus_coquereli
ENSG00000165832	TRUB1	76	92.045	ENSPVAG00000007575	TRUB1	100	92.045	Pteropus_vampyrus
ENSG00000165832	TRUB1	72	67.063	ENSPNYG00000018614	trub1	91	67.063	Pundamilia_nyererei
ENSG00000165832	TRUB1	74	59.615	ENSPNAG00000006881	trub1	88	58.456	Pygocentrus_nattereri
ENSG00000165832	TRUB1	99	81.662	ENSRNOG00000017321	Trub1	99	81.662	Rattus_norvegicus
ENSG00000165832	TRUB1	100	87.429	ENSRBIG00000033423	TRUB1	100	87.429	Rhinopithecus_bieti
ENSG00000165832	TRUB1	100	97.143	ENSRROG00000033902	TRUB1	100	97.143	Rhinopithecus_roxellana
ENSG00000165832	TRUB1	100	95.726	ENSSBOG00000024237	TRUB1	100	95.726	Saimiri_boliviensis_boliviensis
ENSG00000165832	TRUB1	72	80.078	ENSSHAG00000009346	TRUB1	86	80.469	Sarcophilus_harrisii
ENSG00000165832	TRUB1	70	70.370	ENSSFOG00015022124	trub1	83	70.370	Scleropages_formosus
ENSG00000165832	TRUB1	70	68.293	ENSSMAG00000001020	trub1	88	68.293	Scophthalmus_maximus
ENSG00000165832	TRUB1	69	69.167	ENSSDUG00000016414	trub1	88	69.106	Seriola_dumerili
ENSG00000165832	TRUB1	69	69.583	ENSSLDG00000015486	trub1	88	69.512	Seriola_lalandi_dorsalis
ENSG00000165832	TRUB1	85	74.747	ENSSPUG00000001642	TRUB1	96	77.143	Sphenodon_punctatus
ENSG00000165832	TRUB1	76	66.288	ENSSPAG00000001217	trub1	94	66.288	Stegastes_partitus
ENSG00000165832	TRUB1	99	87.679	ENSSSCG00000010653	TRUB1	99	87.679	Sus_scrofa
ENSG00000165832	TRUB1	77	75.926	ENSTGUG00000010971	TRUB1	97	75.735	Taeniopygia_guttata
ENSG00000165832	TRUB1	72	76.680	ENSTBEG00000002880	TRUB1	99	76.680	Tupaia_belangeri
ENSG00000165832	TRUB1	72	90.438	ENSTTRG00000005767	TRUB1	100	89.394	Tursiops_truncatus
ENSG00000165832	TRUB1	96	94.345	ENSUAMG00000024876	TRUB1	99	93.696	Ursus_americanus
ENSG00000165832	TRUB1	84	96.610	ENSUMAG00000002411	TRUB1	99	89.685	Ursus_maritimus
ENSG00000165832	TRUB1	99	92.264	ENSVPAG00000005507	TRUB1	99	92.264	Vicugna_pacos
ENSG00000165832	TRUB1	99	91.117	ENSVVUG00000010085	TRUB1	83	91.404	Vulpes_vulpes
ENSG00000165832	TRUB1	77	66.418	ENSXETG00000023828	trub1	97	66.418	Xenopus_tropicalis
ENSG00000165832	TRUB1	70	65.021	ENSXCOG00000017847	trub1	86	65.021	Xiphophorus_couchianus
ENSG00000165832	TRUB1	70	65.306	ENSXMAG00000014701	trub1	88	65.306	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0005634	nucleus	28073919.	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005829	cytosol	28073919.	IDA	Component
GO:0006400	tRNA modification	21873635.	IBA	Process
GO:0009982	pseudouridine synthase activity	21873635.	IBA	Function
GO:0009982	pseudouridine synthase activity	28073919.	IDA	Function
GO:1990481	mRNA pseudouridine synthesis	21873635.	IBA	Process
GO:1990481	mRNA pseudouridine synthesis	28073919.	IDA	Process