EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165916 (Gene tree)
Gene ID: 5702
Gene Symbol: PSMC3
Alias: TBP1|TBP-1
Full Name: proteasome 26S subunit, ATPase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,705 bases
Position: chr11:47,418,769-47,426,473
Accession: 9549
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21857920	Validation of endogenous control genes for gene expression studies on human ocular surface epithelium.	PLoS One	2011	Kulkarni B	doi: 10.1371/journal.pone.0022301

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000619920	PSMC3-213	1580	XM_017018026	ENSP00000481029	439 (aa)	XP_016873515	P17980
ENST00000531653	PSMC3-211	498	-	-	- (aa)	-	-
ENST00000530887	PSMC3-208	891	-	ENSP00000437291	52 (aa)	-	E9PMW0
ENST00000529500	PSMC3-206	563	-	-	- (aa)	-	-
ENST00000526993	PSMC3-203	580	-	ENSP00000435141	184 (aa)	-	E9PLG2
ENST00000528362	PSMC3-205	546	-	-	- (aa)	-	-
ENST00000602866	PSMC3-212	1373	-	ENSP00000473652	423 (aa)	-	R4GNH3
ENST00000527906	PSMC3-204	604	-	ENSP00000432103	37 (aa)	-	E9PS45
ENST00000530912	PSMC3-209	1390	-	ENSP00000433097	397 (aa)	-	E9PM69
ENST00000298852	PSMC3-201	1544	-	ENSP00000298852	439 (aa)	-	P17980
ENST00000531051	PSMC3-210	777	-	ENSP00000432970	257 (aa)	-	E9PN50
ENST00000530651	PSMC3-207	905	-	ENSP00000431144	301 (aa)	-	E9PMD8
ENST00000524447	PSMC3-202	935	-	ENSP00000433596	311 (aa)	-	E9PKD5

Gene Model

Click here to download ENSG00000165916's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165916	Serum Albumin	1E-7	23022100
ENSG00000165916	Body Height	2E-9	23563607
ENSG00000165916	Serum Albumin	8E-8	23022100

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165916	rs10838708	11	47419962	G	Height	23563607	[NR]	1.15	EFO_0004339
ENSG00000165916	rs2293579	11	47419207	A	Serum albumin level	23022100	[0.0060-0.0126] unit increase	0.0093	EFO_0004535
ENSG00000165916	rs2293579	11	47419207	A	Serum albumin level	23022100	[0.0055-0.0117] unit increase	0.0086	EFO_0004535
ENSG00000165916	rs2242511	11	47420113	T	Cognitive performance	30038396	[0.015-0.031] unit increase	0.0231	EFO_0008354
ENSG00000165916	rs10838708	11	47419962	G	Insomnia symptoms (never/rarely vs. usually)	30804566	[1.01-1.03]	1.02	EFO_0007876
ENSG00000165916	rs3781627	11	47419921	A	Neuroticism	30643256	[0.0074-0.0136] unit increase	0.010487369	EFO_0007660
ENSG00000165916	rs3781627	11	47419921	A	Depressive symptoms	30643256	[0.0047-0.0087] unit increase	0.006675154	EFO_0007006
ENSG00000165916	rs3781627	11	47419921	A	Life satisfaction	30643256	[0.0059-0.0112] unit increase	0.00852457	EFO_0007869
ENSG00000165916	rs3781627	11	47419921	A	Positive affect	30643256	[0.0056-0.0104] unit increase	0.00802266	EFO_0007869

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165916's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165916	PSMC3	89	41.152	WBGene00004502	rpt-2	84	44.275	Caenorhabditis_elegans
ENSG00000165916	PSMC3	92	42.145	WBGene00004503	rpt-3	92	42.145	Caenorhabditis_elegans
ENSG00000165916	PSMC3	75	48.684	WBGene00004501	rpt-1	70	48.684	Caenorhabditis_elegans
ENSG00000165916	PSMC3	90	45.119	ENSG00000100764	PSMC1	95	61.250	Homo_sapiens
ENSG00000165916	PSMC3	78	51.768	ENSG00000087191	PSMC5	88	48.169	Homo_sapiens
ENSG00000165916	PSMC3	75	49.013	ENSG00000161057	PSMC2	76	49.013	Homo_sapiens
ENSG00000165916	PSMC3	78	46.129	ENSG00000100519	PSMC6	93	46.774	Homo_sapiens
ENSG00000165916	PSMC3	75	51.839	YDL007W	RPT2	68	51.839	Saccharomyces_cerevisiae
ENSG00000165916	PSMC3	94	38.956	YGL048C	RPT6	81	47.463	Saccharomyces_cerevisiae
ENSG00000165916	PSMC3	74	48.148	YKL145W	RPT1	63	48.148	Saccharomyces_cerevisiae
ENSG00000165916	PSMC3	93	37.942	YDR394W	RPT3	85	38.961	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0000932	P-body	-	ISS	Component
GO:0001824	blastocyst development	-	IEA	Process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005515	protein binding	16763564.19490896.24255178.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	2194290.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	1429620.	ISS	Function
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0036402	proteasome-activating ATPase activity	-	IEA	Function
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0042802	identical protein binding	25416956.	IPI	Function
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0043921	modulation by host of viral transcription	2194290.8419915.	IDA	Process
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	19853614.	IDA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901800	positive regulation of proteasomal protein catabolic process	-	IEA	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component