EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000165997 (Gene tree)
Gene ID: 221079
Gene Symbol: ARL5B
Alias: ARL8
Full Name: ADP ribosylation factor like GTPase 5B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 22,305 bases
Position: chr10:18,659,335-18,681,639
Accession: 23052
RBP type: canonical RBP
Summary: ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000366487	MMR_HSR1	PF01926.23	2e-06	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27296148	Replication of Tobamovirus RNA.	Annu Rev Phytopathol	2016 Aug 4	Ishibashi K	doi: 10.1146/annurev-phyto-080615-100217
23658455	The resistance protein Tm-1 inhibits formation of a Tomato mosaic virus replication protein-host membrane protein complex.	J Virol	2013 Jul	Ishibashi K	doi: 10.1128/JVI.00743-13
22174675	A host small GTP-binding protein ARL8 plays crucial roles in tobamovirus RNA replication.	PLoS Pathog	2011 Dec	Nishikiori M	doi: 10.1371/journal.ppat.1002409

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000377275	ARL5B-201	7196	XM_005252400	ENSP00000366487	179 (aa)	XP_005252457	Q96KC2

Gene Model

Click here to download ENSG00000165997's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000165997	Hemoglobins	7.4699170927818E-6	17903294
ENSG00000165997	Hemoglobins	5.14544946779431E-6	17903294
ENSG00000165997	Hip	8.0804976604787E-5	17903296
ENSG00000165997	C-Reactive Protein	7.6520000E-005	-
ENSG00000165997	Death, Sudden, Cardiac	4E-7	21658281
ENSG00000165997	Coronary Artery Bypass	7E-6	26385043
ENSG00000165997	Atrial Fibrillation	7E-6	26385043

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000165997	rs10829156	10	18661626	?	Sudden cardiac arrest	21658281	[1.16-1.41]	1.28	EFO_0004278

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000165997's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000165997	ARL5B	100	96.089	ENSAPOG00000016146	arl8	100	96.089	Acanthochromis_polyacanthus
ENSG00000165997	ARL5B	100	98.889	ENSAMEG00000012973	ARL5B	99	98.889	Ailuropoda_melanoleuca
ENSG00000165997	ARL5B	100	86.592	ENSACIG00000016662	arl8	100	86.592	Amphilophus_citrinellus
ENSG00000165997	ARL5B	60	97.222	ENSAOCG00000024181	-	100	97.222	Amphiprion_ocellaris
ENSG00000165997	ARL5B	100	96.089	ENSAOCG00000020462	arl8	100	96.089	Amphiprion_ocellaris
ENSG00000165997	ARL5B	100	96.089	ENSAPEG00000015271	arl8	100	96.089	Amphiprion_percula
ENSG00000165997	ARL5B	92	95.152	ENSATEG00000004632	arl8	99	95.152	Anabas_testudineus
ENSG00000165997	ARL5B	100	99.441	ENSACAG00000005634	ARL5B	100	99.441	Anolis_carolinensis
ENSG00000165997	ARL5B	100	100.000	ENSANAG00000022959	ARL5B	99	100.000	Aotus_nancymaae
ENSG00000165997	ARL5B	100	95.531	ENSACLG00000000787	arl8	100	95.531	Astatotilapia_calliptera
ENSG00000165997	ARL5B	100	94.972	ENSAMXG00000010445	arl8	100	94.972	Astyanax_mexicanus
ENSG00000165997	ARL5B	100	100.000	ENSBTAG00000043964	ARL5B	99	100.000	Bos_taurus
ENSG00000165997	ARL5B	100	100.000	ENSCJAG00000039276	ARL5B	99	100.000	Callithrix_jacchus
ENSG00000165997	ARL5B	100	100.000	ENSCAFG00000004413	ARL5B	99	100.000	Canis_familiaris
ENSG00000165997	ARL5B	100	100.000	ENSCAFG00020012127	ARL5B	99	100.000	Canis_lupus_dingo
ENSG00000165997	ARL5B	100	100.000	ENSCHIG00000026796	ARL5B	99	100.000	Capra_hircus
ENSG00000165997	ARL5B	100	99.441	ENSTSYG00000026727	ARL5B	99	99.441	Carlito_syrichta
ENSG00000165997	ARL5B	91	100.000	ENSCPOG00000005856	ARL5B	100	100.000	Cavia_porcellus
ENSG00000165997	ARL5B	100	99.441	ENSCCAG00000035559	ARL5B	99	99.441	Cebus_capucinus
ENSG00000165997	ARL5B	100	100.000	ENSCATG00000032291	ARL5B	99	100.000	Cercocebus_atys
ENSG00000165997	ARL5B	100	100.000	ENSCLAG00000007016	ARL5B	100	100.000	Chinchilla_lanigera
ENSG00000165997	ARL5B	100	100.000	ENSCSAG00000012564	ARL5B	99	100.000	Chlorocebus_sabaeus
ENSG00000165997	ARL5B	100	97.765	ENSCPBG00000015064	ARL5B	100	97.765	Chrysemys_picta_bellii
ENSG00000165997	ARL5B	100	100.000	ENSCANG00000042699	ARL5B	99	100.000	Colobus_angolensis_palliatus
ENSG00000165997	ARL5B	100	100.000	ENSCGRG00001016642	Arl5b	99	100.000	Cricetulus_griseus_chok1gshd
ENSG00000165997	ARL5B	93	98.795	ENSCGRG00000017854	Arl5b	100	100.000	Cricetulus_griseus_crigri
ENSG00000165997	ARL5B	100	94.972	ENSCSEG00000000522	arl8	100	94.972	Cynoglossus_semilaevis
ENSG00000165997	ARL5B	100	96.089	ENSCVAG00000006913	arl8	100	96.089	Cyprinodon_variegatus
ENSG00000165997	ARL5B	100	96.089	ENSDARG00000094709	arl8	100	96.089	Danio_rerio
ENSG00000165997	ARL5B	100	98.324	ENSDNOG00000010331	ARL5B	100	98.324	Dasypus_novemcinctus
ENSG00000165997	ARL5B	94	98.214	ENSDORG00000027820	Arl5b	98	98.214	Dipodomys_ordii
ENSG00000165997	ARL5B	98	72.159	FBgn0035866	Arl5	98	72.159	Drosophila_melanogaster
ENSG00000165997	ARL5B	99	86.517	ENSEBUG00000016214	arl8	99	86.517	Eptatretus_burgeri
ENSG00000165997	ARL5B	100	99.441	ENSEASG00005019941	ARL5B	99	99.441	Equus_asinus_asinus
ENSG00000165997	ARL5B	100	99.441	ENSECAG00000009195	ARL5B	99	99.441	Equus_caballus
ENSG00000165997	ARL5B	100	71.508	ENSEEUG00000004551	ARL5B	100	71.508	Erinaceus_europaeus
ENSG00000165997	ARL5B	100	94.413	ENSELUG00000022956	arl8	100	94.413	Esox_lucius
ENSG00000165997	ARL5B	100	100.000	ENSFCAG00000015495	ARL5B	99	100.000	Felis_catus
ENSG00000165997	ARL5B	91	99.387	ENSFDAG00000010860	ARL5B	100	99.387	Fukomys_damarensis
ENSG00000165997	ARL5B	100	98.324	ENSGALG00000008557	ARL5B	100	98.324	Gallus_gallus
ENSG00000165997	ARL5B	100	95.531	ENSGACG00000004052	arl8	100	95.531	Gasterosteus_aculeatus
ENSG00000165997	ARL5B	92	97.561	ENSGAGG00000011435	ARL5B	65	97.561	Gopherus_agassizii
ENSG00000165997	ARL5B	100	95.531	ENSHBUG00000009050	arl8	100	96.341	Haplochromis_burtoni
ENSG00000165997	ARL5B	100	99.441	ENSHGLG00000007428	ARL5B	100	99.390	Heterocephalus_glaber_female
ENSG00000165997	ARL5B	93	98.795	ENSHGLG00100016910	ARL5B	99	98.795	Heterocephalus_glaber_male
ENSG00000165997	ARL5B	92	95.122	ENSHCOG00000015779	arl8	95	93.939	Hippocampus_comes
ENSG00000165997	ARL5B	100	95.531	ENSIPUG00000006168	arl5b	100	96.341	Ictalurus_punctatus
ENSG00000165997	ARL5B	100	100.000	ENSSTOG00000027859	ARL5B	99	100.000	Ictidomys_tridecemlineatus
ENSG00000165997	ARL5B	91	100.000	ENSJJAG00000006129	Arl5b	100	100.000	Jaculus_jaculus
ENSG00000165997	ARL5B	100	96.089	ENSKMAG00000013576	arl8	100	96.089	Kryptolebias_marmoratus
ENSG00000165997	ARL5B	100	94.972	ENSLBEG00000017173	arl8	100	94.972	Labrus_bergylta
ENSG00000165997	ARL5B	92	97.561	ENSLACG00000015068	ARL5B	90	97.561	Latimeria_chalumnae
ENSG00000165997	ARL5B	100	95.531	ENSLOCG00000010851	arl8	100	95.531	Lepisosteus_oculatus
ENSG00000165997	ARL5B	100	99.444	ENSLAFG00000001487	ARL5B	99	99.444	Loxodonta_africana
ENSG00000165997	ARL5B	100	100.000	ENSMFAG00000036453	ARL5B	99	100.000	Macaca_fascicularis
ENSG00000165997	ARL5B	100	100.000	ENSMMUG00000007453	ARL5B	99	100.000	Macaca_mulatta
ENSG00000165997	ARL5B	100	100.000	ENSMNEG00000006331	ARL5B	99	100.000	Macaca_nemestrina
ENSG00000165997	ARL5B	100	100.000	ENSMLEG00000029794	ARL5B	99	100.000	Mandrillus_leucophaeus
ENSG00000165997	ARL5B	100	95.531	ENSMAMG00000004884	arl8	100	95.531	Mastacembelus_armatus
ENSG00000165997	ARL5B	100	95.531	ENSMZEG00005000976	arl8	100	95.531	Maylandia_zebra
ENSG00000165997	ARL5B	99	92.778	ENSMGAG00000007409	ARL5B	99	92.778	Meleagris_gallopavo
ENSG00000165997	ARL5B	100	100.000	ENSMAUG00000003245	Arl5b	99	100.000	Mesocricetus_auratus
ENSG00000165997	ARL5B	100	100.000	ENSMICG00000006011	ARL5B	99	100.000	Microcebus_murinus
ENSG00000165997	ARL5B	100	100.000	ENSMOCG00000013705	Arl5b	99	100.000	Microtus_ochrogaster
ENSG00000165997	ARL5B	100	95.531	ENSMMOG00000004265	arl8	99	95.531	Mola_mola
ENSG00000165997	ARL5B	99	98.876	ENSMODG00000009449	ARL5B	99	98.876	Monodelphis_domestica
ENSG00000165997	ARL5B	100	94.972	ENSMALG00000020370	ARL5B	100	94.972	Monopterus_albus
ENSG00000165997	ARL5B	100	100.000	MGP_CAROLIEiJ_G0023197	Arl5b	99	100.000	Mus_caroli
ENSG00000165997	ARL5B	100	100.000	ENSMUSG00000017418	Arl5b	99	100.000	Mus_musculus
ENSG00000165997	ARL5B	100	100.000	MGP_PahariEiJ_G0024654	Arl5b	99	100.000	Mus_pahari
ENSG00000165997	ARL5B	100	100.000	MGP_SPRETEiJ_G0024113	Arl5b	99	100.000	Mus_spretus
ENSG00000165997	ARL5B	100	100.000	ENSMPUG00000011906	ARL5B	99	100.000	Mustela_putorius_furo
ENSG00000165997	ARL5B	100	94.444	ENSMLUG00000001833	ARL5B	99	94.444	Myotis_lucifugus
ENSG00000165997	ARL5B	100	100.000	ENSNGAG00000006384	Arl5b	99	100.000	Nannospalax_galili
ENSG00000165997	ARL5B	100	95.531	ENSNBRG00000015782	arl8	99	95.531	Neolamprologus_brichardi
ENSG00000165997	ARL5B	100	100.000	ENSNLEG00000027383	ARL5B	99	100.000	Nomascus_leucogenys
ENSG00000165997	ARL5B	99	98.315	ENSMEUG00000007929	ARL5B	99	98.315	Notamacropus_eugenii
ENSG00000165997	ARL5B	100	100.000	ENSODEG00000013924	ARL5B	99	100.000	Octodon_degus
ENSG00000165997	ARL5B	100	95.531	ENSONIG00000006036	arl8	100	95.531	Oreochromis_niloticus
ENSG00000165997	ARL5B	100	95.531	ENSOANG00000005704	ARL5B	100	95.531	Ornithorhynchus_anatinus
ENSG00000165997	ARL5B	100	100.000	ENSOCUG00000014876	ARL5B	99	100.000	Oryctolagus_cuniculus
ENSG00000165997	ARL5B	100	94.972	ENSORLG00000010847	arl8	100	94.972	Oryzias_latipes
ENSG00000165997	ARL5B	100	94.413	ENSORLG00020009947	arl8	100	94.413	Oryzias_latipes_hni
ENSG00000165997	ARL5B	100	94.972	ENSORLG00015009927	arl8	100	94.972	Oryzias_latipes_hsok
ENSG00000165997	ARL5B	100	94.972	ENSOMEG00000003634	arl8	100	94.972	Oryzias_melastigma
ENSG00000165997	ARL5B	63	99.115	ENSOGAG00000006248	ARL5B	100	99.115	Otolemur_garnettii
ENSG00000165997	ARL5B	100	100.000	ENSOARG00000017814	ARL5B	100	100.000	Ovis_aries
ENSG00000165997	ARL5B	100	100.000	ENSPPAG00000014300	ARL5B	99	100.000	Pan_paniscus
ENSG00000165997	ARL5B	100	100.000	ENSPPRG00000007093	ARL5B	100	100.000	Panthera_pardus
ENSG00000165997	ARL5B	100	100.000	ENSPTIG00000011231	ARL5B	100	100.000	Panthera_tigris_altaica
ENSG00000165997	ARL5B	100	100.000	ENSPTRG00000002341	ARL5B	99	100.000	Pan_troglodytes
ENSG00000165997	ARL5B	100	100.000	ENSPANG00000023140	ARL5B	99	100.000	Papio_anubis
ENSG00000165997	ARL5B	92	93.293	ENSPKIG00000011377	ARL5B	85	93.293	Paramormyrops_kingsleyae
ENSG00000165997	ARL5B	100	96.648	ENSPSIG00000014201	ARL5B	100	97.110	Pelodiscus_sinensis
ENSG00000165997	ARL5B	100	96.089	ENSPMGG00000002868	arl8	100	96.089	Periophthalmus_magnuspinnatus
ENSG00000165997	ARL5B	100	100.000	ENSPEMG00000012290	Arl5b	99	100.000	Peromyscus_maniculatus_bairdii
ENSG00000165997	ARL5B	100	82.682	ENSPMAG00000006880	arl8	100	82.682	Petromyzon_marinus
ENSG00000165997	ARL5B	92	98.171	ENSPCIG00000008947	ARL5B	97	98.171	Phascolarctos_cinereus
ENSG00000165997	ARL5B	100	96.089	ENSPFOG00000016633	arl8	99	96.089	Poecilia_formosa
ENSG00000165997	ARL5B	100	96.089	ENSPLAG00000021807	arl8	100	96.089	Poecilia_latipinna
ENSG00000165997	ARL5B	100	96.089	ENSPMEG00000022283	arl8	100	96.089	Poecilia_mexicana
ENSG00000165997	ARL5B	100	96.089	ENSPREG00000008262	arl8	100	96.089	Poecilia_reticulata
ENSG00000165997	ARL5B	100	84.358	ENSPPYG00000002132	ARL5B	100	84.358	Pongo_abelii
ENSG00000165997	ARL5B	100	100.000	ENSPCOG00000016365	ARL5B	99	100.000	Propithecus_coquereli
ENSG00000165997	ARL5B	100	99.441	ENSPVAG00000006330	ARL5B	100	99.441	Pteropus_vampyrus
ENSG00000165997	ARL5B	100	98.883	ENSRNOG00000018714	Arl5b	99	98.883	Rattus_norvegicus
ENSG00000165997	ARL5B	100	100.000	ENSRBIG00000034745	ARL5B	99	100.000	Rhinopithecus_bieti
ENSG00000165997	ARL5B	100	100.000	ENSRROG00000035354	ARL5B	99	100.000	Rhinopithecus_roxellana
ENSG00000165997	ARL5B	100	100.000	ENSSBOG00000029492	ARL5B	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000165997	ARL5B	94	97.024	ENSSHAG00000007585	ARL5B	88	97.024	Sarcophilus_harrisii
ENSG00000165997	ARL5B	100	93.296	ENSSFOG00015002122	arl5b	100	93.296	Scleropages_formosus
ENSG00000165997	ARL5B	100	95.531	ENSSMAG00000011578	arl8	100	95.531	Scophthalmus_maximus
ENSG00000165997	ARL5B	100	96.089	ENSSDUG00000007515	ARL5B	100	96.089	Seriola_dumerili
ENSG00000165997	ARL5B	100	96.089	ENSSLDG00000021379	ARL5B	100	96.089	Seriola_lalandi_dorsalis
ENSG00000165997	ARL5B	91	100.000	ENSSARG00000013610	ARL5B	100	100.000	Sorex_araneus
ENSG00000165997	ARL5B	100	98.324	ENSSPUG00000014073	ARL5B	100	98.324	Sphenodon_punctatus
ENSG00000165997	ARL5B	100	96.089	ENSSPAG00000012402	arl8	100	96.951	Stegastes_partitus
ENSG00000165997	ARL5B	100	100.000	ENSSSCG00000031456	ARL5B	99	100.000	Sus_scrofa
ENSG00000165997	ARL5B	68	92.623	ENSTGUG00000016302	-	100	92.623	Taeniopygia_guttata
ENSG00000165997	ARL5B	92	98.780	ENSTGUG00000001236	-	99	98.780	Taeniopygia_guttata
ENSG00000165997	ARL5B	100	95.531	ENSTRUG00000020453	arl8	100	95.531	Takifugu_rubripes
ENSG00000165997	ARL5B	100	95.000	ENSTNIG00000005852	arl8	99	95.000	Tetraodon_nigroviridis
ENSG00000165997	ARL5B	91	97.546	ENSTBEG00000004162	ARL5B	100	97.546	Tupaia_belangeri
ENSG00000165997	ARL5B	100	100.000	ENSTTRG00000008411	ARL5B	100	100.000	Tursiops_truncatus
ENSG00000165997	ARL5B	100	100.000	ENSUAMG00000014901	ARL5B	99	100.000	Ursus_americanus
ENSG00000165997	ARL5B	100	100.000	ENSUMAG00000013390	ARL5B	99	100.000	Ursus_maritimus
ENSG00000165997	ARL5B	99	100.000	ENSVVUG00000003807	ARL5B	99	100.000	Vulpes_vulpes
ENSG00000165997	ARL5B	100	94.413	ENSXETG00000022765	arl5b	99	94.413	Xenopus_tropicalis
ENSG00000165997	ARL5B	99	90.960	ENSXCOG00000011539	arl8	81	90.960	Xiphophorus_couchianus
ENSG00000165997	ARL5B	100	96.089	ENSXMAG00000002296	arl8	100	96.089	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005802	trans-Golgi network	21873635.	IBA	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0016192	vesicle-mediated transport	21873635.	IBA	Process
GO:1903292	protein localization to Golgi membrane	21873635.	IBA	Process
GO:1903292	protein localization to Golgi membrane	25795912.	IMP	Process