EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166166 (Gene tree)
Gene ID: 115708
Gene Symbol: TRMT61A
Alias: FLJ40452|GCD14|Gcd14p|hTRM61|C14orf172
Full Name: tRNA methyltransferase 61A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 7,902 bases
Position: chr14:103,529,172-103,537,073
Accession: 23790
RBP type: canonical RBP
Summary: (TRNA Methyltransferase 61A) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity. An important paralog of this gene is TRMT61B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000374399	GCD14	PF08704.10	3.6e-104	1	1
ENSP00000299202	GCD14	PF08704.10	4.5e-74	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000299202	TRMT61A-201	2827	-	ENSP00000299202	191 (aa)	-	H0Y2Q1
ENST00000389749	TRMT61A-202	3229	-	ENSP00000374399	289 (aa)	-	Q96FX7

Gene Model

Click here to download ENSG00000166166's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000166166	rs911555	14	103533010	C	Intelligence (MTAG)	29326435	[0.013-0.025] unit decrease	0.01857964	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166166's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166166	TRMT61A	99	70.990	ENSAPOG00000004599	trmt61a	99	70.990	Acanthochromis_polyacanthus
ENSG00000166166	TRMT61A	100	95.156	ENSAMEG00000018154	TRMT61A	100	95.156	Ailuropoda_melanoleuca
ENSG00000166166	TRMT61A	99	66.327	ENSACIG00000023818	trmt61a	99	66.327	Amphilophus_citrinellus
ENSG00000166166	TRMT61A	99	69.966	ENSAOCG00000016986	trmt61a	99	69.966	Amphiprion_ocellaris
ENSG00000166166	TRMT61A	99	69.625	ENSAPEG00000003541	trmt61a	99	69.625	Amphiprion_percula
ENSG00000166166	TRMT61A	99	67.667	ENSATEG00000017286	trmt61a	99	67.667	Anabas_testudineus
ENSG00000166166	TRMT61A	99	67.647	ENSAPLG00000011344	TRMT61A	98	67.647	Anas_platyrhynchos
ENSG00000166166	TRMT61A	99	71.972	ENSACAG00000000860	TRMT61A	99	71.972	Anolis_carolinensis
ENSG00000166166	TRMT61A	100	98.270	ENSANAG00000020615	TRMT61A	100	98.270	Aotus_nancymaae
ENSG00000166166	TRMT61A	99	66.327	ENSACLG00000010779	trmt61a	99	66.327	Astatotilapia_calliptera
ENSG00000166166	TRMT61A	100	64.935	ENSAMXG00000037952	trmt61a	100	64.935	Astyanax_mexicanus
ENSG00000166166	TRMT61A	100	93.772	ENSBTAG00000031327	TRMT61A	100	93.772	Bos_taurus
ENSG00000166166	TRMT61A	81	49.576	WBGene00012192	W02A11.1	75	49.576	Caenorhabditis_elegans
ENSG00000166166	TRMT61A	100	98.616	ENSCJAG00000017117	TRMT61A	100	98.616	Callithrix_jacchus
ENSG00000166166	TRMT61A	100	94.810	ENSCAFG00000029557	TRMT61A	100	94.810	Canis_familiaris
ENSG00000166166	TRMT61A	100	95.848	ENSCAFG00020008720	TRMT61A	100	95.848	Canis_lupus_dingo
ENSG00000166166	TRMT61A	100	93.772	ENSCHIG00000021168	TRMT61A	100	93.772	Capra_hircus
ENSG00000166166	TRMT61A	100	93.426	ENSTSYG00000025609	TRMT61A	100	93.426	Carlito_syrichta
ENSG00000166166	TRMT61A	99	94.444	ENSCAPG00000003680	TRMT61A	99	94.444	Cavia_aperea
ENSG00000166166	TRMT61A	99	94.444	ENSCPOG00000033200	TRMT61A	99	94.444	Cavia_porcellus
ENSG00000166166	TRMT61A	99	98.611	ENSCCAG00000021969	TRMT61A	99	98.611	Cebus_capucinus
ENSG00000166166	TRMT61A	100	98.616	ENSCATG00000000028	TRMT61A	100	98.616	Cercocebus_atys
ENSG00000166166	TRMT61A	100	94.464	ENSCLAG00000007887	TRMT61A	100	94.464	Chinchilla_lanigera
ENSG00000166166	TRMT61A	100	97.578	ENSCSAG00000010059	TRMT61A	100	97.578	Chlorocebus_sabaeus
ENSG00000166166	TRMT61A	69	94.472	ENSCHOG00000010189	TRMT61A	100	94.472	Choloepus_hoffmanni
ENSG00000166166	TRMT61A	99	69.281	ENSCPBG00000020287	TRMT61A	99	69.281	Chrysemys_picta_bellii
ENSG00000166166	TRMT61A	100	51.148	ENSCING00000018222	-	100	51.148	Ciona_intestinalis
ENSG00000166166	TRMT61A	89	55.039	ENSCSAVG00000006556	-	90	55.039	Ciona_savignyi
ENSG00000166166	TRMT61A	100	98.270	ENSCANG00000031243	TRMT61A	100	98.270	Colobus_angolensis_palliatus
ENSG00000166166	TRMT61A	100	91.379	ENSCGRG00001020952	Trmt61a	100	91.379	Cricetulus_griseus_chok1gshd
ENSG00000166166	TRMT61A	100	91.379	ENSCGRG00000005700	Trmt61a	100	91.379	Cricetulus_griseus_crigri
ENSG00000166166	TRMT61A	99	67.797	ENSCSEG00000013165	trmt61a	99	67.797	Cynoglossus_semilaevis
ENSG00000166166	TRMT61A	99	66.776	ENSCVAG00000018399	trmt61a	99	66.776	Cyprinodon_variegatus
ENSG00000166166	TRMT61A	99	67.785	ENSDARG00000008480	trmt61a	100	75.419	Danio_rerio
ENSG00000166166	TRMT61A	100	65.461	ENSDNOG00000035967	TRMT61A	100	66.118	Dasypus_novemcinctus
ENSG00000166166	TRMT61A	100	92.734	ENSDORG00000014905	Trmt61a	100	92.734	Dipodomys_ordii
ENSG00000166166	TRMT61A	100	46.349	FBgn0039407	CG14544	99	46.349	Drosophila_melanogaster
ENSG00000166166	TRMT61A	69	85.930	ENSETEG00000008670	TRMT61A	100	85.930	Echinops_telfairi
ENSG00000166166	TRMT61A	93	57.812	ENSEBUG00000005170	-	66	51.064	Eptatretus_burgeri
ENSG00000166166	TRMT61A	100	95.502	ENSEASG00005004127	TRMT61A	100	95.502	Equus_asinus_asinus
ENSG00000166166	TRMT61A	100	95.502	ENSECAG00000012599	TRMT61A	100	95.502	Equus_caballus
ENSG00000166166	TRMT61A	99	71.672	ENSELUG00000012611	trmt61a	99	71.672	Esox_lucius
ENSG00000166166	TRMT61A	100	95.502	ENSFCAG00000030816	TRMT61A	100	95.502	Felis_catus
ENSG00000166166	TRMT61A	99	67.647	ENSFALG00000002855	TRMT61A	99	67.647	Ficedula_albicollis
ENSG00000166166	TRMT61A	100	92.042	ENSFDAG00000007454	TRMT61A	100	92.042	Fukomys_damarensis
ENSG00000166166	TRMT61A	99	66.447	ENSFHEG00000010814	trmt61a	99	66.118	Fundulus_heteroclitus
ENSG00000166166	TRMT61A	84	74.380	ENSGMOG00000011395	trmt61a	100	74.380	Gadus_morhua
ENSG00000166166	TRMT61A	99	67.647	ENSGALG00000011522	TRMT61A	99	67.647	Gallus_gallus
ENSG00000166166	TRMT61A	99	66.777	ENSGAFG00000011815	trmt61a	99	67.442	Gambusia_affinis
ENSG00000166166	TRMT61A	99	69.697	ENSGACG00000004779	trmt61a	99	69.697	Gasterosteus_aculeatus
ENSG00000166166	TRMT61A	99	69.281	ENSGAGG00000015121	TRMT61A	99	69.281	Gopherus_agassizii
ENSG00000166166	TRMT61A	100	100.000	ENSGGOG00000007401	TRMT61A	100	100.000	Gorilla_gorilla
ENSG00000166166	TRMT61A	99	66.667	ENSHBUG00000022709	trmt61a	99	66.667	Haplochromis_burtoni
ENSG00000166166	TRMT61A	100	92.042	ENSHGLG00000005604	TRMT61A	100	92.042	Heterocephalus_glaber_female
ENSG00000166166	TRMT61A	100	92.042	ENSHGLG00100008206	TRMT61A	100	92.042	Heterocephalus_glaber_male
ENSG00000166166	TRMT61A	99	68.881	ENSHCOG00000000889	trmt61a	98	68.881	Hippocampus_comes
ENSG00000166166	TRMT61A	100	67.101	ENSIPUG00000003613	trmt61a	100	67.101	Ictalurus_punctatus
ENSG00000166166	TRMT61A	100	92.517	ENSSTOG00000009792	TRMT61A	100	92.517	Ictidomys_tridecemlineatus
ENSG00000166166	TRMT61A	100	92.388	ENSJJAG00000000428	Trmt61a	100	92.388	Jaculus_jaculus
ENSG00000166166	TRMT61A	99	68.621	ENSKMAG00000018005	trmt61a	99	68.621	Kryptolebias_marmoratus
ENSG00000166166	TRMT61A	99	68.243	ENSLBEG00000004835	trmt61a	99	68.243	Labrus_bergylta
ENSG00000166166	TRMT61A	99	66.667	ENSLACG00000010801	TRMT61A	99	66.667	Latimeria_chalumnae
ENSG00000166166	TRMT61A	99	72.014	ENSLOCG00000009920	trmt61a	99	72.355	Lepisosteus_oculatus
ENSG00000166166	TRMT61A	100	91.349	ENSLAFG00000014714	TRMT61A	100	91.349	Loxodonta_africana
ENSG00000166166	TRMT61A	100	98.616	ENSMFAG00000032239	TRMT61A	100	98.616	Macaca_fascicularis
ENSG00000166166	TRMT61A	100	97.578	ENSMMUG00000007673	TRMT61A	100	97.578	Macaca_mulatta
ENSG00000166166	TRMT61A	100	98.616	ENSMNEG00000036125	TRMT61A	100	98.616	Macaca_nemestrina
ENSG00000166166	TRMT61A	100	98.616	ENSMLEG00000027585	TRMT61A	100	98.616	Mandrillus_leucophaeus
ENSG00000166166	TRMT61A	99	69.000	ENSMAMG00000000062	trmt61a	99	69.000	Mastacembelus_armatus
ENSG00000166166	TRMT61A	99	66.327	ENSMZEG00005001914	trmt61a	99	66.327	Maylandia_zebra
ENSG00000166166	TRMT61A	99	66.667	ENSMGAG00000013412	TRMT61A	99	66.667	Meleagris_gallopavo
ENSG00000166166	TRMT61A	100	92.069	ENSMAUG00000007728	Trmt61a	100	92.069	Mesocricetus_auratus
ENSG00000166166	TRMT61A	100	95.156	ENSMICG00000047207	TRMT61A	100	95.156	Microcebus_murinus
ENSG00000166166	TRMT61A	100	91.379	ENSMOCG00000014726	Trmt61a	100	91.379	Microtus_ochrogaster
ENSG00000166166	TRMT61A	99	72.028	ENSMMOG00000014772	trmt61a	99	72.028	Mola_mola
ENSG00000166166	TRMT61A	99	74.913	ENSMODG00000013507	TRMT61A	69	74.913	Monodelphis_domestica
ENSG00000166166	TRMT61A	96	65.990	ENSMALG00000021531	trmt61a	74	65.500	Monopterus_albus
ENSG00000166166	TRMT61A	100	92.069	MGP_CAROLIEiJ_G0018137	Trmt61a	100	92.069	Mus_caroli
ENSG00000166166	TRMT61A	100	91.034	ENSMUSG00000060950	Trmt61a	100	95.652	Mus_musculus
ENSG00000166166	TRMT61A	100	92.414	MGP_PahariEiJ_G0029894	Trmt61a	100	92.414	Mus_pahari
ENSG00000166166	TRMT61A	100	91.379	MGP_SPRETEiJ_G0018986	Trmt61a	100	91.379	Mus_spretus
ENSG00000166166	TRMT61A	100	93.772	ENSMPUG00000002358	TRMT61A	100	93.772	Mustela_putorius_furo
ENSG00000166166	TRMT61A	100	92.069	ENSNGAG00000021119	Trmt61a	100	92.069	Nannospalax_galili
ENSG00000166166	TRMT61A	99	67.347	ENSNBRG00000023686	trmt61a	99	67.347	Neolamprologus_brichardi
ENSG00000166166	TRMT61A	100	72.664	ENSNLEG00000016202	-	100	72.664	Nomascus_leucogenys
ENSG00000166166	TRMT61A	97	77.936	ENSMEUG00000005233	TRMT61A	100	77.936	Notamacropus_eugenii
ENSG00000166166	TRMT61A	90	91.860	ENSOPRG00000009039	TRMT61A	97	91.860	Ochotona_princeps
ENSG00000166166	TRMT61A	100	93.772	ENSODEG00000001775	TRMT61A	100	93.772	Octodon_degus
ENSG00000166166	TRMT61A	99	67.347	ENSONIG00000012420	trmt61a	99	67.347	Oreochromis_niloticus
ENSG00000166166	TRMT61A	93	69.110	ENSOANG00000000785	-	99	69.110	Ornithorhynchus_anatinus
ENSG00000166166	TRMT61A	100	95.502	ENSOCUG00000022502	TRMT61A	100	95.502	Oryctolagus_cuniculus
ENSG00000166166	TRMT61A	99	69.463	ENSORLG00000017903	trmt61a	99	69.463	Oryzias_latipes
ENSG00000166166	TRMT61A	99	69.799	ENSORLG00020013741	trmt61a	99	69.799	Oryzias_latipes_hni
ENSG00000166166	TRMT61A	99	69.463	ENSORLG00015010153	trmt61a	91	69.463	Oryzias_latipes_hsok
ENSG00000166166	TRMT61A	99	68.350	ENSOMEG00000003744	-	99	68.350	Oryzias_melastigma
ENSG00000166166	TRMT61A	100	94.464	ENSOGAG00000027762	TRMT61A	100	94.464	Otolemur_garnettii
ENSG00000166166	TRMT61A	62	96.629	ENSOARG00000005895	TRMT61A	92	96.629	Ovis_aries
ENSG00000166166	TRMT61A	100	100.000	ENSPPAG00000027799	TRMT61A	100	100.000	Pan_paniscus
ENSG00000166166	TRMT61A	100	95.502	ENSPPRG00000009410	TRMT61A	100	95.502	Panthera_pardus
ENSG00000166166	TRMT61A	69	97.990	ENSPTIG00000012664	TRMT61A	69	97.990	Panthera_tigris_altaica
ENSG00000166166	TRMT61A	100	100.000	ENSPTRG00000006757	TRMT61A	100	100.000	Pan_troglodytes
ENSG00000166166	TRMT61A	100	98.270	ENSPANG00000007028	TRMT61A	100	98.270	Papio_anubis
ENSG00000166166	TRMT61A	99	68.581	ENSPKIG00000019170	-	99	68.581	Paramormyrops_kingsleyae
ENSG00000166166	TRMT61A	99	69.608	ENSPSIG00000015186	TRMT61A	99	69.608	Pelodiscus_sinensis
ENSG00000166166	TRMT61A	99	67.110	ENSPMGG00000011374	trmt61a	99	67.110	Periophthalmus_magnuspinnatus
ENSG00000166166	TRMT61A	100	91.034	ENSPEMG00000023413	Trmt61a	100	91.034	Peromyscus_maniculatus_bairdii
ENSG00000166166	TRMT61A	99	66.558	ENSPMAG00000009190	TRMT61A	99	66.558	Petromyzon_marinus
ENSG00000166166	TRMT61A	69	84.500	ENSPCIG00000011257	-	67	84.500	Phascolarctos_cinereus
ENSG00000166166	TRMT61A	99	67.893	ENSPFOG00000007249	trmt61a	99	68.227	Poecilia_formosa
ENSG00000166166	TRMT61A	99	67.559	ENSPLAG00000013604	trmt61a	99	67.893	Poecilia_latipinna
ENSG00000166166	TRMT61A	99	68.562	ENSPMEG00000006985	trmt61a	99	68.562	Poecilia_mexicana
ENSG00000166166	TRMT61A	99	67.442	ENSPREG00000005313	trmt61a	99	67.893	Poecilia_reticulata
ENSG00000166166	TRMT61A	98	99.296	ENSPPYG00000006172	-	72	99.296	Pongo_abelii
ENSG00000166166	TRMT61A	97	90.391	ENSPCAG00000010827	TRMT61A	100	90.391	Procavia_capensis
ENSG00000166166	TRMT61A	100	95.848	ENSPCOG00000028487	TRMT61A	100	95.848	Propithecus_coquereli
ENSG00000166166	TRMT61A	99	66.667	ENSPNYG00000016989	trmt61a	99	66.667	Pundamilia_nyererei
ENSG00000166166	TRMT61A	100	65.461	ENSPNAG00000029500	trmt61a	100	65.461	Pygocentrus_nattereri
ENSG00000166166	TRMT61A	100	92.069	ENSRNOG00000011398	Trmt61a	100	92.069	Rattus_norvegicus
ENSG00000166166	TRMT61A	100	97.924	ENSRBIG00000042669	TRMT61A	100	97.924	Rhinopithecus_bieti
ENSG00000166166	TRMT61A	100	97.924	ENSRROG00000042448	TRMT61A	100	97.924	Rhinopithecus_roxellana
ENSG00000166166	TRMT61A	83	39.924	YJL125C	GCD14	68	39.924	Saccharomyces_cerevisiae
ENSG00000166166	TRMT61A	100	95.502	ENSSBOG00000022999	TRMT61A	100	95.502	Saimiri_boliviensis_boliviensis
ENSG00000166166	TRMT61A	69	83.500	ENSSHAG00000016357	TRMT61A	99	83.500	Sarcophilus_harrisii
ENSG00000166166	TRMT61A	99	69.536	ENSSFOG00015013951	trmt61a	99	69.536	Scleropages_formosus
ENSG00000166166	TRMT61A	99	69.463	ENSSMAG00000005682	trmt61a	99	69.463	Scophthalmus_maximus
ENSG00000166166	TRMT61A	99	65.781	ENSSDUG00000004840	trmt61a	99	65.781	Seriola_dumerili
ENSG00000166166	TRMT61A	99	66.777	ENSSLDG00000014160	trmt61a	99	66.777	Seriola_lalandi_dorsalis
ENSG00000166166	TRMT61A	99	68.301	ENSSPUG00000004293	TRMT61A	99	68.301	Sphenodon_punctatus
ENSG00000166166	TRMT61A	99	70.990	ENSSPAG00000017259	trmt61a	99	70.990	Stegastes_partitus
ENSG00000166166	TRMT61A	100	94.464	ENSSSCG00000034738	TRMT61A	100	94.464	Sus_scrofa
ENSG00000166166	TRMT61A	99	70.370	ENSTGUG00000012865	-	100	70.370	Taeniopygia_guttata
ENSG00000166166	TRMT61A	99	70.169	ENSTRUG00000007942	trmt61a	99	70.169	Takifugu_rubripes
ENSG00000166166	TRMT61A	99	71.080	ENSTNIG00000012391	trmt61a	99	71.080	Tetraodon_nigroviridis
ENSG00000166166	TRMT61A	98	92.933	ENSTTRG00000006456	TRMT61A	91	92.933	Tursiops_truncatus
ENSG00000166166	TRMT61A	100	94.810	ENSUAMG00000012092	TRMT61A	81	94.810	Ursus_americanus
ENSG00000166166	TRMT61A	84	97.942	ENSUMAG00000024893	TRMT61A	69	97.942	Ursus_maritimus
ENSG00000166166	TRMT61A	100	95.848	ENSVVUG00000000754	TRMT61A	100	95.848	Vulpes_vulpes
ENSG00000166166	TRMT61A	99	66.445	ENSXETG00000026907	trmt61a	99	66.445	Xenopus_tropicalis
ENSG00000166166	TRMT61A	92	64.211	ENSXCOG00000004760	trmt61a	90	59.535	Xiphophorus_couchianus
ENSG00000166166	TRMT61A	99	67.442	ENSXMAG00000018447	trmt61a	99	67.442	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006400	tRNA modification	-	TAS	Process
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	21873635.	IBA	Function
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0031515	tRNA (m1A) methyltransferase complex	21873635.	IBA	Component
GO:0061953	mRNA (adenine-N1-)-methyltransferase activity	29072297.29107537.	IDA	Function
GO:0080009	mRNA methylation	29072297.29107537.	IDA	Process