EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166197 (Gene tree)
Gene ID: 9221
Gene Symbol: NOLC1
Alias: P130|KIAA0035|NOPP140|NOPP130
Full Name: nucleolar and coiled-body phosphoprotein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 11,696 bases
Position: chr10:102,152,176-102,163,871
Accession: 15608
RBP type: canonical RBP
Summary: (Nucleolar And Coiled-Body Phosphoprotein 1) is a Protein Coding gene. Diseases associated with NOLC1 include Treacher Collins Syndrome 1 and Noonan Syndrome 1. Gene Ontology (GO) annotations related to this gene include GTP binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000474710	SRP40_C	PF05022.12	1.9e-27	1	1
ENSP00000475080	SRP40_C	PF05022.12	1.9e-27	1	1
ENSP00000359024	SRP40_C	PF05022.12	1.9e-27	1	1
ENSP00000385410	SRP40_C	PF05022.12	1.9e-27	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
7798307	NAP57, a mammalian nucleolar protein with a putative homolog in yeast and bacteria.	J Cell Biol	1994 Dec	Meier UT	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461421	NOLC1-203	777	-	ENSP00000473927	258 (aa)	-	S4R349
ENST00000488254	NOLC1-207	2441	-	ENSP00000475080	700 (aa)	-	Q14978
ENST00000464969	NOLC1-204	2288	-	ENSP00000473910	73 (aa)	-	S4R341
ENST00000476468	NOLC1-205	844	-	ENSP00000474140	281 (aa)	-	S4R3C2
ENST00000603946	NOLC1-208	3217	-	ENSP00000474924	46 (aa)	-	S4R402
ENST00000370007	NOLC1-201	3727	-	ENSP00000359024	708 (aa)	-	A0A0A0MRM9
ENST00000477977	NOLC1-206	660	-	-	- (aa)	-	-
ENST00000405356	NOLC1-202	3967	XM_005270273	ENSP00000385410	709 (aa)	XP_005270330	Q14978
ENST00000605788	NOLC1-209	3932	-	ENSP00000474710	699 (aa)	-	Q14978

Gene Model

Click here to download ENSG00000166197's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166197's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166197	NOLC1	100	97.500	ENSAMEG00000017687	NOLC1	100	81.627	Ailuropoda_melanoleuca
ENSG00000166197	NOLC1	93	93.023	ENSANAG00000026475	-	100	83.546	Aotus_nancymaae
ENSG00000166197	NOLC1	99	92.500	ENSBTAG00000007435	NOLC1	100	77.997	Bos_taurus
ENSG00000166197	NOLC1	97	97.500	ENSCJAG00000017832	NOLC1	100	86.434	Callithrix_jacchus
ENSG00000166197	NOLC1	100	95.000	ENSCAFG00000010062	NOLC1	100	77.997	Canis_familiaris
ENSG00000166197	NOLC1	100	95.000	ENSCAFG00020010146	NOLC1	100	78.298	Canis_lupus_dingo
ENSG00000166197	NOLC1	99	92.500	ENSCHIG00000016755	NOLC1	100	71.849	Capra_hircus
ENSG00000166197	NOLC1	94	73.920	ENSTSYG00000011322	NOLC1	100	74.030	Carlito_syrichta
ENSG00000166197	NOLC1	60	79.688	ENSCAPG00000008758	-	83	78.462	Cavia_aperea
ENSG00000166197	NOLC1	93	90.698	ENSCPOG00000004504	NOLC1	95	72.199	Cavia_porcellus
ENSG00000166197	NOLC1	100	86.017	ENSCCAG00000031293	NOLC1	100	87.006	Cebus_capucinus
ENSG00000166197	NOLC1	100	93.599	ENSCATG00000020949	NOLC1	100	93.599	Cercocebus_atys
ENSG00000166197	NOLC1	100	90.223	ENSCSAG00000005465	NOLC1	100	90.503	Chlorocebus_sabaeus
ENSG00000166197	NOLC1	100	90.336	ENSCANG00000032550	NOLC1	100	89.776	Colobus_angolensis_palliatus
ENSG00000166197	NOLC1	93	90.698	ENSCGRG00001009806	Nolc1	71	67.807	Cricetulus_griseus_chok1gshd
ENSG00000166197	NOLC1	93	90.698	ENSCGRG00000005530	Nolc1	71	67.807	Cricetulus_griseus_crigri
ENSG00000166197	NOLC1	100	95.122	ENSDNOG00000025256	NOLC1	82	95.122	Dasypus_novemcinctus
ENSG00000166197	NOLC1	92	97.500	ENSDORG00000001056	Nolc1	100	76.891	Dipodomys_ordii
ENSG00000166197	NOLC1	93	90.698	ENSETEG00000019260	NOLC1	100	63.866	Echinops_telfairi
ENSG00000166197	NOLC1	100	97.500	ENSEASG00005007519	NOLC1	93	87.736	Equus_asinus_asinus
ENSG00000166197	NOLC1	100	97.500	ENSECAG00000024700	NOLC1	100	80.726	Equus_caballus
ENSG00000166197	NOLC1	93	86.047	ENSEEUG00000003212	NOLC1	89	78.667	Erinaceus_europaeus
ENSG00000166197	NOLC1	99	97.500	ENSFCAG00000001239	NOLC1	100	78.852	Felis_catus
ENSG00000166197	NOLC1	93	88.372	ENSFDAG00000006050	NOLC1	100	71.770	Fukomys_damarensis
ENSG00000166197	NOLC1	78	54.386	ENSGALG00000041124	NOLC1	59	73.770	Gallus_gallus
ENSG00000166197	NOLC1	100	98.025	ENSGGOG00000002158	NOLC1	100	98.025	Gorilla_gorilla
ENSG00000166197	NOLC1	93	90.698	ENSHGLG00000003156	NOLC1	100	71.709	Heterocephalus_glaber_female
ENSG00000166197	NOLC1	93	90.698	ENSHGLG00100008172	NOLC1	100	71.809	Heterocephalus_glaber_male
ENSG00000166197	NOLC1	100	90.000	ENSSTOG00000002168	NOLC1	100	77.684	Ictidomys_tridecemlineatus
ENSG00000166197	NOLC1	93	90.698	ENSJJAG00000021131	Nolc1	71	79.317	Jaculus_jaculus
ENSG00000166197	NOLC1	100	97.500	ENSLAFG00000014245	NOLC1	100	74.790	Loxodonta_africana
ENSG00000166197	NOLC1	100	92.603	ENSMFAG00000044654	NOLC1	100	92.461	Macaca_fascicularis
ENSG00000166197	NOLC1	100	92.176	ENSMMUG00000001183	NOLC1	100	91.892	Macaca_mulatta
ENSG00000166197	NOLC1	100	92.978	ENSMLEG00000040773	NOLC1	100	92.697	Mandrillus_leucophaeus
ENSG00000166197	NOLC1	100	82.730	ENSMICG00000011811	NOLC1	100	82.008	Microcebus_murinus
ENSG00000166197	NOLC1	93	90.698	ENSMOCG00000015232	Nolc1	100	72.805	Microtus_ochrogaster
ENSG00000166197	NOLC1	93	83.721	MGP_CAROLIEiJ_G0023027	Nolc1	100	67.906	Mus_caroli
ENSG00000166197	NOLC1	93	83.721	ENSMUSG00000015176	Nolc1	100	69.413	Mus_musculus
ENSG00000166197	NOLC1	98	89.744	MGP_PahariEiJ_G0014517	Nolc1	100	68.118	Mus_pahari
ENSG00000166197	NOLC1	93	83.721	MGP_SPRETEiJ_G0023948	Nolc1	100	68.575	Mus_spretus
ENSG00000166197	NOLC1	100	92.500	ENSMPUG00000016887	NOLC1	100	80.028	Mustela_putorius_furo
ENSG00000166197	NOLC1	100	90.000	ENSMLUG00000001726	NOLC1	100	78.801	Myotis_lucifugus
ENSG00000166197	NOLC1	93	90.698	ENSNGAG00000024139	Nolc1	100	77.228	Nannospalax_galili
ENSG00000166197	NOLC1	100	95.070	ENSNLEG00000015012	NOLC1	100	95.070	Nomascus_leucogenys
ENSG00000166197	NOLC1	87	97.500	ENSOPRG00000009381	NOLC1	92	77.531	Ochotona_princeps
ENSG00000166197	NOLC1	96	95.000	ENSODEG00000006304	NOLC1	100	68.652	Octodon_degus
ENSG00000166197	NOLC1	96	97.500	ENSOCUG00000000516	-	100	79.408	Oryctolagus_cuniculus
ENSG00000166197	NOLC1	93	93.023	ENSOGAG00000016359	NOLC1	100	77.635	Otolemur_garnettii
ENSG00000166197	NOLC1	99	92.500	ENSOARG00000017556	NOLC1	100	79.014	Ovis_aries
ENSG00000166197	NOLC1	100	96.434	ENSPPAG00000038082	NOLC1	100	96.434	Pan_paniscus
ENSG00000166197	NOLC1	99	97.500	ENSPPRG00000003072	NOLC1	100	78.881	Panthera_pardus
ENSG00000166197	NOLC1	93	93.023	ENSPTIG00000014862	NOLC1	100	77.424	Panthera_tigris_altaica
ENSG00000166197	NOLC1	100	98.573	ENSPTRG00000023882	NOLC1	100	98.573	Pan_troglodytes
ENSG00000166197	NOLC1	100	93.172	ENSPANG00000021014	NOLC1	100	91.465	Papio_anubis
ENSG00000166197	NOLC1	100	96.434	ENSPPYG00000002595	NOLC1	100	96.434	Pongo_abelii
ENSG00000166197	NOLC1	87	97.500	ENSPCAG00000008388	NOLC1	80	97.500	Procavia_capensis
ENSG00000166197	NOLC1	100	80.672	ENSPCOG00000019070	-	100	80.084	Propithecus_coquereli
ENSG00000166197	NOLC1	99	97.500	ENSPVAG00000004050	NOLC1	100	79.666	Pteropus_vampyrus
ENSG00000166197	NOLC1	93	88.372	ENSRNOG00000018704	Nolc1	100	70.605	Rattus_norvegicus
ENSG00000166197	NOLC1	100	87.009	ENSRBIG00000032216	NOLC1	100	87.145	Rhinopithecus_bieti
ENSG00000166197	NOLC1	100	92.045	ENSRROG00000038056	NOLC1	100	92.188	Rhinopithecus_roxellana
ENSG00000166197	NOLC1	97	97.500	ENSSBOG00000031205	NOLC1	100	88.983	Saimiri_boliviensis_boliviensis
ENSG00000166197	NOLC1	93	69.767	ENSSHAG00000002222	-	68	51.462	Sarcophilus_harrisii
ENSG00000166197	NOLC1	93	90.698	ENSSARG00000004111	NOLC1	100	75.000	Sorex_araneus
ENSG00000166197	NOLC1	93	88.372	ENSSSCG00000010576	NOLC1	100	80.000	Sus_scrofa
ENSG00000166197	NOLC1	100	95.000	ENSTTRG00000014974	NOLC1	100	80.780	Tursiops_truncatus
ENSG00000166197	NOLC1	93	93.023	ENSUAMG00000028059	NOLC1	100	82.163	Ursus_americanus
ENSG00000166197	NOLC1	100	97.500	ENSUMAG00000023063	NOLC1	100	82.087	Ursus_maritimus
ENSG00000166197	NOLC1	93	90.698	ENSVPAG00000005767	NOLC1	89	73.243	Vicugna_pacos
ENSG00000166197	NOLC1	100	95.000	ENSVVUG00000002661	NOLC1	100	75.706	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	7657714.	TAS	Process
GO:0001042	RNA polymerase I core binding	26399832.	IDA	Function
GO:0001650	fibrillar center	-	IDA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	17620599.22190034.26399832.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006364	rRNA processing	7657714.	TAS	Process
GO:0006417	regulation of translation	26399832.	IMP	Process
GO:0006970	response to osmotic stress	-	IEA	Process
GO:0007000	nucleolus organization	-	IEA	Process
GO:0008134	transcription factor binding	-	IEA	Function
GO:0008139	nuclear localization sequence binding	-	IEA	Function
GO:0008284	positive regulation of cell proliferation	-	IEA	Process
GO:0014029	neural crest formation	26399832.	IMP	Process
GO:0014032	neural crest cell development	26399832.	IMP	Process
GO:0015030	Cajal body	-	IEA	Component
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0031428	box C/D snoRNP complex	-	IEA	Component
GO:0031429	box H/ACA snoRNP complex	-	IEA	Component
GO:0033979	box H/ACA snoRNA metabolic process	-	IEA	Process
GO:0034512	box C/D snoRNA binding	-	IEA	Function
GO:0034513	box H/ACA snoRNA binding	-	IEA	Function
GO:0042306	regulation of protein import into nucleus	-	IEA	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	IEA	Process
GO:0046982	protein heterodimerization activity	26399832.	IPI	Function
GO:0062064	box C/D snoRNP complex binding	-	IEA	Function
GO:0062065	box H/ACA snoRNP complex binding	-	IEA	Function