EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166199 (Gene tree)
Gene ID: 221120
Gene Symbol: ALKBH3
Alias: DEPC-1
Full Name: alkB homolog 3, alpha-ketoglutaratedependent dioxygenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 39,469 bases
Position: chr11:43,880,807-43,920,275
Accession: 30141
RBP type: canonical RBP
Summary: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000302232	2OG-FeII_Oxy_2	PF13532.6	8.4e-29	1	1
ENSP00000433614	2OG-FeII_Oxy_2	PF13532.6	1.5e-23	1	1
ENSP00000435848	2OG-FeII_Oxy_2	PF13532.6	1.7e-16	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000529434	ALKBH3-205	682	-	-	- (aa)	-	-
ENST00000530754	ALKBH3-206	582	-	-	- (aa)	-	-
ENST00000527029	ALKBH3-203	569	-	-	- (aa)	-	-
ENST00000302708	ALKBH3-201	1474	-	ENSP00000302232	286 (aa)	-	Q96Q83
ENST00000533200	ALKBH3-211	517	-	-	- (aa)	-	-
ENST00000529366	ALKBH3-204	747	-	ENSP00000435848	223 (aa)	-	E9PSA5
ENST00000524742	ALKBH3-202	842	-	ENSP00000434229	60 (aa)	-	E9PRD0
ENST00000532129	ALKBH3-208	725	-	ENSP00000433614	156 (aa)	-	H0YDH4
ENST00000530803	ALKBH3-207	1557	-	ENSP00000436788	170 (aa)	-	Q96Q83
ENST00000532962	ALKBH3-210	1371	-	ENSP00000434832	171 (aa)	-	E9PN35
ENST00000532410	ALKBH3-209	648	-	-	- (aa)	-	-
ENST00000534171	ALKBH3-212	764	-	ENSP00000432259	66 (aa)	-	E9PRJ2

Gene Model

Click here to download ENSG00000166199's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000166199	rs7115013	11	43913042	?	Body mass index	30595370			EFO_0004340
ENSG00000166199	rs11037728	11	43904800	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166199's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166199	ALKBH3	97	61.184	ENSAPOG00000008495	alkbh3	95	53.819	Acanthochromis_polyacanthus
ENSG00000166199	ALKBH3	100	88.112	ENSAMEG00000004842	ALKBH3	97	88.112	Ailuropoda_melanoleuca
ENSG00000166199	ALKBH3	96	61.074	ENSACIG00000011887	alkbh3	100	54.255	Amphilophus_citrinellus
ENSG00000166199	ALKBH3	97	60.526	ENSAOCG00000023500	alkbh3	95	53.472	Amphiprion_ocellaris
ENSG00000166199	ALKBH3	97	60.526	ENSAPEG00000011723	alkbh3	95	53.125	Amphiprion_percula
ENSG00000166199	ALKBH3	97	59.868	ENSATEG00000021785	alkbh3	95	53.497	Anabas_testudineus
ENSG00000166199	ALKBH3	98	52.189	ENSACAG00000000855	ALKBH3	98	52.862	Anolis_carolinensis
ENSG00000166199	ALKBH3	100	94.810	ENSANAG00000033941	ALKBH3	100	94.810	Aotus_nancymaae
ENSG00000166199	ALKBH3	97	61.184	ENSACLG00000023226	alkbh3	96	53.684	Astatotilapia_calliptera
ENSG00000166199	ALKBH3	96	63.758	ENSAMXG00000037076	alkbh3	98	57.295	Astyanax_mexicanus
ENSG00000166199	ALKBH3	100	87.063	ENSBTAG00000009518	ALKBH3	100	87.063	Bos_taurus
ENSG00000166199	ALKBH3	100	93.833	ENSCJAG00000011353	ALKBH3	100	95.423	Callithrix_jacchus
ENSG00000166199	ALKBH3	99	87.324	ENSCAFG00000006657	ALKBH3	98	87.633	Canis_familiaris
ENSG00000166199	ALKBH3	99	87.676	ENSCAFG00020006841	ALKBH3	98	87.986	Canis_lupus_dingo
ENSG00000166199	ALKBH3	100	87.063	ENSCHIG00000017579	ALKBH3	100	87.063	Capra_hircus
ENSG00000166199	ALKBH3	99	90.493	ENSTSYG00000005498	ALKBH3	99	90.493	Carlito_syrichta
ENSG00000166199	ALKBH3	99	82.807	ENSCAPG00000004995	ALKBH3	99	82.807	Cavia_aperea
ENSG00000166199	ALKBH3	99	86.667	ENSCPOG00000005138	ALKBH3	99	86.667	Cavia_porcellus
ENSG00000166199	ALKBH3	100	93.772	ENSCCAG00000036907	ALKBH3	100	93.772	Cebus_capucinus
ENSG00000166199	ALKBH3	100	98.601	ENSCATG00000035646	ALKBH3	100	98.601	Cercocebus_atys
ENSG00000166199	ALKBH3	99	86.316	ENSCLAG00000016579	ALKBH3	99	86.316	Chinchilla_lanigera
ENSG00000166199	ALKBH3	100	96.154	ENSCSAG00000005539	ALKBH3	100	96.154	Chlorocebus_sabaeus
ENSG00000166199	ALKBH3	100	88.927	ENSCHOG00000001407	ALKBH3	100	88.927	Choloepus_hoffmanni
ENSG00000166199	ALKBH3	99	69.930	ENSCPBG00000012575	ALKBH3	99	69.930	Chrysemys_picta_bellii
ENSG00000166199	ALKBH3	94	52.381	ENSCING00000007764	-	98	57.616	Ciona_intestinalis
ENSG00000166199	ALKBH3	95	50.676	ENSCSAVG00000000783	-	98	43.369	Ciona_savignyi
ENSG00000166199	ALKBH3	100	98.333	ENSCANG00000018698	ALKBH3	100	98.252	Colobus_angolensis_palliatus
ENSG00000166199	ALKBH3	100	89.161	ENSCGRG00001014489	Alkbh3	100	89.161	Cricetulus_griseus_chok1gshd
ENSG00000166199	ALKBH3	100	89.161	ENSCGRG00000017661	Alkbh3	100	89.161	Cricetulus_griseus_crigri
ENSG00000166199	ALKBH3	97	58.553	ENSCSEG00000000814	alkbh3	95	52.249	Cynoglossus_semilaevis
ENSG00000166199	ALKBH3	97	59.211	ENSCVAG00000009432	alkbh3	95	53.979	Cyprinodon_variegatus
ENSG00000166199	ALKBH3	99	54.861	ENSDARG00000045606	alkbh3	97	54.861	Danio_rerio
ENSG00000166199	ALKBH3	100	89.860	ENSDNOG00000036652	ALKBH3	100	89.860	Dasypus_novemcinctus
ENSG00000166199	ALKBH3	99	89.474	ENSDORG00000000083	Alkbh3	99	89.474	Dipodomys_ordii
ENSG00000166199	ALKBH3	99	89.046	ENSEASG00005014856	ALKBH3	96	89.046	Equus_asinus_asinus
ENSG00000166199	ALKBH3	99	89.399	ENSECAG00000010673	ALKBH3	96	89.399	Equus_caballus
ENSG00000166199	ALKBH3	100	73.333	ENSEEUG00000002183	ALKBH3	77	64.126	Erinaceus_europaeus
ENSG00000166199	ALKBH3	83	68.992	ENSELUG00000003260	alkbh3	94	48.084	Esox_lucius
ENSG00000166199	ALKBH3	100	90.210	ENSFCAG00000029461	ALKBH3	100	90.210	Felis_catus
ENSG00000166199	ALKBH3	84	83.969	ENSFALG00000012361	ALKBH3	98	66.786	Ficedula_albicollis
ENSG00000166199	ALKBH3	99	86.316	ENSFDAG00000012666	ALKBH3	99	86.316	Fukomys_damarensis
ENSG00000166199	ALKBH3	97	60.526	ENSFHEG00000018735	alkbh3	95	53.979	Fundulus_heteroclitus
ENSG00000166199	ALKBH3	97	59.091	ENSGMOG00000019146	alkbh3	96	52.797	Gadus_morhua
ENSG00000166199	ALKBH3	82	85.156	ENSGALG00000041309	ALKBH3	68	67.925	Gallus_gallus
ENSG00000166199	ALKBH3	97	57.895	ENSGAFG00000005814	alkbh3	97	51.527	Gambusia_affinis
ENSG00000166199	ALKBH3	99	54.417	ENSGACG00000006950	alkbh3	99	54.417	Gasterosteus_aculeatus
ENSG00000166199	ALKBH3	83	83.846	ENSGAGG00000013151	ALKBH3	99	78.000	Gopherus_agassizii
ENSG00000166199	ALKBH3	100	100.000	ENSGGOG00000001931	ALKBH3	100	99.650	Gorilla_gorilla
ENSG00000166199	ALKBH3	97	61.184	ENSHBUG00000008513	alkbh3	96	53.684	Haplochromis_burtoni
ENSG00000166199	ALKBH3	99	86.316	ENSHGLG00000019437	ALKBH3	99	88.421	Heterocephalus_glaber_female
ENSG00000166199	ALKBH3	99	84.305	ENSHGLG00100004468	ALKBH3	99	81.053	Heterocephalus_glaber_male
ENSG00000166199	ALKBH3	96	61.333	ENSIPUG00000017036	alkbh3	98	55.124	Ictalurus_punctatus
ENSG00000166199	ALKBH3	100	88.839	ENSSTOG00000006060	ALKBH3	100	90.747	Ictidomys_tridecemlineatus
ENSG00000166199	ALKBH3	99	85.211	ENSJJAG00000018577	-	98	85.211	Jaculus_jaculus
ENSG00000166199	ALKBH3	97	59.868	ENSKMAG00000006499	alkbh3	95	53.684	Kryptolebias_marmoratus
ENSG00000166199	ALKBH3	99	53.710	ENSLBEG00000004226	alkbh3	95	53.710	Labrus_bergylta
ENSG00000166199	ALKBH3	96	68.667	ENSLACG00000017208	ALKBH3	99	60.627	Latimeria_chalumnae
ENSG00000166199	ALKBH3	96	62.000	ENSLOCG00000001237	alkbh3	100	54.093	Lepisosteus_oculatus
ENSG00000166199	ALKBH3	100	93.706	ENSLAFG00000003441	ALKBH3	100	93.706	Loxodonta_africana
ENSG00000166199	ALKBH3	100	97.552	ENSMFAG00000031334	ALKBH3	100	97.552	Macaca_fascicularis
ENSG00000166199	ALKBH3	100	97.902	ENSMNEG00000042403	ALKBH3	100	97.902	Macaca_nemestrina
ENSG00000166199	ALKBH3	100	98.333	ENSMLEG00000038324	ALKBH3	100	98.252	Mandrillus_leucophaeus
ENSG00000166199	ALKBH3	97	59.868	ENSMAMG00000023051	alkbh3	95	55.245	Mastacembelus_armatus
ENSG00000166199	ALKBH3	97	61.184	ENSMZEG00005011786	alkbh3	96	53.684	Maylandia_zebra
ENSG00000166199	ALKBH3	86	82.090	ENSMGAG00000010479	ALKBH3	99	69.333	Meleagris_gallopavo
ENSG00000166199	ALKBH3	99	90.845	ENSMAUG00000009317	Alkbh3	99	90.845	Mesocricetus_auratus
ENSG00000166199	ALKBH3	99	95.423	ENSMICG00000014651	ALKBH3	99	95.423	Microcebus_murinus
ENSG00000166199	ALKBH3	99	84.965	ENSMOCG00000012816	Alkbh3	99	84.965	Microtus_ochrogaster
ENSG00000166199	ALKBH3	97	59.211	ENSMMOG00000020327	alkbh3	93	47.902	Mola_mola
ENSG00000166199	ALKBH3	85	87.879	ENSMODG00000019863	-	97	81.328	Monodelphis_domestica
ENSG00000166199	ALKBH3	97	61.842	ENSMALG00000017888	alkbh3	95	55.363	Monopterus_albus
ENSG00000166199	ALKBH3	99	86.316	MGP_CAROLIEiJ_G0023995	Alkbh3	99	86.316	Mus_caroli
ENSG00000166199	ALKBH3	99	85.965	ENSMUSG00000040174	Alkbh3	99	85.965	Mus_musculus
ENSG00000166199	ALKBH3	99	85.263	MGP_PahariEiJ_G0025431	Alkbh3	99	85.263	Mus_pahari
ENSG00000166199	ALKBH3	99	85.965	MGP_SPRETEiJ_G0024905	Alkbh3	99	85.965	Mus_spretus
ENSG00000166199	ALKBH3	100	89.161	ENSMPUG00000006151	ALKBH3	100	89.161	Mustela_putorius_furo
ENSG00000166199	ALKBH3	99	90.493	ENSMLUG00000029289	ALKBH3	99	90.493	Myotis_lucifugus
ENSG00000166199	ALKBH3	99	87.633	ENSNGAG00000004591	Alkbh3	99	87.633	Nannospalax_galili
ENSG00000166199	ALKBH3	97	60.526	ENSNBRG00000016311	alkbh3	96	50.342	Neolamprologus_brichardi
ENSG00000166199	ALKBH3	100	98.333	ENSNLEG00000027521	ALKBH3	100	98.252	Nomascus_leucogenys
ENSG00000166199	ALKBH3	84	86.260	ENSMEUG00000007604	ALKBH3	99	84.286	Notamacropus_eugenii
ENSG00000166199	ALKBH3	99	87.676	ENSOPRG00000006771	ALKBH3	99	87.676	Ochotona_princeps
ENSG00000166199	ALKBH3	99	84.965	ENSODEG00000017204	ALKBH3	99	84.965	Octodon_degus
ENSG00000166199	ALKBH3	97	60.526	ENSONIG00000015605	alkbh3	97	53.846	Oreochromis_niloticus
ENSG00000166199	ALKBH3	83	88.372	ENSOANG00000009208	ALKBH3	97	70.175	Ornithorhynchus_anatinus
ENSG00000166199	ALKBH3	99	89.161	ENSOCUG00000016359	ALKBH3	99	89.161	Oryctolagus_cuniculus
ENSG00000166199	ALKBH3	99	55.088	ENSORLG00000001437	alkbh3	95	55.088	Oryzias_latipes
ENSG00000166199	ALKBH3	100	50.000	ENSORLG00020002409	alkbh3	96	53.101	Oryzias_latipes_hni
ENSG00000166199	ALKBH3	86	67.910	ENSORLG00015016266	alkbh3	95	54.639	Oryzias_latipes_hsok
ENSG00000166199	ALKBH3	99	53.559	ENSOMEG00000003835	alkbh3	95	53.559	Oryzias_melastigma
ENSG00000166199	ALKBH3	99	94.386	ENSOGAG00000009107	ALKBH3	97	94.386	Otolemur_garnettii
ENSG00000166199	ALKBH3	100	86.364	ENSOARG00000001123	ALKBH3	100	86.364	Ovis_aries
ENSG00000166199	ALKBH3	100	100.000	ENSPPAG00000028729	ALKBH3	100	100.000	Pan_paniscus
ENSG00000166199	ALKBH3	100	90.210	ENSPPRG00000005278	ALKBH3	100	90.210	Panthera_pardus
ENSG00000166199	ALKBH3	100	88.462	ENSPTIG00000019393	ALKBH3	100	88.462	Panthera_tigris_altaica
ENSG00000166199	ALKBH3	100	100.000	ENSPTRG00000003523	ALKBH3	100	100.000	Pan_troglodytes
ENSG00000166199	ALKBH3	100	92.361	ENSPANG00000003104	ALKBH3	100	92.361	Papio_anubis
ENSG00000166199	ALKBH3	86	67.910	ENSPKIG00000021815	alkbh3	98	50.190	Paramormyrops_kingsleyae
ENSG00000166199	ALKBH3	100	68.889	ENSPSIG00000011933	ALKBH3	96	69.432	Pelodiscus_sinensis
ENSG00000166199	ALKBH3	99	47.535	ENSPMGG00000008862	alkbh3	93	47.535	Periophthalmus_magnuspinnatus
ENSG00000166199	ALKBH3	100	87.762	ENSPEMG00000019372	Alkbh3	100	87.762	Peromyscus_maniculatus_bairdii
ENSG00000166199	ALKBH3	99	53.153	ENSPMAG00000001119	alkbh3	99	53.937	Petromyzon_marinus
ENSG00000166199	ALKBH3	99	76.408	ENSPCIG00000021794	ALKBH3	97	76.408	Phascolarctos_cinereus
ENSG00000166199	ALKBH3	97	59.868	ENSPFOG00000002705	alkbh3	95	53.633	Poecilia_formosa
ENSG00000166199	ALKBH3	97	59.868	ENSPLAG00000002355	alkbh3	95	53.846	Poecilia_latipinna
ENSG00000166199	ALKBH3	97	59.868	ENSPMEG00000004476	alkbh3	95	52.941	Poecilia_mexicana
ENSG00000166199	ALKBH3	99	53.846	ENSPREG00000005505	alkbh3	90	53.846	Poecilia_reticulata
ENSG00000166199	ALKBH3	100	98.333	ENSPPYG00000003342	ALKBH3	97	97.193	Pongo_abelii
ENSG00000166199	ALKBH3	100	88.811	ENSPCAG00000002955	ALKBH3	100	88.811	Procavia_capensis
ENSG00000166199	ALKBH3	99	94.737	ENSPCOG00000020139	ALKBH3	99	94.737	Propithecus_coquereli
ENSG00000166199	ALKBH3	100	87.500	ENSPVAG00000011569	ALKBH3	99	88.380	Pteropus_vampyrus
ENSG00000166199	ALKBH3	97	61.184	ENSPNYG00000010362	alkbh3	96	53.684	Pundamilia_nyererei
ENSG00000166199	ALKBH3	96	63.333	ENSPNAG00000015943	alkbh3	95	57.092	Pygocentrus_nattereri
ENSG00000166199	ALKBH3	99	86.667	ENSRNOG00000021678	Alkbh3	97	86.667	Rattus_norvegicus
ENSG00000166199	ALKBH3	100	97.203	ENSRBIG00000034161	ALKBH3	100	97.203	Rhinopithecus_bieti
ENSG00000166199	ALKBH3	100	97.203	ENSRROG00000042173	ALKBH3	100	97.203	Rhinopithecus_roxellana
ENSG00000166199	ALKBH3	100	94.810	ENSSBOG00000023947	ALKBH3	100	94.810	Saimiri_boliviensis_boliviensis
ENSG00000166199	ALKBH3	99	75.704	ENSSHAG00000006189	ALKBH3	98	75.704	Sarcophilus_harrisii
ENSG00000166199	ALKBH3	99	53.546	ENSSFOG00015003566	alkbh3	98	53.546	Scleropages_formosus
ENSG00000166199	ALKBH3	97	59.211	ENSSMAG00000004404	alkbh3	95	53.265	Scophthalmus_maximus
ENSG00000166199	ALKBH3	97	59.868	ENSSDUG00000000513	alkbh3	95	52.797	Seriola_dumerili
ENSG00000166199	ALKBH3	97	60.526	ENSSLDG00000003080	alkbh3	95	52.797	Seriola_lalandi_dorsalis
ENSG00000166199	ALKBH3	99	68.881	ENSSPUG00000005861	ALKBH3	99	68.881	Sphenodon_punctatus
ENSG00000166199	ALKBH3	97	59.868	ENSSPAG00000020713	alkbh3	94	54.181	Stegastes_partitus
ENSG00000166199	ALKBH3	100	90.559	ENSSSCG00000040937	ALKBH3	100	90.559	Sus_scrofa
ENSG00000166199	ALKBH3	84	81.679	ENSTGUG00000010222	ALKBH3	99	68.980	Taeniopygia_guttata
ENSG00000166199	ALKBH3	97	55.921	ENSTRUG00000021459	alkbh3	86	50.174	Takifugu_rubripes
ENSG00000166199	ALKBH3	97	55.921	ENSTNIG00000010385	alkbh3	96	53.103	Tetraodon_nigroviridis
ENSG00000166199	ALKBH3	99	88.421	ENSTBEG00000016697	ALKBH3	99	88.421	Tupaia_belangeri
ENSG00000166199	ALKBH3	100	88.811	ENSTTRG00000005121	ALKBH3	100	88.811	Tursiops_truncatus
ENSG00000166199	ALKBH3	100	85.315	ENSUAMG00000025129	ALKBH3	99	90.947	Ursus_americanus
ENSG00000166199	ALKBH3	100	89.161	ENSUMAG00000015602	ALKBH3	100	89.161	Ursus_maritimus
ENSG00000166199	ALKBH3	99	90.493	ENSVPAG00000000215	ALKBH3	99	90.493	Vicugna_pacos
ENSG00000166199	ALKBH3	99	86.620	ENSVVUG00000017283	ALKBH3	98	86.620	Vulpes_vulpes
ENSG00000166199	ALKBH3	94	71.918	ENSXETG00000022230	alkbh3	99	55.052	Xenopus_tropicalis
ENSG00000166199	ALKBH3	80	56.000	ENSXCOG00000000737	alkbh3	65	60.606	Xiphophorus_couchianus
ENSG00000166199	ALKBH3	97	57.895	ENSXMAG00000013123	alkbh3	95	53.710	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	22055184.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006281	DNA repair	16858410.	IDA	Process
GO:0006307	DNA dealkylation involved in DNA repair	21873635.	IBA	Process
GO:0006307	DNA dealkylation involved in DNA repair	16858410.22055184.	IDA	Process
GO:0006307	DNA dealkylation involved in DNA repair	-	TAS	Process
GO:0008198	ferrous iron binding	21873635.	IBA	Function
GO:0008198	ferrous iron binding	16858410.	IDA	Function
GO:0008283	cell proliferation	22055184.	IMP	Process
GO:0031418	L-ascorbic acid binding	-	IEA	Function
GO:0035552	oxidative single-stranded DNA demethylation	21873635.	IBA	Process
GO:0035552	oxidative single-stranded DNA demethylation	16858410.	IDA	Process
GO:0035552	oxidative single-stranded DNA demethylation	22055184.	IMP	Process
GO:0035553	oxidative single-stranded RNA demethylation	21873635.	IBA	Process
GO:0035553	oxidative single-stranded RNA demethylation	26863196.26863410.	IDA	Process
GO:0043734	DNA-N1-methyladenine dioxygenase activity	21873635.	IBA	Function
GO:0043734	DNA-N1-methyladenine dioxygenase activity	16858410.	IDA	Function
GO:0043734	DNA-N1-methyladenine dioxygenase activity	22055184.	IMP	Function
GO:0051747	cytosine C-5 DNA demethylase activity	-	IEA	Function
GO:1990930	RNA N1-methyladenosine dioxygenase activity	21873635.	IBA	Function
GO:1990930	RNA N1-methyladenosine dioxygenase activity	26863196.26863410.	IDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28205560	AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.	Sci Rep	2017 Feb 13	Ueda Y	doi: 10.1038/srep42271.
17968469	Prostate cancer antigen-1 as a potential novel marker for prostate cancer.	Asian J Androl	2007 Nov	Liu BQ	-
28679371	CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer.	BMC Cancer	2017 Jul 5	Stefansson OA	doi: 10.1186/s12885-017-3453-8.
22515525	anti-tumor effect of AlkB homolog 3 knockdown in hormone- independent prostate cancer cells.	Curr Cancer Drug Targets	2012 Sep	Koike K	-
22826605	PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.	Cancer Res	2012 Sep 15	Yamato I	doi: 10.1158/0008-5472.CAN-12-0328
22055184	DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.	Mol Cell	2011 Nov 4	Dango S	doi: 10.1016/j.molcel.2011.08.039.
21285982	ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.	Br J Cancer	2011 Feb 15	Tasaki M	doi: 10.1038/sj.bjc.6606012

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr11	43898930	Intron	novel		0.19
BLCA	chr11	43898567	Intron	novel		0.41
BLCA	chr11	43898473	Intron	novel		0.16
BLCA	chr11	43901592	Missense_Mutation	rs765627435	N179S	0.3	2OG-FeII_Oxy_2
BLCA	chr11	43899125	Intron	novel		0.4
BLCA	chr11	43898084	Intron	novel		0.09
BLCA	chr11	43899243	Intron	novel		0.26
BLCA	chr11	43899177	Intron	novel		0.25
BLCA	chr11	43898710	Intron	novel		0.36
BRCA	chr11	43883980	Splice_Region	novel		0.37
BRCA	chr11	43899511	Intron	novel		0.25
BRCA	chr11	43919086	Missense_Mutation	NA	D240N	0.29
BRCA	chr11	43919925	Missense_Mutation	novel	V259G	0.27
BRCA	chr11	43898868	Intron	novel		0.19
BRCA	chr11	43899413	Intron	novel		0.42
BRCA	chr11	43898758	Intron	novel		0.2
CESC	chr11	43919922	Missense_Mutation	NA	R258Q	0.45
CESC	chr11	43898358	Intron	novel		0.36
CESC	chr11	43899592	Intron	novel		0.48
CESC	chr11	43901608	Silent	rs778056760	E184E	0.42
CESC	chr11	43889755	Silent	novel	V99V	0.37
COAD	chr11	43898077	Intron	novel		0.22
COAD	chr11	43897900	Intron	novel		0.22
COAD	chr11	43897729	Intron	novel		0.33
COAD	chr11	43897900	Intron	novel		0.35
COAD	chr11	43901617	Silent	rs375368904	S187S	0.44
COAD	chr11	43898086	Intron	novel		0.49
COAD	chr11	43897463	Intron	novel		0.32
COAD	chr11	43898383	Intron	novel		0.42
COAD	chr11	43920044	3'UTR	rs772588878		0.2
COAD	chr11	43897829	Intron	novel		0.09
COAD	chr11	43898713	Intron	novel		0.12
COAD	chr11	43901532	Missense_Mutation	rs202134415	R159H	0.41	2OG-FeII_Oxy_2
COAD	chr11	43899324	Intron	novel		0.27
COAD	chr11	43899446	Intron	novel		0.22
COAD	chr11	43897759	Intron	novel		0.35
COAD	chr11	43897900	Intron	novel		0.3
ESCA	chr11	43882687	Missense_Mutation	novel	G12E	0.8
ESCA	chr11	43897339	Intron	novel		0.41
ESCA	chr11	43882677	Nonsense_Mutation	novel	R9*	0.16
ESCA	chr11	43897897	Intron	novel		0.39
ESCA	chr11	43898891	Intron	novel		0.4
GBM	chr11	43919943	Missense_Mutation	novel	S265C	0.67
GBM	chr11	43919946	Missense_Mutation	novel	R266I	0.12
GBM	chr11	43892067	Missense_Mutation	novel	T133A	0.44	2OG-FeII_Oxy_2
GBM	chr11	43901644	Silent	rs747645982	P196P	0.11
GBM	chr11	43898204	Intron	novel		0.27
GBM	chr11	43919940	Missense_Mutation	novel	H264R	0.2
HNSC	chr11	43889823	Missense_Mutation	novel	R122T	0.28	2OG-FeII_Oxy_2
HNSC	chr11	43898974	Intron	novel		0.16
HNSC	chr11	43898821	Intron	novel		0.25
HNSC	chr11	43884004	Missense_Mutation	novel	P69T	0.06
HNSC	chr11	43901542	Missense_Mutation	novel	K162N	0.25	2OG-FeII_Oxy_2
HNSC	chr11	43897780	Intron	novel		0.19
HNSC	chr11	43897488	Intron	novel		0.15
HNSC	chr11	43919917	Splice_Site	novel	X257_splice	0.15
KICH	chr11	43899446	Intron	novel		0.48
KIRP	chr11	43884015	Splice_Region	NA	I72I	0.4
LGG	chr11	43898700	Intron	novel		0.17
LGG	chr11	43898848	Intron	novel		0.45
LIHC	chr11	43901603	Missense_Mutation	NA	N183Y	0.42	2OG-FeII_Oxy_2
LIHC	chr11	43898602	Intron	novel		0.47
LIHC	chr11	43899035	Intron	novel		0.21
LUAD	chr11	43886618	Silent	NA	V77V	0.16
LUAD	chr11	43897540	Intron	novel		0.33
LUAD	chr11	43897722	Intron	novel		0.3
LUAD	chr11	43897723	Intron	novel		0.3
LUAD	chr11	43919100	Missense_Mutation	NA	L244F	0.11
LUAD	chr11	43897625	Intron	novel		0.21
LUAD	chr11	43899470	Intron	novel		0.3
LUAD	chr11	43899589	Intron	novel		0.44
LUAD	chr11	43886609	Silent	NA	R74R	0.12
LUAD	chr11	43919118	Silent	novel	A250A	0.26
LUAD	chr11	43919086	Missense_Mutation	NA	D240Y	0.24
LUAD	chr11	43898093	Intron	novel		0.42
LUSC	chr11	43899508	Intron	novel		0.34
LUSC	chr11	43898463	Intron	novel		0.27
LUSC	chr11	43919069	Missense_Mutation	novel	R234I	0.17
LUSC	chr11	43899499	Intron	novel		0.22
LUSC	chr11	43898110	Intron	novel		0.48
LUSC	chr11	43901694	Missense_Mutation	novel	R213L	0.2	2OG-FeII_Oxy_2
LUSC	chr11	43898926	Intron	novel		0.29
LUSC	chr11	43898575	Intron	novel		0.35
LUSC	chr11	43899469	Intron	novel		0.25
LUSC	chr11	43899388	Intron	novel		0.38
LUSC	chr11	43882629	5'UTR	novel		0.21
LUSC	chr11	43898504	Intron	novel		0.5
LUSC	chr11	43901555	Missense_Mutation	NA	E167Q	0.48	2OG-FeII_Oxy_2
LUSC	chr11	43899417	Intron	novel		0.38
LUSC	chr11	43897541	Intron	novel		0.22
LUSC	chr11	43901620	Silent	NA	V188V	0.41
LUSC	chr11	43899030	Intron	novel		0.28
OV	chr11	43899106	Intron	novel		0.13
OV	chr11	43919918	Missense_Mutation	novel	H257D	0.37
OV	chr11	43898635	Intron	novel		0.4
OV	chr11	43898033	Intron	novel		0.31
OV	chr11	43898277	Intron	novel		0.26
OV	chr11	43898275	Intron	novel		0.35
OV	chr11	43897741	Intron	novel		0.46
OV	chr11	43898319	Intron	novel		0.08
PRAD	chr11	43897282	Intron	novel		0.34
PRAD	chr11	43897231	Intron	novel		0.44
PRAD	chr11	43898356	Intron	novel		0.19
READ	chr11	43898010	Intron	novel		0.31
READ	chr11	43901542	Silent	NA	K162K	0.19
READ	chr11	43899475	Intron	novel		0.21
READ	chr11	43898091	Intron	novel		0.16
SKCM	chr11	43898585	Intron	novel		0.08
SKCM	chr11	43898778	Intron	novel		0.26
SKCM	chr11	43901661	Missense_Mutation	NA	P202L	0.41	2OG-FeII_Oxy_2
SKCM	chr11	43899388	Intron	novel		0.44
SKCM	chr11	43899523	Intron	novel		0.31
SKCM	chr11	43898086	Intron	novel		0.06
SKCM	chr11	43901667	Missense_Mutation	novel	I204N	0.46	2OG-FeII_Oxy_2
SKCM	chr11	43898455	Intron	novel		0.52
SKCM	chr11	43899023	Intron	novel		0.5
SKCM	chr11	43898317	Intron	novel		0.36
SKCM	chr11	43892046	Missense_Mutation	NA	T126A	0.26	2OG-FeII_Oxy_2
SKCM	chr11	43882640	5'UTR	rs766880377		0.11
SKCM	chr11	43886639	Silent	novel	P84P	0.48
SKCM	chr11	43897660	Intron	novel		0.48
SKCM	chr11	43898230	Intron	novel		0.5
SKCM	chr11	43898231	Intron	novel		0.5
SKCM	chr11	43898270	Intron	novel		0.45
SKCM	chr11	43901661	Missense_Mutation	NA	P202L	0.13	2OG-FeII_Oxy_2
SKCM	chr11	43897199	Intron	novel		0.47
SKCM	chr11	43898171	Intron	novel		0.38
SKCM	chr11	43920038	3'UTR	novel		0.34
SKCM	chr11	43919949	Missense_Mutation	NA	E267V	0.26
SKCM	chr11	43897842	Intron	novel		0.16
STAD	chr11	43897900	Intron	novel		0.19
STAD	chr11	43901531	Missense_Mutation	rs137865466	R159C	0.24	2OG-FeII_Oxy_2
STAD	chr11	43897245	Intron	rs562999286		0.08
STAD	chr11	43899600	Intron	novel		0.57
STAD	chr11	43897556	Intron	novel		0.2
STAD	chr11	43897294	Intron	novel		0.05
STAD	chr11	43899617	Intron	novel		0.44
STAD	chr11	43883173	Missense_Mutation	novel	F56L	0.47
STAD	chr11	43899032	Intron	novel		0.25
STAD	chr11	43898575	Intron	novel		0.36
STAD	chr11	43886627	Silent	NA	I80I	0.1
STAD	chr11	43898868	Intron	novel		0.27
STAD	chr11	43901547	Missense_Mutation	rs200996094	R164H	0.2	2OG-FeII_Oxy_2
STAD	chr11	43892129	Splice_Region	NA	H153H	0.22
STAD	chr11	43897864	Intron	novel		0.3
THCA	chr11	43897947	Intron	novel		0.13
THCA	chr11	43899236	Intron	novel		0.09
UCEC	chr11	43898166	Intron	novel		0.34
UCEC	chr11	43899363	Intron	novel		0.46
UCEC	chr11	43919128	Missense_Mutation	NA	D254N	0.42
UCEC	chr11	43898258	Intron	novel		0.32
UCEC	chr11	43898432	Intron	novel		0.4
UCEC	chr11	43919118	Silent	rs758142104	A250A	0.27
UCEC	chr11	43920035	3'UTR	novel		0.35
UCEC	chr11	43899017	Intron	novel		0.07
UCEC	chr11	43897301	Intron	NA		0.39
UCEC	chr11	43897728	Intron	novel		0.15
UCEC	chr11	43897692	Intron	novel		0.35
UCEC	chr11	43920180	3'UTR	novel		0.23
UCEC	chr11	43897819	Intron	novel		0.23
UCEC	chr11	43898657	Intron	novel		0.32
UCEC	chr11	43919118	Silent	rs758142104	A250A	0.16
UCEC	chr11	43899470	Intron	novel		0.4
UCEC	chr11	43899274	Intron	novel		0.23
UCEC	chr11	43899441	Intron	novel		0.28
UCEC	chr11	43901537	Silent	novel	L161L	0.14
UCEC	chr11	43897718	Intron	novel		0.19
UCEC	chr11	43898753	Intron	novel		0.23
UCEC	chr11	43901704	Missense_Mutation	novel	E216D	0.09	2OG-FeII_Oxy_2
UCEC	chr11	43897934	Intron	novel		0.13
UCEC	chr11	43899040	Intron	novel		0.22
UCEC	chr11	43919973	Missense_Mutation	NA	R275Q	0.25
UCEC	chr11	43899030	Intron	novel		0.12
UCEC	chr11	43919096	Missense_Mutation	novel	T243I	0.2
UCEC	chr11	43897964	Intron	novel		0.36
UCEC	chr11	43897934	Intron	novel		0.5
UCEC	chr11	43884008	Missense_Mutation	rs762849148	R70Q	0.4
UCEC	chr11	43897954	Intron	novel		0.36
UCEC	chr11	43901562	Missense_Mutation	novel	T169I	0.1	2OG-FeII_Oxy_2
UCEC	chr11	43920044	3'UTR	rs772588878		0.42
UCEC	chr11	43897478	Intron	novel		0.33
UCEC	chr11	43898098	Intron	novel		0.37
UCEC	chr11	43901617	Silent	rs375368904	S187S	0.39
UCEC	chr11	43898683	Intron	novel		0.27
UCEC	chr11	43897900	Intron	novel		0.39
UCEC	chr11	43897523	Intron	novel		0.33
UCEC	chr11	43889777	Missense_Mutation	novel	E107K	0.51	2OG-FeII_Oxy_2
UCEC	chr11	43901601	Missense_Mutation	rs372711510	R182H	0.43	2OG-FeII_Oxy_2
UCEC	chr11	43897610	Intron	novel		0.34
UCEC	chr11	43899141	Intron	novel		0.46
UCEC	chr11	43899443	Intron	novel		0.21
UCEC	chr11	43897786	Intron	novel		0.54
UCEC	chr11	43898777	Intron	novel		0.42
UCEC	chr11	43897900	Intron	novel		0.18
UCEC	chr11	43920159	3'UTR	novel		0.13
UCEC	chr11	43899371	Intron	novel		0.36
UCEC	chr11	43897760	Intron	novel		0.39
UCEC	chr11	43899167	Intron	novel		0.5
UCEC	chr11	43897318	Intron	novel		0.45
UCEC	chr11	43899636	Intron	novel		0.46
UCEC	chr11	43901601	Missense_Mutation	rs372711510	R182H	0.4	2OG-FeII_Oxy_2
UCEC	chr11	43897759	Intron	novel		0.29
UCEC	chr11	43889813	Missense_Mutation	novel	T119A	0.58	2OG-FeII_Oxy_2
UCEC	chr11	43901532	Missense_Mutation	rs202134415	R159H	0.42	2OG-FeII_Oxy_2
UCEC	chr11	43901694	Missense_Mutation	rs776707628	R213H	0.34	2OG-FeII_Oxy_2
UCEC	chr11	43901682	Missense_Mutation	novel	F209S	0.18	2OG-FeII_Oxy_2
UCEC	chr11	43882664	Missense_Mutation	NA	K4N	0.18
UCEC	chr11	43897900	Intron	novel		0.45
UCEC	chr11	43898952	Intron	novel		0.29
UCEC	chr11	43901693	Missense_Mutation	rs373202806	R213C	0.33	2OG-FeII_Oxy_2
UCEC	chr11	43882674	Missense_Mutation	novel	A8T	0.1
UCEC	chr11	43897900	Intron	novel		0.16
UCEC	chr11	43901671	Silent	novel	A205A	0.41
UCEC	chr11	43897321	Intron	novel		0.32
UCEC	chr11	43920041	3'UTR	novel		0.53
UCEC	chr11	43899255	Intron	novel		0.11
UCEC	chr11	43882697	Silent	novel	A15A	0.21
UCEC	chr11	43892129	Splice_Region	NA	H153H	0.44
UCEC	chr11	43899272	Intron	novel		0.53
UCEC	chr11	43897505	Intron	novel		0.35
UCEC	chr11	43889759	Nonsense_Mutation	novel	E101*	0.32	2OG-FeII_Oxy_2
UCEC	chr11	43889748	Missense_Mutation	rs542847003	V97A	0.21	2OG-FeII_Oxy_2
UCEC	chr11	43897556	Intron	novel		0.17
UCEC	chr11	43897734	Intron	novel		0.18
UCEC	chr11	43898856	Intron	novel		0.17
UCEC	chr11	43919117	Missense_Mutation	rs745683816	A250V	0.35
UCEC	chr11	43897900	Intron	novel		0.38
UCEC	chr11	43898714	Intron	novel		0.22
UCEC	chr11	43901697	Missense_Mutation	NA	T214I	0.32	2OG-FeII_Oxy_2
UCEC	chr11	43897891	Intron	novel		0.2
UCEC	chr11	43897255	Intron	rs753573140		0.39
UCEC	chr11	43897951	Intron	novel		0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1739	0.018342
GBM	DEL	0.1404	0.014054
PRAD	DEL	0.0569	0.0050014
TGCT	DEL	0.6067	0.21504

Survival Analysis

Cancer	P-value	Q-value
ACC	0.039	Kaplan-Meier Survival Analysis
UCS	0.036	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
BLCA	0.021	Kaplan-Meier Survival Analysis
KICH	0.033	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
LUAD	0.035	Kaplan-Meier Survival Analysis