EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166200 (Gene tree)
Gene ID: 9318
Gene Symbol: COPS2
Alias: TRIP15|ALIEN|CSN2
Full Name: COP9 signalosome subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 49,594 bases
Position: chr15:49,106,068-49,155,661
Accession: 30747
RBP type: non-canonical RBP
Summary: (COP9 Signalosome Subunit 2) is a Protein Coding gene. Diseases associated with COPS2 include Xeroderma Pigmentosum, Complementation Group E and Decubitus Ulcer. Among its related pathways are Clathrin-mediated endocytosis and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transcription corepressor activity. An important paralog of this gene is PSMD11.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24928548	Gene expression analysis in MCF-7 breast cancer cells treated with recombinant bromelain.	Appl Biochem Biotechnol	2014 Aug	Fouz N	doi: 10.1007/s12010-014-0947-6

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000561248	COPS2-208	575	-	ENSP00000453412	183 (aa)	-	H0YM03
ENST00000560240	COPS2-207	514	-	ENSP00000453546	55 (aa)	-	H0YMC2
ENST00000542928	COPS2-203	1580	-	ENSP00000443664	379 (aa)	-	B4DIH5
ENST00000299259	COPS2-201	2036	-	ENSP00000299259	450 (aa)	-	P61201
ENST00000388901	COPS2-202	6628	-	ENSP00000373553	443 (aa)	-	P61201
ENST00000559016	COPS2-206	570	-	-	- (aa)	-	-
ENST00000558545	COPS2-204	668	-	-	- (aa)	-	-
ENST00000558843	COPS2-205	803	-	ENSP00000452944	263 (aa)	-	H0YKU5

Gene Model

Click here to download ENSG00000166200's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000166200	rs79234094	15	49117330	A	Lung function (FEV1/FVC)	30804560	[0.022-0.032] unit increase	0.0268	EFO_0004713
ENSG00000166200	rs79234094	15	49117330	A	Peak expiratory flow	30804560	[0.015-0.027] unit increase	0.0209

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166200's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166200	COPS2	100	100.000	ENSMUSG00000027206	Cops2	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000338	protein deneddylation	19141280.	IDA	Process
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	Process
GO:0001833	inner cell mass cell proliferation	-	IEA	Process
GO:0003714	transcription corepressor activity	21873635.	IBA	Function
GO:0005515	protein binding	17438371.20399188.21911577.23441852.24421388.25043011.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	9535219.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	7776974.	TAS	Process
GO:0006468	protein phosphorylation	9535219.	IDA	Process
GO:0007165	signal transduction	9535219.	NAS	Process
GO:0008180	COP9 signalosome	21873635.	IBA	Component
GO:0008180	COP9 signalosome	9535219.18850735.	IDA	Component
GO:0030182	neuron differentiation	-	IEA	Process
GO:0035914	skeletal muscle cell differentiation	-	IEA	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045892	negative regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:1903507	negative regulation of nucleic acid-templated transcription	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17968325	Cellular senescence bypass screen identifies new putative tumor suppressor genes.	Oncogene	2008 Mar 27	Leal JF	-
17929852	The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.	J Proteome Res	2007 Nov	Fegers I	-
26942699	DDA1 promotes stage IIB-IIC colon cancer progression by activating NF??B/CSN2/GSK-3β signaling.	Oncotarget	2016 Apr 12	Zhao S	doi: 10.18632/oncotarget.7847.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	49130809	Nonsense_Mutation	NA	Q319*	0.17
BLCA	chr15	49144997	Missense_Mutation	NA	D46N	0.42
BLCA	chr15	49139575	Missense_Mutation	NA	E109Q	0.49
BLCA	chr15	49139602	Missense_Mutation	rs745372669	R100W	0.2
BLCA	chr15	49145071	Missense_Mutation	NA	S21C	0.26
BLCA	chr15	49128748	Missense_Mutation	novel	D381H	0.29
BLCA	chr15	49130781	Frame_Shift_Del	novel	*K328Dfs12**	0.36
BLCA	chr15	49133946	Missense_Mutation	NA	P293Q	0.49
BLCA	chr15	49139554	Missense_Mutation	NA	L116I	0.43
BLCA	chr15	49134086	Missense_Mutation	novel	L246F	0.07
BRCA	chr15	49127916	3'UTR	novel		0.06
BRCA	chr15	49128741	Missense_Mutation	NA	A383V	0.29
BRCA	chr15	49134035	Silent	rs372907163	K263K	0.29
CESC	chr15	49134086	Missense_Mutation	novel	L246F	0.11
CESC	chr15	49127955	Missense_Mutation	NA	A443T	0.1
CESC	chr15	49127854	3'UTR	novel		0.14
CESC	chr15	49129477	Missense_Mutation	NA	K376N	0.46
CESC	chr15	49125941	3'UTR	novel		0.38
COAD	chr15	49133812	Splice_Site	NA	X299_splice	0.44
COAD	chr15	49134047	Frame_Shift_Del	novel	*F259Lfs19**	0.29
COAD	chr15	49127821	3'UTR	novel		0.31
COAD	chr15	49127984	Missense_Mutation	NA	S433Y	0.32
COAD	chr15	49139602	Silent	NA	R100R	0.28
COAD	chr15	49128082	Silent	novel	G400G	0.32
COAD	chr15	49134484	Frame_Shift_Ins	novel	*G191Rfs21**	0.11
COAD	chr15	49144989	Frame_Shift_Del	novel	*A49Rfs3**	0.39
COAD	chr15	49137164	Frame_Shift_Ins	novel	*H176Tfs7**	0.14
COAD	chr15	49137178	Missense_Mutation	NA	I171N	0.37
COAD	chr15	49134361	Silent	rs780336002	L232L	0.82
COAD	chr15	49155599	5'UTR	novel		0.2
GBM	chr15	49155599	5'UTR	novel		0.17
GBM	chr15	49155896	5'Flank	novel		0.62
GBM	chr15	49130801	Missense_Mutation	novel	N321K	0.15
HNSC	chr15	49128735	In_Frame_Del	novel	I380_V385delinsM	0.12
HNSC	chr15	49134047	Frame_Shift_Del	novel	*F259Lfs19**	0.27
HNSC	chr15	49155566	Missense_Mutation	novel	E5Q	0.1
HNSC	chr15	49137430	Frame_Shift_Del	novel	*L127Tfs6**	0.07
HNSC	chr15	49144273	Nonsense_Mutation	NA	W67*	0.32
KIRC	chr15	49128024	Nonsense_Mutation	NA	R420*	0.07
KIRC	chr15	49137190	Missense_Mutation	NA	K167R	0.16
KIRP	chr15	49129530	Missense_Mutation	NA	L359F	0.42
LGG	chr15	49155574	Missense_Mutation	NA	S2C	0.48
LGG	chr15	49134420	In_Frame_Del	novel	N211del	0.1
LGG	chr15	49134063	Missense_Mutation	novel	A254V	0.37
LUAD	chr15	49155548	Missense_Mutation	novel	D11H	0.32
LUAD	chr15	49134084	Missense_Mutation	NA	R247T	0.2
LUAD	chr15	49139628	Missense_Mutation	NA	R91T	0.15
LUAD	chr15	49139601	Missense_Mutation	NA	R100L	0.4
LUAD	chr15	49155610	5'UTR	novel		0.3
LUAD	chr15	49155591	5'UTR	rs191066853		0.18
LUAD	chr15	49134341	Splice_Region	novel	R238R	0.38
LUSC	chr15	49155659	5'Flank	NA		0.4
LUSC	chr15	49133761	Splice_Region	NA	V315V	0.3
LUSC	chr15	49134006	Missense_Mutation	novel	R273Q	0.78
LUSC	chr15	49137228	Splice_Site	NA	X155_splice	0.19
LUSC	chr15	49133787	Missense_Mutation	rs758202372	E307Q	0.12
LUSC	chr15	49155659	5'Flank	NA		0.36
LUSC	chr15	49128712	Missense_Mutation	NA	I393V	0.38
OV	chr15	49145013	Silent	novel	K40K	0.04
OV	chr15	49155578	Translation_Start_Site	novel	M1?	0.95
PAAD	chr15	49155853	5'Flank	novel		0.14
PAAD	chr15	49139602	Missense_Mutation	rs745372669	R100W	0.07
READ	chr15	49155859	5'Flank	novel		0.43
READ	chr15	49134019	Missense_Mutation	NA	G269R	0.33
READ	chr15	49134414	Missense_Mutation	NA	L214R	0.35
SARC	chr15	49139605	Missense_Mutation	novel	I99F	0.4
SKCM	chr15	49155659	5'Flank	NA		0.33
SKCM	chr15	49139568	Missense_Mutation	novel	S111F	0.59
SKCM	chr15	49144273	Nonsense_Mutation	NA	W67*	0.13
SKCM	chr15	49128727	Silent	NA	L388L	0.14
SKCM	chr15	49139559	Missense_Mutation	NA	S114F	0.28
SKCM	chr15	49144971	Silent	NA	F54F	0.19
SKCM	chr15	49144981	Missense_Mutation	NA	L51S	0.23
SKCM	chr15	49155928	5'Flank	novel		0.38
SKCM	chr15	49155659	5'Flank	NA		0.33
SKCM	chr15	49134029	Nonsense_Mutation	NA	Y265*	0.1
SKCM	chr15	49144271	Missense_Mutation	NA	G68R	0.29
SKCM	chr15	49130809	Nonsense_Mutation	NA	Q319*	0.19
STAD	chr15	49155829	5'Flank	novel		0.31
STAD	chr15	49130722	Missense_Mutation	NA	E348K	0.28
STAD	chr15	49139602	Missense_Mutation	rs745372669	R100W	0.39
STAD	chr15	49130716	Splice_Region	novel		0.27
STAD	chr15	49144267	Missense_Mutation	NA	F69C	0.3
STAD	chr15	49134072	Missense_Mutation	NA	F251C	0.84
STAD	chr15	49133803	Silent	rs148364582	P301P	0.38
STAD	chr15	49134046	Frame_Shift_Ins	novel	E260*	0.24
STAD	chr15	49134047	Frame_Shift_Del	novel	*F259Lfs19**	0.35
STAD	chr15	49155636	5'UTR	rs141286814		0.32
STAD	chr15	49134484	Frame_Shift_Ins	novel	*G191Rfs21**	0.24
STAD	chr15	49139603	Missense_Mutation	novel	I99M	0.24
STAD	chr15	49155970	5'Flank	novel		0.18
UCEC	chr15	49134480	Missense_Mutation	NA	T192I	0.22
UCEC	chr15	49127401	3'UTR	novel		0.17
UCEC	chr15	49133770	Silent	rs778626729	T312T	0.15
UCEC	chr15	49139543	Silent	novel	I119I	0.06
UCEC	chr15	49137156	Silent	novel	S178S	0.32
UCEC	chr15	49139617	Missense_Mutation	novel	L95I	0.46
UCEC	chr15	49134046	Frame_Shift_Ins	novel	E260*	0.23
UCEC	chr15	49126328	3'UTR	novel		0.21
UCEC	chr15	49127192	3'UTR	novel		0.33
UCEC	chr15	49134051	Missense_Mutation	NA	F258C	0.42
UCEC	chr15	49128046	Missense_Mutation	NA	D412E	0.31
UCEC	chr15	49134055	Missense_Mutation	NA	D257Y	0.33
UCEC	chr15	49127475	3'UTR	novel		0.24
UCEC	chr15	49134338	Splice_Site	novel	X239_splice	0.15
UCEC	chr15	49127984	Missense_Mutation	NA	S433Y	0.38
UCEC	chr15	49133958	Missense_Mutation	NA	S289L	0.49
UCEC	chr15	49139543	Silent	novel	I119I	0.54
UCEC	chr15	49145025	Nonsense_Mutation	novel	Y36*	0.44
UCEC	chr15	49133958	Missense_Mutation	NA	S289L	0.32
UCEC	chr15	49128074	Missense_Mutation	NA	D403V	0.41
UCEC	chr15	49144297	Missense_Mutation	novel	E59G	0.05
UCEC	chr15	49126294	3'UTR	novel		0.08
UCEC	chr15	49126519	3'UTR	novel		0.22
UCEC	chr15	49127409	3'UTR	novel		0.18
UCEC	chr15	49139553	Missense_Mutation	novel	L116R	0.19
UCEC	chr15	49155896	5'Flank	novel		0.15
UCEC	chr15	49127627	3'UTR	novel		0.41
UCEC	chr15	49126096	3'UTR	novel		0.5
UCEC	chr15	49127864	3'UTR	novel		0.26
UCEC	chr15	49139577	Missense_Mutation	novel	S108Y	0.45
UCEC	chr15	49126345	3'UTR	novel		0.56
UCEC	chr15	49126546	3'UTR	novel		0.36
UCEC	chr15	49127984	Missense_Mutation	NA	S433Y	0.12
UCEC	chr15	49133989	Missense_Mutation	novel	Y279H	0.1
UCEC	chr15	49137178	Missense_Mutation	NA	I171N	0.37
UCEC	chr15	49127519	3'UTR	novel		0.59
UCEC	chr15	49137178	Missense_Mutation	NA	I171N	0.17
UCEC	chr15	49134071	Nonsense_Mutation	novel	*E252Rfs3**	0.08
UCEC	chr15	49155985	5'Flank	novel		0.49
UCEC	chr15	49134481	Nonsense_Mutation	novel	G191_T192insGSFLYGLA*	0.04
UCEC	chr15	49130747	Silent	novel	D339D	0.3
UCEC	chr15	49134435	Missense_Mutation	novel	A207V	0.23
UCEC	chr15	49139543	Silent	novel	I119I	0.44
UCEC	chr15	49134092	Missense_Mutation	novel	M244I	0.48
UCEC	chr15	49127460	3'UTR	novel		0.38
UCEC	chr15	49134007	Nonsense_Mutation	NA	R273*	0.45
UCEC	chr15	49155599	5'UTR	novel		0.45
UCEC	chr15	49127729	3'UTR	novel		0.36
UCEC	chr15	49128081	Nonsense_Mutation	novel	R401*	0.49
UCEC	chr15	49134464	Missense_Mutation	novel	I197M	0.07

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2111	0.079424
CESC	DEL	0.1864	0.00049652
HNSC	DEL	0.1571	0.11567
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1007	0.2062
LIHC	DEL	0.173	3.0903e-07
LUAD	DEL	0.3585	0.050802
MESO	DEL	0.1494	0.075661
PAAD	DEL	0.1196	0.13216
READ	DEL	0.4424	0.025797

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.019	Kaplan-Meier Survival Analysis
ACC	0.032	Kaplan-Meier Survival Analysis
HNSC	0.0012	Kaplan-Meier Survival Analysis
SKCM	0.0011	Kaplan-Meier Survival Analysis
KIRP	0.0015	Kaplan-Meier Survival Analysis
PAAD	0.0048	Kaplan-Meier Survival Analysis
PCPG	0.019	Kaplan-Meier Survival Analysis
KICH	0.028	Kaplan-Meier Survival Analysis
DLBC	0.014	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742