EuRBPDB

Description

Ensembl ID: ENSG00000166477 (Gene tree)
Gene ID: 123169
Gene Symbol: LEO1
Alias: N
Full Name: LEO1 homolog, Paf1/RNA polymerase II complex component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 33,782 bases
Position: chr15:51,938,025-51,971,806
Accession: 30401
RBP type: non-canonical RBP
Summary: LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000299601	LEO1-201	2193	XM_017021911	ENSP00000299601	666 (aa)	XP_016877400	Q8WVC0
ENST00000315141	LEO1-202	1981	-	ENSP00000314610	606 (aa)	-	Q8WVC0
ENST00000558949	LEO1-203	630	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000166477	rs2554341	15	51938495	?	Tenofovir clearance in HIV infection	26148204			EFO_0009279\|EFO_0000764
ENSG00000166477	rs2554321	15	51942335	?	Tenofovir clearance in HIV infection	26148204			EFO_0009279\|EFO_0000764

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0001711	endodermal cell fate commitment	-	ISS	Process
GO:0005515	protein binding	15923622.16024656.16630820.19136632.19410543.20178742.25416956.26496610.29774127.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005813	centrosome	-	IDA	Component
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006378	mRNA polyadenylation	21329879.	IMP	Process
GO:0010390	histone monoubiquitination	16307923.	IDA	Process
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016593	Cdc73/Paf1 complex	16307923.18987311.20178742.	IDA	Component
GO:0019827	stem cell population maintenance	19345177.	IDA	Process
GO:0031442	positive regulation of mRNA 3'-end processing	21329879.	IMP	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	20178742.	IDA	Process
GO:0033523	histone H2B ubiquitination	16307923.	IDA	Process
GO:0045638	negative regulation of myeloid cell differentiation	20541477.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20178742.	IDA	Process
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	Process
GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	21873635.	IBA	Function