EuRBPDB

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  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000166741 (Gene tree)
Gene ID
4837
Gene Symbol
NNMT
Alias
N
Full Name
nicotinamide N-methyltransferase
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
55,499 bases
Position
chr11:114,257,787-114,313,285
Accession
7861
RBP type
non-canonical RBP
Summary
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000545255NNMT-207515--- (aa)--
ENST00000541754NNMT-205716--- (aa)--
ENST00000541090NNMT-204351--- (aa)--
ENST00000546313NNMT-208665--- (aa)--
ENST00000299964NNMT-2011610-ENSP00000299964264 (aa)-P40261
ENST00000535185NNMT-202379--- (aa)--
ENST00000535401NNMT-2031867-ENSP00000441434264 (aa)-P40261
ENST00000542647NNMT-206511--- (aa)--
Gene Model
Click here to download ENSG00000166741's gene model file
Pathways
Pathway IDPathway NameSource
hsa00760Nicotinate and nicotinamide metabolismKEGG
hsa01100Metabolic pathwaysKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000166741Parkinson Disease5.772E-517052657
ENSG00000166741Brain2.96932238908242E-617903297
ENSG00000166741Brain2.13101322484707E-617903297
ENSG00000166741Brain3E-617903297
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166741's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005737cytoplasm21873635.IBAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0008112nicotinamide N-methyltransferase activity21873635.IBAFunction
GO:0008112nicotinamide N-methyltransferase activity-TASFunction
GO:0010243response to organonitrogen compound-IEAProcess
GO:0030760pyridine N-methyltransferase activity-TASFunction
GO:0031100animal organ regeneration-IEAProcess
GO:0032259methylation-TASProcess
GO:0034356NAD biosynthesis via nicotinamide riboside salvage pathway-TASProcess
GO:0042493response to drug-IEAProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19216803Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis.J Exp Clin Cancer Res2009 Feb 16Kim Jdoi: 10.1186/1756-9966-28-20.
17922140Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells.J Cancer Res Clin Oncol2008 MayTomida M-
23097023Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: potential for the development of a urine-based diagnostic test.Cell Biochem Biophys2013 AprSartini Ddoi: 10.1007/s12013-012-9451-1.
29974846Involvement of transforming growth factor beta 1 in the transcriptional regulation of nicotinamide N-methyltransferase in clear cell renal cell carcinoma.Cell Mol Biol (Noisy-le-grand)2018 May 30Campagna R-
15486044Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells.Mol Endocrinol2005 FebXu J-
23479363Composite three-marker assay for early detection of kidney cancer.Cancer Epidemiol Biomarkers Prev2013 MarSu Kim Ddoi: 10.1158/1055-9965.EPI-12-1156.
19242722Serum levels of nicotinamide N-methyltransferase in patients with lung cancer.J Cancer Res Clin Oncol2009 SepTomida Mdoi: 10.1007/s00432-009-0563-y
23455543NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.Nat Chem Biol2013 MayUlanovskaya OAdoi: 10.1038/nchembio.1204
25201588Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells.Arch Biochem Biophys2014 Dec 15Xie Xdoi: 10.1016/j.abb.2014.08.017
16166432Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer.Clin Cancer Res2005 Sep 15Roessler M-
22628313Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease.Biol Chem2012 MaySartini Ddoi: 10.1515/hsz-2012-0112.
16676400Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells.Thyroid2006 FebXu J-
12216074A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer.Int J Cancer2002 Oct 10Kassem HSh-
24558488Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway.PLoS One2014 Feb 18Zhang Jdoi: 10.1371/journal.pone.0089202
29277772Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.Anticancer Res2018 JanIshibashi K-
27323852Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway.Oncotarget2016 Jul 19Xie Xdoi: 10.18632/oncotarget.9962.
26942567Expression profile and prognostic value of NNMT in patients with pancreatic cancer.Oncotarget2016 Apr 12Xu Ydoi: 10.18632/oncotarget.7891.
28412735Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT.Oncotarget2017 Apr 18Kanska Jdoi: 10.18632/oncotarget.15429.
29148015Clinical performance and utility of a NNMT-based urine test for bladder cancer.Int J Biol Markers2018 JanPozzi Vdoi: 10.5301/ijbm.5000311.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr11114312154Missense_Mutationrs749992560D158H0.33
BLCAchr11114297990Missense_MutationnovelG65D0.4
BLCAchr11114297977Missense_Mutationrs768238759D61N0.13
BLCAchr111142965345'UTRnovel0.13
BRCAchr11114298132SilentNAT112T0.17
CESCchr11114298103Nonsense_MutationnovelE103*0.53
CESCchr11114296608Missense_Mutationrs141072720R18W0.31
COADchr11114312378Silentrs536229777I232I0.4
COADchr11114297968SilentnovelL58L0.05
COADchr11114298051SilentnovelD85D0.07
COADchr11114312385Missense_MutationnovelF235V0.36
COADchr11114312298Missense_MutationNAI206L0.31
COADchr11114298096Frame_Shift_DelNAE101Afs*50.36
ESCAchr11114312455Missense_MutationnovelR258T0.43
GBMchr11114312052Missense_Mutationrs768961761G124S0.24
GBMchr11114312461Missense_MutationnovelL260Q0.04
HNSCchr11114312055Missense_MutationnovelP125T0.14
HNSCchr11114312149Missense_Mutationrs777589054P156L0.38
HNSCchr11114298068Missense_MutationnovelL91Q0.78
LGGchr11114312130Missense_MutationNAG150R0.55
LUADchr11114312240SilentnovelL186L0.3
LUADchr11114296588Missense_MutationnovelY11C0.07
LUADchr11114312332Missense_MutationNAG217V0.08
LUADchr11114312046Missense_MutationNAV122L0.41
LUADchr11114296706SilentNAC50C0.17
LUADchr11114296633Missense_MutationNAK26R0.31
LUADchr11114312122Missense_MutationNAQ147R0.05
LUADchr11114312447SilentNAL255L0.35
LUADchr11114298086Missense_MutationnovelW97L0.87
LUSCchr11114297985SilentnovelG63G0.25
LUSCchr11114297986Missense_MutationnovelS64T0.25
LUSCchr11114312240SilentnovelL186L0.12
LUSCchr111142965085'UTRnovel0.09
LUSCchr111142964875'UTRnovel0.74
LUSCchr11114312282Missense_MutationnovelK200N0.14
OVchr11114298073Missense_MutationnovelE93K0.06
OVchr11114296642Missense_MutationNAS29C0.19
OVchr11114312097Missense_MutationnovelL139M0.06
PRADchr11114312452Missense_Mutationrs576476423A257V0.11
PRADchr11114298027SilentnovelS77S0.42
READchr11114296620Nonsense_MutationnovelE22*0.45
READchr11114312379Missense_Mutationrs750805211E233K0.46
SKCMchr11114312247Missense_MutationNAP189S0.22
SKCMchr11114312379Missense_Mutationrs750805211E233K0.36
SKCMchr11114312131Missense_MutationNAG150E0.21
SKCMchr11114312267SilentNAI195I0.89
SKCMchr11114298027SilentNAS77S0.66
SKCMchr11114296611Missense_MutationNAD19N0.31
SKCMchr111143125053'UTRnovel0.13
SKCMchr111142965115'UTRnovel0.5
SKCMchr11114296697SilentNAK47K0.56
SKCMchr11114312253Missense_MutationnovelG191S1
SKCMchr11114312254Missense_MutationnovelG191D1
SKCMchr11114298153Silentrs747266840G119G0.18
SKCMchr11114298034Missense_MutationNAE80K0.64
SKCMchr11114298152Missense_Mutationrs775077728G119E0.2
SKCMchr11114298153Silentrs747266840G119G0.14
SKCMchr11114312430Missense_Mutationrs556654096E250K0.62
SKCMchr11114312146Missense_MutationNAP155L0.15
SKCMchr11114298050Missense_MutationNAD85G0.3
SKCMchr11114312430Missense_Mutationrs556654096E250K0.38
SKCMchr111143125043'UTRnovel0.79
SKCMchr11114312064Nonsense_MutationNAE128*0.62
SKCMchr11114312264SilentNAV194V0.85
STADchr11114312186Silentrs375449921A168A0.38
STADchr11114298070Nonsense_MutationNAQ92*0.12
STADchr11114312275Missense_Mutationrs375954126A198V0.15
STADchr11114312207SilentnovelT175T0.1
STADchr11114312324Frame_Shift_DelnovelL216Wfs*60.1
STADchr11114298042Silentrs776243737V82V0.18
STADchr111142965465'UTRnovel0.26
STADchr11114312141SilentNAP153P0.1
UCECchr11114312379Missense_Mutationrs750805211E233K0.31
UCECchr11114312378Silentrs536229777I232I0.38
UCECchr11114296603Missense_MutationnovelN16S0.42
UCECchr11114296689Missense_MutationNAL45I0.32
UCECchr11114312275Missense_Mutationrs375954126A198V0.49
UCECchr11114296697Missense_MutationnovelK47N0.16
UCECchr11114296668Missense_MutationnovelL38I0.4
UCECchr11114298039Silentrs777640476I81I0.57
UCECchr11114312379Missense_Mutationrs750805211E233K0.29
UCECchr11114297983Missense_MutationnovelG63C0.4
UCECchr11114298108Silentrs780881498A104A0.27
UCECchr11114312232Missense_Mutationrs752304293G184S0.38
UCECchr111142965535'UTRrs1130689090.49
UCECchr11114312379Missense_Mutationrs750805211E233K0.44
UCECchr111142963925'UTRnovel0.35
UCECchr11114312069Missense_MutationnovelE129D0.47
UCECchr11114296612Missense_MutationnovelD19A0.29
UCECchr11114312301Missense_MutationnovelG207C0.12
UCECchr11114298030SilentNAF78F0.43
UCECchr111142963065'UTRnovel0.29
UCECchr11114296689Missense_MutationNAL45I0.23
UCECchr11114312098Missense_MutationNAL139P0.33
UCECchr111142964215'UTRnovel0.43
UCECchr11114297953Missense_Mutationrs139308303G53S0.33
UCECchr111142964485'UTRnovel0.34
UCECchr11114312095Missense_MutationnovelV138A0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.2990.00015732
BRCADEL0.46947.1709e-58
CESCDEL0.50171.0762e-32
CHOLDEL0.30560.048655
ESCAAMP0.10330.018342
HNSCDEL0.41381.8879e-21
KIRPDEL0.10422.839e-05
LIHCDEL0.20270.00030497
LUADDEL0.17644.2393e-06
MESODEL0.19540.0023183
PRADDEL0.10160.00026046
READDEL0.20.054114
SARCDEL0.44361.8105e-09
SKCMDEL0.47683.6825e-28
STADDEL0.16788.3734e-05
TGCTDEL0.76670.21504
UCSDEL0.41070.086462

Survival Analysis
CancerP-value Q-value
THYM0.027

Kaplan-Meier Survival Analysis

KIRC0.0043

Kaplan-Meier Survival Analysis

STAD0.0007

Kaplan-Meier Survival Analysis

SARC0.021

Kaplan-Meier Survival Analysis

MESO0.015

Kaplan-Meier Survival Analysis

HNSC0.00055

Kaplan-Meier Survival Analysis

SKCM0.00051

Kaplan-Meier Survival Analysis

LUSC0.038

Kaplan-Meier Survival Analysis

COAD0.044

Kaplan-Meier Survival Analysis

PCPG0.037

Kaplan-Meier Survival Analysis

BLCA0.049

Kaplan-Meier Survival Analysis

LAML0.0031

Kaplan-Meier Survival Analysis

CHOL0.014

Kaplan-Meier Survival Analysis

UVM0.0053

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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