EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166794 (Gene tree)
Gene ID: 5479
Gene Symbol: PPIB
Alias: CYPB|OI9|PPIase|B|CYP-S1|SCYLP
Full Name: peptidylprolyl isomerase B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,394 bases
Position: chr15:64,155,812-64,163,205
Accession: 9255
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15764595	Role of cyclophilin B in activation of interferon regulatory factor-3.	J Biol Chem	2005 May 6	Obata Y	-
16317665	Treating hepatitis C: can you teach old dogs new tricks?	Hepatology	2005 Dec	Rice CM	-
15989969	Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.	Mol Cell	2005 Jul 1	Watashi K	-
16611911	Diverse effects of cyclosporine on hepatitis C virus strain replication.	J Virol	2006 May	Ishii N	-
17600342	Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.	Hepatology	2007 Oct	Fernandes F	-
22426501	Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription.	Int J Mol Med	2012 Jun	Dieriks B	doi: 10.3892/ijmm.2012.937
19940140	Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases.	J Biol Chem	2010 Jan 15	Deligny A	doi: 10.1074/jbc.M109.018184
17588944	The heparin/heparan sulfate sequence that interacts with cyclophilin B contains a 3-O-sulfated N-unsubstituted glucosamine residue.	J Biol Chem	2007 Aug 17	Vanpouille C	-
17267519	Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis.	Glycobiology	2007 May	Pakula R	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558492	PPIB-202	381	-	-	- (aa)	-	-
ENST00000561048	PPIB-203	1208	-	-	- (aa)	-	-
ENST00000300026	PPIB-201	1081	-	ENSP00000300026	216 (aa)	-	P23284

Gene Model

Click here to download ENSG00000166794's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166794's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166794	PPIB	100	93.981	ENSMUSG00000032383	Ppib	100	93.981	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000413	protein peptidyl-prolyl isomerization	20676357.	IDA	Process
GO:0000413	protein peptidyl-prolyl isomerization	-	ISS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	21873635.	IBA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	20676357.	IDA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	-	ISS	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	2000394.	NAS	Function
GO:0005515	protein binding	15095401.15989969.21280149.21516116.22665516.25416956.30021884.	IPI	Function
GO:0005515	protein binding	-	ISS	Function
GO:0005518	collagen binding	21873635.	IBA	Function
GO:0005518	collagen binding	-	ISS	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005783	endoplasmic reticulum	20089953.	IDA	Component
GO:0005788	endoplasmic reticulum lumen	1530944.	NAS	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005790	smooth endoplasmic reticulum	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0016018	cyclosporin A binding	21873635.	IBA	Function
GO:0016018	cyclosporin A binding	20676357.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0032991	protein-containing complex	-	ISS	Component
GO:0034663	endoplasmic reticulum chaperone complex	-	IEA	Component
GO:0040018	positive regulation of multicellular organism growth	20089953.	IMP	Process
GO:0042026	protein refolding	21873635.	IBA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0044794	positive regulation by host of viral process	15989969.	IMP	Process
GO:0044829	positive regulation by host of viral genome replication	15989969.	IMP	Process
GO:0048471	perinuclear region of cytoplasm	15989969.	IDA	Component
GO:0050821	protein stabilization	20089953.	IMP	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0060348	bone development	20089953.	IMP	Process
GO:0061077	chaperone-mediated protein folding	22665516.	IDA	Process
GO:0061077	chaperone-mediated protein folding	20089953.	IMP	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0070063	RNA polymerase binding	15989969.	IPI	Function
GO:1901873	regulation of post-translational protein modification	20089953.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26125731	Expression and role of cyclophilin B in stomach cancer.	Genet Mol Res	2015 May 22	Meng DQ	doi: 10.4238/2015.May.22.5.
22484812	Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker.	J Clin Invest	2012 May	Ray P	doi: 10.1172/JCI62385
20237142	Cyclophilin B as a co-regulator of prolactin-induced gene expression and function in breast cancer cells.	J Mol Endocrinol	2010 Jun	Fang F	doi: 10.1677/JME-09-0140
30430148	A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis.	Chem Commun (Camb)	2018 Nov 27	Pan W	doi: 10.1039/c8cc06796a.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	64162882	Silent	NA	E35E	0.27
BLCA	chr15	64160164	Missense_Mutation	novel	R95G	0.19
BLCA	chr15	64162043	Missense_Mutation	rs750682454	E83Q	0.21
BLCA	chr15	64162124	Missense_Mutation	NA	D56Y	0.23
BLCA	chr15	64162145	Missense_Mutation	novel	D49H	0.57
BRCA	chr15	64162038	Splice_Region	novel		0.15
BRCA	chr15	64156900	Missense_Mutation	novel	I118T	0.37
BRCA	chr15	64156859	Missense_Mutation	NA	H132Y	0.21
CESC	chr15	64162127	Nonsense_Mutation	NA	E55*	0.21
COAD	chr15	64156080	Silent	novel	I198I	0.27
COAD	chr15	64160179	Missense_Mutation	novel	N90D	0.32
COAD	chr15	64156895	Missense_Mutation	rs755547351	G120S	0.1
COAD	chr15	64162084	Frame_Shift_Del	rs771118063	*V69Sfs6**	0.21
COAD	chr15	64160164	Missense_Mutation	rs757275030	R95C	0.3
DLBC	chr15	64162915	Silent	novel	F24F	0.17
ESCA	chr15	64162870	Silent	novel	G39G	0.28
ESCA	chr15	64160164	Missense_Mutation	rs757275030	R95C	0.14
GBM	chr15	64160174	Frame_Shift_Del	novel	*S91Rfs6**	0.08
HNSC	chr15	64156855	Missense_Mutation	rs766970513	Y133C	0.23
HNSC	chr15	64163013	5'UTR	novel		0.14
KIRP	chr15	64162156	Splice_Site	NA	X46_splice	0.43
LIHC	chr15	64163011	5'UTR	rs772067068		0.24
LUAD	chr15	64162921	Silent	NA	V22V	0.1
LUAD	chr15	64160134	Nonsense_Mutation	novel	G105*	0.63
LUSC	chr15	64162865	Missense_Mutation	NA	K41I	0.24
OV	chr15	64162992	5'UTR	novel		0.62
OV	chr15	64156853	Missense_Mutation	NA	G134W	0.46
OV	chr15	64160187	Missense_Mutation	novel	G87D	0.11
OV	chr15	64162047	Silent	novel	T81T	0.05
SARC	chr15	64160147	Silent	novel	F100F	0.28
SKCM	chr15	64162971	Frame_Shift_Ins	novel	*E6Ffs34**	0.11
SKCM	chr15	64162973	Frame_Shift_Ins	novel	*S5Cfs31**	0.04
SKCM	chr15	64163030	5'UTR	novel		0.5
SKCM	chr15	64163054	5'UTR	novel		0.27
SKCM	chr15	64160173	Missense_Mutation	NA	K92E	0.22
SKCM	chr15	64156910	Splice_Site	novel	X115_splice	0.31
SKCM	chr15	64163030	5'UTR	novel		0.52
SKCM	chr15	64163030	5'UTR	novel		0.6
SKCM	chr15	64156035	Silent	rs767641975	I213I	0.52
SKCM	chr15	64163030	5'UTR	novel		0.58
SKCM	chr15	64163030	5'UTR	novel		0.34
SKCM	chr15	64163030	5'UTR	novel		0.44
SKCM	chr15	64156884	Missense_Mutation	NA	F123L	0.36
SKCM	chr15	64156804	Missense_Mutation	novel	S150F	0.26
STAD	chr15	64156851	Silent	novel	G134G	0.26
STAD	chr15	64162145	Frame_Shift_Ins	novel	D49*	0.33
STAD	chr15	64156915	Splice_Region	novel		0.26
STAD	chr15	64162991	5'UTR	novel		0.18
THYM	chr15	64160048	Intron	novel		0.34
UCEC	chr15	64160168	Missense_Mutation	NA	F93L	0.21
UCEC	chr15	64162895	Missense_Mutation	novel	S31Y	0.09
UCEC	chr15	64156849	Missense_Mutation	novel	P135L	0.38
UCEC	chr15	64156034	Missense_Mutation	rs759753798	A214T	0.36
UCEC	chr15	64160059	Intron	novel		0.46
UCEC	chr15	64156789	Missense_Mutation	rs772552633	T155M	0.13
UCEC	chr15	64159891	Intron	novel		0.36
UCEC	chr15	64160147	Missense_Mutation	novel	F100L	0.36
UCEC	chr15	64162858	Silent	NA	T43T	0.33
UCEC	chr15	64159988	Intron	novel		0.29
UCEC	chr15	64156784	Missense_Mutation	novel	V157I	0.11
UCEC	chr15	64160010	Intron	novel		0.38
UCEC	chr15	64156105	Missense_Mutation	rs200864554	R190Q	0.31
UCEC	chr15	64156756	Missense_Mutation	novel	H166R	0.05
UCEC	chr15	64156888	Missense_Mutation	rs780409157	R122H	0.31
UCEC	chr15	64159977	Intron	novel		0.2
UCEC	chr15	64162890	Missense_Mutation	novel	A33T	0.29
UCEC	chr15	64160110	Missense_Mutation	novel	T113A	0.38
UCEC	chr15	64156789	Missense_Mutation	rs772552633	T155M	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KICH	AMP	0.2727	0.21756
LGG	AMP	0.0156	0.19963
PAAD	AMP	0.0598	0.20695
PAAD	DEL	0.1087	0.13216

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0003	Kaplan-Meier Survival Analysis
HNSC	0.00061	Kaplan-Meier Survival Analysis
PRAD	0.033	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
BRCA	0.015	Kaplan-Meier Survival Analysis
KIRP	0.0035	Kaplan-Meier Survival Analysis
CESC	0.0051	Kaplan-Meier Survival Analysis
KICH	0.03	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.00017	Kaplan-Meier Survival Analysis
LUAD	0.034	Kaplan-Meier Survival Analysis
UVM	0.00016	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742