EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166902 (Gene tree)
Gene ID: 54948
Gene Symbol: MRPL16
Alias: FLJ20484|PNAS-111
Full Name: mitochondrial ribosomal protein L16
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,738 bases
Position: chr11:59,806,135-59,810,872
Accession: 14476
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000300151	Ribosomal_L16	PF00252.18	4e-29	1	1
ENSP00000436592	Ribosomal_L16	PF00252.18	8e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000525470	MRPL16-202	922	-	-	- (aa)	-	-
ENST00000534340	MRPL16-204	574	-	ENSP00000436592	86 (aa)	-	E9PI14
ENST00000300151	MRPL16-201	1182	-	ENSP00000300151	251 (aa)	-	Q9NX20
ENST00000531802	MRPL16-203	557	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000166902's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166902's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166902	MRPL16	99	65.882	ENSAPOG00000003818	mrpl16	87	58.482	Acanthochromis_polyacanthus
ENSG00000166902	MRPL16	100	90.698	ENSAMEG00000014289	MRPL16	100	89.243	Ailuropoda_melanoleuca
ENSG00000166902	MRPL16	99	67.059	ENSACIG00000022204	mrpl16	91	56.356	Amphilophus_citrinellus
ENSG00000166902	MRPL16	99	67.059	ENSAOCG00000002647	mrpl16	87	58.036	Amphiprion_ocellaris
ENSG00000166902	MRPL16	99	67.059	ENSAPEG00000020339	mrpl16	87	58.036	Amphiprion_percula
ENSG00000166902	MRPL16	99	68.235	ENSATEG00000012565	mrpl16	87	60.000	Anabas_testudineus
ENSG00000166902	MRPL16	99	72.941	ENSACAG00000009952	MRPL16	99	65.737	Anolis_carolinensis
ENSG00000166902	MRPL16	100	98.837	ENSANAG00000029141	MRPL16	100	95.219	Aotus_nancymaae
ENSG00000166902	MRPL16	99	68.235	ENSACLG00000024282	mrpl16	99	53.815	Astatotilapia_calliptera
ENSG00000166902	MRPL16	99	72.941	ENSAMXG00000014688	mrpl16	93	60.444	Astyanax_mexicanus
ENSG00000166902	MRPL16	100	87.649	ENSBTAG00000021188	MRPL16	100	87.649	Bos_taurus
ENSG00000166902	MRPL16	90	44.156	WBGene00011412	mrpl-16	97	30.705	Caenorhabditis_elegans
ENSG00000166902	MRPL16	100	96.512	ENSCJAG00000016306	MRPL16	100	94.422	Callithrix_jacchus
ENSG00000166902	MRPL16	100	91.860	ENSCAFG00000031711	-	100	88.446	Canis_familiaris
ENSG00000166902	MRPL16	100	91.860	ENSCAFG00000029686	-	99	84.980	Canis_familiaris
ENSG00000166902	MRPL16	100	91.860	ENSCAFG00020000230	MRPL16	100	88.446	Canis_lupus_dingo
ENSG00000166902	MRPL16	100	88.446	ENSCHIG00000012712	MRPL16	100	88.446	Capra_hircus
ENSG00000166902	MRPL16	100	95.349	ENSTSYG00000013336	MRPL16	100	92.032	Carlito_syrichta
ENSG00000166902	MRPL16	100	86.047	ENSCPOG00000005035	MRPL16	100	84.861	Cavia_porcellus
ENSG00000166902	MRPL16	100	97.674	ENSCCAG00000035372	MRPL16	100	94.422	Cebus_capucinus
ENSG00000166902	MRPL16	100	96.813	ENSCATG00000035790	MRPL16	100	96.813	Cercocebus_atys
ENSG00000166902	MRPL16	100	84.884	ENSCLAG00000003811	MRPL16	100	82.470	Chinchilla_lanigera
ENSG00000166902	MRPL16	100	97.674	ENSCSAG00000006107	MRPL16	100	97.211	Chlorocebus_sabaeus
ENSG00000166902	MRPL16	100	88.372	ENSCHOG00000009976	MRPL16	100	71.315	Choloepus_hoffmanni
ENSG00000166902	MRPL16	100	76.744	ENSCPBG00000009578	MRPL16	100	67.729	Chrysemys_picta_bellii
ENSG00000166902	MRPL16	92	44.304	ENSCING00000020946	-	85	39.103	Ciona_intestinalis
ENSG00000166902	MRPL16	100	95.618	ENSCANG00000027375	MRPL16	100	95.618	Colobus_angolensis_palliatus
ENSG00000166902	MRPL16	100	87.209	ENSCGRG00001000785	Mrpl16	100	85.259	Cricetulus_griseus_chok1gshd
ENSG00000166902	MRPL16	100	87.209	ENSCGRG00000015073	Mrpl16	100	86.190	Cricetulus_griseus_crigri
ENSG00000166902	MRPL16	95	63.415	ENSCSEG00000006169	mrpl16	87	56.000	Cynoglossus_semilaevis
ENSG00000166902	MRPL16	99	65.882	ENSCVAG00000013739	mrpl16	89	58.696	Cyprinodon_variegatus
ENSG00000166902	MRPL16	99	65.882	ENSCVAG00000014885	mrpl16	89	58.696	Cyprinodon_variegatus
ENSG00000166902	MRPL16	100	70.930	ENSDARG00000075325	mrpl16	97	62.791	Danio_rerio
ENSG00000166902	MRPL16	81	63.547	ENSDNOG00000041871	-	100	63.547	Dasypus_novemcinctus
ENSG00000166902	MRPL16	100	89.535	ENSDNOG00000034262	-	100	86.853	Dasypus_novemcinctus
ENSG00000166902	MRPL16	100	91.860	ENSDORG00000024946	Mrpl16	100	88.446	Dipodomys_ordii
ENSG00000166902	MRPL16	98	69.048	FBgn0023519	mRpL16	99	47.303	Drosophila_melanogaster
ENSG00000166902	MRPL16	100	90.698	ENSETEG00000011252	MRPL16	100	69.841	Echinops_telfairi
ENSG00000166902	MRPL16	100	68.605	ENSEBUG00000001257	mrpl16	89	60.173	Eptatretus_burgeri
ENSG00000166902	MRPL16	100	92.430	ENSEASG00005007994	MRPL16	100	92.430	Equus_asinus_asinus
ENSG00000166902	MRPL16	100	92.829	ENSECAG00000014926	MRPL16	100	92.829	Equus_caballus
ENSG00000166902	MRPL16	100	84.462	ENSEEUG00000011076	MRPL16	100	84.462	Erinaceus_europaeus
ENSG00000166902	MRPL16	99	68.235	ENSELUG00000002608	mrpl16	87	60.444	Esox_lucius
ENSG00000166902	MRPL16	100	90.698	ENSFCAG00000007540	MRPL16	100	89.243	Felis_catus
ENSG00000166902	MRPL16	100	76.744	ENSFALG00000012123	MRPL16	99	71.905	Ficedula_albicollis
ENSG00000166902	MRPL16	100	89.535	ENSFDAG00000012285	MRPL16	97	90.265	Fukomys_damarensis
ENSG00000166902	MRPL16	99	67.059	ENSFHEG00000015359	mrpl16	90	58.403	Fundulus_heteroclitus
ENSG00000166902	MRPL16	100	67.442	ENSGMOG00000008546	mrpl16	85	60.494	Gadus_morhua
ENSG00000166902	MRPL16	100	80.233	ENSGALG00000029419	MRPL16	100	71.859	Gallus_gallus
ENSG00000166902	MRPL16	99	64.706	ENSGAFG00000012264	mrpl16	92	55.000	Gambusia_affinis
ENSG00000166902	MRPL16	99	63.529	ENSGACG00000015363	mrpl16	91	56.356	Gasterosteus_aculeatus
ENSG00000166902	MRPL16	100	75.581	ENSGAGG00000023594	MRPL16	100	67.331	Gopherus_agassizii
ENSG00000166902	MRPL16	100	98.837	ENSGGOG00000015703	MRPL16	100	98.406	Gorilla_gorilla
ENSG00000166902	MRPL16	99	68.235	ENSHBUG00000001596	mrpl16	92	56.904	Haplochromis_burtoni
ENSG00000166902	MRPL16	100	89.535	ENSHGLG00000010777	MRPL16	100	85.259	Heterocephalus_glaber_female
ENSG00000166902	MRPL16	100	89.535	ENSHGLG00100010477	MRPL16	100	85.259	Heterocephalus_glaber_male
ENSG00000166902	MRPL16	98	67.857	ENSHCOG00000003499	mrpl16	97	57.965	Hippocampus_comes
ENSG00000166902	MRPL16	99	69.412	ENSIPUG00000009966	mrpl16	91	61.277	Ictalurus_punctatus
ENSG00000166902	MRPL16	100	89.641	ENSSTOG00000021462	MRPL16	100	89.641	Ictidomys_tridecemlineatus
ENSG00000166902	MRPL16	100	90.698	ENSJJAG00000018928	Mrpl16	100	88.048	Jaculus_jaculus
ENSG00000166902	MRPL16	99	68.235	ENSKMAG00000022035	mrpl16	94	56.303	Kryptolebias_marmoratus
ENSG00000166902	MRPL16	99	64.706	ENSLBEG00000013193	mrpl16	88	59.111	Labrus_bergylta
ENSG00000166902	MRPL16	100	77.907	ENSLACG00000002060	MRPL16	94	68.085	Latimeria_chalumnae
ENSG00000166902	MRPL16	99	70.588	ENSLOCG00000010979	mrpl16	89	62.667	Lepisosteus_oculatus
ENSG00000166902	MRPL16	100	88.446	ENSLAFG00000001490	MRPL16	100	88.446	Loxodonta_africana
ENSG00000166902	MRPL16	100	96.813	ENSMFAG00000002379	MRPL16	100	96.813	Macaca_fascicularis
ENSG00000166902	MRPL16	100	96.813	ENSMMUG00000022321	MRPL16	100	96.813	Macaca_mulatta
ENSG00000166902	MRPL16	100	96.414	ENSMNEG00000040325	MRPL16	100	96.414	Macaca_nemestrina
ENSG00000166902	MRPL16	100	95.349	ENSMLEG00000033890	MRPL16	100	88.845	Mandrillus_leucophaeus
ENSG00000166902	MRPL16	99	68.235	ENSMAMG00000003085	mrpl16	100	58.798	Mastacembelus_armatus
ENSG00000166902	MRPL16	99	68.235	ENSMZEG00005000716	mrpl16	92	56.904	Maylandia_zebra
ENSG00000166902	MRPL16	100	75.581	ENSMGAG00000003328	MRPL16	88	67.857	Meleagris_gallopavo
ENSG00000166902	MRPL16	100	87.209	ENSMAUG00000011181	Mrpl16	100	85.657	Mesocricetus_auratus
ENSG00000166902	MRPL16	100	93.023	ENSMICG00000011027	MRPL16	100	89.243	Microcebus_murinus
ENSG00000166902	MRPL16	100	87.209	ENSMOCG00000003604	Mrpl16	100	86.853	Microtus_ochrogaster
ENSG00000166902	MRPL16	99	64.706	ENSMMOG00000018112	mrpl16	91	57.627	Mola_mola
ENSG00000166902	MRPL16	99	81.176	ENSMODG00000020205	MRPL16	100	74.900	Monodelphis_domestica
ENSG00000166902	MRPL16	99	69.412	ENSMALG00000016263	mrpl16	94	58.750	Monopterus_albus
ENSG00000166902	MRPL16	100	89.535	MGP_CAROLIEiJ_G0022733	Mrpl16	100	84.861	Mus_caroli
ENSG00000166902	MRPL16	100	89.535	ENSMUSG00000024683	Mrpl16	100	84.462	Mus_musculus
ENSG00000166902	MRPL16	100	89.535	MGP_PahariEiJ_G0014227	Mrpl16	100	83.665	Mus_pahari
ENSG00000166902	MRPL16	100	89.535	MGP_SPRETEiJ_G0023648	Mrpl16	100	84.462	Mus_spretus
ENSG00000166902	MRPL16	100	90.698	ENSMPUG00000014583	MRPL16	100	90.438	Mustela_putorius_furo
ENSG00000166902	MRPL16	100	78.486	ENSMLUG00000027025	-	100	78.486	Myotis_lucifugus
ENSG00000166902	MRPL16	100	89.535	ENSMLUG00000011224	-	100	89.243	Myotis_lucifugus
ENSG00000166902	MRPL16	100	90.698	ENSNGAG00000010636	Mrpl16	100	87.251	Nannospalax_galili
ENSG00000166902	MRPL16	99	68.235	ENSNBRG00000017868	mrpl16	92	56.904	Neolamprologus_brichardi
ENSG00000166902	MRPL16	100	97.674	ENSNLEG00000013137	MRPL16	100	97.211	Nomascus_leucogenys
ENSG00000166902	MRPL16	99	81.176	ENSMEUG00000016437	MRPL16	100	80.476	Notamacropus_eugenii
ENSG00000166902	MRPL16	100	91.860	ENSOPRG00000014638	-	100	87.302	Ochotona_princeps
ENSG00000166902	MRPL16	100	87.209	ENSODEG00000001664	MRPL16	100	84.064	Octodon_degus
ENSG00000166902	MRPL16	99	68.235	ENSONIG00000003122	mrpl16	92	56.904	Oreochromis_niloticus
ENSG00000166902	MRPL16	100	91.860	ENSOCUG00000013390	MRPL16	100	91.235	Oryctolagus_cuniculus
ENSG00000166902	MRPL16	99	68.235	ENSORLG00000026229	mrpl16	87	58.667	Oryzias_latipes
ENSG00000166902	MRPL16	99	68.235	ENSORLG00020016055	mrpl16	65	58.667	Oryzias_latipes_hni
ENSG00000166902	MRPL16	99	68.235	ENSORLG00015014562	mrpl16	82	58.667	Oryzias_latipes_hsok
ENSG00000166902	MRPL16	99	67.059	ENSOMEG00000016848	mrpl16	87	58.667	Oryzias_melastigma
ENSG00000166902	MRPL16	100	94.186	ENSOGAG00000001486	MRPL16	100	92.032	Otolemur_garnettii
ENSG00000166902	MRPL16	100	87.209	ENSOARG00000012266	MRPL16	100	84.861	Ovis_aries
ENSG00000166902	MRPL16	100	100.000	ENSPPAG00000038990	MRPL16	100	99.203	Pan_paniscus
ENSG00000166902	MRPL16	100	90.698	ENSPPRG00000013233	MRPL16	100	89.243	Panthera_pardus
ENSG00000166902	MRPL16	100	90.698	ENSPTIG00000014818	MRPL16	92	90.517	Panthera_tigris_altaica
ENSG00000166902	MRPL16	100	100.000	ENSPTRG00000003700	MRPL16	100	99.602	Pan_troglodytes
ENSG00000166902	MRPL16	100	96.512	ENSPANG00000010272	MRPL16	100	96.414	Papio_anubis
ENSG00000166902	MRPL16	99	67.059	ENSPKIG00000010334	mrpl16	99	59.072	Paramormyrops_kingsleyae
ENSG00000166902	MRPL16	100	77.907	ENSPSIG00000016182	MRPL16	100	69.323	Pelodiscus_sinensis
ENSG00000166902	MRPL16	99	72.941	ENSPMGG00000001444	mrpl16	100	57.031	Periophthalmus_magnuspinnatus
ENSG00000166902	MRPL16	100	88.372	ENSPEMG00000001887	Mrpl16	100	86.853	Peromyscus_maniculatus_bairdii
ENSG00000166902	MRPL16	100	73.256	ENSPMAG00000001603	mrpl16	84	61.261	Petromyzon_marinus
ENSG00000166902	MRPL16	100	79.070	ENSPCIG00000009443	MRPL16	100	78.486	Phascolarctos_cinereus
ENSG00000166902	MRPL16	99	68.235	ENSPFOG00000009144	mrpl16	88	58.407	Poecilia_formosa
ENSG00000166902	MRPL16	100	67.442	ENSPLAG00000010811	mrpl16	88	58.407	Poecilia_latipinna
ENSG00000166902	MRPL16	99	68.235	ENSPMEG00000023095	mrpl16	88	58.407	Poecilia_mexicana
ENSG00000166902	MRPL16	100	66.279	ENSPREG00000021826	mrpl16	96	57.965	Poecilia_reticulata
ENSG00000166902	MRPL16	100	96.414	ENSPPYG00000003227	MRPL16	100	96.414	Pongo_abelii
ENSG00000166902	MRPL16	100	93.023	ENSPCAG00000008055	MRPL16	100	89.243	Procavia_capensis
ENSG00000166902	MRPL16	100	91.860	ENSPCOG00000025205	MRPL16	100	91.235	Propithecus_coquereli
ENSG00000166902	MRPL16	100	91.235	ENSPVAG00000012250	MRPL16	100	91.235	Pteropus_vampyrus
ENSG00000166902	MRPL16	99	68.235	ENSPNYG00000003647	mrpl16	92	56.904	Pundamilia_nyererei
ENSG00000166902	MRPL16	99	68.235	ENSPNAG00000010473	mrpl16	88	58.667	Pygocentrus_nattereri
ENSG00000166902	MRPL16	100	87.209	ENSRNOG00000021005	Mrpl16	100	83.665	Rattus_norvegicus
ENSG00000166902	MRPL16	100	96.512	ENSRBIG00000018289	MRPL16	100	96.414	Rhinopithecus_bieti
ENSG00000166902	MRPL16	100	96.813	ENSRROG00000040273	MRPL16	100	96.813	Rhinopithecus_roxellana
ENSG00000166902	MRPL16	100	95.349	ENSSBOG00000005353	MRPL16	94	93.365	Saimiri_boliviensis_boliviensis
ENSG00000166902	MRPL16	100	79.070	ENSSHAG00000006665	MRPL16	100	75.697	Sarcophilus_harrisii
ENSG00000166902	MRPL16	99	70.588	ENSSFOG00015008725	mrpl16	89	62.857	Scleropages_formosus
ENSG00000166902	MRPL16	100	63.953	ENSSMAG00000021324	mrpl16	93	57.778	Scophthalmus_maximus
ENSG00000166902	MRPL16	99	65.882	ENSSDUG00000006482	mrpl16	91	55.932	Seriola_dumerili
ENSG00000166902	MRPL16	99	65.882	ENSSLDG00000000994	mrpl16	91	55.932	Seriola_lalandi_dorsalis
ENSG00000166902	MRPL16	100	87.209	ENSSARG00000004666	MRPL16	100	88.571	Sorex_araneus
ENSG00000166902	MRPL16	100	74.419	ENSSPUG00000018047	MRPL16	100	65.737	Sphenodon_punctatus
ENSG00000166902	MRPL16	99	65.882	ENSSPAG00000017237	mrpl16	87	56.696	Stegastes_partitus
ENSG00000166902	MRPL16	100	90.698	ENSSSCG00000013118	MRPL16	100	89.641	Sus_scrofa
ENSG00000166902	MRPL16	100	72.093	ENSTGUG00000006277	MRPL16	100	68.919	Taeniopygia_guttata
ENSG00000166902	MRPL16	88	63.158	ENSTRUG00000017231	mrpl16	90	51.271	Takifugu_rubripes
ENSG00000166902	MRPL16	99	65.882	ENSTNIG00000009438	mrpl16	88	59.292	Tetraodon_nigroviridis
ENSG00000166902	MRPL16	100	89.535	ENSTBEG00000007959	MRPL16	100	88.446	Tupaia_belangeri
ENSG00000166902	MRPL16	100	90.698	ENSTTRG00000009428	MRPL16	100	89.641	Tursiops_truncatus
ENSG00000166902	MRPL16	100	91.860	ENSUAMG00000009824	MRPL16	99	92.237	Ursus_americanus
ENSG00000166902	MRPL16	100	91.860	ENSUMAG00000018814	MRPL16	99	92.237	Ursus_maritimus
ENSG00000166902	MRPL16	100	90.698	ENSVVUG00000026682	MRPL16	99	85.141	Vulpes_vulpes
ENSG00000166902	MRPL16	100	65.116	ENSXETG00000024210	mrpl16	89	58.850	Xenopus_tropicalis
ENSG00000166902	MRPL16	99	64.706	ENSXCOG00000002880	mrpl16	91	57.965	Xiphophorus_couchianus
ENSG00000166902	MRPL16	99	64.706	ENSXMAG00000019187	mrpl16	92	55.833	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0019843	rRNA binding	21873635.	IBA	Function
GO:0032543	mitochondrial translation	21873635.	IBA	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process