EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000166913 (Gene tree)
Gene ID: 7529
Gene Symbol: YWHAB
Alias: YWHAA
Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 22,934 bases
Position: chr20:44,885,599-44,908,532
Accession: 12849
RBP type: non-canonical RBP
Summary: This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000477896	YWHAB-205	410	-	-	- (aa)	-	-
ENST00000633979	YWHAB-208	689	XM_017028040	ENSP00000488178	81 (aa)	XP_016883529	A0A0J9YWZ2
ENST00000428262	YWHAB-203	648	-	ENSP00000394729	100 (aa)	-	Q4VY19
ENST00000479421	YWHAB-206	1097	-	ENSP00000487924	149 (aa)	-	A0A0J9YWE8
ENST00000372839	YWHAB-202	3109	XM_017028039	ENSP00000361930	246 (aa)	XP_016883528	P31946
ENST00000445830	YWHAB-204	556	-	ENSP00000394558	74 (aa)	-	Q4VY20
ENST00000353703	YWHAB-201	3049	-	ENSP00000300161	246 (aa)	-	P31946
ENST00000631616	YWHAB-207	5867	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000166913's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa05160	Hepatitis C	KEGG
hsa05161	Hepatitis B	KEGG
hsa05203	Viral carcinogenesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000166913	Platelet Function Tests	1.6716000E-005	-
ENSG00000166913	Platelet Function Tests	7.7900000E-006	-
ENSG00000166913	Platelet Function Tests	4.4200000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000166913	rs2284265	20	44888400	C	Blood protein levels	30072576	[0.13-0.23] unit increase	0.176	EFO_0007937
ENSG00000166913	rs2425670	20	44893088	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000166913	rs8356	20	44907814	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166913's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000166913	YWHAB	97	86.111	WBGene00001502	ftt-2	99	78.776	Caenorhabditis_elegans
ENSG00000166913	YWHAB	96	90.141	FBgn0004907	14-3-3zeta	98	79.424	Drosophila_melanogaster
ENSG00000166913	YWHAB	95	92.857	ENSG00000164924	YWHAZ	100	92.157	Homo_sapiens
ENSG00000166913	YWHAB	95	87.143	ENSG00000134308	YWHAQ	99	81.818	Homo_sapiens
ENSG00000166913	YWHAB	100	100.000	ENSMUSG00000018326	Ywhab	100	98.780	Mus_musculus
ENSG00000166913	YWHAB	95	92.857	ENSMUSG00000022285	Ywhaz	100	92.308	Mus_musculus
ENSG00000166913	YWHAB	95	87.143	ENSMUSG00000076432	Ywhaq	99	81.818	Mus_musculus
ENSG00000166913	YWHAB	93	72.464	ENSMUSG00000047281	Sfn	96	68.201	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0005515	protein binding	7644510.7882972.7935795.8085158.9341175.10713667.10958686.11157475.11697890.11886850.12582162.12620389.12963375.14688255.14701738.14743216.15023544.15159416.15860732.15883195.16672054.16672277.16775625.16868027.16959763.17085597.17170118.17229891.17923693.17974916.18308725.18460465.18771726.19172738.19329994.19439659.19470455.19592491.19595761.19640509.19860830.20025850.20048001.20169078.20642453.20936779.21224381.21262972.21278420.21771788.21972092.22078878.22190034.23572552.23602568.23622247.23752268.24255178.24366813.24510904.24947832.25588844.25852190.26496610.28330616.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	10869435.12963375.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005774	vacuolar membrane	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006605	protein targeting	-	IEA	Process
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0017053	transcriptional repressor complex	-	IEA	Component
GO:0019899	enzyme binding	17255105.	IPI	Function
GO:0019904	protein domain specific binding	11984006.	IPI	Function
GO:0035308	negative regulation of protein dephosphorylation	17255105.	IDA	Process
GO:0035329	hippo signaling	-	TAS	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042802	identical protein binding	17085597.23622247.	IPI	Function
GO:0042826	histone deacetylase binding	10869435.	IPI	Function
GO:0043085	positive regulation of catalytic activity	17255105.	IDA	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	21224381.	IMP	Process
GO:0045892	negative regulation of transcription, DNA-templated	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	12963375.	IDA	Component
GO:0050815	phosphoserine residue binding	10869435.	IPI	Function
GO:0051219	phosphoprotein binding	10869435.	IPI	Function
GO:0051220	cytoplasmic sequestering of protein	10869435.	IDA	Process
GO:0051291	protein heterooligomerization	-	IEA	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	19199708.20458337.	HDA	Component
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
12582162	The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.	J Biol Chem	2003 Apr 18	Li Y	-
25228695	Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach.	J Biol Chem	2014 Nov 7	Jasinski-Bergner S	doi: 10.1074/jbc.M114.556290
21598387	Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker.	Proteomics	2011 Jun	Tseng CW	doi: 10.1002/pmic.201000449

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	44901588	Missense_Mutation	NA	E19K	0.47
BLCA	chr20	44906421	Missense_Mutation	NA	G242R	0.29
BRCA	chr20	44901717	Missense_Mutation	NA	R62C	0.24
BRCA	chr20	44905048	Missense_Mutation	NA	R169C	0.24
BRCA	chr20	44904978	Silent	novel	S145S	0.34
CESC	chr20	44901786	Missense_Mutation	novel	R85C	0.31
COAD	chr20	44901654	Missense_Mutation	NA	E41K	0.35
COAD	chr20	44906455	3'UTR	novel		0.16
COAD	chr20	44901702	Missense_Mutation	NA	R57C	0.36
COAD	chr20	44906516	3'UTR	novel		0.39
ESCA	chr20	44905027	Missense_Mutation	novel	M162V	0.4
GBM	chr20	44901630	Nonsense_Mutation	novel	E33*	0.36
HNSC	chr20	44905087	Missense_Mutation	novel	E182Q	0.05
HNSC	chr20	44901536	Translation_Start_Site	novel	M1?	0.18
HNSC	chr20	44901698	Silent	rs745735230	G55G	0.31
KIRC	chr20	44905131	Splice_Region	NA	T196T	0.14
KIRP	chr20	44901575	Silent	rs148717452	L14L	0.62
LAML	chr20	44906464	3'UTR	novel		0.06
LGG	chr20	44906038	Missense_Mutation	novel	N209S	0.33
LGG	chr20	44904062	Missense_Mutation	novel	K124E	0.35
LGG	chr20	44901762	Missense_Mutation	rs142757633	K77Q	0.27
LUAD	chr20	44901706	Missense_Mutation	NA	R58L	0.18
LUAD	chr20	44901620	Silent	NA	K29K	0.23
LUSC	chr20	44901673	Missense_Mutation	NA	S47F	0.4
OV	chr20	44904004	Missense_Mutation	NA	D104E	0.38
OV	chr20	44906082	Missense_Mutation	novel	R224W	0.06
PAAD	chr20	44901818	Silent	novel	I95I	0.17
PRAD	chr20	44901591	Nonsense_Mutation	novel	R20*	0.45
SARC	chr20	44904007	Silent	NA	K105K	0.45
SKCM	chr20	44901679	Missense_Mutation	NA	A49V	0.12
SKCM	chr20	44901701	Silent	novel	A56A	0.38
SKCM	chr20	44904049	Silent	NA	F119F	0.16
STAD	chr20	44901671	Silent	NA	L46L	0.09
STAD	chr20	44906417	Silent	rs150381005	D240D	0.44
STAD	chr20	44901592	Missense_Mutation	NA	R20Q	0.23
STAD	chr20	44901654	Missense_Mutation	NA	E41K	0.15
THYM	chr20	44906704	3'UTR	novel		0.08
UCEC	chr20	44906686	3'UTR	novel		0.07
UCEC	chr20	44908042	3'UTR	novel		0.47
UCEC	chr20	44908175	3'UTR	novel		0.53
UCEC	chr20	44905048	Missense_Mutation	NA	R169C	0.07
UCEC	chr20	44906506	3'UTR	novel		0.58
UCEC	chr20	44908157	3'UTR	novel		0.39
UCEC	chr20	44908268	3'UTR	novel		0.31
UCEC	chr20	44908157	3'UTR	novel		0.35
UCEC	chr20	44901641	Silent	NA	H36H	0.38
UCEC	chr20	44901706	Missense_Mutation	rs11556823	R58H	0.46
UCEC	chr20	44905131	Splice_Region	NA	T196T	0.37
UCEC	chr20	44908325	3'UTR	rs545470627		0.33
UCEC	chr20	44906007	Missense_Mutation	novel	D199N	0.29
UCEC	chr20	44906032	Missense_Mutation	rs374058745	T207M	0.51
UCEC	chr20	44908509	3'UTR	novel		0.56
UCEC	chr20	44906834	3'UTR	novel		0.47
UCEC	chr20	44905048	Missense_Mutation	NA	R169C	0.32
UCEC	chr20	44908157	3'UTR	novel		0.37
UCEC	chr20	44906782	3'UTR	novel		0.26
UCEC	chr20	44905048	Missense_Mutation	NA	R169C	0.5
UCEC	chr20	44908175	3'UTR	novel		0.21
UCEC	chr20	44901791	Silent	novel	E86E	0.04
UCEC	chr20	44904978	Silent	rs760401900	S145S	0.27
UCEC	chr20	44908175	3'UTR	novel		0.05
UCEC	chr20	44906640	3'UTR	novel		0.33
UCEC	chr20	44905003	Missense_Mutation	novel	A154S	0.16
UCEC	chr20	44906542	3'UTR	novel		0.55
UCEC	chr20	44906953	3'UTR	novel		0.33
UCEC	chr20	44908175	3'UTR	novel		0.54
UCEC	chr20	44904978	Silent	rs760401900	S145S	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746
LUAD	DEL	0.1221	0.18308
PRAD	AMP	0.0488	0.07085

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0016	Kaplan-Meier Survival Analysis
KIRC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.0011	Kaplan-Meier Survival Analysis
LUSC	0.023	Kaplan-Meier Survival Analysis
BRCA	0.0011	Kaplan-Meier Survival Analysis
ESCA	0.022	Kaplan-Meier Survival Analysis
PAAD	0.0069	Kaplan-Meier Survival Analysis
LAML	0.0021	Kaplan-Meier Survival Analysis
KICH	0.05	Kaplan-Meier Survival Analysis
UCEC	0.00048	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LUAD	0.05	Kaplan-Meier Survival Analysis
UVM	0.0013	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742