EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000166986 (Gene tree)
Gene ID
4141
Gene Symbol
MARS
Alias
MetRS|SPG70|CMT2U
Full Name
methionyl-tRNA synthetase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
42,125 bases
Position
chr12:57,475,445-57,517,569
Accession
6898
RBP type
canonical RBP
Summary
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000262027tRNA-synt_1gPF09334.118.7e-14611
ENSP00000447914tRNA-synt_1gPF09334.115.5e-3111
ENSP00000449071tRNA-synt_1gPF09334.112.4e-1411
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15078106The tRNA-interacting factor p43 associates with mammalian arginyl-tRNA synthetase but does not modify its tRNA aminoacylation properties.Biochemistry2004 Apr 20Guigou L-
1329109RNA binding determinant in some class I tRNA synthetases identified by alignment-guided mutagenesis.Proc Natl Acad Sci U S A1992 Oct 15Shepard A-
11714285The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function.Biochemistry2001 Nov 27Kaminska M-
11118226A recurrent general RNA binding domain appended to plant methionyl-tRNA synthetase acts as a cis-acting cofactor for aminoacylation.EMBO J2000 Dec 15Kaminska M-
10673435The 2.0 A crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules.Structure2000 Feb 15Sugiura I-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000550449MARS-221739--- (aa)--
ENST00000548202MARS-211796--- (aa)--
ENST00000628866MARS-2332583-ENSP0000048673895 (aa)-F8W0M7
ENST00000552007MARS-227434-ENSP0000044857671 (aa)-F8VS26
ENST00000548146MARS-210558--- (aa)--
ENST00000551172MARS-222699-ENSP00000448378124 (aa)-H0YI27
ENST00000546481MARS-205561--- (aa)--
ENST00000549603MARS-219402--- (aa)--
ENST00000549048MARS-216755--- (aa)--
ENST00000548944MARS-215294-ENSP0000044907158 (aa)-H0YIC2
ENST00000551805MARS-224479--- (aa)--
ENST00000552371MARS-228699-ENSP00000447914233 (aa)-H0YHV5
ENST00000548674MARS-213749--- (aa)--
ENST00000548714MARS-214567--- (aa)--
ENST00000548630MARS-212557--- (aa)--
ENST00000547501MARS-208510-ENSP00000447145110 (aa)-F8W0S4
ENST00000551842MARS-225662--- (aa)--
ENST00000537638MARS-2033592-ENSP00000446168546 (aa)-P56192
ENST00000546971MARS-206711--- (aa)--
ENST00000553123MARS-231724--- (aa)--
ENST00000630571MARS-234216-ENSP0000048595171 (aa)-F8VS26
ENST00000547665MARS-209670-ENSP00000448910119 (aa)-H0YI94
ENST00000549133MARS-218493--- (aa)--
ENST00000552499MARS-229555-ENSP0000044733581 (aa)-H0YHL6
ENST00000549074MARS-217532-ENSP00000447258114 (aa)-F8VZZ9
ENST00000553162MARS-232575--- (aa)--
ENST00000630803MARS-235183-ENSP0000048635660 (aa)-F8VPL7
ENST00000551431MARS-223559-ENSP0000044672995 (aa)-F8W0M7
ENST00000552914MARS-230734-ENSP00000449787219 (aa)-H0YIP0
ENST00000447721MARS-2021328--- (aa)--
ENST00000547062MARS-207571--- (aa)--
ENST00000551892MARS-226748-ENSP0000045001860 (aa)-F8VPL7
ENST00000545888MARS-2042979-ENSP00000439307140 (aa)-F5H2V6
ENST00000549827MARS-220465--- (aa)--
ENST00000262027MARS-2012905XM_006719398ENSP00000262027900 (aa)XP_006719461P56192
Gene Model
Click here to download ENSG00000166986's gene model file
Pathways
Pathway IDPathway NameSource
hsa00450Selenocompound metabolismKEGG
hsa00970Aminoacyl-tRNA biosynthesisKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000166986's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000166986MARS9173.585ENSAPOG00000020238mars10064.030Acanthochromis_polyacanthus
ENSG00000166986MARS10093.889ENSAMEG00000004962MARS10093.889Ailuropoda_melanoleuca
ENSG00000166986MARS9173.585ENSACIG00000016271mars10068.108Amphilophus_citrinellus
ENSG00000166986MARS10063.814ENSAOCG00000011411mars10064.030Amphiprion_ocellaris
ENSG00000166986MARS10063.922ENSAPEG00000008610mars10064.139Amphiprion_percula
ENSG00000166986MARS9171.698ENSATEG00000025019mars10063.312Anabas_testudineus
ENSG00000166986MARS9179.245ENSAPLG00000014821MARS10072.248Anas_platyrhynchos
ENSG00000166986MARS9967.889ENSACAG00000006698MARS9967.889Anolis_carolinensis
ENSG00000166986MARS10096.464ENSANAG00000027589MARS10096.464Aotus_nancymaae
ENSG00000166986MARS9962.798ENSACLG00000018937mars10063.015Astatotilapia_calliptera
ENSG00000166986MARS9173.585ENSAMXG00000017335mars10062.156Astyanax_mexicanus
ENSG00000166986MARS10092.889ENSBTAG00000018405MARS10092.889Bos_taurus
ENSG00000166986MARS9950.617WBGene00003415mars-19157.853Caenorhabditis_elegans
ENSG00000166986MARS10096.778ENSCJAG00000007249MARS10096.778Callithrix_jacchus
ENSG00000166986MARS10093.889ENSCAFG00000000229MARS10094.111Canis_familiaris
ENSG00000166986MARS10093.889ENSCAFG00020023661MARS10094.111Canis_lupus_dingo
ENSG00000166986MARS10092.444ENSCHIG00000027023MARS10092.444Capra_hircus
ENSG00000166986MARS10092.333ENSTSYG00000005193MARS10092.333Carlito_syrichta
ENSG00000166986MARS9184.906ENSCAPG00000014448MARS9983.841Cavia_aperea
ENSG00000166986MARS10091.111ENSCPOG00000012866MARS10091.111Cavia_porcellus
ENSG00000166986MARS10096.035ENSCCAG00000032206MARS10096.035Cebus_capucinus
ENSG00000166986MARS10097.342ENSCATG00000038907MARS10097.342Cercocebus_atys
ENSG00000166986MARS9792.466ENSCLAG00000012164MARS9992.449Chinchilla_lanigera
ENSG00000166986MARS10096.429ENSCSAG00000004852MARS10096.358Chlorocebus_sabaeus
ENSG00000166986MARS9493.421ENSCHOG00000001035-5495.652Choloepus_hoffmanni
ENSG00000166986MARS9970.000ENSCPBG00000017136MARS10068.612Chrysemys_picta_bellii
ENSG00000166986MARS8862.745ENSCING00000018550-9960.972Ciona_intestinalis
ENSG00000166986MARS8866.667ENSCSAVG00000006145-9964.348Ciona_savignyi
ENSG00000166986MARS10097.453ENSCANG00000034583MARS10097.453Colobus_angolensis_palliatus
ENSG00000166986MARS9893.548ENSCGRG00001019238Mars10091.000Cricetulus_griseus_chok1gshd
ENSG00000166986MARS9893.548ENSCGRG00000017321Mars10091.000Cricetulus_griseus_crigri
ENSG00000166986MARS9171.698ENSCSEG00000010816mars9963.974Cynoglossus_semilaevis
ENSG00000166986MARS9171.698ENSCVAG00000009314mars9962.773Cyprinodon_variegatus
ENSG00000166986MARS9173.585ENSDARG00000034396mars9763.716Danio_rerio
ENSG00000166986MARS9992.844ENSDNOG00000017502MARS10091.410Dasypus_novemcinctus
ENSG00000166986MARS10092.444ENSDORG00000007127Mars10092.444Dipodomys_ordii
ENSG00000166986MARS9559.649FBgn0034401MetRS8649.290Drosophila_melanogaster
ENSG00000166986MARS9884.615ENSETEG00000007106MARS10090.112Echinops_telfairi
ENSG00000166986MARS8170.213ENSEBUG00000010439mars8761.905Eptatretus_burgeri
ENSG00000166986MARS10094.333ENSEASG00005007208MARS10094.333Equus_asinus_asinus
ENSG00000166986MARS10094.333ENSECAG00000015175MARS10094.333Equus_caballus
ENSG00000166986MARS9989.855ENSEEUG00000015503MARS8988.350Erinaceus_europaeus
ENSG00000166986MARS9173.585ENSELUG00000010453mars10063.337Esox_lucius
ENSG00000166986MARS10094.556ENSFCAG00000002083MARS10094.556Felis_catus
ENSG00000166986MARS9173.585ENSFALG00000010128MARS7780.000Ficedula_albicollis
ENSG00000166986MARS10090.333ENSFDAG00000010217MARS10090.333Fukomys_damarensis
ENSG00000166986MARS9171.698ENSFHEG00000016374mars10062.826Fundulus_heteroclitus
ENSG00000166986MARS9173.585ENSGMOG00000007987mars10062.637Gadus_morhua
ENSG00000166986MARS9173.585ENSGALG00000039315MARS9567.381Gallus_gallus
ENSG00000166986MARS9171.698ENSGAFG00000013461mars10063.666Gambusia_affinis
ENSG00000166986MARS9173.585ENSGACG00000006474mars10063.449Gasterosteus_aculeatus
ENSG00000166986MARS10071.605ENSGAGG00000011640MARS9773.196Gopherus_agassizii
ENSG00000166986MARS10099.000ENSGGOG00000001982MARS10099.000Gorilla_gorilla
ENSG00000166986MARS9170.617ENSHBUG00000009575mars9670.617Haplochromis_burtoni
ENSG00000166986MARS10092.667ENSHGLG00000013493MARS10092.667Heterocephalus_glaber_female
ENSG00000166986MARS9983.750ENSHGLG00000019739-9679.594Heterocephalus_glaber_female
ENSG00000166986MARS9983.750ENSHGLG00100004906-9678.467Heterocephalus_glaber_male
ENSG00000166986MARS10092.667ENSHGLG00100006885MARS10092.667Heterocephalus_glaber_male
ENSG00000166986MARS9169.811ENSHCOG00000001090mars10061.388Hippocampus_comes
ENSG00000166986MARS9169.811ENSIPUG00000024410mars9864.649Ictalurus_punctatus
ENSG00000166986MARS9169.811ENSIPUG00000024413mars9873.401Ictalurus_punctatus
ENSG00000166986MARS10093.008ENSSTOG00000001128MARS10092.786Ictidomys_tridecemlineatus
ENSG00000166986MARS10092.572ENSJJAG00000018827Mars10092.572Jaculus_jaculus
ENSG00000166986MARS9962.907ENSKMAG00000012408mars9964.543Kryptolebias_marmoratus
ENSG00000166986MARS9171.698ENSLBEG00000013609mars10062.863Labrus_bergylta
ENSG00000166986MARS9674.359ENSLACG00000018854MARS10069.560Latimeria_chalumnae
ENSG00000166986MARS10091.898ENSLAFG00000013525MARS10091.898Loxodonta_africana
ENSG00000166986MARS10097.889ENSMFAG00000010123MARS10097.889Macaca_fascicularis
ENSG00000166986MARS100100.000ENSMMUG00000011277MARS100100.000Macaca_mulatta
ENSG00000166986MARS10096.429ENSMNEG00000044464MARS10096.235Macaca_nemestrina
ENSG00000166986MARS9897.436ENSMLEG00000034638MARS10099.083Mandrillus_leucophaeus
ENSG00000166986MARS9566.667ENSMAMG00000010012mars9764.198Mastacembelus_armatus
ENSG00000166986MARS9962.581ENSMZEG00005007092mars10062.798Maylandia_zebra
ENSG00000166986MARS9173.585ENSMGAG00000004209-9879.239Meleagris_gallopavo
ENSG00000166986MARS9892.473ENSMAUG00000011482Mars10087.889Mesocricetus_auratus
ENSG00000166986MARS10094.556ENSMICG00000032056MARS10094.556Microcebus_murinus
ENSG00000166986MARS10091.333ENSMOCG00000010941Mars10091.333Microtus_ochrogaster
ENSG00000166986MARS9468.354ENSMMOG00000007461mars9962.390Mola_mola
ENSG00000166986MARS9171.698ENSMALG00000010005mars10063.152Monopterus_albus
ENSG00000166986MARS9891.398MGP_CAROLIEiJ_G0015891Mars10089.357Mus_caroli
ENSG00000166986MARS10089.468ENSMUSG00000040354Mars10089.468Mus_musculus
ENSG00000166986MARS10090.244MGP_PahariEiJ_G0031194Mars10090.244Mus_pahari
ENSG00000166986MARS10089.579MGP_SPRETEiJ_G0016717Mars10089.579Mus_spretus
ENSG00000166986MARS10093.444ENSMPUG00000001831MARS10093.444Mustela_putorius_furo
ENSG00000166986MARS10092.222ENSMLUG00000001037MARS10092.222Myotis_lucifugus
ENSG00000166986MARS10093.126ENSNGAG00000018824Mars10093.126Nannospalax_galili
ENSG00000166986MARS8872.549ENSNBRG00000004105mars10065.703Neolamprologus_brichardi
ENSG00000166986MARS10097.556ENSNLEG00000017297MARS10097.556Nomascus_leucogenys
ENSG00000166986MARS9978.750ENSMEUG00000007195MARS10084.108Notamacropus_eugenii
ENSG00000166986MARS10090.714ENSOPRG00000006518MARS10089.333Ochotona_princeps
ENSG00000166986MARS10092.444ENSODEG00000001752MARS10092.444Octodon_degus
ENSG00000166986MARS9962.299ENSONIG00000005090mars10062.084Oreochromis_niloticus
ENSG00000166986MARS9973.770ENSOANG00000013318MARS10076.667Ornithorhynchus_anatinus
ENSG00000166986MARS10092.889ENSOCUG00000007373MARS10092.889Oryctolagus_cuniculus
ENSG00000166986MARS9962.297ENSORLG00000005405mars10062.514Oryzias_latipes
ENSG00000166986MARS9962.473ENSORLG00020017397mars10062.690Oryzias_latipes_hni
ENSG00000166986MARS9962.297ENSORLG00015012976mars10062.514Oryzias_latipes_hsok
ENSG00000166986MARS9962.024ENSOMEG00000018411mars10062.677Oryzias_melastigma
ENSG00000166986MARS10093.267ENSOGAG00000005226MARS10093.267Otolemur_garnettii
ENSG00000166986MARS10092.444ENSOARG00000006477MARS10092.444Ovis_aries
ENSG00000166986MARS10097.357ENSPPAG00000025147MARS10097.357Pan_paniscus
ENSG00000166986MARS10094.556ENSPPRG00000023243MARS10094.556Panthera_pardus
ENSG00000166986MARS10094.444ENSPTIG00000006721MARS10094.444Panthera_tigris_altaica
ENSG00000166986MARS10099.556ENSPTRG00000005135MARS10099.556Pan_troglodytes
ENSG00000166986MARS10097.785ENSPANG00000009140MARS10097.785Papio_anubis
ENSG00000166986MARS9963.965ENSPKIG00000002833mars10063.965Paramormyrops_kingsleyae
ENSG00000166986MARS9475.000ENSPSIG00000013607MARS10047.417Pelodiscus_sinensis
ENSG00000166986MARS9073.077ENSPMGG00000014847mars9962.704Periophthalmus_magnuspinnatus
ENSG00000166986MARS10091.131ENSPEMG00000000046Mars10091.131Peromyscus_maniculatus_bairdii
ENSG00000166986MARS10084.368ENSPCIG00000023765MARS10084.368Phascolarctos_cinereus
ENSG00000166986MARS9171.698ENSPFOG00000006998mars10063.388Poecilia_formosa
ENSG00000166986MARS9171.698ENSPLAG00000017870mars10063.279Poecilia_latipinna
ENSG00000166986MARS9171.698ENSPMEG00000008197mars10063.279Poecilia_mexicana
ENSG00000166986MARS9171.698ENSPREG00000008123mars10062.842Poecilia_reticulata
ENSG00000166986MARS10098.000ENSPPYG00000004691MARS10098.000Pongo_abelii
ENSG00000166986MARS9993.750ENSPCAG00000016037MARS10084.125Procavia_capensis
ENSG00000166986MARS10094.889ENSPCOG00000017598MARS10094.889Propithecus_coquereli
ENSG00000166986MARS9889.247ENSPVAG00000012112MARS8285.954Pteropus_vampyrus
ENSG00000166986MARS9962.581ENSPNYG00000013809mars10062.798Pundamilia_nyererei
ENSG00000166986MARS10063.095ENSPNAG00000017290mars10064.216Pygocentrus_nattereri
ENSG00000166986MARS10090.798ENSRNOG00000025459Mars10090.798Rattus_norvegicus
ENSG00000166986MARS9898.291ENSRBIG00000044782MARS9995.838Rhinopithecus_bieti
ENSG00000166986MARS10096.792ENSRROG00000042331MARS10096.792Rhinopithecus_roxellana
ENSG00000166986MARS9549.091YGR264CMES17651.394Saccharomyces_cerevisiae
ENSG00000166986MARS9995.000ENSSBOG00000022875MARS10093.230Saimiri_boliviensis_boliviensis
ENSG00000166986MARS10085.255ENSSHAG00000007182MARS10085.255Sarcophilus_harrisii
ENSG00000166986MARS9962.882ENSSFOG00015011038mars9963.348Scleropages_formosus
ENSG00000166986MARS10062.730ENSSMAG00000012409mars10063.164Scophthalmus_maximus
ENSG00000166986MARS10063.272ENSSDUG00000019070mars10063.489Seriola_dumerili
ENSG00000166986MARS9071.154ENSSLDG00000005561mars9863.626Seriola_lalandi_dorsalis
ENSG00000166986MARS10086.429ENSSARG00000002477MARS9289.126Sorex_araneus
ENSG00000166986MARS9968.257ENSSPUG00000007756MARS9971.995Sphenodon_punctatus
ENSG00000166986MARS9963.705ENSSPAG00000022691mars10063.774Stegastes_partitus
ENSG00000166986MARS10093.889ENSSSCG00000023318MARS9593.889Sus_scrofa
ENSG00000166986MARS9073.077ENSTRUG00000014774mars10062.773Takifugu_rubripes
ENSG00000166986MARS9961.787ENSTNIG00000007060mars10061.787Tetraodon_nigroviridis
ENSG00000166986MARS9992.500ENSTBEG00000000303MARS8889.157Tupaia_belangeri
ENSG00000166986MARS9993.750ENSTTRG00000013088MARS7594.551Tursiops_truncatus
ENSG00000166986MARS10090.714ENSUAMG00000019284-9691.684Ursus_americanus
ENSG00000166986MARS10093.778ENSUMAG00000019826MARS10093.778Ursus_maritimus
ENSG00000166986MARS9888.889ENSVPAG00000008665MARS6692.308Vicugna_pacos
ENSG00000166986MARS10094.000ENSVVUG00000017940MARS10094.000Vulpes_vulpes
ENSG00000166986MARS9076.923ENSXETG00000025174mars10074.959Xenopus_tropicalis
ENSG00000166986MARS9171.698ENSXCOG00000013878mars10063.417Xiphophorus_couchianus
ENSG00000166986MARS9171.698ENSXMAG00000017920mars10063.497Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000049tRNA binding-IEAFunction
GO:0004825methionine-tRNA ligase activity11714285.IDAFunction
GO:0004825methionine-tRNA ligase activity-TASFunction
GO:0005524ATP binding-IEAFunction
GO:0005730nucleolus10791971.IDAComponent
GO:0005737cytoplasm10791971.22424946.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol19289464.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006418tRNA aminoacylation for protein translation-TASProcess
GO:0006431methionyl-tRNA aminoacylation11714285.IDAProcess
GO:0009267cellular response to starvation10791971.IDAProcess
GO:0009303rRNA transcription10791971.IMPProcess
GO:0016020membrane19946888.HDAComponent
GO:0017101aminoacyl-tRNA synthetase multienzyme complex10791971.19131329.IDAComponent
GO:0032869cellular response to insulin stimulus10791971.IDAProcess
GO:0036120cellular response to platelet-derived growth factor stimulus10791971.IDAProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071364cellular response to epidermal growth factor stimulus10791971.IDAProcess
GO:1901838positive regulation of transcription of nucleolar large rRNA by RNA polymerase I10791971.IMPProcess

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