EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167112 (Gene tree)
Gene ID: 26995
Gene Symbol: TRUB2
Alias: CLONE24922
Full Name: TruB pseudouridine synthase family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 17,582 bases
Position: chr9:128,305,161-128,322,742
Accession: 17170
RBP type: canonical RBP
Summary: Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000361982	TruB_N	PF01509.18	7.2e-27	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000372890	TRUB2-201	5719	-	ENSP00000361982	331 (aa)	-	O95900
ENST00000460320	TRUB2-202	933	-	-	- (aa)	-	-
ENST00000461180	TRUB2-203	560	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000167112's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167112	Waist Circumference	7E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167112	rs11539570	9	128322349	A	Obesity-related traits	23251661	[NR] cm/y increase	0.02	EFO_0004342

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167112's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000167112	TRUB2	62	35.096	ENSG00000165832	TRUB1	58	35.096

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167112	TRUB2	84	44.604	ENSAPOG00000018284	-	76	59.124	Acanthochromis_polyacanthus
ENSG00000167112	TRUB2	62	59.024	ENSAPOG00000015733	trub2	74	59.024	Acanthochromis_polyacanthus
ENSG00000167112	TRUB2	99	84.242	ENSAMEG00000015395	TRUB2	99	84.242	Ailuropoda_melanoleuca
ENSG00000167112	TRUB2	84	54.317	ENSACIG00000016500	trub2	84	54.317	Amphilophus_citrinellus
ENSG00000167112	TRUB2	84	57.914	ENSAOCG00000002330	trub2	82	57.914	Amphiprion_ocellaris
ENSG00000167112	TRUB2	84	58.273	ENSAPEG00000013177	trub2	82	58.273	Amphiprion_percula
ENSG00000167112	TRUB2	85	56.028	ENSATEG00000011371	trub2	89	56.028	Anabas_testudineus
ENSG00000167112	TRUB2	87	60.554	ENSAPLG00000009254	TRUB2	94	61.034	Anas_platyrhynchos
ENSG00000167112	TRUB2	88	67.010	ENSACAG00000007331	TRUB2	88	67.010	Anolis_carolinensis
ENSG00000167112	TRUB2	94	91.961	ENSANAG00000036234	TRUB2	100	91.961	Aotus_nancymaae
ENSG00000167112	TRUB2	84	53.957	ENSACLG00000010793	trub2	84	53.957	Astatotilapia_calliptera
ENSG00000167112	TRUB2	84	57.857	ENSAMXG00000031679	trub2	80	57.857	Astyanax_mexicanus
ENSG00000167112	TRUB2	50	85.976	ENSBTAG00000004663	TRUB2	100	85.976	Bos_taurus
ENSG00000167112	TRUB2	54	82.022	ENSBTAG00000055269	-	81	82.022	Bos_taurus
ENSG00000167112	TRUB2	100	90.937	ENSCJAG00000020009	TRUB2	100	90.937	Callithrix_jacchus
ENSG00000167112	TRUB2	100	83.988	ENSCAFG00000020068	TRUB2	100	83.988	Canis_familiaris
ENSG00000167112	TRUB2	54	87.079	ENSCAFG00020017325	-	100	87.079	Canis_lupus_dingo
ENSG00000167112	TRUB2	100	83.686	ENSCHIG00000021160	TRUB2	100	83.686	Capra_hircus
ENSG00000167112	TRUB2	98	86.503	ENSTSYG00000034163	TRUB2	98	86.503	Carlito_syrichta
ENSG00000167112	TRUB2	87	81.250	ENSCAPG00000000223	TRUB2	97	81.250	Cavia_aperea
ENSG00000167112	TRUB2	98	81.538	ENSCPOG00000013535	TRUB2	98	81.538	Cavia_porcellus
ENSG00000167112	TRUB2	98	88.308	ENSCCAG00000028463	-	97	88.308	Cebus_capucinus
ENSG00000167112	TRUB2	100	90.634	ENSCCAG00000026531	-	100	90.634	Cebus_capucinus
ENSG00000167112	TRUB2	100	93.958	ENSCATG00000038234	TRUB2	100	93.958	Cercocebus_atys
ENSG00000167112	TRUB2	98	81.173	ENSCLAG00000001702	TRUB2	99	80.923	Chinchilla_lanigera
ENSG00000167112	TRUB2	100	87.952	ENSCSAG00000014117	TRUB2	100	87.952	Chlorocebus_sabaeus
ENSG00000167112	TRUB2	100	83.384	ENSCHOG00000001555	TRUB2	100	83.384	Choloepus_hoffmanni
ENSG00000167112	TRUB2	90	66.779	ENSCPBG00000025186	TRUB2	88	66.779	Chrysemys_picta_bellii
ENSG00000167112	TRUB2	87	35.714	ENSCSAVG00000003930	-	90	35.714	Ciona_savignyi
ENSG00000167112	TRUB2	100	85.196	ENSCANG00000016135	TRUB2	100	85.196	Colobus_angolensis_palliatus
ENSG00000167112	TRUB2	100	79.154	ENSCGRG00001024441	Trub2	100	79.154	Cricetulus_griseus_chok1gshd
ENSG00000167112	TRUB2	100	79.154	ENSCGRG00000005633	Trub2	100	79.154	Cricetulus_griseus_crigri
ENSG00000167112	TRUB2	84	55.197	ENSCSEG00000001331	trub2	83	55.197	Cynoglossus_semilaevis
ENSG00000167112	TRUB2	83	55.596	ENSCVAG00000009901	trub2	83	55.596	Cyprinodon_variegatus
ENSG00000167112	TRUB2	83	56.679	ENSDARG00000028379	trub2	79	56.679	Danio_rerio
ENSG00000167112	TRUB2	99	55.090	ENSDNOG00000043967	-	100	55.090	Dasypus_novemcinctus
ENSG00000167112	TRUB2	98	82.209	ENSDNOG00000045679	-	98	82.209	Dasypus_novemcinctus
ENSG00000167112	TRUB2	100	80.539	ENSDORG00000016222	Trub2	98	83.226	Dipodomys_ordii
ENSG00000167112	TRUB2	83	33.096	FBgn0033060	CG7849	88	33.096	Drosophila_melanogaster
ENSG00000167112	TRUB2	90	85.906	ENSETEG00000009114	TRUB2	92	85.906	Echinops_telfairi
ENSG00000167112	TRUB2	74	44.737	ENSEBUG00000015723	trub2	85	44.737	Eptatretus_burgeri
ENSG00000167112	TRUB2	100	84.894	ENSEASG00005016819	TRUB2	100	84.894	Equus_asinus_asinus
ENSG00000167112	TRUB2	100	85.498	ENSECAG00000023520	TRUB2	100	85.498	Equus_caballus
ENSG00000167112	TRUB2	97	85.047	ENSEEUG00000008908	TRUB2	98	85.047	Erinaceus_europaeus
ENSG00000167112	TRUB2	85	56.122	ENSELUG00000002376	trub2	92	56.122	Esox_lucius
ENSG00000167112	TRUB2	100	84.985	ENSFCAG00000005839	TRUB2	100	84.985	Felis_catus
ENSG00000167112	TRUB2	81	64.045	ENSFALG00000001364	TRUB2	86	64.794	Ficedula_albicollis
ENSG00000167112	TRUB2	99	80.303	ENSFDAG00000021374	TRUB2	99	80.303	Fukomys_damarensis
ENSG00000167112	TRUB2	86	50.000	ENSFHEG00000014655	trub2	85	50.000	Fundulus_heteroclitus
ENSG00000167112	TRUB2	82	47.970	ENSGMOG00000000981	trub2	90	47.970	Gadus_morhua
ENSG00000167112	TRUB2	87	61.806	ENSGALG00000004920	TRUB2	71	61.806	Gallus_gallus
ENSG00000167112	TRUB2	84	56.475	ENSGAFG00000010107	trub2	87	53.925	Gambusia_affinis
ENSG00000167112	TRUB2	84	56.584	ENSGACG00000001476	trub2	84	56.584	Gasterosteus_aculeatus
ENSG00000167112	TRUB2	89	67.905	ENSGAGG00000022872	TRUB2	88	67.905	Gopherus_agassizii
ENSG00000167112	TRUB2	100	98.187	ENSGGOG00000014780	TRUB2	100	98.187	Gorilla_gorilla
ENSG00000167112	TRUB2	84	54.676	ENSHBUG00000022384	trub2	84	54.676	Haplochromis_burtoni
ENSG00000167112	TRUB2	100	79.758	ENSHGLG00000016715	TRUB2	100	79.758	Heterocephalus_glaber_female
ENSG00000167112	TRUB2	100	79.758	ENSHGLG00100016548	TRUB2	100	79.758	Heterocephalus_glaber_male
ENSG00000167112	TRUB2	84	57.857	ENSHCOG00000017748	trub2	86	57.857	Hippocampus_comes
ENSG00000167112	TRUB2	100	81.269	ENSSTOG00000008024	-	100	81.269	Ictidomys_tridecemlineatus
ENSG00000167112	TRUB2	99	80.734	ENSSTOG00000022617	-	99	80.734	Ictidomys_tridecemlineatus
ENSG00000167112	TRUB2	98	73.375	ENSJJAG00000019181	Trub2	97	73.375	Jaculus_jaculus
ENSG00000167112	TRUB2	83	55.596	ENSKMAG00000007861	trub2	83	55.596	Kryptolebias_marmoratus
ENSG00000167112	TRUB2	84	54.643	ENSLBEG00000000907	trub2	83	54.643	Labrus_bergylta
ENSG00000167112	TRUB2	88	66.323	ENSLACG00000001515	TRUB2	86	66.323	Latimeria_chalumnae
ENSG00000167112	TRUB2	87	60.481	ENSLOCG00000000885	trub2	95	60.481	Lepisosteus_oculatus
ENSG00000167112	TRUB2	91	88.742	ENSLAFG00000002174	TRUB2	99	88.742	Loxodonta_africana
ENSG00000167112	TRUB2	100	93.353	ENSMFAG00000000881	TRUB2	100	93.353	Macaca_fascicularis
ENSG00000167112	TRUB2	100	93.051	ENSMMUG00000014146	TRUB2	100	93.051	Macaca_mulatta
ENSG00000167112	TRUB2	100	93.051	ENSMNEG00000011189	TRUB2	100	93.051	Macaca_nemestrina
ENSG00000167112	TRUB2	100	93.656	ENSMLEG00000037270	TRUB2	100	93.656	Mandrillus_leucophaeus
ENSG00000167112	TRUB2	84	57.194	ENSMAMG00000023643	trub2	92	57.194	Mastacembelus_armatus
ENSG00000167112	TRUB2	84	54.317	ENSMZEG00005016018	trub2	84	54.317	Maylandia_zebra
ENSG00000167112	TRUB2	60	68.500	ENSMGAG00000003894	TRUB2	100	68.500	Meleagris_gallopavo
ENSG00000167112	TRUB2	100	79.456	ENSMAUG00000010403	Trub2	100	79.456	Mesocricetus_auratus
ENSG00000167112	TRUB2	100	86.707	ENSMICG00000047032	TRUB2	100	86.707	Microcebus_murinus
ENSG00000167112	TRUB2	91	84.053	ENSMOCG00000014291	Trub2	99	84.053	Microtus_ochrogaster
ENSG00000167112	TRUB2	84	57.651	ENSMMOG00000021674	trub2	86	57.651	Mola_mola
ENSG00000167112	TRUB2	88	75.342	ENSMODG00000005940	TRUB2	99	75.342	Monodelphis_domestica
ENSG00000167112	TRUB2	91	56.311	ENSMALG00000021231	trub2	91	56.311	Monopterus_albus
ENSG00000167112	TRUB2	100	82.175	MGP_CAROLIEiJ_G0023368	Trub2	100	82.175	Mus_caroli
ENSG00000167112	TRUB2	100	81.571	ENSMUSG00000039826	Trub2	100	81.571	Mus_musculus
ENSG00000167112	TRUB2	100	81.873	MGP_PahariEiJ_G0024826	Trub2	100	81.873	Mus_pahari
ENSG00000167112	TRUB2	100	81.571	MGP_SPRETEiJ_G0024286	Trub2	100	81.571	Mus_spretus
ENSG00000167112	TRUB2	100	82.175	ENSMPUG00000013206	TRUB2	91	82.175	Mustela_putorius_furo
ENSG00000167112	TRUB2	98	84.520	ENSMLUG00000005256	TRUB2	97	84.520	Myotis_lucifugus
ENSG00000167112	TRUB2	100	80.060	ENSNGAG00000018679	Trub2	100	80.060	Nannospalax_galili
ENSG00000167112	TRUB2	84	54.480	ENSNBRG00000016294	trub2	84	54.480	Neolamprologus_brichardi
ENSG00000167112	TRUB2	100	96.677	ENSNLEG00000017556	TRUB2	100	96.677	Nomascus_leucogenys
ENSG00000167112	TRUB2	93	75.321	ENSMEUG00000000484	TRUB2	100	75.321	Notamacropus_eugenii
ENSG00000167112	TRUB2	99	77.576	ENSOPRG00000001981	TRUB2	100	77.576	Ochotona_princeps
ENSG00000167112	TRUB2	98	81.288	ENSODEG00000017292	TRUB2	99	81.288	Octodon_degus
ENSG00000167112	TRUB2	84	54.317	ENSONIG00000004230	trub2	84	54.317	Oreochromis_niloticus
ENSG00000167112	TRUB2	56	80.749	ENSOANG00000029023	-	83	80.749	Ornithorhynchus_anatinus
ENSG00000167112	TRUB2	99	80.243	ENSOCUG00000026296	TRUB2	91	80.363	Oryctolagus_cuniculus
ENSG00000167112	TRUB2	84	55.000	ENSORLG00000020011	trub2	84	55.000	Oryzias_latipes
ENSG00000167112	TRUB2	98	50.155	ENSORLG00020011028	trub2	92	50.155	Oryzias_latipes_hni
ENSG00000167112	TRUB2	84	55.197	ENSORLG00015007494	trub2	86	55.197	Oryzias_latipes_hsok
ENSG00000167112	TRUB2	94	53.698	ENSOMEG00000006702	trub2	95	53.698	Oryzias_melastigma
ENSG00000167112	TRUB2	100	83.686	ENSOARG00000010579	-	100	83.686	Ovis_aries
ENSG00000167112	TRUB2	76	80.952	ENSOARG00000003785	-	100	80.952	Ovis_aries
ENSG00000167112	TRUB2	100	98.792	ENSPPAG00000043146	TRUB2	100	98.792	Pan_paniscus
ENSG00000167112	TRUB2	100	84.985	ENSPPRG00000006307	TRUB2	100	84.985	Panthera_pardus
ENSG00000167112	TRUB2	100	84.685	ENSPTIG00000012366	TRUB2	100	84.685	Panthera_tigris_altaica
ENSG00000167112	TRUB2	100	98.489	ENSPTRG00000021423	TRUB2	100	98.489	Pan_troglodytes
ENSG00000167112	TRUB2	100	98.489	ENSPTRG00000052151	-	100	98.489	Pan_troglodytes
ENSG00000167112	TRUB2	100	94.260	ENSPANG00000025856	TRUB2	100	94.260	Papio_anubis
ENSG00000167112	TRUB2	83	56.159	ENSPKIG00000019769	trub2	90	56.159	Paramormyrops_kingsleyae
ENSG00000167112	TRUB2	89	62.712	ENSPSIG00000015701	TRUB2	99	62.712	Pelodiscus_sinensis
ENSG00000167112	TRUB2	91	51.746	ENSPMGG00000010206	trub2	99	51.746	Periophthalmus_magnuspinnatus
ENSG00000167112	TRUB2	100	80.723	ENSPEMG00000017893	Trub2	100	80.723	Peromyscus_maniculatus_bairdii
ENSG00000167112	TRUB2	89	77.365	ENSPCIG00000026731	TRUB2	95	77.365	Phascolarctos_cinereus
ENSG00000167112	TRUB2	84	55.556	ENSPFOG00000018018	trub2	74	55.556	Poecilia_formosa
ENSG00000167112	TRUB2	84	55.197	ENSPLAG00000010484	trub2	80	55.197	Poecilia_latipinna
ENSG00000167112	TRUB2	91	52.824	ENSPMEG00000012913	trub2	89	52.824	Poecilia_mexicana
ENSG00000167112	TRUB2	84	54.676	ENSPREG00000002549	trub2	82	54.676	Poecilia_reticulata
ENSG00000167112	TRUB2	98	94.785	ENSPPYG00000019650	TRUB2	100	94.785	Pongo_abelii
ENSG00000167112	TRUB2	100	86.103	ENSPCAG00000015068	TRUB2	100	86.103	Procavia_capensis
ENSG00000167112	TRUB2	100	87.311	ENSPCOG00000017100	TRUB2	100	87.311	Propithecus_coquereli
ENSG00000167112	TRUB2	90	86.532	ENSPVAG00000001224	TRUB2	99	86.532	Pteropus_vampyrus
ENSG00000167112	TRUB2	84	54.317	ENSPNYG00000013666	trub2	84	54.317	Pundamilia_nyererei
ENSG00000167112	TRUB2	97	52.615	ENSPNAG00000017292	trub2	91	52.615	Pygocentrus_nattereri
ENSG00000167112	TRUB2	96	79.560	ENSRNOG00000043189	Trub2	98	79.560	Rattus_norvegicus
ENSG00000167112	TRUB2	100	86.103	ENSRBIG00000006965	TRUB2	100	86.103	Rhinopithecus_bieti
ENSG00000167112	TRUB2	100	94.260	ENSRROG00000042928	TRUB2	100	94.260	Rhinopithecus_roxellana
ENSG00000167112	TRUB2	100	90.634	ENSSBOG00000022439	TRUB2	100	90.634	Saimiri_boliviensis_boliviensis
ENSG00000167112	TRUB2	84	57.914	ENSSFOG00015013391	trub2	89	57.914	Scleropages_formosus
ENSG00000167112	TRUB2	97	52.648	ENSSMAG00000020820	trub2	97	52.648	Scophthalmus_maximus
ENSG00000167112	TRUB2	84	55.000	ENSSDUG00000016928	trub2	84	55.000	Seriola_dumerili
ENSG00000167112	TRUB2	84	55.755	ENSSLDG00000024701	trub2	83	55.755	Seriola_lalandi_dorsalis
ENSG00000167112	TRUB2	90	63.123	ENSSPUG00000015515	TRUB2	90	63.123	Sphenodon_punctatus
ENSG00000167112	TRUB2	91	57.377	ENSSPAG00000017865	trub2	90	57.377	Stegastes_partitus
ENSG00000167112	TRUB2	100	86.707	ENSSSCG00000005645	TRUB2	99	85.763	Sus_scrofa
ENSG00000167112	TRUB2	79	66.031	ENSTGUG00000003704	TRUB2	100	66.031	Taeniopygia_guttata
ENSG00000167112	TRUB2	89	51.014	ENSTRUG00000015499	trub2	89	51.014	Takifugu_rubripes
ENSG00000167112	TRUB2	84	55.516	ENSTNIG00000014721	trub2	96	55.516	Tetraodon_nigroviridis
ENSG00000167112	TRUB2	68	81.333	ENSTBEG00000000586	TRUB2	100	81.333	Tupaia_belangeri
ENSG00000167112	TRUB2	100	80.363	ENSTTRG00000016486	TRUB2	100	80.363	Tursiops_truncatus
ENSG00000167112	TRUB2	99	83.939	ENSUAMG00000020276	TRUB2	96	83.939	Ursus_americanus
ENSG00000167112	TRUB2	99	83.939	ENSUMAG00000022051	TRUB2	96	83.939	Ursus_maritimus
ENSG00000167112	TRUB2	96	66.246	ENSVPAG00000005793	TRUB2	100	66.246	Vicugna_pacos
ENSG00000167112	TRUB2	95	83.861	ENSVVUG00000013451	TRUB2	90	83.861	Vulpes_vulpes
ENSG00000167112	TRUB2	94	61.935	ENSXETG00000003973	trub2	95	61.935	Xenopus_tropicalis
ENSG00000167112	TRUB2	84	55.755	ENSXCOG00000008759	trub2	83	55.755	Xiphophorus_couchianus
ENSG00000167112	TRUB2	84	55.755	ENSXMAG00000015478	trub2	83	55.755	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001522	pseudouridine synthesis	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	27499296.	IPI	Function
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0009982	pseudouridine synthase activity	-	IEA	Function
GO:0070131	positive regulation of mitochondrial translation	27667664.	IMP	Process