EuRBPDB

Description

Ensembl ID: ENSG00000167196 (Gene tree)
Gene ID: 26263
Gene Symbol: FBXO22
Alias: FBX22|FISTC1
Full Name: F-box protein 22
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 38,652 bases
Position: chr15:75,903,859-75,942,510
Accession: 13593
RBP type: non-canonical RBP
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000569022	FBXO22-207	2164	-	ENSP00000457531	46 (aa)	-	Q8NEZ5
ENST00000569054	FBXO22-208	782	XM_011521447	ENSP00000457569	160 (aa)	XP_011519749	H3BUC1
ENST00000565131	FBXO22-206	471	-	-	- (aa)	-	-
ENST00000453211	FBXO22-202	1486	-	ENSP00000396442	276 (aa)	-	Q8NEZ5
ENST00000569749	FBXO22-209	1496	-	ENSP00000456198	93 (aa)	-	H3BRE0
ENST00000308275	FBXO22-201	10725	-	ENSP00000307833	403 (aa)	-	Q8NEZ5
ENST00000561885	FBXO22-203	722	-	ENSP00000458022	153 (aa)	-	H3BVA4
ENST00000565036	FBXO22-205	725	-	ENSP00000457177	241 (aa)	-	H3BTH6
ENST00000564220	FBXO22-204	316	-	ENSP00000457297	78 (aa)	-	H3BTR7

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0004842	ubiquitin-protein transferase activity	10531037.	TAS	Function
GO:0005515	protein binding	26496610.27705803.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006464	cellular protein modification process	10531035.	TAS	Process
GO:0006511	ubiquitin-dependent protein catabolic process	10531035.	TAS	Process
GO:0006913	nucleocytoplasmic transport	-	IEA	Process
GO:0009267	cellular response to starvation	-	IEA	Process
GO:0030018	Z disc	-	IEA	Component
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0048742	regulation of skeletal muscle fiber development	-	IEA	Process