EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167264 (Gene tree)
Gene ID: 54920
Gene Symbol: DUS2
Alias: FLJ20399|SMM1|DUS2L
Full Name: dihydrouridine synthase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 91,578 bases
Position: chr16:67,987,746-68,079,323
Accession: 26014
RBP type: canonical RBP
Summary: This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000409498	dsrm	PF00035.26	2.8e-06	1	1
ENSP00000351769	dsrm	PF00035.26	3.1e-06	1	1
ENSP00000455229	dsrm	PF00035.26	3.1e-06	1	1
ENSP00000351769	Dus	PF01207.17	7.1e-53	1	1
ENSP00000455229	Dus	PF01207.17	7.1e-53	1	1
ENSP00000463498	Dus	PF01207.17	5.4e-39	1	1
ENSP00000409498	Dus	PF01207.17	2.2e-34	1	1
ENSP00000461659	Dus	PF01207.17	1.4e-28	1	1
ENSP00000461244	Dus	PF01207.17	9.8e-15	1	1
ENSP00000454252	Dus	PF01207.17	1.3e-10	1	1
ENSP00000455977	Dus	PF01207.17	2.5e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30605527	Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.	Nucleic Acids Res	2019 Apr 8	Bou-Nader C	doi: 10.1093/nar/gky1302.
15994936	A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis.	Cancer Res	2005 Jul 1	Kato T	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000566306	DUS2-209	544	-	ENSP00000454252	115 (aa)	-	H3BM64
ENST00000358896	DUS2-201	1933	-	ENSP00000351769	493 (aa)	-	Q9NX74
ENST00000564975	DUS2-206	833	-	-	- (aa)	-	-
ENST00000575677	DUS2-215	570	-	ENSP00000461659	158 (aa)	-	I3L4Y9
ENST00000571081	DUS2-214	570	-	ENSP00000458906	88 (aa)	-	I3L1K5
ENST00000565263	DUS2-207	2310	-	ENSP00000455229	493 (aa)	-	Q9NX74
ENST00000570709	DUS2-213	569	-	ENSP00000461244	123 (aa)	-	I3L4H0
ENST00000564781	DUS2-205	540	-	ENSP00000456677	51 (aa)	-	H3BSF3
ENST00000562246	DUS2-204	736	-	ENSP00000463498	208 (aa)	-	J3QLD5
ENST00000565980	DUS2-208	685	-	-	- (aa)	-	-
ENST00000568099	DUS2-211	540	-	ENSP00000455977	107 (aa)	-	H3BQX4
ENST00000569289	DUS2-212	373	-	ENSP00000456261	41 (aa)	-	H3BRI6
ENST00000561965	DUS2-203	1712	-	ENSP00000457292	87 (aa)	-	H3BTR3
ENST00000432752	DUS2-202	1864	-	ENSP00000409498	458 (aa)	-	E7EUN9
ENST00000567100	DUS2-210	567	-	ENSP00000454424	81 (aa)	-	H3BMK6
ENST00000576994	DUS2-216	571	-	ENSP00000458152	73 (aa)	-	I3L0K0

Gene Model

Click here to download ENSG00000167264's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167264	rs255052	16	67991092	A	HDL cholesterol	18193043	[NR] mg/dl increase	0.74	EFO_0004612
ENSG00000167264	rs56303487	16	67995836	?	High density lipoprotein cholesterol levels	29403010	[0.054-0.084] unit increase novel	0.06921	EFO_0004612

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167264's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167264	DUS2	99	79.747	ENSAPOG00000014250	dus2	89	67.763	Acanthochromis_polyacanthus
ENSG00000167264	DUS2	67	89.968	ENSAMEG00000008115	DUS2	100	89.968	Ailuropoda_melanoleuca
ENSG00000167264	DUS2	99	77.707	ENSAOCG00000023179	dus2	98	66.111	Amphiprion_ocellaris
ENSG00000167264	DUS2	100	78.049	ENSAPEG00000012860	dus2	89	63.596	Amphiprion_percula
ENSG00000167264	DUS2	99	77.070	ENSATEG00000011729	dus2	91	65.934	Anabas_testudineus
ENSG00000167264	DUS2	100	84.553	ENSACAG00000009757	DUS2	98	73.486	Anolis_carolinensis
ENSG00000167264	DUS2	100	99.130	ENSANAG00000023126	DUS2	100	96.748	Aotus_nancymaae
ENSG00000167264	DUS2	96	80.795	ENSACLG00000023737	dus2	90	68.151	Astatotilapia_calliptera
ENSG00000167264	DUS2	96	80.132	ENSAMXG00000017685	dus2	90	67.181	Astyanax_mexicanus
ENSG00000167264	DUS2	100	94.712	ENSBTAG00000014644	DUS2	100	91.684	Bos_taurus
ENSG00000167264	DUS2	97	52.288	WBGene00013201	dus-2	97	41.190	Caenorhabditis_elegans
ENSG00000167264	DUS2	100	99.130	ENSCJAG00000015797	DUS2	100	96.349	Callithrix_jacchus
ENSG00000167264	DUS2	100	95.122	ENSCAFG00000020326	DUS2	100	91.075	Canis_familiaris
ENSG00000167264	DUS2	100	95.122	ENSCAFG00020019787	DUS2	100	91.075	Canis_lupus_dingo
ENSG00000167264	DUS2	100	95.122	ENSCHIG00000023088	DUS2	100	83.164	Capra_hircus
ENSG00000167264	DUS2	100	98.261	ENSTSYG00000013135	DUS2	100	92.901	Carlito_syrichta
ENSG00000167264	DUS2	100	96.522	ENSCPOG00000013747	DUS2	100	90.872	Cavia_porcellus
ENSG00000167264	DUS2	100	99.130	ENSCCAG00000000046	DUS2	100	96.349	Cebus_capucinus
ENSG00000167264	DUS2	100	100.000	ENSCATG00000030756	DUS2	100	98.472	Cercocebus_atys
ENSG00000167264	DUS2	100	95.652	ENSCLAG00000004546	DUS2	99	91.870	Chinchilla_lanigera
ENSG00000167264	DUS2	100	100.000	ENSCSAG00000004050	DUS2	100	98.377	Chlorocebus_sabaeus
ENSG00000167264	DUS2	72	91.333	ENSCHOG00000002632	-	65	91.613	Choloepus_hoffmanni
ENSG00000167264	DUS2	100	82.911	ENSCPBG00000012099	DUS2	86	77.143	Chrysemys_picta_bellii
ENSG00000167264	DUS2	97	66.883	ENSCSAVG00000002472	-	98	54.091	Ciona_savignyi
ENSG00000167264	DUS2	100	100.000	ENSCANG00000031996	DUS2	100	98.035	Colobus_angolensis_palliatus
ENSG00000167264	DUS2	100	98.261	ENSCGRG00001012463	Dus2	99	90.244	Cricetulus_griseus_chok1gshd
ENSG00000167264	DUS2	100	98.261	ENSCGRG00000008944	Dus2	99	90.244	Cricetulus_griseus_crigri
ENSG00000167264	DUS2	96	78.146	ENSCSEG00000021697	dus2	81	65.188	Cynoglossus_semilaevis
ENSG00000167264	DUS2	96	78.146	ENSCVAG00000022050	dus2	88	66.815	Cyprinodon_variegatus
ENSG00000167264	DUS2	100	77.358	ENSDARG00000077607	dus2	97	77.698	Danio_rerio
ENSG00000167264	DUS2	92	86.374	ENSDNOG00000018578	DUS2	95	86.374	Dasypus_novemcinctus
ENSG00000167264	DUS2	92	78.860	ENSDORG00000001654	Dus2	95	78.860	Dipodomys_ordii
ENSG00000167264	DUS2	80	87.879	FBgn0030554	CG1434	96	48.571	Drosophila_melanogaster
ENSG00000167264	DUS2	98	90.000	ENSETEG00000005320	DUS2	100	74.807	Echinops_telfairi
ENSG00000167264	DUS2	100	74.510	ENSEBUG00000001597	dus2	89	71.635	Eptatretus_burgeri
ENSG00000167264	DUS2	100	97.561	ENSEASG00005020405	DUS2	100	89.655	Equus_asinus_asinus
ENSG00000167264	DUS2	100	97.561	ENSECAG00000023209	DUS2	100	92.292	Equus_caballus
ENSG00000167264	DUS2	98	87.500	ENSEEUG00000004923	DUS2	83	86.617	Erinaceus_europaeus
ENSG00000167264	DUS2	100	76.250	ENSELUG00000017339	dus2	91	65.948	Esox_lucius
ENSG00000167264	DUS2	100	96.203	ENSFCAG00000010417	DUS2	100	92.698	Felis_catus
ENSG00000167264	DUS2	100	82.278	ENSFALG00000007759	DUS2	96	72.727	Ficedula_albicollis
ENSG00000167264	DUS2	100	97.561	ENSFDAG00000016111	DUS2	100	89.858	Fukomys_damarensis
ENSG00000167264	DUS2	56	54.373	ENSFHEG00000013105	dus2	76	54.373	Fundulus_heteroclitus
ENSG00000167264	DUS2	96	78.146	ENSGMOG00000011112	dus2	95	63.656	Gadus_morhua
ENSG00000167264	DUS2	100	81.013	ENSGALG00000048067	DUS2	100	70.850	Gallus_gallus
ENSG00000167264	DUS2	100	75.200	ENSGAFG00000003850	dus2	88	67.706	Gambusia_affinis
ENSG00000167264	DUS2	96	79.470	ENSGACG00000008159	dus2	93	65.351	Gasterosteus_aculeatus
ENSG00000167264	DUS2	100	84.177	ENSGAGG00000004570	DUS2	86	77.582	Gopherus_agassizii
ENSG00000167264	DUS2	93	97.817	ENSGGOG00000007381	DUS2	100	99.038	Gorilla_gorilla
ENSG00000167264	DUS2	96	80.795	ENSHBUG00000020267	dus2	99	65.751	Haplochromis_burtoni
ENSG00000167264	DUS2	100	95.890	ENSHGLG00000018885	DUS2	100	89.858	Heterocephalus_glaber_female
ENSG00000167264	DUS2	100	95.890	ENSHGLG00100013033	DUS2	100	89.858	Heterocephalus_glaber_male
ENSG00000167264	DUS2	96	79.470	ENSHCOG00000009462	dus2	94	61.024	Hippocampus_comes
ENSG00000167264	DUS2	96	80.132	ENSIPUG00000023029	DUS2	89	68.527	Ictalurus_punctatus
ENSG00000167264	DUS2	100	95.192	ENSSTOG00000002066	DUS2	100	90.669	Ictidomys_tridecemlineatus
ENSG00000167264	DUS2	92	81.948	ENSJJAG00000000630	Dus2	94	81.948	Jaculus_jaculus
ENSG00000167264	DUS2	60	58.333	ENSKMAG00000012644	dus2	68	58.333	Kryptolebias_marmoratus
ENSG00000167264	DUS2	100	76.136	ENSLBEG00000005839	dus2	90	64.929	Labrus_bergylta
ENSG00000167264	DUS2	96	82.895	ENSLACG00000005839	DUS2	93	72.284	Latimeria_chalumnae
ENSG00000167264	DUS2	96	83.444	ENSLOCG00000008097	dus2	94	70.975	Lepisosteus_oculatus
ENSG00000167264	DUS2	100	94.521	ENSLAFG00000014594	DUS2	99	91.057	Loxodonta_africana
ENSG00000167264	DUS2	100	100.000	ENSMFAG00000046270	DUS2	100	98.472	Macaca_fascicularis
ENSG00000167264	DUS2	100	100.000	ENSMMUG00000021841	DUS2	100	98.472	Macaca_mulatta
ENSG00000167264	DUS2	100	100.000	ENSMNEG00000032376	DUS2	100	98.472	Macaca_nemestrina
ENSG00000167264	DUS2	91	98.317	ENSMLEG00000027642	DUS2	100	98.317	Mandrillus_leucophaeus
ENSG00000167264	DUS2	96	78.808	ENSMAMG00000013827	dus2	89	67.857	Mastacembelus_armatus
ENSG00000167264	DUS2	96	80.795	ENSMZEG00005024219	dus2	90	68.151	Maylandia_zebra
ENSG00000167264	DUS2	100	82.911	ENSMGAG00000004019	DUS2	92	75.824	Meleagris_gallopavo
ENSG00000167264	DUS2	100	96.522	ENSMICG00000011354	DUS2	99	92.886	Microcebus_murinus
ENSG00000167264	DUS2	100	97.561	ENSMOCG00000012829	Dus2	99	88.821	Microtus_ochrogaster
ENSG00000167264	DUS2	99	75.410	ENSMMOG00000018654	dus2	95	60.132	Mola_mola
ENSG00000167264	DUS2	100	87.805	ENSMODG00000005295	DUS2	99	75.911	Monodelphis_domestica
ENSG00000167264	DUS2	92	81.481	ENSMALG00000015752	dus2	99	60.600	Monopterus_albus
ENSG00000167264	DUS2	100	97.561	ENSMUSG00000031901	Dus2	99	90.447	Mus_musculus
ENSG00000167264	DUS2	100	97.561	MGP_PahariEiJ_G0023109	Dus2	99	89.634	Mus_pahari
ENSG00000167264	DUS2	100	97.561	MGP_SPRETEiJ_G0032627	Dus2	99	90.447	Mus_spretus
ENSG00000167264	DUS2	100	96.203	ENSMPUG00000006925	DUS2	100	90.264	Mustela_putorius_furo
ENSG00000167264	DUS2	100	97.561	ENSMLUG00000005904	DUS2	100	91.684	Myotis_lucifugus
ENSG00000167264	DUS2	100	84.990	ENSNGAG00000013003	Dus2	100	91.353	Nannospalax_galili
ENSG00000167264	DUS2	96	80.795	ENSNBRG00000018031	dus2	89	62.252	Neolamprologus_brichardi
ENSG00000167264	DUS2	95	97.872	ENSNLEG00000005100	DUS2	100	98.608	Nomascus_leucogenys
ENSG00000167264	DUS2	99	85.057	ENSMEUG00000002725	-	65	85.000	Notamacropus_eugenii
ENSG00000167264	DUS2	98	95.000	ENSOPRG00000013920	DUS2	99	82.077	Ochotona_princeps
ENSG00000167264	DUS2	96	81.457	ENSONIG00000010614	dus2	99	66.738	Oreochromis_niloticus
ENSG00000167264	DUS2	100	97.561	ENSOCUG00000010043	DUS2	100	92.292	Oryctolagus_cuniculus
ENSG00000167264	DUS2	100	78.616	ENSORLG00000000833	dus2	91	66.302	Oryzias_latipes
ENSG00000167264	DUS2	99	76.923	ENSORLG00020003904	dus2	91	65.419	Oryzias_latipes_hni
ENSG00000167264	DUS2	100	77.027	ENSORLG00015018864	dus2	97	61.163	Oryzias_latipes_hsok
ENSG00000167264	DUS2	96	79.470	ENSOMEG00000020631	dus2	90	65.924	Oryzias_melastigma
ENSG00000167264	DUS2	92	90.308	ENSOGAG00000016897	DUS2	99	90.308	Otolemur_garnettii
ENSG00000167264	DUS2	100	95.673	ENSOARG00000003325	DUS2	100	91.278	Ovis_aries
ENSG00000167264	DUS2	100	99.391	ENSPPAG00000029892	DUS2	100	99.391	Pan_paniscus
ENSG00000167264	DUS2	100	96.203	ENSPPRG00000006182	DUS2	100	92.901	Panthera_pardus
ENSG00000167264	DUS2	100	96.203	ENSPTIG00000021168	DUS2	100	92.901	Panthera_tigris_altaica
ENSG00000167264	DUS2	100	99.391	ENSPTRG00000008259	DUS2	100	99.391	Pan_troglodytes
ENSG00000167264	DUS2	100	100.000	ENSPANG00000022609	DUS2	100	98.472	Papio_anubis
ENSG00000167264	DUS2	100	81.646	ENSPKIG00000021221	dus2	90	67.544	Paramormyrops_kingsleyae
ENSG00000167264	DUS2	100	82.278	ENSPSIG00000003478	DUS2	89	76.484	Pelodiscus_sinensis
ENSG00000167264	DUS2	97	79.221	ENSPMGG00000022665	dus2	87	68.080	Periophthalmus_magnuspinnatus
ENSG00000167264	DUS2	100	98.261	ENSPEMG00000016993	Dus2	99	90.854	Peromyscus_maniculatus_bairdii
ENSG00000167264	DUS2	60	48.936	ENSPMAG00000004695	-	100	48.936	Petromyzon_marinus
ENSG00000167264	DUS2	100	84.810	ENSPCIG00000028064	DUS2	99	75.000	Phascolarctos_cinereus
ENSG00000167264	DUS2	100	74.684	ENSPFOG00000000030	dus2	82	67.261	Poecilia_formosa
ENSG00000167264	DUS2	76	60.221	ENSPLAG00000001324	dus2	82	64.589	Poecilia_latipinna
ENSG00000167264	DUS2	88	75.556	ENSPREG00000001095	dus2	93	59.909	Poecilia_reticulata
ENSG00000167264	DUS2	100	100.000	ENSPPYG00000007482	DUS2	100	98.174	Pongo_abelii
ENSG00000167264	DUS2	91	88.889	ENSPCAG00000001415	DUS2	99	88.889	Procavia_capensis
ENSG00000167264	DUS2	100	97.561	ENSPCOG00000026045	DUS2	99	92.683	Propithecus_coquereli
ENSG00000167264	DUS2	99	94.444	ENSPVAG00000016624	DUS2	100	86.468	Pteropus_vampyrus
ENSG00000167264	DUS2	96	80.795	ENSPNYG00000022914	dus2	90	67.929	Pundamilia_nyererei
ENSG00000167264	DUS2	90	86.957	ENSPNAG00000030006	dus2	91	67.841	Pygocentrus_nattereri
ENSG00000167264	DUS2	100	97.561	ENSRNOG00000019819	Dus2	99	89.228	Rattus_norvegicus
ENSG00000167264	DUS2	100	100.000	ENSRBIG00000028682	DUS2	100	97.817	Rhinopithecus_bieti
ENSG00000167264	DUS2	100	100.000	ENSRROG00000040280	DUS2	100	97.817	Rhinopithecus_roxellana
ENSG00000167264	DUS2	82	61.905	YNR015W	SMM1	78	38.742	Saccharomyces_cerevisiae
ENSG00000167264	DUS2	99	98.611	ENSSBOG00000028381	DUS2	100	91.685	Saimiri_boliviensis_boliviensis
ENSG00000167264	DUS2	100	87.975	ENSSHAG00000009332	DUS2	99	76.065	Sarcophilus_harrisii
ENSG00000167264	DUS2	96	83.444	ENSSFOG00015010105	dus2	89	70.889	Scleropages_formosus
ENSG00000167264	DUS2	100	76.250	ENSSMAG00000000641	dus2	91	65.066	Scophthalmus_maximus
ENSG00000167264	DUS2	99	77.564	ENSSDUG00000017399	dus2	90	66.592	Seriola_dumerili
ENSG00000167264	DUS2	99	77.564	ENSSLDG00000000751	dus2	90	66.592	Seriola_lalandi_dorsalis
ENSG00000167264	DUS2	88	84.101	ENSSARG00000014170	DUS2	99	84.101	Sorex_araneus
ENSG00000167264	DUS2	100	80.488	ENSSPUG00000012818	DUS2	92	75.824	Sphenodon_punctatus
ENSG00000167264	DUS2	96	80.132	ENSSPAG00000003814	dus2	88	67.157	Stegastes_partitus
ENSG00000167264	DUS2	100	97.561	ENSSSCG00000022098	DUS2	100	91.684	Sus_scrofa
ENSG00000167264	DUS2	100	82.911	ENSTGUG00000007016	DUS2	100	75.551	Taeniopygia_guttata
ENSG00000167264	DUS2	92	82.716	ENSTRUG00000022441	dus2	87	67.261	Takifugu_rubripes
ENSG00000167264	DUS2	94	80.172	ENSTNIG00000005616	dus2	96	60.480	Tetraodon_nigroviridis
ENSG00000167264	DUS2	99	98.113	ENSTBEG00000006443	DUS2	100	89.431	Tupaia_belangeri
ENSG00000167264	DUS2	100	97.561	ENSTTRG00000014610	DUS2	85	96.491	Tursiops_truncatus
ENSG00000167264	DUS2	100	95.570	ENSUAMG00000016114	DUS2	100	91.684	Ursus_americanus
ENSG00000167264	DUS2	100	95.570	ENSUMAG00000019192	DUS2	100	92.089	Ursus_maritimus
ENSG00000167264	DUS2	99	95.000	ENSVPAG00000002580	DUS2	100	84.350	Vicugna_pacos
ENSG00000167264	DUS2	100	95.062	ENSVVUG00000012887	DUS2	100	91.075	Vulpes_vulpes
ENSG00000167264	DUS2	98	73.039	ENSXETG00000005436	dus2	93	64.795	Xenopus_tropicalis
ENSG00000167264	DUS2	96	76.821	ENSXCOG00000000879	dus2	93	67.038	Xiphophorus_couchianus
ENSG00000167264	DUS2	100	76.543	ENSXMAG00000012268	dus2	88	67.038	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002943	tRNA dihydrouridine synthesis	-	IEA	Process
GO:0003725	double-stranded RNA binding	18096616.	IDA	Function
GO:0004860	protein kinase inhibitor activity	18096616.	IDA	Function
GO:0005515	protein binding	18096616.	IPI	Function
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006469	negative regulation of protein kinase activity	-	IEA	Process
GO:0017150	tRNA dihydrouridine synthase activity	-	IEA	Function
GO:0050660	flavin adenine dinucleotide binding	-	IEA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0060548	negative regulation of cell death	18096616.	IDA	Process