EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167281 (Gene tree)
Gene ID: 146713
Gene Symbol: RBFOX3
Alias: FOX-3|NeuN|HRNBP3
Full Name: RNA binding fox-1 homolog 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 521,757 bases
Position: chr17:79,089,345-79,611,101
Accession: 27097
RBP type: canonical RBP
Summary: This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000468693	Fox-1_C	PF12414.8	4.2e-45	1	1
ENSP00000463653	Fox-1_C	PF12414.8	1.6e-44	1	1
ENSP00000462007	Fox-1_C	PF12414.8	1.7e-44	1	1
ENSP00000463964	Fox-1_C	PF12414.8	1.7e-40	1	1
ENSP00000497797	Fox-1_C	PF12414.8	2.6e-40	1	1
ENSP00000464186	Fox-1_C	PF12414.8	2.7e-40	1	1
ENSP00000465367	Fox-1_C	PF12414.8	3.9e-18	1	1
ENSP00000463653	RRM_1	PF00076.22	2e-18	1	1
ENSP00000497797	RRM_1	PF00076.22	2.1e-18	1	1
ENSP00000462007	RRM_1	PF00076.22	2.2e-18	1	1
ENSP00000464186	RRM_1	PF00076.22	2.5e-18	1	1
ENSP00000463964	RRM_1	PF00076.22	0.00028	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28839469	RBFOX3 Promotes Tumor Growth and Progression via hTERT Signaling and Predicts a Poor Prognosis in Hepatocellular Carcinoma.	Theranostics	2017 Jul 22	Liu T	doi: 10.7150/thno.19506
27142678	Genetic variants in RBFOX3 are associated with sleep latency.	Eur J Hum Genet	2016 Oct	Amin N	doi: 10.1038/ejhg.2016.31
25760045	Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects.	Curr HIV Res	2015	Hahn YK	-
30475774	Rbfox3/NeuN Regulates Alternative Splicing of Tau Exon 10.	J Alzheimers Dis	2018	Gu J	doi: 10.3233/JAD-180882.
24603971	Detection of chromosomal breakpoints in patients with developmental delay and speech disorders.	PLoS One	2014 Mar 6	Utami KH	doi: 10.1371/journal.pone.0090852
29170129	Rbfox family proteins make the homo- and hetero-oligomeric complexes.	Biochem Biophys Res Commun	2018 Jan 1	Choi S	doi: 10.1016/j.bbrc.2017.11.128
23420872	Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development.	J Cell Biol	2013 Feb 18	Kim KK	doi: 10.1083/jcb.201206146.
20042473	Autoregulation of Fox protein expression to produce dominant negative splicing factors.	RNA	2010 Feb	Damianov A	doi: 10.1261/rna.1838210
21747913	NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2.	PLoS One	2011	Dredge BK	doi: 10.1371/journal.pone.0021585
25044120	Isoform-specific proteasomal degradation of Rbfox3 during chicken embryonic development.	Biochem Biophys Res Commun	2014 Aug 8	Kim KK	doi: 10.1016/j.bbrc.2014.07.057
23701460	RNA protein interaction in neurons.	Annu Rev Neurosci	2013 Jul 8	Darnell RB	doi: 10.1146/annurev-neuro-062912-114322
26724814	Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice.	Histochem Cell Biol	2016 May	Ma X	doi: 10.1007/s00418-015-1393-4
27432190	Transforming Growth Factor-β-Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells.	Mol Cells	2016 Aug 31	Kim YE	doi: 10.14348/molcells.2016.0150
28126724	RBFOX3 regulates Claudin-1 expression in human lung tissue via attenuation of proteasomal degradation.	Biosci Rep	2017 Feb 23	Kim YE	doi: 10.1042/BSR20160623
26952657	Identification and characterization of the RNA-binding protein Rbfox3 in zebrafish embryo.	Biochem Biophys Res Commun	2016 Apr 1	Won M	doi: 10.1016/j.bbrc.2016.03.005
29689552	RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways.	Cell Physiol Biochem	2018	Liu T	doi: 10.1159/000489153
31142229	Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.	Autophagy	2019 May 29:1-17	Ivankovic D	doi: 10.1080/15548627.2019.1615302
31234698	Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.	Autophagy	2019 Jun 24:1-19	Jung S	doi: 10.1080/15548627.2019.1630222
31238788	PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.	Autophagy	2019 Jun 25:1-20	Sarkar C	doi: 10.1080/15548627.2019.1628538
19713214	Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors.	J Biol Chem	2009 Nov 6	Kim KK	doi: 10.1074/jbc.M109.052969

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000582043	RBFOX3-206	1143	XM_017024209	ENSP00000463964	328 (aa)	XP_016879698	J3QQZ2
ENST00000648001	RBFOX3-213	2461	-	ENSP00000497797	314 (aa)	-	-
ENST00000578998	RBFOX3-202	3072	-	-	- (aa)	-	-
ENST00000580508	RBFOX3-204	260	-	ENSP00000467872	52 (aa)	-	K7EQK7
ENST00000584778	RBFOX3-212	1547	XM_011524365	ENSP00000462007	325 (aa)	XP_011522667	A6NFN3
ENST00000582139	RBFOX3-207	154	-	ENSP00000464946	4 (aa)	-	UPI0002670C04
ENST00000582344	RBFOX3-208	321	-	-	- (aa)	-	-
ENST00000580155	RBFOX3-203	1519	XM_017024210	ENSP00000463653	312 (aa)	XP_016879699	A6NFN3
ENST00000578887	RBFOX3-201	2694	-	-	- (aa)	-	-
ENST00000582880	RBFOX3-209	877	-	ENSP00000465367	75 (aa)	-	K7EJX6
ENST00000581393	RBFOX3-205	1201	-	-	- (aa)	-	-
ENST00000583458	RBFOX3-211	2934	XM_011524359	ENSP00000464186	358 (aa)	XP_011522661	J3QRF4
ENST00000582894	RBFOX3-210	611	-	ENSP00000468693	131 (aa)	-	K7ESF7

Gene Model

Click here to download ENSG00000167281's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167281	Body Mass Index	8.8182262902108E-5	17903300
ENSG00000167281	Body Mass Index	7.88068046499522E-5	17903300
ENSG00000167281	Body Weight	7.09730491779869E-5	17903300
ENSG00000167281	Cholesterol, HDL	4.22168387819166E-5	17903299
ENSG00000167281	Cholesterol, HDL	4.58170185810847E-5	17903299
ENSG00000167281	Parkinson Disease	4.94E-5	21829596
ENSG00000167281	Triglycerides	1.8580000E-005	-
ENSG00000167281	Triglycerides	1.1790000E-005	-
ENSG00000167281	Lipids	4.6590000E-005	-
ENSG00000167281	Lipids	3.5700000E-006	-
ENSG00000167281	Platelet Function Tests	8.5300000E-006	-
ENSG00000167281	Platelet Function Tests	9.4700000E-006	-
ENSG00000167281	Platelet Function Tests	9.4400000E-006	-
ENSG00000167281	Platelet Function Tests	1.7700000E-006	-
ENSG00000167281	Platelet Function Tests	1.7557700E-005	-
ENSG00000167281	Platelet Function Tests	8.5071425E-006	-
ENSG00000167281	Child Development Disorders, Pervasive	7.6700000E-006	-
ENSG00000167281	Child Development Disorders, Pervasive	6.3000000E-005	-
ENSG00000167281	Leptin	3.0290000E-005	-
ENSG00000167281	Insulin-Like Growth Factor I	2.5290000E-005	-
ENSG00000167281	Cardiovascular Diseases	2.3100000E-005	-
ENSG00000167281	S-(3-hydroxypropyl)cysteine N-acetate	3E-8	26053186
ENSG00000167281	Smoking	3E-8	26053186
ENSG00000167281	Uric Acid	2E-6	25811787
ENSG00000167281	Body Mass Index	2E-6	25811787
ENSG00000167281	Sleep	1E-7	27142678
ENSG00000167281	3-hydroxy-1-methylpropylmercapturic acid	3E-9	26053186
ENSG00000167281	Smoking	3E-9	26053186
ENSG00000167281	Autosomal dominant compelling helio ophthalmic outburst syndrome	2E-9	27182965
ENSG00000167281	Angiotensin-Converting Enzyme Inhibitors	6E-9	28030426
ENSG00000167281	Obesity	4E-7	25811787
ENSG00000167281	Uric Acid	4E-7	25811787
ENSG00000167281	Uric Acid	3E-8	25811787
ENSG00000167281	Body Mass Index	3E-8	25811787
ENSG00000167281	Body Mass Index	4E-6	25673413
ENSG00000167281	Hypersensitivity	7E-6	23817569

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167281	rs2061538	17	79116480	G	Angiotensin-converting enzyme inhibitor intolerance	28030426	[1.324419-1.762525]	1.527849	EFO_0005325
ENSG00000167281	rs7211029	17	79145226	?	Sleep latency	27142678	[0.011-0.049] unit decrease	0.03	EFO_0005280
ENSG00000167281	rs898534	17	79277431	G	Urate levels (BMI interaction)	25811787	[0.0081-0.0199] unit decrease	0.014	EFO_0004531\|EFO_0004340
ENSG00000167281	rs1000791	17	79269796	T	Urate levels in obese individuals	25811787	[0.13-0.29] kg/m2 decrease	0.209	EFO_0007041\|EFO_0004531
ENSG00000167281	rs79211555	17	79309121	?	3-hydroxypropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	1.6521	EFO_0004318\|EFO_0007014
ENSG00000167281	rs79211555	17	79309121	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	1.5956	EFO_0004318\|EFO_0007015
ENSG00000167281	rs1316453	17	79414777	C	Self-reported allergy	23817569	[0.035-0.090] unit increase	0.0624	EFO_0003785
ENSG00000167281	rs2612778	17	79154725	?	Mononucleosis	28928442	[0.038-0.092] unit decrease	0.0651	EFO_0008403
ENSG00000167281	rs150755563	17	79102749	?	Shingles	28928442	[0.12-0.3] unit increase	0.2093	EFO_0008401
ENSG00000167281	rs117691352	17	79090739	A	Facial morphology (factor 16)	28441456	[0.32-0.69] unit increase	0.5077	EFO_0007841
ENSG00000167281	rs898534	17	79277431	G	Urate levels (BMI interaction)	25811787	[0.0098-0.0237] unit decrease	0.016758949	EFO_0004531\|EFO_0004340
ENSG00000167281	rs11867552	17	79175813	T	Lower body strength	27325353	NR Z score decrease	4.54	EFO_0007999
ENSG00000167281	rs2612765	17	79182300	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000167281	rs12949587	17	79365094	?	Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)	30738427	[3.88-16.16]	7.92	EFO_0007675\|EFO_1001480\|EFO_0008336

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167281's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000167281	RBFOX3	100	77.143	ENSG00000078328	RBFOX1	80	78.333
ENSG00000167281	RBFOX3	99	69.880	ENSG00000100320	RBFOX2	92	58.944

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167281	RBFOX3	99	89.231	ENSAPOG00000021630	rbfox3b	81	80.000	Acanthochromis_polyacanthus
ENSG00000167281	RBFOX3	81	89.583	ENSAPOG00000015658	-	80	93.103	Acanthochromis_polyacanthus
ENSG00000167281	RBFOX3	100	92.424	ENSAMEG00000014170	RBFOX3	84	92.424	Ailuropoda_melanoleuca
ENSG00000167281	RBFOX3	100	78.344	ENSACIG00000010817	rbfox3b	94	75.415	Amphilophus_citrinellus
ENSG00000167281	RBFOX3	95	69.085	ENSACIG00000003768	-	72	73.563	Amphilophus_citrinellus
ENSG00000167281	RBFOX3	100	82.803	ENSAOCG00000012358	rbfox3b	81	80.000	Amphiprion_ocellaris
ENSG00000167281	RBFOX3	95	76.412	ENSAOCG00000010786	-	71	93.103	Amphiprion_ocellaris
ENSG00000167281	RBFOX3	81	89.583	ENSAPEG00000015891	-	71	93.103	Amphiprion_percula
ENSG00000167281	RBFOX3	96	78.000	ENSAPEG00000019081	rbfox3b	73	93.103	Amphiprion_percula
ENSG00000167281	RBFOX3	92	81.818	ENSATEG00000023101	-	92	76.568	Anabas_testudineus
ENSG00000167281	RBFOX3	100	73.256	ENSATEG00000019945	rbfox3b	95	73.112	Anabas_testudineus
ENSG00000167281	RBFOX3	100	90.764	ENSACAG00000016093	RBFOX3	83	91.639	Anolis_carolinensis
ENSG00000167281	RBFOX3	100	98.476	ENSANAG00000023457	RBFOX3	100	98.397	Aotus_nancymaae
ENSG00000167281	RBFOX3	99	90.667	ENSACLG00000025552	-	81	81.395	Astatotilapia_calliptera
ENSG00000167281	RBFOX3	99	89.231	ENSACLG00000020011	rbfox3b	95	82.000	Astatotilapia_calliptera
ENSG00000167281	RBFOX3	92	86.777	ENSAMXG00000037246	rbfox3a	90	83.168	Astyanax_mexicanus
ENSG00000167281	RBFOX3	100	76.825	ENSAMXG00000042841	rbfox3b	85	74.000	Astyanax_mexicanus
ENSG00000167281	RBFOX3	100	97.561	ENSBTAG00000006280	RBFOX3	100	97.561	Bos_taurus
ENSG00000167281	RBFOX3	100	98.603	ENSCJAG00000009563	RBFOX3	100	98.603	Callithrix_jacchus
ENSG00000167281	RBFOX3	89	100.000	ENSCAFG00000005547	RBFOX3	85	99.160	Canis_familiaris
ENSG00000167281	RBFOX3	100	99.045	ENSCAFG00020008126	RBFOX3	96	98.607	Canis_lupus_dingo
ENSG00000167281	RBFOX3	99	100.000	ENSCHIG00000009124	RBFOX3	96	97.256	Capra_hircus
ENSG00000167281	RBFOX3	100	99.164	ENSTSYG00000029617	RBFOX3	100	99.164	Carlito_syrichta
ENSG00000167281	RBFOX3	54	96.450	ENSCAPG00000010217	RBFOX3	100	96.450	Cavia_aperea
ENSG00000167281	RBFOX3	100	97.792	ENSCPOG00000021703	RBFOX3	100	96.979	Cavia_porcellus
ENSG00000167281	RBFOX3	100	98.476	ENSCCAG00000028450	RBFOX3	100	98.476	Cebus_capucinus
ENSG00000167281	RBFOX3	100	99.679	ENSCATG00000018349	RBFOX3	100	99.679	Cercocebus_atys
ENSG00000167281	RBFOX3	100	98.730	ENSCLAG00000006449	RBFOX3	100	98.176	Chinchilla_lanigera
ENSG00000167281	RBFOX3	100	99.679	ENSCSAG00000002355	RBFOX3	100	99.679	Chlorocebus_sabaeus
ENSG00000167281	RBFOX3	99	96.154	ENSCPBG00000010904	RBFOX3	95	88.889	Chrysemys_picta_bellii
ENSG00000167281	RBFOX3	100	100.000	ENSCANG00000043120	RBFOX3	100	99.679	Colobus_angolensis_palliatus
ENSG00000167281	RBFOX3	100	96.203	ENSCGRG00001019476	Rbfox3	100	96.061	Cricetulus_griseus_chok1gshd
ENSG00000167281	RBFOX3	100	96.203	ENSCGRG00000003268	Rbfox3	100	96.061	Cricetulus_griseus_crigri
ENSG00000167281	RBFOX3	100	66.562	ENSCSEG00000020606	RBFOX3	83	67.133	Cynoglossus_semilaevis
ENSG00000167281	RBFOX3	100	77.848	ENSCSEG00000015567	RBFOX3	72	93.103	Cynoglossus_semilaevis
ENSG00000167281	RBFOX3	100	82.803	ENSCVAG00000006882	rbfox3b	81	80.000	Cyprinodon_variegatus
ENSG00000167281	RBFOX3	99	85.385	ENSDARG00000074310	rbfox3b	96	73.214	Danio_rerio
ENSG00000167281	RBFOX3	89	88.034	ENSDARG00000010083	rbfox3a	94	81.230	Danio_rerio
ENSG00000167281	RBFOX3	97	87.541	ENSDNOG00000039391	RBFOX3	81	87.541	Dasypus_novemcinctus
ENSG00000167281	RBFOX3	99	95.946	ENSDORG00000005352	Rbfox3	95	81.341	Dipodomys_ordii
ENSG00000167281	RBFOX3	85	61.818	ENSEBUG00000013559	RBFOX3	71	63.281	Eptatretus_burgeri
ENSG00000167281	RBFOX3	99	74.815	ENSEBUG00000002129	RBFOX3	88	71.885	Eptatretus_burgeri
ENSG00000167281	RBFOX3	100	97.771	ENSEASG00005005059	RBFOX3	100	97.771	Equus_asinus_asinus
ENSG00000167281	RBFOX3	100	97.452	ENSECAG00000023811	RBFOX3	100	97.452	Equus_caballus
ENSG00000167281	RBFOX3	99	97.333	ENSEEUG00000013974	RBFOX3	92	81.449	Erinaceus_europaeus
ENSG00000167281	RBFOX3	99	90.541	ENSELUG00000017963	rbfox3b	95	69.000	Esox_lucius
ENSG00000167281	RBFOX3	99	98.462	ENSFCAG00000002555	RBFOX3	100	97.115	Felis_catus
ENSG00000167281	RBFOX3	100	71.692	ENSFALG00000012288	RBFOX3	81	75.684	Ficedula_albicollis
ENSG00000167281	RBFOX3	99	94.805	ENSFDAG00000007489	RBFOX3	100	92.541	Fukomys_damarensis
ENSG00000167281	RBFOX3	89	88.793	ENSFHEG00000008550	rbfox3b	95	70.000	Fundulus_heteroclitus
ENSG00000167281	RBFOX3	99	89.189	ENSGMOG00000019304	-	95	65.823	Gadus_morhua
ENSG00000167281	RBFOX3	95	94.613	ENSGALG00000032889	RBFOX3	83	94.613	Gallus_gallus
ENSG00000167281	RBFOX3	97	80.719	ENSGAFG00000005025	rbfox3b	86	80.000	Gambusia_affinis
ENSG00000167281	RBFOX3	99	89.333	ENSGACG00000002138	-	92	72.000	Gasterosteus_aculeatus
ENSG00000167281	RBFOX3	99	97.297	ENSGAGG00000020025	RBFOX3	95	88.889	Gopherus_agassizii
ENSG00000167281	RBFOX3	100	100.000	ENSGGOG00000012546	RBFOX3	100	100.000	Gorilla_gorilla
ENSG00000167281	RBFOX3	99	89.333	ENSHBUG00000023098	-	86	81.063	Haplochromis_burtoni
ENSG00000167281	RBFOX3	99	89.231	ENSHBUG00000018099	rbfox3b	81	79.667	Haplochromis_burtoni
ENSG00000167281	RBFOX3	100	97.179	ENSHGLG00000008679	RBFOX3	100	96.429	Heterocephalus_glaber_female
ENSG00000167281	RBFOX3	100	92.790	ENSHGLG00100014739	RBFOX3	92	90.258	Heterocephalus_glaber_male
ENSG00000167281	RBFOX3	96	76.589	ENSHCOG00000007444	RBFOX3	77	76.923	Hippocampus_comes
ENSG00000167281	RBFOX3	100	70.253	ENSHCOG00000001863	RBFOX3	80	89.655	Hippocampus_comes
ENSG00000167281	RBFOX3	100	65.988	ENSIPUG00000021966	rbfox3b	88	75.949	Ictalurus_punctatus
ENSG00000167281	RBFOX3	99	92.000	ENSIPUG00000012010	rbfox3a	90	81.518	Ictalurus_punctatus
ENSG00000167281	RBFOX3	99	98.667	ENSSTOG00000026817	RBFOX3	97	96.053	Ictidomys_tridecemlineatus
ENSG00000167281	RBFOX3	99	100.000	ENSJJAG00000014167	Rbfox3	100	98.171	Jaculus_jaculus
ENSG00000167281	RBFOX3	100	82.803	ENSKMAG00000006726	rbfox3b	81	80.000	Kryptolebias_marmoratus
ENSG00000167281	RBFOX3	89	93.162	ENSLBEG00000022508	-	81	82.392	Labrus_bergylta
ENSG00000167281	RBFOX3	99	89.231	ENSLBEG00000004030	rbfox3b	94	75.083	Labrus_bergylta
ENSG00000167281	RBFOX3	95	76.074	ENSLACG00000018409	-	83	78.287	Latimeria_chalumnae
ENSG00000167281	RBFOX3	99	93.333	ENSLOCG00000012267	rbfox3a	90	87.043	Lepisosteus_oculatus
ENSG00000167281	RBFOX3	100	96.111	ENSLAFG00000016623	RBFOX3	96	96.111	Loxodonta_africana
ENSG00000167281	RBFOX3	100	99.721	ENSMFAG00000002247	RBFOX3	100	99.721	Macaca_fascicularis
ENSG00000167281	RBFOX3	100	99.695	ENSMMUG00000023028	RBFOX3	100	99.695	Macaca_mulatta
ENSG00000167281	RBFOX3	100	99.359	ENSMNEG00000041147	RBFOX3	100	99.359	Macaca_nemestrina
ENSG00000167281	RBFOX3	100	99.679	ENSMLEG00000025686	RBFOX3	100	99.679	Mandrillus_leucophaeus
ENSG00000167281	RBFOX3	100	77.885	ENSMAMG00000019810	rbfox3b	94	74.832	Mastacembelus_armatus
ENSG00000167281	RBFOX3	99	73.571	ENSMAMG00000020600	-	85	73.443	Mastacembelus_armatus
ENSG00000167281	RBFOX3	99	89.231	ENSMZEG00005000781	rbfox3b	81	79.667	Maylandia_zebra
ENSG00000167281	RBFOX3	99	55.125	ENSMZEG00005003055	-	59	89.630	Maylandia_zebra
ENSG00000167281	RBFOX3	62	92.188	ENSMGAG00000005600	RBFOX3	73	92.188	Meleagris_gallopavo
ENSG00000167281	RBFOX3	100	95.886	ENSMAUG00000013543	Rbfox3	96	94.798	Mesocricetus_auratus
ENSG00000167281	RBFOX3	100	99.363	ENSMICG00000014898	RBFOX3	100	97.115	Microcebus_murinus
ENSG00000167281	RBFOX3	100	96.508	ENSMOCG00000015373	Rbfox3	100	96.049	Microtus_ochrogaster
ENSG00000167281	RBFOX3	100	80.251	ENSMMOG00000020193	rbfox3b	81	79.470	Mola_mola
ENSG00000167281	RBFOX3	95	93.939	ENSMODG00000002089	RBFOX3	83	93.939	Monodelphis_domestica
ENSG00000167281	RBFOX3	99	89.333	ENSMALG00000018270	-	85	89.655	Monopterus_albus
ENSG00000167281	RBFOX3	99	89.231	ENSMALG00000020407	rbfox3b	81	79.000	Monopterus_albus
ENSG00000167281	RBFOX3	100	96.825	MGP_CAROLIEiJ_G0017487	Rbfox3	100	97.633	Mus_caroli
ENSG00000167281	RBFOX3	100	96.825	ENSMUSG00000025576	Rbfox3	100	97.241	Mus_musculus
ENSG00000167281	RBFOX3	100	97.152	MGP_PahariEiJ_G0018614	Rbfox3	100	97.931	Mus_pahari
ENSG00000167281	RBFOX3	100	97.143	MGP_SPRETEiJ_G0018331	Rbfox3	100	97.633	Mus_spretus
ENSG00000167281	RBFOX3	99	100.000	ENSMPUG00000012319	RBFOX3	91	87.966	Mustela_putorius_furo
ENSG00000167281	RBFOX3	100	97.460	ENSNGAG00000018006	Rbfox3	100	96.960	Nannospalax_galili
ENSG00000167281	RBFOX3	100	73.482	ENSNBRG00000022885	-	77	93.103	Neolamprologus_brichardi
ENSG00000167281	RBFOX3	100	80.892	ENSNBRG00000010102	rbfox3b	74	92.593	Neolamprologus_brichardi
ENSG00000167281	RBFOX3	100	70.091	ENSNLEG00000000153	-	82	100.000	Nomascus_leucogenys
ENSG00000167281	RBFOX3	100	65.924	ENSMEUG00000004218	-	75	96.552	Notamacropus_eugenii
ENSG00000167281	RBFOX3	99	78.161	ENSOPRG00000016279	-	69	96.629	Ochotona_princeps
ENSG00000167281	RBFOX3	100	98.730	ENSODEG00000009433	RBFOX3	100	98.176	Octodon_degus
ENSG00000167281	RBFOX3	100	81.329	ENSONIG00000007282	-	87	82.060	Oreochromis_niloticus
ENSG00000167281	RBFOX3	99	89.189	ENSONIG00000009549	rbfox3b	92	74.212	Oreochromis_niloticus
ENSG00000167281	RBFOX3	80	95.000	ENSOCUG00000014217	RBFOX3	78	80.702	Oryctolagus_cuniculus
ENSG00000167281	RBFOX3	99	90.541	ENSORLG00000000905	rbfox3b	65	79.402	Oryzias_latipes
ENSG00000167281	RBFOX3	99	90.541	ENSORLG00020018030	rbfox3b	81	79.667	Oryzias_latipes_hni
ENSG00000167281	RBFOX3	99	89.231	ENSORLG00015009200	rbfox3b	85	93.103	Oryzias_latipes_hsok
ENSG00000167281	RBFOX3	96	76.000	ENSOMEG00000014677	rbfox3b	76	76.995	Oryzias_melastigma
ENSG00000167281	RBFOX3	100	97.115	ENSOGAG00000029595	RBFOX3	85	96.203	Otolemur_garnettii
ENSG00000167281	RBFOX3	99	72.727	ENSOARG00000002908	RBFOX3	84	67.791	Ovis_aries
ENSG00000167281	RBFOX3	93	100.000	ENSPPAG00000025383	RBFOX3	99	100.000	Pan_paniscus
ENSG00000167281	RBFOX3	100	95.251	ENSPPRG00000007819	RBFOX3	100	95.251	Panthera_pardus
ENSG00000167281	RBFOX3	100	100.000	ENSPTRG00000009727	RBFOX3	100	100.000	Pan_troglodytes
ENSG00000167281	RBFOX3	100	99.679	ENSPANG00000019837	RBFOX3	100	99.679	Papio_anubis
ENSG00000167281	RBFOX3	99	93.333	ENSPKIG00000010299	rbfox3a	73	84.314	Paramormyrops_kingsleyae
ENSG00000167281	RBFOX3	99	74.324	ENSPKIG00000022633	-	80	66.107	Paramormyrops_kingsleyae
ENSG00000167281	RBFOX3	96	72.222	ENSPMGG00000008000	rbfox3b	77	81.818	Periophthalmus_magnuspinnatus
ENSG00000167281	RBFOX3	100	96.508	ENSPEMG00000010500	Rbfox3	100	96.353	Peromyscus_maniculatus_bairdii
ENSG00000167281	RBFOX3	99	83.333	ENSPMAG00000008689	rbfox3b	93	76.842	Petromyzon_marinus
ENSG00000167281	RBFOX3	99	97.297	ENSPCIG00000005766	RBFOX3	96	94.186	Phascolarctos_cinereus
ENSG00000167281	RBFOX3	99	89.231	ENSPFOG00000018294	rbfox3b	92	68.966	Poecilia_formosa
ENSG00000167281	RBFOX3	99	78.462	ENSPLAG00000000481	rbfox3b	66	93.103	Poecilia_latipinna
ENSG00000167281	RBFOX3	89	88.793	ENSPMEG00000022997	rbfox3b	95	70.000	Poecilia_mexicana
ENSG00000167281	RBFOX3	100	83.175	ENSPREG00000012886	rbfox3b	86	80.333	Poecilia_reticulata
ENSG00000167281	RBFOX3	91	93.684	ENSPPYG00000008704	RBFOX3	84	93.684	Pongo_abelii
ENSG00000167281	RBFOX3	99	92.357	ENSPCAG00000001401	RBFOX3	97	93.143	Procavia_capensis
ENSG00000167281	RBFOX3	100	99.682	ENSPCOG00000012689	RBFOX3	100	98.045	Propithecus_coquereli
ENSG00000167281	RBFOX3	100	85.127	ENSPVAG00000015243	RBFOX3	96	86.957	Pteropus_vampyrus
ENSG00000167281	RBFOX3	96	78.000	ENSPNYG00000010414	rbfox3b	74	92.593	Pundamilia_nyererei
ENSG00000167281	RBFOX3	100	76.923	ENSPNYG00000009079	-	73	93.103	Pundamilia_nyererei
ENSG00000167281	RBFOX3	83	87.234	ENSPNAG00000018173	rbfox3b	82	72.449	Pygocentrus_nattereri
ENSG00000167281	RBFOX3	99	93.333	ENSPNAG00000002889	rbfox3a	81	82.838	Pygocentrus_nattereri
ENSG00000167281	RBFOX3	100	97.152	ENSRNOG00000003386	Rbfox3	100	96.815	Rattus_norvegicus
ENSG00000167281	RBFOX3	100	100.000	ENSRBIG00000040449	RBFOX3	87	99.679	Rhinopithecus_bieti
ENSG00000167281	RBFOX3	100	99.679	ENSRROG00000000766	RBFOX3	100	99.679	Rhinopithecus_roxellana
ENSG00000167281	RBFOX3	99	100.000	ENSSBOG00000031591	RBFOX3	100	98.603	Saimiri_boliviensis_boliviensis
ENSG00000167281	RBFOX3	89	98.276	ENSSHAG00000016076	RBFOX3	95	83.502	Sarcophilus_harrisii
ENSG00000167281	RBFOX3	96	68.667	ENSSFOG00015004716	RBFOX3	84	68.896	Scleropages_formosus
ENSG00000167281	RBFOX3	99	93.333	ENSSFOG00015023260	rbfox3a	81	85.714	Scleropages_formosus
ENSG00000167281	RBFOX3	99	89.231	ENSSMAG00000012618	rbfox3b	71	76.266	Scophthalmus_maximus
ENSG00000167281	RBFOX3	100	80.442	ENSSMAG00000019052	-	95	79.801	Scophthalmus_maximus
ENSG00000167281	RBFOX3	99	73.381	ENSSDUG00000015801	-	76	93.103	Seriola_dumerili
ENSG00000167281	RBFOX3	89	88.793	ENSSDUG00000023183	rbfox3b	95	70.000	Seriola_dumerili
ENSG00000167281	RBFOX3	99	74.286	ENSSLDG00000016098	-	74	93.103	Seriola_lalandi_dorsalis
ENSG00000167281	RBFOX3	100	82.803	ENSSLDG00000000149	rbfox3b	81	80.000	Seriola_lalandi_dorsalis
ENSG00000167281	RBFOX3	89	98.276	ENSSPUG00000011733	RBFOX3	95	89.701	Sphenodon_punctatus
ENSG00000167281	RBFOX3	87	74.453	ENSSPAG00000004898	-	75	73.725	Stegastes_partitus
ENSG00000167281	RBFOX3	96	78.000	ENSSPAG00000017571	rbfox3b	79	70.100	Stegastes_partitus
ENSG00000167281	RBFOX3	99	98.667	ENSSSCG00000039498	RBFOX3	96	97.152	Sus_scrofa
ENSG00000167281	RBFOX3	100	77.848	ENSTRUG00000004894	rbfox3b	86	75.974	Takifugu_rubripes
ENSG00000167281	RBFOX3	100	73.775	ENSTNIG00000011278	rbfox3b	83	71.471	Tetraodon_nigroviridis
ENSG00000167281	RBFOX3	92	69.578	ENSTBEG00000004296	-	89	69.578	Tupaia_belangeri
ENSG00000167281	RBFOX3	100	91.720	ENSTTRG00000003676	RBFOX3	96	92.128	Tursiops_truncatus
ENSG00000167281	RBFOX3	100	97.756	ENSUAMG00000004668	RBFOX3	100	97.756	Ursus_americanus
ENSG00000167281	RBFOX3	100	99.045	ENSVVUG00000017864	RBFOX3	100	98.718	Vulpes_vulpes
ENSG00000167281	RBFOX3	99	70.000	ENSXETG00000020236	rbfox3	84	65.075	Xenopus_tropicalis
ENSG00000167281	RBFOX3	100	81.270	ENSXCOG00000018262	rbfox3b	95	74.247	Xiphophorus_couchianus
ENSG00000167281	RBFOX3	99	89.231	ENSXMAG00000012939	rbfox3b	81	80.000	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0007399	nervous system development	21873635.	IBA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0043204	perikaryon	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27432190	Transforming Growth Factor-β-Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells.	Mol Cells	2016 Aug 31	Kim YE	doi: 10.14348/molcells.2016.0150

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr17	79097710	Missense_Mutation	novel	G202R	0.19
ACC	chr17	79115534	Missense_Mutation	novel	E61V	0.26
ACC	chr17	79115535	Nonsense_Mutation	novel	E61*	0.26
BRCA	chr17	79090706	3'Flank	novel		0.46
BRCA	chr17	79115646	Frame_Shift_Del	novel	*E21Pfs108**	0.12
BRCA	chr17	79096686	Silent	novel	V254V	0.08
BRCA	chr17	79115560	Missense_Mutation	NA	Q52H	0.1
BRCA	chr17	79090681	3'Flank	novel		0.75
BRCA	chr17	79097358	Missense_Mutation	novel	R230Q	0.1
CESC	chr17	79097723	Silent	NA	V197V	0.39
CESC	chr17	79097704	Missense_Mutation	novel	E204Q	0.22
CESC	chr17	79235797	5'UTR	novel		0.35
COAD	chr17	79096676	Missense_Mutation	NA	G258R	0.21
COAD	chr17	79097375	Silent	NA	G224G	0.32
COAD	chr17	79090833	3'UTR	rs112694129		0.32
COAD	chr17	79090770	3'Flank	novel		0.49
COAD	chr17	79096664	Missense_Mutation	NA	A262T	0.44
COAD	chr17	79097324	Silent	NA	A241A	0.48
COAD	chr17	79090770	3'Flank	novel		0.22
COAD	chr17	79097309	Frame_Shift_Del	novel	*I247Sfs77**	0.35
COAD	chr17	79094526	Silent	NA	Y287Y	0.27
COAD	chr17	79090833	3'UTR	rs112694129		0.3
COAD	chr17	79090833	3'UTR	rs112694129		0.28
ESCA	chr17	79097421	Missense_Mutation	novel	T209M	0.31
ESCA	chr17	79090807	3'Flank	rs551241985		0.38
ESCA	chr17	79090833	3'UTR	rs112694129		0.4
HNSC	chr17	79086978	3'Flank	novel		0.35
LGG	chr17	79087046	3'Flank	novel		0.75
LIHC	chr17	79094340	Intron	novel		0.5
MESO	chr17	79087176	3'Flank	novel		0.34
READ	chr17	79097723	Silent	NA	V197V	0.14
READ	chr17	79106752	Missense_Mutation	NA	L87F	0.29
READ	chr17	79104084	Missense_Mutation	novel	R135W	0.47	Fox-1_C
SARC	chr17	79115630	Missense_Mutation	novel	P29L	0.33
TGCT	chr17	79094377	Intron	novel		0.33
THCA	chr17	79086976	3'Flank	novel		0.19
UCEC	chr17	79097309	Frame_Shift_Del	novel	*I247Sfs77**	0.29
UCEC	chr17	79095518	Silent	rs551189632	S284S	0.06
UCEC	chr17	79106654	Silent	NA	F119F	0.55
UCEC	chr17	79115514	Missense_Mutation	rs557599713	A68T	0.33
UCEC	chr17	79106654	Silent	NA	F119F	0.33
UCEC	chr17	79089710	3'Flank	novel		0.14
UCEC	chr17	79307736	5'UTR	novel		0.37
UCEC	chr17	79106780	Silent	NA	D77D	0.38
UCEC	chr17	79096680	Silent	NA	Q256Q	0.23
UCEC	chr17	79106741	Silent	novel	S90S	0.38
UCEC	chr17	79090824	3'UTR	rs745889715		0.42
UCEC	chr17	79101631	Missense_Mutation	NA	T174M	0.11
UCEC	chr17	79103165	Silent	NA	I168I	0.21
UCEC	chr17	79106743	Missense_Mutation	NA	S90P	0.32
UCEC	chr17	79090520	3'Flank	novel		0.46
UCEC	chr17	79087074	3'Flank	novel		0.35
UCEC	chr17	79087194	3'Flank	novel		0.18
UCEC	chr17	79090327	3'Flank	novel		0.29
UCEC	chr17	79089482	3'Flank	novel		0.19
UCEC	chr17	79089869	3'Flank	novel		0.46
UCEC	chr17	79106654	Silent	NA	F119F	0.17
UCEC	chr17	79090807	3'Flank	rs551241985		0.37
UCEC	chr17	79090843	3'UTR	novel		0.46
UCEC	chr17	79086791	3'Flank	novel		0.43
UCEC	chr17	79104111	Missense_Mutation	novel	L126V	0.5	Fox-1_C
UCEC	chr17	79101604	Missense_Mutation	rs542684395	T183M	0.44
UCEC	chr17	79089600	3'Flank	novel		0.4
UCEC	chr17	79097723	Silent	NA	V197V	0.43
UCEC	chr17	79235766	Splice_Region	novel		0.17
UCEC	chr17	79089418	3'Flank	novel		0.16
UCEC	chr17	79106704	Missense_Mutation	novel	V103I	0.3	Fox-1_C
UCEC	chr17	79097699	Missense_Mutation	novel	F205L	0.23
UCEC	chr17	79096657	Missense_Mutation	novel	I264S	0.08
UCEC	chr17	79086706	3'Flank	novel		0.42
UCEC	chr17	79115515	Silent	novel	I67I	0.35
UCEC	chr17	79090431	3'Flank	novel		0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3946	0.00012456
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0663	1.52e-05
OV	AMP	0.2694	7.4951e-06
SARC	AMP	0.2218	0.032181
SKCM	AMP	0.297	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0085	Kaplan-Meier Survival Analysis
ACC	0.024	Kaplan-Meier Survival Analysis
UCS	0.042	Kaplan-Meier Survival Analysis
SKCM	0.039	Kaplan-Meier Survival Analysis
ESCA	0.008	Kaplan-Meier Survival Analysis
KIRP	0.0008	Kaplan-Meier Survival Analysis
LAML	0.00015	Kaplan-Meier Survival Analysis
LGG	0.00071	Kaplan-Meier Survival Analysis
THCA	0.047	Kaplan-Meier Survival Analysis