EuRBPDB

Description

Ensembl ID: ENSG00000167447 (Gene tree)
Gene ID: 55181
Gene Symbol: SMG8
Alias: FLJ10587|FLJ23205|C17orf71
Full Name: SMG8 nonsense mediated mRNA decay factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 5,851 bases
Position: chr17:59,209,400-59,215,250
Accession: 25551
RBP type: non-canonical RBP
Summary: (SMG8 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Gene Expression. An important paralog of this gene is ENSG00000265303.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000580498	SMG8-204	785	-	-	- (aa)	-	-
ENST00000300917	SMG8-201	3263	-	ENSP00000300917	991 (aa)	-	Q8ND04
ENST00000582469	SMG8-206	1144	-	ENSP00000462931	271 (aa)	-	J3KTD7
ENST00000543872	SMG8-202	3477	-	ENSP00000438748	991 (aa)	-	Q8ND04
ENST00000580798	SMG8-205	583	-	ENSP00000463175	32 (aa)	-	J3QKP6
ENST00000578922	SMG8-203	2178	-	ENSP00000462119	588 (aa)	-	Q8ND04

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167447	Peroxidases	3E-12	23620142

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167447	rs6503905	17	59210093	A	Circulating myeloperoxidase levels (plasma)	23620142	[0.040-0.080] unit decrease	0.06	EFO_0005243

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	19417104.	IMP	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0005515	protein binding	19417104.20817927.26496610.	IPI	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005829	cytosol	-	TAS	Component
GO:0045859	regulation of protein kinase activity	19417104.	IMP	Process