EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167657 (Gene tree)
Gene ID: 1613
Gene Symbol: DAPK3
Alias: ZIP|ZIPK
Full Name: death associated protein kinase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,671 bases
Position: chr19:3,958,453-3,971,123
Accession: 2676
RBP type: canonical RBP
Summary: Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000471154	RIO1	PF01163.22	0.00018	1	1
ENSP00000472988	RIO1	PF01163.22	0.00018	1	1
ENSP00000301264	RIO1	PF01163.22	0.00067	1	1
ENSP00000442973	RIO1	PF01163.22	0.00067	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29566767	Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts.	Arthritis Res Ther	2018 Mar 22	Suzuki K	doi: 10.1186/s13075-018-1552-9.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000601824	DAPK3-207	599	-	ENSP00000472988	158 (aa)	-	M0R0D0
ENST00000594894	DAPK3-204	617	-	ENSP00000470168	92 (aa)	-	M0QYY8
ENST00000595279	DAPK3-205	2058	-	-	- (aa)	-	-
ENST00000593844	DAPK3-203	626	-	ENSP00000470115	141 (aa)	-	M0QYW5
ENST00000301264	DAPK3-201	2105	-	ENSP00000301264	454 (aa)	-	O43293
ENST00000545797	DAPK3-202	2257	XM_005259508	ENSP00000442973	454 (aa)	XP_005259565	O43293
ENST00000596311	DAPK3-206	671	-	ENSP00000471154	158 (aa)	-	M0R0D0

Gene Model

Click here to download ENSG00000167657's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04140	Autophagy - animal	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05219	Bladder cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167657	Pancreatic Neoplasms	7.903E-05	22523087
ENSG00000167657	Language	3E-7	25226531

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167657	rs1654584	19	3970685	G	Expressive vocabulary in infants	25226531	[0.056-0.126] unit decrease	0.091	EFO_0006316

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167657's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167657	DAPK3	100	91.139	ENSAPOG00000005339	dapk3	99	80.088	Acanthochromis_polyacanthus
ENSG00000167657	DAPK3	100	98.734	ENSAMEG00000006056	DAPK3	100	94.053	Ailuropoda_melanoleuca
ENSG00000167657	DAPK3	100	91.139	ENSACIG00000007416	dapk3	99	78.540	Amphilophus_citrinellus
ENSG00000167657	DAPK3	100	91.772	ENSAOCG00000023366	dapk3	99	80.752	Amphiprion_ocellaris
ENSG00000167657	DAPK3	100	91.772	ENSAPEG00000021762	dapk3	99	80.752	Amphiprion_percula
ENSG00000167657	DAPK3	100	99.367	ENSBTAG00000020417	DAPK3	100	94.934	Bos_taurus
ENSG00000167657	DAPK3	100	100.000	ENSCJAG00000015041	DAPK3	100	100.000	Callithrix_jacchus
ENSG00000167657	DAPK3	100	99.367	ENSCAFG00000019167	DAPK3	100	95.374	Canis_familiaris
ENSG00000167657	DAPK3	100	99.367	ENSCAFG00020018374	DAPK3	100	95.374	Canis_lupus_dingo
ENSG00000167657	DAPK3	100	99.367	ENSCHIG00000018026	DAPK3	100	94.934	Capra_hircus
ENSG00000167657	DAPK3	100	98.101	ENSTSYG00000035745	DAPK3	100	97.857	Carlito_syrichta
ENSG00000167657	DAPK3	100	97.872	ENSCPOG00000031679	DAPK3	100	94.053	Cavia_porcellus
ENSG00000167657	DAPK3	100	98.582	ENSCLAG00000009010	DAPK3	100	95.374	Chinchilla_lanigera
ENSG00000167657	DAPK3	100	100.000	ENSCSAG00000010873	DAPK3	100	98.899	Chlorocebus_sabaeus
ENSG00000167657	DAPK3	100	94.937	ENSCPBG00000011124	DAPK3	100	79.386	Chrysemys_picta_bellii
ENSG00000167657	DAPK3	100	100.000	ENSCANG00000003009	DAPK3	100	98.899	Colobus_angolensis_palliatus
ENSG00000167657	DAPK3	100	92.405	ENSCVAG00000018536	dapk3	98	81.124	Cyprinodon_variegatus
ENSG00000167657	DAPK3	100	91.139	ENSDARG00000074447	dapk3	98	82.207	Danio_rerio
ENSG00000167657	DAPK3	100	100.000	ENSEASG00005022305	DAPK3	100	93.833	Equus_asinus_asinus
ENSG00000167657	DAPK3	100	95.732	ENSECAG00000012570	DAPK3	100	93.478	Equus_caballus
ENSG00000167657	DAPK3	100	99.367	ENSFCAG00000013501	DAPK3	100	94.053	Felis_catus
ENSG00000167657	DAPK3	100	92.405	ENSFHEG00000009227	dapk3	98	81.348	Fundulus_heteroclitus
ENSG00000167657	DAPK3	100	91.772	ENSGMOG00000012530	dapk3	98	82.883	Gadus_morhua
ENSG00000167657	DAPK3	100	92.405	ENSGAFG00000020067	dapk3	98	81.124	Gambusia_affinis
ENSG00000167657	DAPK3	100	89.873	ENSGACG00000016942	dapk3	98	80.674	Gasterosteus_aculeatus
ENSG00000167657	DAPK3	100	100.000	ENSGGOG00000002018	DAPK3	100	99.559	Gorilla_gorilla
ENSG00000167657	DAPK3	95	93.533	ENSHGLG00000009769	DAPK3	100	93.533	Heterocephalus_glaber_female
ENSG00000167657	DAPK3	100	97.163	ENSHGLG00100012309	DAPK3	100	94.934	Heterocephalus_glaber_male
ENSG00000167657	DAPK3	100	97.163	ENSSTOG00000005038	DAPK3	100	94.493	Ictidomys_tridecemlineatus
ENSG00000167657	DAPK3	100	92.405	ENSKMAG00000022041	dapk3	98	81.757	Kryptolebias_marmoratus
ENSG00000167657	DAPK3	100	91.139	ENSLBEG00000013792	dapk3	99	80.580	Labrus_bergylta
ENSG00000167657	DAPK3	100	93.038	ENSLOCG00000001875	dapk3	97	83.519	Lepisosteus_oculatus
ENSG00000167657	DAPK3	100	100.000	ENSLAFG00000029621	DAPK3	100	92.070	Loxodonta_africana
ENSG00000167657	DAPK3	100	100.000	ENSMFAG00000028991	DAPK3	100	98.899	Macaca_fascicularis
ENSG00000167657	DAPK3	100	100.000	ENSMMUG00000022765	DAPK3	100	98.899	Macaca_mulatta
ENSG00000167657	DAPK3	100	100.000	ENSMICG00000046071	DAPK3	100	97.357	Microcebus_murinus
ENSG00000167657	DAPK3	100	91.139	ENSMMOG00000020516	dapk3	98	79.279	Mola_mola
ENSG00000167657	DAPK3	100	96.203	ENSMODG00000000718	DAPK3	100	90.529	Monodelphis_domestica
ENSG00000167657	DAPK3	100	96.454	ENSMUSG00000034974	Dapk3	100	95.312	Mus_musculus
ENSG00000167657	DAPK3	100	99.367	ENSMPUG00000004467	DAPK3	100	94.934	Mustela_putorius_furo
ENSG00000167657	DAPK3	100	100.000	ENSMLUG00000006239	DAPK3	100	94.934	Myotis_lucifugus
ENSG00000167657	DAPK3	100	96.454	ENSNGAG00000020954	Dapk3	100	83.921	Nannospalax_galili
ENSG00000167657	DAPK3	100	96.203	ENSMEUG00000003969	DAPK3	100	87.665	Notamacropus_eugenii
ENSG00000167657	DAPK3	100	97.872	ENSODEG00000014160	DAPK3	100	93.612	Octodon_degus
ENSG00000167657	DAPK3	96	89.631	ENSOANG00000003319	DAPK3	100	89.631	Ornithorhynchus_anatinus
ENSG00000167657	DAPK3	100	91.772	ENSOMEG00000012168	dapk3	98	81.348	Oryzias_melastigma
ENSG00000167657	DAPK3	100	99.367	ENSOGAG00000010293	DAPK3	100	96.256	Otolemur_garnettii
ENSG00000167657	DAPK3	100	99.367	ENSOARG00000011263	DAPK3	100	92.070	Ovis_aries
ENSG00000167657	DAPK3	100	99.780	ENSPPAG00000029008	DAPK3	100	99.780	Pan_paniscus
ENSG00000167657	DAPK3	100	98.734	ENSPPRG00000002025	DAPK3	100	89.035	Panthera_pardus
ENSG00000167657	DAPK3	100	100.000	ENSPTRG00000010286	DAPK3	100	100.000	Pan_troglodytes
ENSG00000167657	DAPK3	100	100.000	ENSPANG00000018995	DAPK3	100	98.899	Papio_anubis
ENSG00000167657	DAPK3	100	89.241	ENSPMGG00000014858	dapk3	95	89.189	Periophthalmus_magnuspinnatus
ENSG00000167657	DAPK3	100	96.203	ENSPCIG00000025399	DAPK3	100	90.749	Phascolarctos_cinereus
ENSG00000167657	DAPK3	100	99.291	ENSPCAG00000014006	DAPK3	100	92.731	Procavia_capensis
ENSG00000167657	DAPK3	100	100.000	ENSPCOG00000023275	DAPK3	100	97.577	Propithecus_coquereli
ENSG00000167657	DAPK3	100	100.000	ENSRROG00000045681	DAPK3	100	98.899	Rhinopithecus_roxellana
ENSG00000167657	DAPK3	100	100.000	ENSSBOG00000032686	DAPK3	100	87.665	Saimiri_boliviensis_boliviensis
ENSG00000167657	DAPK3	100	91.139	ENSSMAG00000015643	dapk3	98	80.449	Scophthalmus_maximus
ENSG00000167657	DAPK3	100	91.139	ENSSDUG00000012176	dapk3	99	80.088	Seriola_dumerili
ENSG00000167657	DAPK3	100	91.139	ENSSLDG00000011269	dapk3	99	79.956	Seriola_lalandi_dorsalis
ENSG00000167657	DAPK3	100	91.139	ENSSPAG00000012830	dapk3	98	81.124	Stegastes_partitus
ENSG00000167657	DAPK3	100	99.367	ENSSSCG00000032170	DAPK3	100	94.493	Sus_scrofa
ENSG00000167657	DAPK3	100	89.873	ENSTRUG00000006459	dapk3	98	79.326	Takifugu_rubripes
ENSG00000167657	DAPK3	100	92.405	ENSTNIG00000014909	dapk3	98	81.124	Tetraodon_nigroviridis
ENSG00000167657	DAPK3	100	100.000	ENSTTRG00000006774	DAPK3	100	94.053	Tursiops_truncatus
ENSG00000167657	DAPK3	100	99.367	ENSUAMG00000023932	DAPK3	100	95.154	Ursus_americanus
ENSG00000167657	DAPK3	100	99.367	ENSVVUG00000004576	DAPK3	100	95.374	Vulpes_vulpes
ENSG00000167657	DAPK3	98	86.957	ENSXETG00000006396	dapk3	99	79.241	Xenopus_tropicalis
ENSG00000167657	DAPK3	100	91.772	ENSXMAG00000000503	dapk3	98	80.899	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	10356987.18239682.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	16756490.	TAS	Function
GO:0005515	protein binding	15292222.15910542.21454679.21988832.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	10356987.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005884	actin filament	-	IEA	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006355	regulation of transcription, DNA-templated	-	TAS	Process
GO:0006468	protein phosphorylation	10356987.	IDA	Process
GO:0006915	apoptotic process	10580117.	IDA	Process
GO:0006915	apoptotic process	12917339.	IMP	Process
GO:0006940	regulation of smooth muscle contraction	-	TAS	Process
GO:0007088	regulation of mitotic nuclear division	-	TAS	Process
GO:0007346	regulation of mitotic cell cycle	21487036.	IMP	Process
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0008140	cAMP response element binding protein binding	14685163.	TAS	Function
GO:0008360	regulation of cell shape	-	IEA	Process
GO:0010506	regulation of autophagy	16756490.	TAS	Process
GO:0016605	PML body	-	IEA	Component
GO:0017048	Rho GTPase binding	23454120.	IDA	Function
GO:0017148	negative regulation of translation	18995835.	IDA	Process
GO:0030182	neuron differentiation	-	IEA	Process
GO:0030335	positive regulation of cell migration	-	IEA	Process
GO:0035556	intracellular signal transduction	10356987.	IDA	Process
GO:0042802	identical protein binding	18239682.21487036.	IPI	Function
GO:0042803	protein homodimerization activity	18239682.	IDA	Function
GO:0042981	regulation of apoptotic process	16756490.	TAS	Process
GO:0043065	positive regulation of apoptotic process	21487036.	IDA	Process
GO:0043519	regulation of myosin II filament organization	-	IEA	Process
GO:0043522	leucine zipper domain binding	10580117.	IPI	Function
GO:0045121	membrane raft	-	IEA	Component
GO:0046777	protein autophosphorylation	18239682.	IDA	Process
GO:0046777	protein autophosphorylation	16756490.	TAS	Process
GO:0051893	regulation of focal adhesion assembly	23454120.	IDA	Process
GO:0071346	cellular response to interferon-gamma	18995835.	IDA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	21454679.	IMP	Process
GO:0097190	apoptotic signaling pathway	-	IEA	Process
GO:2000145	regulation of cell motility	-	TAS	Process
GO:2000249	regulation of actin cytoskeleton reorganization	23454120.	IDA	Process
GO:2000249	regulation of actin cytoskeleton reorganization	-	TAS	Process
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25304685	DAPK3 suppresses acini morphogenesis and is required for mouse development.	Mol Cancer Res	2015 Feb	Kocher BA	doi: 10.1158/1541-7786.MCR-14-0333
19117059	Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer.	Int J Cancer	2009 Apr 1	Bi J	doi: 10.1002/ijc.24164.
21487036	Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.	Cancer Res	2011 Apr 15	Brognard J	doi: 10.1158/0008-5472.CAN-10-3543
26117336	Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.	J Biol Chem	2015 Aug 7	Cai Z	doi: 10.1074/jbc.M115.661504
28075459	Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling.	Oncol Rep	2017 Feb	Kake S	doi: 10.3892/or.2017.5359
26748242	Biophysical changes of ATP binding pocket may explain loss of kinase activity in mutant DAPK3 in cancer: A molecular dynamic simulation analysis.	Gene	2016 Apr 10	Agarwal T	doi: 10.1016/j.gene.2015.12.066
27126362	Activation of AKT negatively regulates the pro-apoptotic function of death-associated protein kinase 3 (DAPK3) in prostate cancer.	Cancer Lett	2016 Jul 28	Das TP	doi: 10.1016/j.canlet.2016.04.028
28731173	Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway.	Oncol Rep	2017 Sep	Tan J	doi: 10.3892/or.2017.5841

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	3964268	Frame_Shift_Del	novel	*E173Sfs13**	0.12
BLCA	chr19	3964873	Missense_Mutation	novel	I61V	0.09	RIO1
BLCA	chr19	3959239	Silent	NA	L409L	0.5
BLCA	chr19	3969724	Missense_Mutation	novel	F4L	0.09
BLCA	chr19	3964649	Silent	rs144975421	I135I	0.26
BRCA	chr19	3964287	Silent	rs758683266	A170A	0.16
BRCA	chr19	3964649	Silent	rs144975421	I135I	0.17
CESC	chr19	3964275	Missense_Mutation	novel	F174L	0.2
CESC	chr19	3964679	Silent	rs763048239	D125D	0.13
CESC	chr19	3961088	Missense_Mutation	novel	D235N	0.33
CESC	chr19	3959478	Missense_Mutation	NA	E330Q	0.22
CESC	chr19	3961611	Intron	novel		0.15
CESC	chr19	3964266	Missense_Mutation	novel	I177M	0.35
CESC	chr19	3964697	Silent	novel	F119F	0.41
CESC	chr19	3964826	Silent	NA	I76I	0.36
COAD	chr19	3964270	Missense_Mutation	novel	N176I	0.25
COAD	chr19	3964759	Missense_Mutation	novel	G99R	0.25	RIO1
COAD	chr19	3964304	Missense_Mutation	novel	A165T	0.56
COAD	chr19	3964908	Missense_Mutation	NA	L49P	0.34	RIO1
COAD	chr19	3964760	Silent	rs775587396	G98G	0.31
COAD	chr19	3964302	Silent	rs777773890	A165A	0.3
COAD	chr19	3960102	Missense_Mutation	rs547931912	R262Q	0.19
GBM	chr19	3959262	Missense_Mutation	novel	A402T	0.45
GBM	chr19	3959629	Silent	NA	R279R	0.28
GBM	chr19	3964817	Silent	novel	L79L	0.23
HNSC	chr19	3964742	Silent	novel	F104F	0.66
HNSC	chr19	3964892	Frame_Shift_Del	novel	V56*	0.24	RIO1
HNSC	chr19	3964694	Silent	NA	L120L	0.28
HNSC	chr19	3964802	Silent	rs779291482	E84E	0.18
HNSC	chr19	3964915	Missense_Mutation	novel	R47C	0.22	RIO1
HNSC	chr19	3964912	Missense_Mutation	novel	R48C	0.18	RIO1
HNSC	chr19	3964696	Missense_Mutation	novel	L120F	0.12	RIO1
KIRC	chr19	3964352	Missense_Mutation	NA	D149N	0.27	RIO1
LGG	chr19	3964269	Missense_Mutation	NA	N176K	0.24
LGG	chr19	3961317	Intron	novel		0.57
LGG	chr19	3964724	Silent	rs749765274	S110S	0.12
LIHC	chr19	3961438	Intron	novel		0.17
LIHC	chr19	3959047	3'UTR	novel		0.29
LUAD	chr19	3960093	Frame_Shift_Ins	novel	*T265Sfs12**	0.12
LUAD	chr19	3964954	Missense_Mutation	NA	G34C	0.11
LUAD	chr19	3964804	Missense_Mutation	NA	E84K	0.14	RIO1
LUAD	chr19	3960092	Silent	NA	T265T	0.05
LUAD	chr19	3961338	Intron	novel		0.6
LUAD	chr19	3959180	Missense_Mutation	NA	S429F	0.33
LUAD	chr19	3959302	Silent	novel	T388T	0.27
LUAD	chr19	3960105	Splice_Site	novel	X261_splice	0.26
LUAD	chr19	3961424	Intron	NA		0.16
LUSC	chr19	3969744	5'UTR	novel		0.94
LUSC	chr19	3964953	Missense_Mutation	novel	G34D	0.15
LUSC	chr19	3964371	Splice_Region	novel	P142P	0.3
LUSC	chr19	3969778	5'UTR	novel		0.48
LUSC	chr19	3959566	Silent	NA	T300T	0.7
LUSC	chr19	3964899	Missense_Mutation	rs199653811	S52I	0.23	RIO1
LUSC	chr19	3959417	Frame_Shift_Del	novel	*H350Pfs78**	0.75
LUSC	chr19	3959149	Silent	NA	R439R	0.33
OV	chr19	3964737	Missense_Mutation	rs369395432	A106V	0.1	RIO1
OV	chr19	3961451	Intron	NA		0.4
OV	chr19	3959486	Missense_Mutation	novel	K327M	0.73
OV	chr19	3964795	Missense_Mutation	novel	T87S	0.11	RIO1
PRAD	chr19	3964649	Silent	rs144975421	I135I	0.14
PRAD	chr19	3964793	Silent	rs754224579	T87T	0.16
READ	chr19	3961016	Missense_Mutation	NA	D259Y	0.3
READ	chr19	3964334	Missense_Mutation	NA	P155T	0.1
READ	chr19	3964633	Missense_Mutation	novel	K141Q	0.19	RIO1
READ	chr19	3961144	Missense_Mutation	novel	P216L	0.4
SKCM	chr19	3961146	Silent	novel	S215S	0.41
SKCM	chr19	3961034	Missense_Mutation	NA	R253C	0.35
SKCM	chr19	3961173	Intron	novel		0.27
SKCM	chr19	3961179	Intron	novel		0.21
SKCM	chr19	3961386	Intron	novel		0.14
SKCM	chr19	3964662	Missense_Mutation	NA	H131R	0.04	RIO1
SKCM	chr19	3964976	Silent	rs767022591	I26I	0.56
SKCM	chr19	3964706	Silent	NA	A116A	0.23
SKCM	chr19	3959145	Silent	novel	L441L	0.78
SKCM	chr19	3964362	Silent	rs112082802	I145I	0.24
SKCM	chr19	3964925	Silent	NA	F43F	0.12
SKCM	chr19	3959322	Missense_Mutation	rs201287470	R382W	0.55
SKCM	chr19	3964253	Missense_Mutation	NA	E182K	0.37
STAD	chr19	3961033	Missense_Mutation	rs745312042	R253H	0.16
STAD	chr19	3959166	Missense_Mutation	NA	V434M	0.41
STAD	chr19	3969679	Silent	NA	L19L	0.52
STAD	chr19	3964937	Silent	NA	Y39Y	0.44
STAD	chr19	3959150	Missense_Mutation	NA	R439H	0.28
STAD	chr19	3964785	Missense_Mutation	novel	V90D	0.31	RIO1
STAD	chr19	3959302	Silent	novel	T388T	0.16
STAD	chr19	3964963	Silent	novel	R31R	0.29
STAD	chr19	3964980	Missense_Mutation	novel	A25V	0.09
STAD	chr19	3959616	Missense_Mutation	NA	R284C	0.33
STAD	chr19	3969702	Missense_Mutation	rs775366216	H12Y	0.09
THCA	chr19	3969788	5'UTR	novel		0.1
UCEC	chr19	3964897	Missense_Mutation	NA	R53W	0.19	RIO1
UCEC	chr19	3964805	Silent	rs750459243	F83F	0.35
UCEC	chr19	3964804	Missense_Mutation	NA	E84K	0.24	RIO1
UCEC	chr19	3961439	Intron	rs767027646		0.38
UCEC	chr19	3964317	Silent	rs771900298	I160I	0.29
UCEC	chr19	3964677	Missense_Mutation	NA	G126D	0.43	RIO1
UCEC	chr19	3964663	Missense_Mutation	novel	H131Y	0.34	RIO1
UCEC	chr19	3964922	Missense_Mutation	novel	I44M	0.42	RIO1
UCEC	chr19	3969687	Missense_Mutation	novel	E17K	0.39
UCEC	chr19	3961316	Intron	NA		0.27
UCEC	chr19	3964962	Missense_Mutation	NA	R31Q	0.39
UCEC	chr19	3964813	Missense_Mutation	novel	D81N	0.26	RIO1
UCEC	chr19	3961082	Missense_Mutation	novel	D237N	0.06
UCEC	chr19	3961161	Splice_Region	novel	L210L	0.12
UCEC	chr19	3964299	Silent	NA	H166H	0.31
UCEC	chr19	3961447	Intron	NA		0.21
UCEC	chr19	3964882	Missense_Mutation	rs779973024	R58W	0.09	RIO1
UCEC	chr19	3959540	Missense_Mutation	novel	S309L	0.31
UCEC	chr19	3969712	Silent	rs764138899	D8D	0.45
UCEC	chr19	3964293	Silent	rs755968884	I168I	0.47
UCEC	chr19	3961028	Silent	novel	L255L	0.06
UCEC	chr19	3963920	Splice_Site	novel	X185_splice	0.41
UCEC	chr19	3964662	Missense_Mutation	NA	H131R	0.2	RIO1
UCEC	chr19	3964730	In_Frame_Del	novel	K108del	0.04	RIO1
UCEC	chr19	3959631	Missense_Mutation	rs781570365	R279W	0.28
UCEC	chr19	3964794	Missense_Mutation	novel	T87M	0.35	RIO1
UCEC	chr19	3964936	Missense_Mutation	novel	A40T	0.5	RIO1
UCEC	chr19	3961235	Intron	novel		0.43
UCEC	chr19	3964840	Missense_Mutation	rs371231370	R72W	0.07	RIO1
UCEC	chr19	3961413	Intron	rs748521837		0.34
UCEC	chr19	3964738	Missense_Mutation	novel	A106S	0.35	RIO1
UCEC	chr19	3961463	Intron	rs779317352		0.41
UCEC	chr19	3969809	5'UTR	novel		0.51

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0556	0.058467
LIHC	DEL	0.1865	4.7028e-08
PAAD	DEL	0.1413	0.0060878
READ	DEL	0.1333	0.23023
STAD	DEL	0.288	1.5798e-05
THCA	DEL	0.016	0.10598
UCEC	DEL	0.2764	4.5149e-49
UCS	DEL	0.7679	8.0449e-14

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0043	Kaplan-Meier Survival Analysis
SARC	0.046	Kaplan-Meier Survival Analysis
MESO	0.015	Kaplan-Meier Survival Analysis
ACC	0.0083	Kaplan-Meier Survival Analysis
SKCM	0.0012	Kaplan-Meier Survival Analysis
PRAD	0.025	Kaplan-Meier Survival Analysis
ESCA	0.0085	Kaplan-Meier Survival Analysis
COAD	0.025	Kaplan-Meier Survival Analysis
PAAD	0.0042	Kaplan-Meier Survival Analysis
LAML	0.049	Kaplan-Meier Survival Analysis
UCEC	0.00017	Kaplan-Meier Survival Analysis
LIHC	0.041	Kaplan-Meier Survival Analysis
LGG	0.0023	Kaplan-Meier Survival Analysis
UVM	0.039	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742