EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167658 (Gene tree)
Gene ID: 1938
Gene Symbol: EEF2
Alias: EEF-2|EF2
Full Name: eukaryotic translation elongation factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 9,414 bases
Position: chr19:3,976,056-3,985,469
Accession: 3214
RBP type: canonical RBP
Summary: This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000307940	GTP_EFTU	PF00009.27	3e-64	1	1
ENSP00000307940	MMR_HSR1	PF01926.23	9e-05	1	1
ENSP00000307940	GTP_EFTU_D2	PF03144.25	7.2e-12	1	1
ENSP00000307940	EFG_IV	PF03764.18	6e-33	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22157746	CPEB2-eEF2 interaction impedes HIF-1α RNA translation.	EMBO J	2012 Feb 15	Chen PJ	doi: 10.1038/emboj.2011.448
19413897	Proteome analysis of Norway maple (Acer platanoides L.) seeds dormancy breaking and germination: influence of abscisic and gibberellic acids.	BMC Plant Biol	2009 May 4	Pawlowski TA	doi: 10.1186/1471-2229-9-48.
3922437	[Comparison of eukaryotic and prokaryotic elongation factors: isoelectric points and molecular masses].	Biokhimiia	1985 Mar	Minich WB	-
2427294	[The ADP-ribosylation site and RNA-binding center are located in different regions of the elongation factor EF-2].	Dokl Akad Nauk SSSR	1986	Davydova EK	-
7999776	Interaction sites of ribosome-bound eukaryotic elongation factor 2 in 18S and 28S rRNA.	Biochemistry	1994 Dec 20	Holmberg L	-
30131676	The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling.	Front Cell Neurosci	2018 Aug 7	Nayak T	doi: 10.3389/fncel.2018.00231
11849993	In vitro interaction of eukaryotic elongation factor 2 with synthetic oligoribonucleotide that mimics GTPase domain of rat 28S ribosomal RNA.	Int J Biochem Cell Biol	2002 Mar	He WJ	-
11681712	Eukaryotic elongation factor 2 can bind to the synthetic oligoribonucleotide that mimics sarcin/ricin domain of rat 28S ribosomal RNA.	Mol Cell Biochem	2001 Jul	Tang S	-
3801485	The ribosomal binding site for eukaryotic elongation factor EF-2 contains 5 S ribosomal RNA.	Biochim Biophys Acta	1987 Jan 28	Nygard O	-
10488095	Replacement of L7/L12.L10 protein complex in Escherichia coli ribosomes with the eukaryotic counterpart changes the specificity of elongation factor binding.	J Biol Chem	1999 Sep 24	Uchiumi T	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000598436	EEF2-205	549	-	-	- (aa)	-	-
ENST00000600720	EEF2-206	573	-	-	- (aa)	-	-
ENST00000594885	EEF2-202	580	-	-	- (aa)	-	-
ENST00000600794	EEF2-207	352	-	ENSP00000471265	85 (aa)	-	M0R0I6
ENST00000596417	EEF2-203	218	-	-	- (aa)	-	-
ENST00000309311	EEF2-201	3164	-	ENSP00000307940	858 (aa)	-	P13639
ENST00000598182	EEF2-204	581	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000167658's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04152	AMPK signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167658's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000167658	EEF2	98	35.398	ENSG00000140598	EFL1	91	49.057
ENSG00000167658	EEF2	99	39.061	ENSG00000108883	EFTUD2	90	39.061
ENSG00000167658	EEF2	75	38.926	ENSG00000168827	GFM1	74	38.926

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167658	EEF2	100	91.375	ENSAPOG00000023780	eef2b	100	91.375	Acanthochromis_polyacanthus
ENSG00000167658	EEF2	100	88.928	ENSAPOG00000004529	-	100	88.928	Acanthochromis_polyacanthus
ENSG00000167658	EEF2	99	99.300	ENSAMEG00000002286	EEF2	99	99.300	Ailuropoda_melanoleuca
ENSG00000167658	EEF2	99	92.127	ENSACIG00000017631	eef2b	99	92.127	Amphilophus_citrinellus
ENSG00000167658	EEF2	100	89.044	ENSACIG00000015246	-	100	89.044	Amphilophus_citrinellus
ENSG00000167658	EEF2	100	91.725	ENSAOCG00000015356	eef2b	100	91.725	Amphiprion_ocellaris
ENSG00000167658	EEF2	100	88.695	ENSAOCG00000017645	-	100	88.695	Amphiprion_ocellaris
ENSG00000167658	EEF2	100	91.725	ENSAPEG00000012820	eef2b	100	91.725	Amphiprion_percula
ENSG00000167658	EEF2	100	88.695	ENSAPEG00000007459	-	100	88.695	Amphiprion_percula
ENSG00000167658	EEF2	100	91.841	ENSATEG00000015820	eef2b	100	91.841	Anabas_testudineus
ENSG00000167658	EEF2	100	88.928	ENSATEG00000024140	-	100	88.928	Anabas_testudineus
ENSG00000167658	EEF2	99	90.326	ENSAPLG00000010503	EEF2	99	90.443	Anas_platyrhynchos
ENSG00000167658	EEF2	100	94.529	ENSACAG00000012275	EEF2	100	94.529	Anolis_carolinensis
ENSG00000167658	EEF2	100	99.534	ENSANAG00000037323	EEF2	100	99.534	Aotus_nancymaae
ENSG00000167658	EEF2	100	92.541	ENSACLG00000003034	eef2b	100	92.541	Astatotilapia_calliptera
ENSG00000167658	EEF2	100	88.928	ENSACLG00000023595	-	100	88.928	Astatotilapia_calliptera
ENSG00000167658	EEF2	100	93.007	ENSAMXG00000006645	eef2b	100	93.007	Astyanax_mexicanus
ENSG00000167658	EEF2	55	90.196	ENSBTAG00000052492	-	100	90.196	Bos_taurus
ENSG00000167658	EEF2	100	99.301	ENSBTAG00000004258	EEF2	100	99.301	Bos_taurus
ENSG00000167658	EEF2	100	78.736	WBGene00001167	eef-2	100	78.736	Caenorhabditis_elegans
ENSG00000167658	EEF2	100	99.534	ENSCJAG00000015045	EEF2	100	99.534	Callithrix_jacchus
ENSG00000167658	EEF2	100	99.534	ENSCAFG00000019158	EEF2	100	99.534	Canis_familiaris
ENSG00000167658	EEF2	99	99.533	ENSCAFG00020018386	-	99	99.533	Canis_lupus_dingo
ENSG00000167658	EEF2	100	99.534	ENSCAFG00020007212	-	100	99.534	Canis_lupus_dingo
ENSG00000167658	EEF2	100	99.301	ENSCHIG00000013910	-	100	99.301	Capra_hircus
ENSG00000167658	EEF2	100	72.494	ENSCHIG00000007833	-	93	72.494	Capra_hircus
ENSG00000167658	EEF2	100	98.485	ENSTSYG00000028021	EEF2	100	98.485	Carlito_syrichta
ENSG00000167658	EEF2	100	94.406	ENSCAPG00000011396	EEF2	100	94.406	Cavia_aperea
ENSG00000167658	EEF2	100	94.172	ENSCPOG00000015697	EEF2	100	94.172	Cavia_porcellus
ENSG00000167658	EEF2	100	99.068	ENSCCAG00000034379	EEF2	100	99.068	Cebus_capucinus
ENSG00000167658	EEF2	100	92.308	ENSCATG00000005903	-	100	92.308	Cercocebus_atys
ENSG00000167658	EEF2	100	99.883	ENSCATG00000039972	-	100	99.883	Cercocebus_atys
ENSG00000167658	EEF2	100	99.650	ENSCLAG00000014112	EEF2	100	99.650	Chinchilla_lanigera
ENSG00000167658	EEF2	100	99.883	ENSCSAG00000010865	EEF2	100	99.883	Chlorocebus_sabaeus
ENSG00000167658	EEF2	87	96.825	ENSCHOG00000005308	EEF2	87	96.825	Choloepus_hoffmanni
ENSG00000167658	EEF2	100	97.786	ENSCPBG00000011117	EEF2	100	97.786	Chrysemys_picta_bellii
ENSG00000167658	EEF2	100	91.385	ENSCPBG00000025689	-	100	91.385	Chrysemys_picta_bellii
ENSG00000167658	EEF2	100	72.992	ENSCING00000009356	-	100	72.992	Ciona_intestinalis
ENSG00000167658	EEF2	99	74.942	ENSCSAVG00000003974	-	100	77.632	Ciona_savignyi
ENSG00000167658	EEF2	92	100.000	ENSCANG00000041316	-	100	100.000	Colobus_angolensis_palliatus
ENSG00000167658	EEF2	94	96.411	ENSCANG00000012921	-	98	97.845	Colobus_angolensis_palliatus
ENSG00000167658	EEF2	100	99.301	ENSCGRG00001021031	Eef2	100	99.301	Cricetulus_griseus_chok1gshd
ENSG00000167658	EEF2	99	99.300	ENSCGRG00000002993	Eef2	99	99.300	Cricetulus_griseus_crigri
ENSG00000167658	EEF2	99	83.431	ENSCSEG00000002828	-	99	83.431	Cynoglossus_semilaevis
ENSG00000167658	EEF2	99	90.898	ENSCSEG00000014097	eef2b	100	90.898	Cynoglossus_semilaevis
ENSG00000167658	EEF2	100	88.578	ENSCVAG00000005478	-	100	88.578	Cyprinodon_variegatus
ENSG00000167658	EEF2	100	92.075	ENSCVAG00000018746	eef2b	100	92.075	Cyprinodon_variegatus
ENSG00000167658	EEF2	100	92.451	ENSDARG00000035256	eef2l2	100	92.451	Danio_rerio
ENSG00000167658	EEF2	100	92.890	ENSDARG00000100371	eef2b	100	92.890	Danio_rerio
ENSG00000167658	EEF2	92	99.111	ENSDNOG00000001613	EEF2	100	99.111	Dasypus_novemcinctus
ENSG00000167658	EEF2	99	99.650	ENSDORG00000012229	Eef2	100	99.650	Dipodomys_ordii
ENSG00000167658	EEF2	100	78.306	FBgn0000559	eEF2	100	78.306	Drosophila_melanogaster
ENSG00000167658	EEF2	91	100.000	ENSETEG00000018414	EEF2	91	100.000	Echinops_telfairi
ENSG00000167658	EEF2	99	82.030	ENSEBUG00000009369	-	99	82.030	Eptatretus_burgeri
ENSG00000167658	EEF2	98	99.285	ENSEASG00005022311	EEF2	100	99.285	Equus_asinus_asinus
ENSG00000167658	EEF2	100	99.184	ENSECAG00000020547	EEF2	100	99.184	Equus_caballus
ENSG00000167658	EEF2	100	91.608	ENSELUG00000018859	eef2b	100	91.608	Esox_lucius
ENSG00000167658	EEF2	100	90.559	ENSELUG00000008109	eef2b	100	90.559	Esox_lucius
ENSG00000167658	EEF2	100	89.884	ENSELUG00000013203	eef2l2	100	89.884	Esox_lucius
ENSG00000167658	EEF2	100	99.417	ENSFCAG00000000909	EEF2	100	99.417	Felis_catus
ENSG00000167658	EEF2	99	97.783	ENSFALG00000000859	EEF2	99	97.783	Ficedula_albicollis
ENSG00000167658	EEF2	100	99.184	ENSFDAG00000010465	EEF2	100	99.184	Fukomys_damarensis
ENSG00000167658	EEF2	100	91.375	ENSFHEG00000002184	-	100	91.375	Fundulus_heteroclitus
ENSG00000167658	EEF2	100	88.345	ENSFHEG00000012721	-	100	88.345	Fundulus_heteroclitus
ENSG00000167658	EEF2	92	85.575	ENSGMOG00000011722	eef2l2	92	85.575	Gadus_morhua
ENSG00000167658	EEF2	100	97.552	ENSGALG00000033884	EEF2	100	97.552	Gallus_gallus
ENSG00000167658	EEF2	100	88.928	ENSGAFG00000002633	-	100	88.928	Gambusia_affinis
ENSG00000167658	EEF2	100	91.608	ENSGAFG00000008341	eef2b	100	91.608	Gambusia_affinis
ENSG00000167658	EEF2	99	89.732	ENSGACG00000015308	eef2b	99	89.732	Gasterosteus_aculeatus
ENSG00000167658	EEF2	100	86.364	ENSGACG00000012793	-	100	86.364	Gasterosteus_aculeatus
ENSG00000167658	EEF2	100	91.036	ENSGAGG00000013607	-	100	91.036	Gopherus_agassizii
ENSG00000167658	EEF2	100	97.669	ENSGAGG00000000728	EEF2	100	97.669	Gopherus_agassizii
ENSG00000167658	EEF2	100	100.000	ENSGGOG00000012869	EEF2	100	100.000	Gorilla_gorilla
ENSG00000167658	EEF2	100	88.928	ENSHBUG00000006381	-	100	88.928	Haplochromis_burtoni
ENSG00000167658	EEF2	100	92.541	ENSHBUG00000021382	eef2b	100	92.541	Haplochromis_burtoni
ENSG00000167658	EEF2	100	98.951	ENSHGLG00000007881	EEF2	100	98.951	Heterocephalus_glaber_female
ENSG00000167658	EEF2	100	98.951	ENSHGLG00100015891	EEF2	100	98.951	Heterocephalus_glaber_male
ENSG00000167658	EEF2	99	87.234	ENSHCOG00000001471	-	100	87.234	Hippocampus_comes
ENSG00000167658	EEF2	100	90.443	ENSHCOG00000001360	eef2b	100	90.443	Hippocampus_comes
ENSG00000167658	EEF2	100	91.492	ENSIPUG00000000950	-	100	91.492	Ictalurus_punctatus
ENSG00000167658	EEF2	100	91.521	ENSIPUG00000007921	eef2l2	98	91.512	Ictalurus_punctatus
ENSG00000167658	EEF2	99	99.650	ENSSTOG00000005050	EEF2	100	99.650	Ictidomys_tridecemlineatus
ENSG00000167658	EEF2	99	99.413	ENSJJAG00000017122	Eef2	100	99.413	Jaculus_jaculus
ENSG00000167658	EEF2	100	88.695	ENSKMAG00000003647	-	100	88.695	Kryptolebias_marmoratus
ENSG00000167658	EEF2	100	91.725	ENSKMAG00000006881	eef2b	100	91.725	Kryptolebias_marmoratus
ENSG00000167658	EEF2	100	87.296	ENSLBEG00000016853	-	100	87.296	Labrus_bergylta
ENSG00000167658	EEF2	100	91.026	ENSLBEG00000001176	eef2b	100	91.026	Labrus_bergylta
ENSG00000167658	EEF2	100	92.191	ENSLACG00000011124	-	100	92.191	Latimeria_chalumnae
ENSG00000167658	EEF2	100	92.200	ENSLACG00000004710	-	100	92.200	Latimeria_chalumnae
ENSG00000167658	EEF2	100	94.063	ENSLOCG00000006634	eef2l2	100	94.063	Lepisosteus_oculatus
ENSG00000167658	EEF2	100	93.364	ENSLOCG00000006185	eef2b	100	93.364	Lepisosteus_oculatus
ENSG00000167658	EEF2	99	99.533	ENSLAFG00000009159	EEF2	99	99.533	Loxodonta_africana
ENSG00000167658	EEF2	100	99.883	ENSMFAG00000040276	-	100	99.883	Macaca_fascicularis
ENSG00000167658	EEF2	54	93.354	ENSMFAG00000040640	-	100	93.354	Macaca_fascicularis
ENSG00000167658	EEF2	50	82.251	ENSMMUG00000042545	-	100	95.333	Macaca_mulatta
ENSG00000167658	EEF2	100	99.883	ENSMMUG00000022767	EEF2	100	99.883	Macaca_mulatta
ENSG00000167658	EEF2	100	99.767	ENSMNEG00000021403	EEF2	100	99.767	Macaca_nemestrina
ENSG00000167658	EEF2	100	99.883	ENSMLEG00000031184	-	100	99.883	Mandrillus_leucophaeus
ENSG00000167658	EEF2	100	89.394	ENSMAMG00000019483	-	100	89.394	Mastacembelus_armatus
ENSG00000167658	EEF2	98	91.459	ENSMAMG00000009410	eef2b	99	91.336	Mastacembelus_armatus
ENSG00000167658	EEF2	100	88.811	ENSMZEG00005007103	-	100	88.811	Maylandia_zebra
ENSG00000167658	EEF2	100	92.541	ENSMZEG00005025634	eef2b	100	92.541	Maylandia_zebra
ENSG00000167658	EEF2	99	96.756	ENSMGAG00000011170	EEF2	99	96.756	Meleagris_gallopavo
ENSG00000167658	EEF2	99	99.300	ENSMAUG00000007062	Eef2	100	99.300	Mesocricetus_auratus
ENSG00000167658	EEF2	100	99.301	ENSMICG00000012772	EEF2	100	99.686	Microcebus_murinus
ENSG00000167658	EEF2	100	83.683	ENSMOCG00000018569	-	100	83.683	Microtus_ochrogaster
ENSG00000167658	EEF2	100	98.951	ENSMOCG00000019369	-	100	98.951	Microtus_ochrogaster
ENSG00000167658	EEF2	86	93.774	ENSMOCG00000019641	-	100	93.774	Microtus_ochrogaster
ENSG00000167658	EEF2	99	84.161	ENSMMOG00000000457	-	100	84.161	Mola_mola
ENSG00000167658	EEF2	99	81.797	ENSMMOG00000010594	eef2b	100	81.797	Mola_mola
ENSG00000167658	EEF2	100	98.601	ENSMODG00000025340	-	100	98.601	Monodelphis_domestica
ENSG00000167658	EEF2	99	97.783	ENSMODG00000000750	-	100	97.783	Monodelphis_domestica
ENSG00000167658	EEF2	100	91.142	ENSMALG00000021333	eef2b	100	91.142	Monopterus_albus
ENSG00000167658	EEF2	100	89.044	ENSMALG00000007652	-	100	89.044	Monopterus_albus
ENSG00000167658	EEF2	100	98.834	MGP_CAROLIEiJ_G0015622	Eef2	100	98.834	Mus_caroli
ENSG00000167658	EEF2	100	99.068	ENSMUSG00000034994	Eef2	100	99.068	Mus_musculus
ENSG00000167658	EEF2	100	99.184	MGP_PahariEiJ_G0031035	Eef2	100	99.184	Mus_pahari
ENSG00000167658	EEF2	100	99.068	MGP_SPRETEiJ_G0016440	Eef2	100	99.068	Mus_spretus
ENSG00000167658	EEF2	89	98.044	ENSMPUG00000004478	EEF2	99	98.044	Mustela_putorius_furo
ENSG00000167658	EEF2	100	98.839	ENSMLUG00000014241	-	100	98.839	Myotis_lucifugus
ENSG00000167658	EEF2	67	82.753	ENSMLUG00000025959	-	98	82.753	Myotis_lucifugus
ENSG00000167658	EEF2	100	99.068	ENSNGAG00000001879	Eef2	100	99.068	Nannospalax_galili
ENSG00000167658	EEF2	100	92.657	ENSNBRG00000020205	eef2b	100	92.657	Neolamprologus_brichardi
ENSG00000167658	EEF2	100	88.811	ENSNBRG00000011329	-	100	88.811	Neolamprologus_brichardi
ENSG00000167658	EEF2	80	92.308	ENSNLEG00000002981	-	91	92.308	Nomascus_leucogenys
ENSG00000167658	EEF2	100	97.203	ENSMEUG00000003973	EEF2	100	97.203	Notamacropus_eugenii
ENSG00000167658	EEF2	74	100.000	ENSOPRG00000003490	-	74	100.000	Ochotona_princeps
ENSG00000167658	EEF2	93	85.965	ENSODEG00000003412	-	99	85.965	Octodon_degus
ENSG00000167658	EEF2	50	96.774	ENSODEG00000012032	-	100	97.783	Octodon_degus
ENSG00000167658	EEF2	100	71.495	ENSODEG00000006175	-	100	71.495	Octodon_degus
ENSG00000167658	EEF2	99	89.265	ENSONIG00000004840	-	99	89.265	Oreochromis_niloticus
ENSG00000167658	EEF2	100	92.308	ENSONIG00000010226	eef2b	100	92.308	Oreochromis_niloticus
ENSG00000167658	EEF2	100	98.951	ENSOANG00000014032	EEF2	100	98.951	Ornithorhynchus_anatinus
ENSG00000167658	EEF2	100	91.841	ENSORLG00000015009	eef2b	100	91.841	Oryzias_latipes
ENSG00000167658	EEF2	100	88.462	ENSORLG00000004622	-	100	88.462	Oryzias_latipes
ENSG00000167658	EEF2	100	88.462	ENSORLG00020003472	-	100	88.462	Oryzias_latipes_hni
ENSG00000167658	EEF2	100	91.725	ENSORLG00020017663	eef2b	100	91.725	Oryzias_latipes_hni
ENSG00000167658	EEF2	100	88.345	ENSORLG00015021481	-	100	88.345	Oryzias_latipes_hsok
ENSG00000167658	EEF2	100	91.841	ENSORLG00015017743	EEF2	100	91.841	Oryzias_latipes_hsok
ENSG00000167658	EEF2	100	92.308	ENSOMEG00000020260	eef2b	100	92.308	Oryzias_melastigma
ENSG00000167658	EEF2	100	89.161	ENSOMEG00000013444	-	100	89.161	Oryzias_melastigma
ENSG00000167658	EEF2	99	98.833	ENSOGAG00000010298	EEF2	99	98.833	Otolemur_garnettii
ENSG00000167658	EEF2	100	99.301	ENSOARG00000011109	EEF2	99	99.184	Ovis_aries
ENSG00000167658	EEF2	100	100.000	ENSPPAG00000042319	EEF2	100	100.000	Pan_paniscus
ENSG00000167658	EEF2	100	99.417	ENSPPRG00000002841	EEF2	100	99.417	Panthera_pardus
ENSG00000167658	EEF2	100	99.417	ENSPTIG00000012837	EEF2	100	99.417	Panthera_tigris_altaica
ENSG00000167658	EEF2	100	100.000	ENSPTRG00000010288	EEF2	100	100.000	Pan_troglodytes
ENSG00000167658	EEF2	100	99.883	ENSPANG00000007589	EEF2	100	99.883	Papio_anubis
ENSG00000167658	EEF2	100	93.357	ENSPKIG00000011101	eef2b	100	93.357	Paramormyrops_kingsleyae
ENSG00000167658	EEF2	100	92.209	ENSPKIG00000014332	eef2l2	100	92.209	Paramormyrops_kingsleyae
ENSG00000167658	EEF2	100	92.890	ENSPKIG00000018903	-	100	92.890	Paramormyrops_kingsleyae
ENSG00000167658	EEF2	100	98.019	ENSPSIG00000011176	EEF2	100	98.019	Pelodiscus_sinensis
ENSG00000167658	EEF2	99	84.247	ENSPMGG00000014692	-	100	84.247	Periophthalmus_magnuspinnatus
ENSG00000167658	EEF2	99	99.183	ENSPEMG00000021167	Eef2	100	99.183	Peromyscus_maniculatus_bairdii
ENSG00000167658	EEF2	100	90.676	ENSPMAG00000001142	-	100	90.676	Petromyzon_marinus
ENSG00000167658	EEF2	100	98.951	ENSPCIG00000025403	EEF2	100	98.951	Phascolarctos_cinereus
ENSG00000167658	EEF2	100	92.075	ENSPFOG00000012825	eef2b	100	92.075	Poecilia_formosa
ENSG00000167658	EEF2	100	88.811	ENSPFOG00000003083	-	100	88.811	Poecilia_formosa
ENSG00000167658	EEF2	100	91.958	ENSPLAG00000019123	eef2b	100	91.962	Poecilia_latipinna
ENSG00000167658	EEF2	100	88.928	ENSPLAG00000009753	-	100	88.928	Poecilia_latipinna
ENSG00000167658	EEF2	100	91.958	ENSPMEG00000000362	EEF2	100	91.958	Poecilia_mexicana
ENSG00000167658	EEF2	100	89.044	ENSPMEG00000003889	-	100	89.044	Poecilia_mexicana
ENSG00000167658	EEF2	100	92.075	ENSPREG00000017633	eef2b	100	92.075	Poecilia_reticulata
ENSG00000167658	EEF2	100	88.345	ENSPREG00000008298	-	100	88.345	Poecilia_reticulata
ENSG00000167658	EEF2	100	100.000	ENSPPYG00000009393	EEF2	100	100.000	Pongo_abelii
ENSG00000167658	EEF2	100	99.184	ENSPCOG00000023522	EEF2	100	99.371	Propithecus_coquereli
ENSG00000167658	EEF2	85	100.000	ENSPVAG00000017495	EEF2	85	100.000	Pteropus_vampyrus
ENSG00000167658	EEF2	100	92.541	ENSPNYG00000006476	eef2b	100	92.541	Pundamilia_nyererei
ENSG00000167658	EEF2	100	88.811	ENSPNYG00000017403	-	100	88.811	Pundamilia_nyererei
ENSG00000167658	EEF2	100	92.191	ENSPNAG00000027010	eef2b	100	92.191	Pygocentrus_nattereri
ENSG00000167658	EEF2	100	92.334	ENSPNAG00000010655	eef2l2	100	92.334	Pygocentrus_nattereri
ENSG00000167658	EEF2	99	92.080	ENSPNAG00000012086	-	100	92.080	Pygocentrus_nattereri
ENSG00000167658	EEF2	100	99.184	ENSRNOG00000020266	Eef2	100	99.184	Rattus_norvegicus
ENSG00000167658	EEF2	99	99.883	ENSRBIG00000044754	EEF2	99	99.883	Rhinopithecus_bieti
ENSG00000167658	EEF2	100	99.883	ENSRROG00000019319	EEF2	100	99.883	Rhinopithecus_roxellana
ENSG00000167658	EEF2	100	66.200	YOR133W	-	100	66.200	Saccharomyces_cerevisiae
ENSG00000167658	EEF2	100	66.200	YDR385W	-	100	66.200	Saccharomyces_cerevisiae
ENSG00000167658	EEF2	100	99.534	ENSSBOG00000006731	-	100	99.534	Saimiri_boliviensis_boliviensis
ENSG00000167658	EEF2	100	84.615	ENSSBOG00000022776	-	100	87.333	Saimiri_boliviensis_boliviensis
ENSG00000167658	EEF2	100	98.951	ENSSHAG00000007539	EEF2	100	98.951	Sarcophilus_harrisii
ENSG00000167658	EEF2	100	92.774	ENSSFOG00015010432	eef2b	100	92.774	Scleropages_formosus
ENSG00000167658	EEF2	100	92.093	ENSSFOG00015018454	eef2l2	100	92.093	Scleropages_formosus
ENSG00000167658	EEF2	100	93.939	ENSSFOG00015004255	-	100	93.939	Scleropages_formosus
ENSG00000167658	EEF2	100	86.830	ENSSMAG00000011593	-	100	86.830	Scophthalmus_maximus
ENSG00000167658	EEF2	100	90.443	ENSSMAG00000003334	eef2b	100	90.443	Scophthalmus_maximus
ENSG00000167658	EEF2	100	91.841	ENSSDUG00000015383	eef2b	100	91.841	Seriola_dumerili
ENSG00000167658	EEF2	100	89.161	ENSSDUG00000005084	-	100	89.161	Seriola_dumerili
ENSG00000167658	EEF2	99	83.939	ENSSLDG00000019218	-	99	83.939	Seriola_lalandi_dorsalis
ENSG00000167658	EEF2	100	89.394	ENSSLDG00000009720	-	100	89.394	Seriola_lalandi_dorsalis
ENSG00000167658	EEF2	91	86.497	ENSSARG00000005757	EEF2	91	86.497	Sorex_araneus
ENSG00000167658	EEF2	100	94.412	ENSSPUG00000014537	-	100	94.412	Sphenodon_punctatus
ENSG00000167658	EEF2	100	96.270	ENSSPUG00000011003	EEF2	100	96.270	Sphenodon_punctatus
ENSG00000167658	EEF2	100	88.112	ENSSPAG00000021897	-	100	88.112	Stegastes_partitus
ENSG00000167658	EEF2	100	99.650	ENSSSCG00000025675	EEF2	100	99.650	Sus_scrofa
ENSG00000167658	EEF2	67	98.249	ENSTGUG00000001004	EEF2	98	98.249	Taeniopygia_guttata
ENSG00000167658	EEF2	100	86.364	ENSTRUG00000017921	-	100	86.364	Takifugu_rubripes
ENSG00000167658	EEF2	92	79.517	ENSTNIG00000010631	-	100	79.517	Tetraodon_nigroviridis
ENSG00000167658	EEF2	100	94.988	ENSTTRG00000006776	EEF2	100	94.988	Tursiops_truncatus
ENSG00000167658	EEF2	99	99.533	ENSUAMG00000022409	EEF2	100	99.573	Ursus_americanus
ENSG00000167658	EEF2	99	99.527	ENSUMAG00000007474	EEF2	100	99.527	Ursus_maritimus
ENSG00000167658	EEF2	83	94.077	ENSVPAG00000011475	EEF2	83	94.077	Vicugna_pacos
ENSG00000167658	EEF2	100	98.135	ENSVVUG00000004661	-	100	98.135	Vulpes_vulpes
ENSG00000167658	EEF2	50	89.362	ENSVVUG00000005618	-	96	89.362	Vulpes_vulpes
ENSG00000167658	EEF2	99	94.522	ENSXETG00000021508	eef2.2	99	94.522	Xenopus_tropicalis
ENSG00000167658	EEF2	100	95.921	ENSXETG00000006391	eef2.1	100	95.921	Xenopus_tropicalis
ENSG00000167658	EEF2	99	88.380	ENSXCOG00000009526	-	99	88.380	Xiphophorus_couchianus
ENSG00000167658	EEF2	99	91.726	ENSXCOG00000008182	eef2b	100	91.726	Xiphophorus_couchianus
ENSG00000167658	EEF2	100	88.578	ENSXMAG00000012630	-	100	88.578	Xiphophorus_maculatus
ENSG00000167658	EEF2	100	91.841	ENSXMAG00000019308	eef2b	100	91.841	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002039	p53 binding	-	IEA	Function
GO:0002244	hematopoietic progenitor cell differentiation	-	IEA	Process
GO:0002931	response to ischemia	-	IEA	Process
GO:0003009	skeletal muscle contraction	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003746	translation elongation factor activity	21873635.	IBA	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	19417104.23823123.25064856.25231979.29128334.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005737	cytoplasm	25064856.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006414	translational elongation	21873635.	IBA	Process
GO:0006414	translational elongation	-	TAS	Process
GO:0007568	aging	-	IEA	Process
GO:0008097	5S rRNA binding	-	IEA	Function
GO:0014009	glial cell proliferation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016235	aggresome	-	IDA	Component
GO:0019901	protein kinase binding	23823123.	IPI	Function
GO:0032355	response to estradiol	-	IEA	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0034976	response to endoplasmic reticulum stress	-	IEA	Process
GO:0035914	skeletal muscle cell differentiation	-	IEA	Process
GO:0042542	response to hydrogen peroxide	-	IEA	Process
GO:0042788	polysomal ribosome	-	IEA	Component
GO:0043022	ribosome binding	21873635.	IBA	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045121	membrane raft	-	IEA	Component
GO:0045202	synapse	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045471	response to ethanol	-	IEA	Process
GO:0045727	positive regulation of translation	23184662.	IMP	Process
GO:0051015	actin filament binding	-	IEA	Function
GO:0051593	response to folic acid	-	IEA	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component
GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	-	IEA	Process
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	18809582.	IDA	Component
GO:2000767	positive regulation of cytoplasmic translation	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24377563	Clinical value of eukaryotic elongation factor 2 (eEF2) in non-small cell lung cancer patients.	Asian Pac J Cancer Prev	2014 Jan	Sun HG	-
24589652	The translation elongation factor eEF2 is a novel tumorassociated antigen overexpressed in various types of cancers.	Int J Oncol	2014 May	Oji Y	doi: 10.3892/ijo.2014.2318
22020937	1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.	J Biol Chem	2011 Dec 23	Chen Z	doi: 10.1074/jbc.M111.301291
16648488	Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.	Mol Cell Biol	2006 May	Connolly E	-
28913610	Eukaryotic Elongation Factor 2 (eEF2) is a Potential Biomarker of Prostate Cancer.	Pathol Oncol Res	2018 Oct	Zhang X	doi: 10.1007/s12253-017-0302-7

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	3979355	Missense_Mutation	novel	E563K	0.45
ACC	chr19	3976664	Missense_Mutation	novel	D823H	0.48
BLCA	chr19	3979427	Missense_Mutation	novel	E539K	0.3
BLCA	chr19	3979842	Missense_Mutation	novel	L524Q	0.43
BLCA	chr19	3977236	Silent	rs777077931	L788L	0.22
BLCA	chr19	3984167	Missense_Mutation	novel	E63K	0.33
BLCA	chr19	3985417	5'UTR	novel		0.28
BLCA	chr19	3982049	Silent	rs532385897	Y265Y	0.52
BLCA	chr19	3979973	Silent	NA	V480V	0.19
BLCA	chr19	3979979	Silent	novel	F478F	0.27
BLCA	chr19	3980670	Missense_Mutation	novel	Y397C	0.4
BLCA	chr19	3977939	Missense_Mutation	novel	I649M	0.38	GTP_EFTU
BLCA	chr19	3983210	Silent	novel	I100I	0.29
BLCA	chr19	3984135	Splice_Site	rs113603517	X73_splice	0.3
BLCA	chr19	3982542	Intron	novel		0.53
BRCA	chr19	3982349	Missense_Mutation	rs778994144	E230K	0.34
BRCA	chr19	3980861	Missense_Mutation	novel	P377L	0.37
BRCA	chr19	3978148	Missense_Mutation	NA	R580C	0.38
BRCA	chr19	3983152	Missense_Mutation	NA	R120G	0.29
BRCA	chr19	3977609	Missense_Mutation	novel	G690V	0.43	GTP_EFTU
BRCA	chr19	3980878	Silent	novel	L371L	0.15
BRCA	chr19	3980546	Silent	NA	K438K	0.14
BRCA	chr19	3977870	Silent	NA	L672L	0.3
BRCA	chr19	3982422	Missense_Mutation	NA	I205M	0.27
BRCA	chr19	3982833	Missense_Mutation	NA	E196K	0.24
CESC	chr19	3984342	Silent	NA	F4F	0.19
CESC	chr19	3982316	Frame_Shift_Del	NA	*E241Rfs13**	0.42
CESC	chr19	3978085	Missense_Mutation	NA	R601W	0.29
CESC	chr19	3982935	In_Frame_Ins	novel	K159_D161dup	0.08
CESC	chr19	3984323	Missense_Mutation	novel	A11T	0.37
CESC	chr19	3977939	Silent	NA	I649I	0.11
CESC	chr19	3976540	3'UTR	novel		0.12
CESC	chr19	3984206	Missense_Mutation	NA	R50W	0.45
COAD	chr19	3978067	Missense_Mutation	novel	R607W	0.27
COAD	chr19	3983160	Missense_Mutation	novel	A117V	0.36
COAD	chr19	3985382	5'UTR	novel		0.36
COAD	chr19	3982034	Silent	rs201754413	N270N	0.22
COAD	chr19	3977918	Silent	rs769162318	G656G	0.3
COAD	chr19	3984136	Missense_Mutation	NA	T73I	0.22
COAD	chr19	3985410	5'UTR	novel		0.38
COAD	chr19	3979942	Missense_Mutation	NA	A491T	0.2
COAD	chr19	3984250	Missense_Mutation	novel	L35P	0.13
COAD	chr19	3979992	Missense_Mutation	novel	G474D	0.23
COAD	chr19	3983211	Missense_Mutation	novel	I100S	0.07
COAD	chr19	3976491	3'UTR	novel		0.5
COAD	chr19	3982316	Frame_Shift_Del	NA	*E241Rfs13**	0.26
COAD	chr19	3984138	Splice_Region	NA	S72S	0.31
COAD	chr19	3976698	Silent	NA	Q811Q	0.31
COAD	chr19	3981984	Missense_Mutation	rs767351133	R287H	0.21
DLBC	chr19	3981391	In_Frame_Del	novel	E317_I321del	0.09
ESCA	chr19	3984218	Missense_Mutation	novel	I46V	0.61
ESCA	chr19	3980010	Missense_Mutation	novel	N468S	0.23
ESCA	chr19	3982034	Silent	rs201754413	N270N	0.39
ESCA	chr19	3982337	Missense_Mutation	novel	A234S	0.17
ESCA	chr19	3980635	Missense_Mutation	NA	R409W	0.43
ESCA	chr19	3985393	5'UTR	novel		0.24
ESCA	chr19	3982017	Missense_Mutation	novel	S276L	0.24
GBM	chr19	3977994	Missense_Mutation	rs201976284	R631Q	0.2	GTP_EFTU
GBM	chr19	3984286	Missense_Mutation	novel	S23Y	0.19
GBM	chr19	3984327	Silent	novel	I9I	0.22
GBM	chr19	3980667	Missense_Mutation	NA	I398S	0.29
HNSC	chr19	3980977	Splice_Region	novel	A338A	0.23
HNSC	chr19	3977873	Silent	novel	Y671Y	0.14
HNSC	chr19	3976543	3'UTR	novel		0.78
HNSC	chr19	3982017	Missense_Mutation	novel	S276L	0.67
HNSC	chr19	3981955	Frame_Shift_Ins	novel	*I297Hfs6**	0.29
HNSC	chr19	3979346	Missense_Mutation	rs749851802	A566T	0.18
HNSC	chr19	3983153	Silent	novel	L119L	0.1
HNSC	chr19	3983265	Missense_Mutation	novel	S82L	0.19
HNSC	chr19	3983261	Silent	novel	E83E	0.27
HNSC	chr19	3979395	Silent	rs758294276	A549A	0.4
HNSC	chr19	3982349	Missense_Mutation	rs778994144	E230K	0.28
HNSC	chr19	3977903	Silent	rs776708734	I661I	0.21
KIRP	chr19	3979987	Missense_Mutation	novel	D476N	0.28
LAML	chr19	3982570	Intron	novel		0.36
LGG	chr19	3980682	Missense_Mutation	novel	P393H	0.34
LGG	chr19	3977236	Silent	rs777077931	L788L	0.33
LIHC	chr19	3985426	5'UTR	novel		0.47
LIHC	chr19	3977455	Frame_Shift_Del	novel	*C728Wfs23**	0.27	GTP_EFTU
LIHC	chr19	3981361	Missense_Mutation	novel	K330T	0.37
LIHC	chr19	3980919	Missense_Mutation	novel	L358V	0.3
LUAD	chr19	3979431	Silent	NA	I537I	0.3
LUAD	chr19	3979401	Silent	NA	A547A	0.23
LUAD	chr19	3982314	Missense_Mutation	novel	E241D	0.2
LUAD	chr19	3984261	Silent	novel	G31G	0.42
LUAD	chr19	3982010	Silent	NA	T278T	0.26
LUAD	chr19	3983182	Frame_Shift_Ins	novel	D110*	0.31
LUAD	chr19	3983170	Nonsense_Mutation	novel	E114*	0.3
LUAD	chr19	3982318	Missense_Mutation	novel	G240V	0.83
LUAD	chr19	3984144	Missense_Mutation	novel	I70M	0.35
LUAD	chr19	3979401	Silent	NA	A547A	0.67
LUAD	chr19	3976628	Missense_Mutation	novel	V835L	0.5
LUAD	chr19	3976629	Silent	novel	V834V	0.53
LUAD	chr19	3984194	Missense_Mutation	novel	T54S	0.21
LUSC	chr19	3985412	5'UTR	novel		0.29
LUSC	chr19	3977848	Missense_Mutation	NA	V680L	0.21	GTP_EFTU
LUSC	chr19	3983136	In_Frame_Ins	novel	G124dup	0.11
LUSC	chr19	3976613	Nonsense_Mutation	novel	K840*	0.21
LUSC	chr19	3979896	Missense_Mutation	novel	R506I	0.19
LUSC	chr19	3977988	Missense_Mutation	NA	R633H	0.34	GTP_EFTU
PAAD	chr19	3976684	Missense_Mutation	novel	H816L	0.15
PAAD	chr19	3980042	Nonsense_Mutation	novel	Y457*	0.11
PAAD	chr19	3980042	Nonsense_Mutation	novel	Y457*	0.13
PAAD	chr19	3977531	Missense_Mutation	NA	R716H	0.25	GTP_EFTU
PAAD	chr19	3981967	Missense_Mutation	novel	I293V	0.18
PRAD	chr19	3984161	Nonsense_Mutation	novel	E65*	0.32
PRAD	chr19	3984205	Missense_Mutation	NA	R50P	0.21
READ	chr19	3982285	Missense_Mutation	novel	K251T	0.53
SARC	chr19	3985432	5'UTR	novel		0.16
SARC	chr19	3985461	5'UTR	rs532051930		0.33
SKCM	chr19	3977902	Missense_Mutation	NA	L662F	0.19	GTP_EFTU
SKCM	chr19	3980663	Silent	novel	S399S	0.39
SKCM	chr19	3982422	Splice_Region	rs375130935	I205I	0.45
SKCM	chr19	3978017	Silent	rs147570651	S623S	0.24
SKCM	chr19	3982906	Silent	rs768630429	P171P	0.23
SKCM	chr19	3984184	Missense_Mutation	novel	T57I	0.16
SKCM	chr19	3979952	Silent	rs780521912	T487T	0.21
SKCM	chr19	3976586	Missense_Mutation	NA	P849S	0.28
SKCM	chr19	3980034	Missense_Mutation	NA	P460L	0.55
SKCM	chr19	3976544	3'UTR	novel		0.56
SKCM	chr19	3982306	Missense_Mutation	novel	L244S	0.48
SKCM	chr19	3976553	3'UTR	novel		0.35
SKCM	chr19	3979428	Silent	rs771347280	I538I	0.46
SKCM	chr19	3981387	Silent	NA	I321I	0.08
SKCM	chr19	3976656	Silent	rs781600560	F825F	0.45
SKCM	chr19	3980664	Missense_Mutation	novel	S399F	0.38
SKCM	chr19	3976544	3'UTR	novel		0.71
SKCM	chr19	3980617	Frame_Shift_Del	novel	*R415Efs11**	0.09
SKCM	chr19	3980618	Frame_Shift_Ins	novel	*V416Lfs18**	0.09
SKCM	chr19	3982422	Splice_Region	rs375130935	I205I	0.4
STAD	chr19	3976715	Missense_Mutation	NA	G806S	0.33
STAD	chr19	3979816	Missense_Mutation	novel	M533V	0.56
STAD	chr19	3977946	Missense_Mutation	NA	R647H	0.3	GTP_EFTU
STAD	chr19	3982024	Missense_Mutation	NA	S274G	0.09
STAD	chr19	3982371	Silent	NA	A222A	0.43
STAD	chr19	3982991	Missense_Mutation	novel	L143P	0.16
STAD	chr19	3980527	Missense_Mutation	novel	K445Q	0.08
STAD	chr19	3977577	Missense_Mutation	NA	R701C	0.47	GTP_EFTU
STAD	chr19	3980046	Missense_Mutation	NA	R456H	0.29
STAD	chr19	3980627	Silent	rs79533804	Y411Y	0.28
STAD	chr19	3976717	Missense_Mutation	novel	G805D	0.42
STAD	chr19	3977230	Missense_Mutation	NA	V790I	0.15
STAD	chr19	3978016	Missense_Mutation	rs757356247	A624T	0.26	GTP_EFTU
STAD	chr19	3976715	Missense_Mutation	NA	G806S	0.36
STAD	chr19	3977947	Missense_Mutation	NA	R647C	0.19	GTP_EFTU
STAD	chr19	3979346	Missense_Mutation	rs749851802	A566T	0.14
THCA	chr19	3982853	Nonsense_Mutation	novel	*I189Rfs3**	0.3
UCEC	chr19	3979940	Silent	NA	A491A	0.42
UCEC	chr19	3980635	Missense_Mutation	NA	R409W	0.26
UCEC	chr19	3977904	Missense_Mutation	novel	I661T	0.35	GTP_EFTU
UCEC	chr19	3981375	Silent	rs750876455	S325S	0.48
UCEC	chr19	3978085	Missense_Mutation	NA	R601W	0.45
UCEC	chr19	3976460	3'UTR	rs368825201		0.37
UCEC	chr19	3976620	Silent	NA	E837E	0.35
UCEC	chr19	3982295	Missense_Mutation	NA	E248K	0.27
UCEC	chr19	3983272	Missense_Mutation	rs35967493	E80K	0.35
UCEC	chr19	3982302	Silent	NA	G245G	0.25
UCEC	chr19	3979986	Missense_Mutation	NA	D476V	0.48
UCEC	chr19	3979346	Missense_Mutation	rs749851802	A566T	0.39
UCEC	chr19	3976655	Missense_Mutation	novel	D826N	0.42
UCEC	chr19	3980606	Silent	rs761179762	S418S	0.22
UCEC	chr19	3976739	Missense_Mutation	rs767823532	A798T	0.2
UCEC	chr19	3979996	Missense_Mutation	NA	V473M	0.14
UCEC	chr19	3977541	Missense_Mutation	rs772490991	A713T	0.28	GTP_EFTU
UCEC	chr19	3977880	Missense_Mutation	NA	V669A	0.32	GTP_EFTU
UCEC	chr19	3982275	Missense_Mutation	novel	E254D	0.15
UCEC	chr19	3983192	Silent	rs548237711	P106P	0.17
UCEC	chr19	3979940	Silent	NA	A491A	0.23
UCEC	chr19	3980616	Missense_Mutation	novel	R415Q	0.42
UCEC	chr19	3982381	Missense_Mutation	novel	H219R	0.41
UCEC	chr19	3982003	Missense_Mutation	rs752584316	E281K	0.41
UCEC	chr19	3982325	Missense_Mutation	rs575523824	A238T	0.3
UCEC	chr19	3984278	Missense_Mutation	novel	A26T	0.36
UCEC	chr19	3977290	Missense_Mutation	novel	V770M	0.24
UCEC	chr19	3982417	Missense_Mutation	novel	P207H	0.34
UCEC	chr19	3979993	Missense_Mutation	novel	G474C	0.39
UCEC	chr19	3976490	3'UTR	novel		0.29
UCEC	chr19	3977559	Missense_Mutation	rs774037219	V707I	0.29	GTP_EFTU
UCEC	chr19	3978152	Silent	novel	S578S	0.35
UCEC	chr19	3982393	Missense_Mutation	novel	G215E	0.53
UCEC	chr19	3982866	Missense_Mutation	novel	V185M	0.39
UCEC	chr19	3984226	Frame_Shift_Ins	NA	*A43Efs17**	0.16
UCEC	chr19	3976739	Missense_Mutation	rs767823532	A798T	0.26
UCEC	chr19	3978066	Missense_Mutation	rs149757304	R607Q	0.44
UCEC	chr19	3981984	Missense_Mutation	rs767351133	R287H	0.41
UCEC	chr19	3982935	Missense_Mutation	NA	R162C	0.21
UCEC	chr19	3977548	Silent	rs776826199	H710H	0.18
UCEC	chr19	3977258	Frame_Shift_Del	novel	*M781Cfs20**	0.33
UCEC	chr19	3981985	Missense_Mutation	NA	R287C	0.41
UCEC	chr19	3982857	Missense_Mutation	rs752043513	I188V	0.69
UCEC	chr19	3978021	Missense_Mutation	novel	V622A	0.29	GTP_EFTU
UCEC	chr19	3982840	Silent	novel	G193G	0.54
UCEC	chr19	3978118	Missense_Mutation	novel	L590F	0.23
UCEC	chr19	3983143	Missense_Mutation	rs778295378	D123N	0.21
UCEC	chr19	3979427	Missense_Mutation	novel	E539K	0.36
UCEC	chr19	3982316	Frame_Shift_Del	NA	*E241Rfs13**	0.44
UCEC	chr19	3982883	Missense_Mutation	novel	Q179R	0.1
UCEC	chr19	3979359	Silent	novel	L561L	0.38
UCEC	chr19	3978121	Missense_Mutation	rs35987350	V589M	0.46
UCEC	chr19	3982508	Intron	novel		0.65
UCEC	chr19	3983137	Missense_Mutation	NA	A125T	0.38
UCEC	chr19	3977472	Missense_Mutation	novel	A736T	0.25	GTP_EFTU
UCEC	chr19	3977586	Missense_Mutation	rs758884682	R698W	0.06	GTP_EFTU
UCEC	chr19	3979377	Missense_Mutation	novel	E555D	0.38
UCEC	chr19	3983226	Missense_Mutation	rs764015216	G95D	0.08
UCEC	chr19	3985433	5'UTR	rs546488032		0.29
UCEC	chr19	3978035	Silent	rs777751138	I617I	0.26
UCEC	chr19	3976478	3'UTR	novel		0.32
UCEC	chr19	3977920	Missense_Mutation	rs772796691	G656S	0.63	GTP_EFTU
UCEC	chr19	3977603	Missense_Mutation	novel	L692P	0.44	GTP_EFTU
UCEC	chr19	3982412	Missense_Mutation	novel	L209I	0.45
UCEC	chr19	3981440	Missense_Mutation	NA	I304V	0.14
UCEC	chr19	3984296	Missense_Mutation	novel	R20C	0.38
UCEC	chr19	3982839	Missense_Mutation	novel	E194K	0.32
UCEC	chr19	3980617	Nonsense_Mutation	novel	R415*	0.17
UCEC	chr19	3982422	Splice_Region	rs375130935	I205I	0.29
UCEC	chr19	3978141	Missense_Mutation	novel	T582M	0.5
UCEC	chr19	3982253	Missense_Mutation	novel	G262S	0.33
UCEC	chr19	3983137	Missense_Mutation	NA	A125T	0.42
UCEC	chr19	3977316	Missense_Mutation	novel	G761E	0.46
UCEC	chr19	3982295	Missense_Mutation	NA	E248K	0.43
UCEC	chr19	3980047	Missense_Mutation	novel	R456C	0.33
UCEC	chr19	3980635	Missense_Mutation	NA	R409W	0.36
UCS	chr19	3979409	In_Frame_Ins	novel	H544_I545insRGRH	0.52
UVM	chr19	3983121	Frame_Shift_Del	novel	*D130Afs26**	0.06

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0556	0.058467
LIHC	DEL	0.1865	4.7028e-08
PAAD	DEL	0.1413	0.0060878
READ	DEL	0.1333	0.23023
STAD	DEL	0.288	1.5798e-05
THCA	DEL	0.016	0.10598
UCEC	DEL	0.2783	4.5149e-49
UCS	DEL	0.7679	8.0449e-14

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.017	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
UCS	0.035	Kaplan-Meier Survival Analysis
SKCM	0.027	Kaplan-Meier Survival Analysis
BRCA	0.049	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
UCEC	0.00042	Kaplan-Meier Survival Analysis
GBM	0.0063	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0059	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742