EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167674 (Gene tree)
Gene ID: 84717
Gene Symbol: HDGFL2
Alias: HRP2|Hdgfrp2
Full Name: HDGF like 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 30,025 bases
Position: chr19:4,472,196-4,502,220
Accession: 14680
RBP type: non-canonical RBP
Summary: This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000592691	HDGFL2-204	740	-	ENSP00000467617	24 (aa)	-	K7EQ06
ENST00000615225	HDGFL2-207	3100	-	ENSP00000477592	473 (aa)	-	A0A087WT54
ENST00000616600	HDGFL2-208	2281	XM_011528376	ENSP00000483345	671 (aa)	XP_011526678	Q7Z4V5
ENST00000592417	HDGFL2-203	1349	-	ENSP00000467513	153 (aa)	-	K7EPS6
ENST00000589486	HDGFL2-202	805	-	ENSP00000465267	121 (aa)	-	K7EJP7
ENST00000619255	HDGFL2-209	320	-	ENSP00000480754	68 (aa)	-	A0A087WX58
ENST00000621835	HDGFL2-210	2255	XM_011528377	ENSP00000483702	670 (aa)	XP_011526679	Q7Z4V5
ENST00000614903	HDGFL2-206	239	-	ENSP00000482480	71 (aa)	-	A0A087WZ99
ENST00000587016	HDGFL2-201	870	-	ENSP00000468175	175 (aa)	-	K7ERA4
ENST00000601353	HDGFL2-205	648	-	ENSP00000471276	97 (aa)	-	M0R0J3

Gene Model

Click here to download ENSG00000167674's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167674	rs8887	19	4502189	C	High light scatter reticulocyte count	27863252	[0.023-0.038] unit decrease	0.03064393	EFO_0007986
ENSG00000167674	rs8887	19	4502189	C	High light scatter reticulocyte percentage of red cells	27863252	[0.019-0.033] unit decrease	0.02616673	EFO_0007986
ENSG00000167674	rs8887	19	4502189	C	Mean corpuscular hemoglobin	27863252	[0.074-0.088] unit increase	0.08133153	EFO_0004527
ENSG00000167674	rs8887	19	4502189	C	Mean corpuscular volume	27863252	[0.062-0.076] unit increase	0.0691261	EFO_0004526
ENSG00000167674	rs11669479	19	4485049	?	Mean corpuscular volume	29403010	[0.029-0.047] unit increase novel	0.0379	EFO_0004526
ENSG00000167674	rs11669479	19	4485049	?	Mean corpuscular hemoglobin	29403010	[0.03-0.049] unit increase novel	0.03927	EFO_0004527
ENSG00000167674	rs8887	19	4502189	C	Hemoglobin concentration	27863252	[0.019-0.034] unit increase	0.02651948	EFO_0004509
ENSG00000167674	rs8887	19	4502189	C	Immature fraction of reticulocytes	27863252	[0.057-0.071] unit decrease	0.06364281	EFO_0007986
ENSG00000167674	rs8887	19	4502189	C	Mean corpuscular hemoglobin concentration	27863252	[0.036-0.05] unit increase	0.04312099	EFO_0004528
ENSG00000167674	rs76608582	19	4474728	?	General cognitive ability	29844566	z-score increase	4.957	EFO_0004337
ENSG00000167674	rs76608582	19	4474728	A	Intelligence	29942086	z-score increase	5.57	EFO_0004337
ENSG00000167674	rs76608582	19	4474728	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000167674	rs76608582	19	4474728	A	Smoking status (ever vs never smokers)	30643258	[0.023-0.043] unit decrease	0.033407107	EFO_0004318
ENSG00000167674	rs8887	19	4502189	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000167674	rs8887	19	4502189	?	Red blood cell count	30595370			EFO_0004305
ENSG00000167674	rs76608582	19	4474728	?	Smoking status	30595370			EFO_0006527
ENSG00000167674	rs76608582	19	4474728	A	Smoking initiation (ever regular vs never regular)	30643251	[0.023-0.046] unit decrease	0.034549292	EFO_0006527
ENSG00000167674	rs76608582	19	4474728	A	Smoking initiation	30617275	[0.022-0.05] unit decrease (replication)	0.036	EFO_0005670

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167674's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167674	HDGFL2	96	77.419	ENSG00000166503	HDGFL3	55	83.333	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21044950.25689719.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0030307	positive regulation of cell growth	25689719.	IMP	Process