EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167721 (Gene tree)
Gene ID: 55720
Gene Symbol: TSR1
Alias: FLJ10534
Full Name: TSR1 ribosome maturation factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 15,005 bases
Position: chr17:2,322,503-2,337,507
Accession: 25542
RBP type: canonical RBP
Summary: (TSR1 Ribosome Maturation Factor) is a Protein Coding gene. Diseases associated with TSR1 include Thymus Gland Disease and Thymus Cancer. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. An important paralog of this gene is BMS1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000459012	AARP2CN	PF08142.12	1.9e-21	1	1
ENSP00000301364	AARP2CN	PF08142.12	5.8e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25028499	Proteome-wide remodeling of protein location and function by stress.	Proc Natl Acad Sci U S A	2014 Jul 29	Lee K	doi: 10.1073/pnas.1318881111

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000575049	TSR1-203	387	-	ENSP00000461192	53 (aa)	-	I3L4E8
ENST00000301364	TSR1-201	5188	-	ENSP00000301364	804 (aa)	-	Q2NL82
ENST00000576202	TSR1-205	573	-	-	- (aa)	-	-
ENST00000571806	TSR1-202	794	-	ENSP00000461498	70 (aa)	-	I3L4T0
ENST00000576112	TSR1-204	1290	-	ENSP00000459012	368 (aa)	-	I3L1Q5

Gene Model

Click here to download ENSG00000167721's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167721's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167721	TSR1	99	54.317	ENSAPOG00000020891	tsr1	99	54.796	Acanthochromis_polyacanthus
ENSG00000167721	TSR1	100	87.377	ENSAMEG00000007599	TSR1	99	86.397	Ailuropoda_melanoleuca
ENSG00000167721	TSR1	98	57.214	ENSACIG00000007090	tsr1	98	57.196	Amphilophus_citrinellus
ENSG00000167721	TSR1	99	55.114	ENSAOCG00000023284	tsr1	99	54.819	Amphiprion_ocellaris
ENSG00000167721	TSR1	94	55.385	ENSAPEG00000008452	tsr1	100	55.071	Amphiprion_percula
ENSG00000167721	TSR1	98	54.897	ENSATEG00000021961	tsr1	98	55.623	Anabas_testudineus
ENSG00000167721	TSR1	90	67.989	ENSAPLG00000013422	TSR1	98	68.536	Anas_platyrhynchos
ENSG00000167721	TSR1	90	55.271	ENSACAG00000000859	TSR1	92	57.785	Anolis_carolinensis
ENSG00000167721	TSR1	100	94.161	ENSANAG00000031071	TSR1	100	94.534	Aotus_nancymaae
ENSG00000167721	TSR1	98	55.678	ENSACLG00000007595	tsr1	97	55.800	Astatotilapia_calliptera
ENSG00000167721	TSR1	98	46.787	ENSAMXG00000008470	tsr1	90	49.543	Astyanax_mexicanus
ENSG00000167721	TSR1	100	90.074	ENSBTAG00000004225	TSR1	100	89.826	Bos_taurus
ENSG00000167721	TSR1	97	38.798	WBGene00006497	tag-151	96	38.645	Caenorhabditis_elegans
ENSG00000167721	TSR1	100	93.540	ENSCJAG00000012456	TSR1	100	93.913	Callithrix_jacchus
ENSG00000167721	TSR1	100	87.732	ENSCAFG00000002106	-	100	87.732	Canis_familiaris
ENSG00000167721	TSR1	98	83.158	ENSCAFG00000019273	-	100	87.405	Canis_familiaris
ENSG00000167721	TSR1	100	87.113	ENSCAFG00020009728	TSR1	100	87.113	Canis_lupus_dingo
ENSG00000167721	TSR1	100	90.323	ENSCHIG00000023935	TSR1	100	90.074	Capra_hircus
ENSG00000167721	TSR1	100	89.317	ENSTSYG00000005468	TSR1	100	89.317	Carlito_syrichta
ENSG00000167721	TSR1	93	87.032	ENSCPOG00000014833	TSR1	99	86.364	Cavia_porcellus
ENSG00000167721	TSR1	99	89.211	ENSCCAG00000028962	TSR1	98	94.645	Cebus_capucinus
ENSG00000167721	TSR1	100	97.267	ENSCATG00000044262	TSR1	100	97.267	Cercocebus_atys
ENSG00000167721	TSR1	100	86.460	ENSCLAG00000005567	TSR1	100	87.205	Chinchilla_lanigera
ENSG00000167721	TSR1	100	97.267	ENSCSAG00000013788	TSR1	100	97.267	Chlorocebus_sabaeus
ENSG00000167721	TSR1	98	69.318	ENSCPBG00000020363	TSR1	96	69.587	Chrysemys_picta_bellii
ENSG00000167721	TSR1	97	46.599	ENSCING00000020658	-	99	46.164	Ciona_intestinalis
ENSG00000167721	TSR1	97	45.786	ENSCSAVG00000001875	-	100	45.081	Ciona_savignyi
ENSG00000167721	TSR1	99	93.158	ENSCANG00000033056	TSR1	100	87.189	Colobus_angolensis_palliatus
ENSG00000167721	TSR1	100	85.199	ENSCGRG00001023942	Tsr1	100	85.697	Cricetulus_griseus_chok1gshd
ENSG00000167721	TSR1	100	78.856	ENSCGRG00000013015	Tsr1	100	80.224	Cricetulus_griseus_crigri
ENSG00000167721	TSR1	99	54.371	ENSCSEG00000013009	tsr1	99	54.012	Cynoglossus_semilaevis
ENSG00000167721	TSR1	99	55.825	ENSCVAG00000000506	tsr1	99	55.947	Cyprinodon_variegatus
ENSG00000167721	TSR1	98	54.733	ENSDARG00000007744	tsr1	97	55.309	Danio_rerio
ENSG00000167721	TSR1	100	87.578	ENSDNOG00000004715	TSR1	100	87.994	Dasypus_novemcinctus
ENSG00000167721	TSR1	100	86.352	ENSDORG00000016371	-	100	85.980	Dipodomys_ordii
ENSG00000167721	TSR1	97	75.641	ENSDORG00000023234	-	100	76.026	Dipodomys_ordii
ENSG00000167721	TSR1	97	43.052	FBgn0037073	Tsr1	96	43.424	Drosophila_melanogaster
ENSG00000167721	TSR1	99	80.840	ENSETEG00000017534	TSR1	91	88.852	Echinops_telfairi
ENSG00000167721	TSR1	95	52.857	ENSEBUG00000013731	TSR1	97	52.857	Eptatretus_burgeri
ENSG00000167721	TSR1	100	89.330	ENSEASG00005009302	TSR1	97	89.082	Equus_asinus_asinus
ENSG00000167721	TSR1	100	89.330	ENSECAG00000009114	TSR1	100	89.082	Equus_caballus
ENSG00000167721	TSR1	98	55.433	ENSELUG00000020984	tsr1	94	55.556	Esox_lucius
ENSG00000167721	TSR1	100	89.578	ENSFCAG00000006313	TSR1	100	89.206	Felis_catus
ENSG00000167721	TSR1	99	67.901	ENSFALG00000006532	TSR1	99	68.804	Ficedula_albicollis
ENSG00000167721	TSR1	100	89.179	ENSFDAG00000006038	TSR1	100	89.179	Fukomys_damarensis
ENSG00000167721	TSR1	99	54.435	ENSFHEG00000003626	tsr1	99	54.502	Fundulus_heteroclitus
ENSG00000167721	TSR1	99	53.121	ENSGMOG00000010336	tsr1	99	53.423	Gadus_morhua
ENSG00000167721	TSR1	99	53.494	ENSGAFG00000012993	tsr1	99	54.447	Gambusia_affinis
ENSG00000167721	TSR1	99	53.922	ENSGACG00000010843	tsr1	99	54.779	Gasterosteus_aculeatus
ENSG00000167721	TSR1	94	47.688	ENSGAGG00000000440	-	98	47.688	Gopherus_agassizii
ENSG00000167721	TSR1	99	69.424	ENSGAGG00000025619	-	99	69.689	Gopherus_agassizii
ENSG00000167721	TSR1	100	99.254	ENSGGOG00000001704	TSR1	100	99.254	Gorilla_gorilla
ENSG00000167721	TSR1	98	55.353	ENSHBUG00000017904	tsr1	99	55.943	Haplochromis_burtoni
ENSG00000167721	TSR1	100	88.337	ENSHGLG00000012806	-	100	87.717	Heterocephalus_glaber_female
ENSG00000167721	TSR1	97	78.562	ENSHGLG00000015688	-	99	78.434	Heterocephalus_glaber_female
ENSG00000167721	TSR1	100	88.337	ENSHGLG00100015392	TSR1	100	87.717	Heterocephalus_glaber_male
ENSG00000167721	TSR1	98	56.838	ENSHCOG00000001432	tsr1	97	56.587	Hippocampus_comes
ENSG00000167721	TSR1	98	54.090	ENSIPUG00000004618	tsr1	98	54.823	Ictalurus_punctatus
ENSG00000167721	TSR1	100	87.624	ENSSTOG00000011819	TSR1	100	87.995	Ictidomys_tridecemlineatus
ENSG00000167721	TSR1	92	80.894	ENSJJAG00000019505	Tsr1	95	80.326	Jaculus_jaculus
ENSG00000167721	TSR1	99	54.024	ENSKMAG00000005763	tsr1	97	54.866	Kryptolebias_marmoratus
ENSG00000167721	TSR1	99	54.031	ENSLBEG00000021823	tsr1	99	54.272	Labrus_bergylta
ENSG00000167721	TSR1	98	64.259	ENSLACG00000002197	TSR1	98	64.384	Latimeria_chalumnae
ENSG00000167721	TSR1	89	58.939	ENSLOCG00000006491	TSR1	97	51.930	Lepisosteus_oculatus
ENSG00000167721	TSR1	72	80.212	ENSLAFG00000022396	-	97	86.219	Loxodonta_africana
ENSG00000167721	TSR1	100	97.516	ENSMFAG00000021330	TSR1	100	97.516	Macaca_fascicularis
ENSG00000167721	TSR1	100	97.267	ENSMMUG00000017519	TSR1	100	97.267	Macaca_mulatta
ENSG00000167721	TSR1	100	97.143	ENSMNEG00000031382	TSR1	100	97.143	Macaca_nemestrina
ENSG00000167721	TSR1	100	97.143	ENSMLEG00000036733	TSR1	100	97.143	Mandrillus_leucophaeus
ENSG00000167721	TSR1	98	55.260	ENSMAMG00000017918	tsr1	97	54.655	Mastacembelus_armatus
ENSG00000167721	TSR1	98	55.854	ENSMZEG00005007477	tsr1	98	55.366	Maylandia_zebra
ENSG00000167721	TSR1	99	67.835	ENSMGAG00000005576	TSR1	98	68.125	Meleagris_gallopavo
ENSG00000167721	TSR1	100	91.439	ENSMICG00000012943	TSR1	100	90.943	Microcebus_murinus
ENSG00000167721	TSR1	100	84.969	ENSMOCG00000022764	Tsr1	100	84.969	Microtus_ochrogaster
ENSG00000167721	TSR1	98	55.240	ENSMMOG00000014280	tsr1	99	54.866	Mola_mola
ENSG00000167721	TSR1	99	78.921	ENSMODG00000010658	TSR1	99	78.921	Monodelphis_domestica
ENSG00000167721	TSR1	98	55.839	ENSMALG00000011681	tsr1	98	55.353	Monopterus_albus
ENSG00000167721	TSR1	100	85.342	MGP_CAROLIEiJ_G0016727	Tsr1	100	85.217	Mus_caroli
ENSG00000167721	TSR1	100	85.714	ENSMUSG00000038335	Tsr1	100	85.590	Mus_musculus
ENSG00000167721	TSR1	100	85.590	MGP_PahariEiJ_G0017864	Tsr1	100	85.466	Mus_pahari
ENSG00000167721	TSR1	100	85.590	MGP_SPRETEiJ_G0017570	Tsr1	100	85.466	Mus_spretus
ENSG00000167721	TSR1	91	79.167	ENSMPUG00000013000	TSR1	100	87.082	Mustela_putorius_furo
ENSG00000167721	TSR1	100	90.819	ENSMLUG00000003505	TSR1	100	90.819	Myotis_lucifugus
ENSG00000167721	TSR1	100	81.522	ENSNGAG00000020455	-	98	81.522	Nannospalax_galili
ENSG00000167721	TSR1	98	55.407	ENSNBRG00000020728	tsr1	97	55.407	Neolamprologus_brichardi
ENSG00000167721	TSR1	99	92.408	ENSNLEG00000017184	TSR1	100	91.169	Nomascus_leucogenys
ENSG00000167721	TSR1	99	73.651	ENSMEUG00000015828	TSR1	99	73.777	Notamacropus_eugenii
ENSG00000167721	TSR1	98	56.442	ENSONIG00000013131	tsr1	98	56.196	Oreochromis_niloticus
ENSG00000167721	TSR1	96	73.522	ENSOANG00000008637	TSR1	100	72.622	Ornithorhynchus_anatinus
ENSG00000167721	TSR1	99	88.875	ENSOCUG00000014256	TSR1	99	88.500	Oryctolagus_cuniculus
ENSG00000167721	TSR1	99	54.258	ENSORLG00000004926	tsr1	99	54.197	Oryzias_latipes
ENSG00000167721	TSR1	99	54.324	ENSORLG00020008792	tsr1	99	54.022	Oryzias_latipes_hni
ENSG00000167721	TSR1	99	54.258	ENSORLG00015013838	tsr1	99	54.197	Oryzias_latipes_hsok
ENSG00000167721	TSR1	99	54.380	ENSOMEG00000004830	tsr1	99	54.874	Oryzias_melastigma
ENSG00000167721	TSR1	100	88.054	ENSOGAG00000004492	TSR1	100	88.300	Otolemur_garnettii
ENSG00000167721	TSR1	100	90.199	ENSOARG00000015437	TSR1	97	89.950	Ovis_aries
ENSG00000167721	TSR1	100	99.876	ENSPPAG00000036355	TSR1	100	99.876	Pan_paniscus
ENSG00000167721	TSR1	100	89.454	ENSPPRG00000015519	-	100	89.454	Panthera_pardus
ENSG00000167721	TSR1	100	89.702	ENSPTIG00000010608	TSR1	100	89.702	Panthera_tigris_altaica
ENSG00000167721	TSR1	100	99.876	ENSPTRG00000008547	TSR1	100	99.876	Pan_troglodytes
ENSG00000167721	TSR1	100	92.919	ENSPANG00000024463	TSR1	100	93.540	Papio_anubis
ENSG00000167721	TSR1	99	55.244	ENSPKIG00000013972	tsr1	99	55.488	Paramormyrops_kingsleyae
ENSG00000167721	TSR1	91	66.667	ENSPSIG00000018258	TSR1	98	69.242	Pelodiscus_sinensis
ENSG00000167721	TSR1	99	57.463	ENSPMGG00000011577	tsr1	98	57.338	Periophthalmus_magnuspinnatus
ENSG00000167721	TSR1	100	84.472	ENSPEMG00000018033	Tsr1	100	84.596	Peromyscus_maniculatus_bairdii
ENSG00000167721	TSR1	99	79.548	ENSPCIG00000009357	TSR1	97	79.825	Phascolarctos_cinereus
ENSG00000167721	TSR1	99	54.909	ENSPFOG00000004483	TSR1	99	56.000	Poecilia_formosa
ENSG00000167721	TSR1	99	54.534	ENSPLAG00000022320	tsr1	99	54.779	Poecilia_latipinna
ENSG00000167721	TSR1	99	54.012	ENSPMEG00000004577	tsr1	99	54.611	Poecilia_mexicana
ENSG00000167721	TSR1	97	54.747	ENSPREG00000010354	tsr1	95	54.803	Poecilia_reticulata
ENSG00000167721	TSR1	100	89.988	ENSPPYG00000007792	TSR1	100	89.864	Pongo_abelii
ENSG00000167721	TSR1	99	83.113	ENSPCAG00000012973	-	71	92.500	Procavia_capensis
ENSG00000167721	TSR1	100	91.067	ENSPCOG00000017928	TSR1	100	90.695	Propithecus_coquereli
ENSG00000167721	TSR1	100	88.944	ENSPVAG00000002162	TSR1	100	89.317	Pteropus_vampyrus
ENSG00000167721	TSR1	98	55.800	ENSPNYG00000016163	tsr1	97	55.922	Pundamilia_nyererei
ENSG00000167721	TSR1	98	54.612	ENSPNAG00000008659	tsr1	98	54.788	Pygocentrus_nattereri
ENSG00000167721	TSR1	100	84.099	ENSRNOG00000002980	Tsr1	100	84.348	Rattus_norvegicus
ENSG00000167721	TSR1	100	96.273	ENSRBIG00000040016	TSR1	100	96.273	Rhinopithecus_bieti
ENSG00000167721	TSR1	100	96.398	ENSRROG00000030361	TSR1	100	96.398	Rhinopithecus_roxellana
ENSG00000167721	TSR1	96	30.580	YDL060W	-	99	30.549	Saccharomyces_cerevisiae
ENSG00000167721	TSR1	100	94.161	ENSSBOG00000020785	TSR1	100	94.534	Saimiri_boliviensis_boliviensis
ENSG00000167721	TSR1	99	78.043	ENSSHAG00000011394	TSR1	99	77.917	Sarcophilus_harrisii
ENSG00000167721	TSR1	98	56.506	ENSSFOG00015005455	tsr1	98	56.382	Scleropages_formosus
ENSG00000167721	TSR1	99	54.077	ENSSMAG00000009504	tsr1	99	53.726	Scophthalmus_maximus
ENSG00000167721	TSR1	99	54.850	ENSSDUG00000012074	tsr1	99	54.916	Seriola_dumerili
ENSG00000167721	TSR1	99	54.874	ENSSLDG00000002031	tsr1	99	54.928	Seriola_lalandi_dorsalis
ENSG00000167721	TSR1	99	81.003	ENSSARG00000000759	TSR1	100	75.682	Sorex_araneus
ENSG00000167721	TSR1	99	68.828	ENSSPUG00000007042	TSR1	98	68.781	Sphenodon_punctatus
ENSG00000167721	TSR1	99	54.850	ENSSPAG00000021951	tsr1	99	54.796	Stegastes_partitus
ENSG00000167721	TSR1	100	89.950	ENSSSCG00000038534	TSR1	100	89.826	Sus_scrofa
ENSG00000167721	TSR1	91	68.750	ENSTGUG00000005883	TSR1	100	69.863	Taeniopygia_guttata
ENSG00000167721	TSR1	98	56.235	ENSTRUG00000004665	tsr1	98	56.740	Takifugu_rubripes
ENSG00000167721	TSR1	98	56.824	ENSTNIG00000016196	tsr1	98	56.824	Tetraodon_nigroviridis
ENSG00000167721	TSR1	79	93.878	ENSTBEG00000015275	-	67	93.878	Tupaia_belangeri
ENSG00000167721	TSR1	100	90.571	ENSTTRG00000001177	TSR1	100	90.447	Tursiops_truncatus
ENSG00000167721	TSR1	100	87.469	ENSUAMG00000025160	TSR1	99	87.722	Ursus_americanus
ENSG00000167721	TSR1	97	87.372	ENSUMAG00000009294	TSR1	99	87.117	Ursus_maritimus
ENSG00000167721	TSR1	99	86.280	ENSVPAG00000000228	TSR1	100	85.481	Vicugna_pacos
ENSG00000167721	TSR1	100	87.485	ENSVVUG00000021767	TSR1	100	87.485	Vulpes_vulpes
ENSG00000167721	TSR1	99	58.824	ENSXETG00000023797	tsr1	100	59.309	Xenopus_tropicalis
ENSG00000167721	TSR1	99	54.701	ENSXCOG00000009635	tsr1	99	54.945	Xiphophorus_couchianus
ENSG00000167721	TSR1	99	54.031	ENSXMAG00000001397	tsr1	96	54.327	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0030688	preribosome, small subunit precursor	21873635.	IBA	Component
GO:0034511	U3 snoRNA binding	21873635.	IBA	Function