EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167815 (Gene tree)
Gene ID: 7001
Gene Symbol: PRDX2
Alias: PRP|NKEFB|TSA|PRXII|PRX2|MGC4104|TDPX1
Full Name: peroxiredoxin 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 5,091 bases
Position: chr19:12,796,820-12,801,910
Accession: 9353
RBP type: non-canonical RBP
Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000301522	PRDX2-201	987	-	ENSP00000301522	198 (aa)	-	P32119
ENST00000334482	PRDX2-202	784	-	ENSP00000334063	136 (aa)	-	A6NIW5
ENST00000466174	PRDX2-203	1717	-	-	- (aa)	-	-
ENST00000498785	PRDX2-206	505	-	-	- (aa)	-	-
ENST00000477555	PRDX2-204	699	-	-	- (aa)	-	-
ENST00000478908	PRDX2-205	413	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000167815's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167815's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167815	PRDX2	100	93.434	ENSMUSG00000005161	Prdx2	100	93.434	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000187	activation of MAPK activity	-	IEA	Process
GO:0002536	respiratory burst involved in inflammatory response	-	IEA	Process
GO:0005515	protein binding	17557078.25402766.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006979	response to oxidative stress	21873635.	IBA	Process
GO:0006979	response to oxidative stress	12943237.	IMP	Process
GO:0006979	response to oxidative stress	11904290.	NAS	Process
GO:0008379	thioredoxin peroxidase activity	21873635.	IBA	Function
GO:0008379	thioredoxin peroxidase activity	8144038.	IDA	Function
GO:0008379	thioredoxin peroxidase activity	18606987.	TAS	Function
GO:0010310	regulation of hydrogen peroxide metabolic process	-	IEA	Process
GO:0016209	antioxidant activity	8144038.	IDA	Function
GO:0016209	antioxidant activity	12943237.	NAS	Function
GO:0019430	removal of superoxide radicals	21873635.	IBA	Process
GO:0019430	removal of superoxide radicals	20978343.	IDA	Process
GO:0030194	positive regulation of blood coagulation	-	IEA	Process
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	-	IEA	Process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IEA	Process
GO:0032496	response to lipopolysaccharide	-	IEA	Process
GO:0034599	cellular response to oxidative stress	20978343.	IDA	Process
GO:0034599	cellular response to oxidative stress	-	TAS	Process
GO:0042098	T cell proliferation	-	IEA	Process
GO:0042744	hydrogen peroxide catabolic process	21873635.	IBA	Process
GO:0042744	hydrogen peroxide catabolic process	18606987.	TAS	Process
GO:0042981	regulation of apoptotic process	12943237.	IMP	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0045321	leukocyte activation	21873635.	IBA	Process
GO:0045454	cell redox homeostasis	21873635.	IBA	Process
GO:0045581	negative regulation of T cell differentiation	-	IEA	Process
GO:0048538	thymus development	-	IEA	Process
GO:0048872	homeostasis of number of cells	-	IEA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component
GO:2000378	negative regulation of reactive oxygen species metabolic process	-	IEA	Process
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21148313	Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair.	J Biol Chem	2011 Mar 11	Lee KW	doi: 10.1074/jbc.M110.179416
29258530	Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer.	J Transl Med	2017 Dec 19	Lv Z	doi: 10.1186/s12967-017-1357-7.
15936593	Identification of differentially expressed proteins during human urinary bladder cancer progression.	Cancer Detect Prev	2005	Memon AA	-
22207736	Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene.	Blood	2012 Mar 8	Agrawal-Singh S	doi: 10.1182/blood-2011-06-358705
26636537	Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.	Oncotarget	2016 Jan 12	Trzeciecka A	doi: 10.18632/oncotarget.6435.
29332450	Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.	Technol Cancer Res Treat	2017 Dec	Zhao S	doi: 10.1177/1533034617732426
21539911	Peroxiredoxin 2 in the nucleus and cytoplasm distinctly regulates androgen receptor activity in prostate cancer cells.	Free Radic Biol Med	2011 Jul 1	Shiota M	doi: 10.1016/j.freeradbiomed.2011.04.001
24234423	Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress.	Mol Cell Biochem	2014 Feb	Lu W	-
22215146	Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer.	J Cancer Res Clin Oncol	2012 Apr	Zhang B	doi: 10.1007/s00432-011-1119-5
19584157	Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women.	Clin Cancer Res	2009 Jul 15	Desmetz C	doi: 10.1158/1078-0432.CCR-08-3307
26021759	An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib.	Exp Mol Med	2015 May 29	Kwon T	doi: 10.1038/emm.2015.24.
23113308	Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.	Bull Exp Biol Med	2012 Oct	Kalinina EV	-
24750185	Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.	Pathol Int	2014 Apr	Hirahashi M	doi: 10.1111/pin.12152.
24222118	Human pancreatic cancer cells with acquired gemcitabine resistance exhibit significant up-regulation of peroxiredoxin-2 compared to sensitive parental cells.	Anticancer Res	2013 Nov	Suenaga S	-
19424615	Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.	Oncol Rep	2009 Jun	Kim K	-
22537621	Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.	Lung Cancer	2012 Aug	Rostila A	doi: 10.1016/j.lungcan.2012.03.024
28125800	Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.	Oncotarget	2017 Feb 28	Peng L	doi: 10.18632/oncotarget.14801.
26866938	Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells.	Stem Cells	2016 May	Kwon T	doi: 10.1002/stem.2323
27894099	Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.	Oncotarget	2016 Dec 27	Wang R	doi: 10.18632/oncotarget.13559.
29422545	Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells.	Exp Mol Med	2018 Feb 9	Hong SH	doi: 10.1038/emm.2017.267.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	12799916	Missense_Mutation	rs758670704	V152M	0.91
BLCA	chr19	12801040	Missense_Mutation	NA	L45V	0.41
BLCA	chr19	12801020	Silent	NA	C51C	0.15
BLCA	chr19	12801009	Missense_Mutation	novel	I55S	0.44
BRCA	chr19	12797028	3'UTR	novel		0.13
BRCA	chr19	12797113	Missense_Mutation	novel	D189Y	0.4
CESC	chr19	12800197	Frame_Shift_Del	novel	*T120Rfs2**	0.08
CESC	chr19	12801004	Missense_Mutation	novel	A57T	0.25
CESC	chr19	12799918	Missense_Mutation	novel	S151F	0.23
COAD	chr19	12796968	3'UTR	novel		0.24
COAD	chr19	12799922	Missense_Mutation	rs755166073	R150C	0.29
COAD	chr19	12797119	Missense_Mutation	rs764907738	V187M	0.28
COAD	chr19	12800285	Missense_Mutation	rs369634820	R91Q	0.26
COAD	chr19	12800223	Missense_Mutation	rs534702204	S112P	0.12
DLBC	chr19	12800642	Intron	novel		0.54
ESCA	chr19	12799909	Missense_Mutation	novel	E154V	0.43
GBM	chr19	12800228	Missense_Mutation	novel	R110L	0.31
GBM	chr19	12801050	Silent	novel	F41F	0.21
HNSC	chr19	12797149	Missense_Mutation	novel	K177E	0.28
KICH	chr19	12801184	Silent	novel	K26K	0.22
KIRP	chr19	12800880	Intron	novel		0.29
LUAD	chr19	12800238	Missense_Mutation	rs746669088	V107M	0.11
LUAD	chr19	12801185	Missense_Mutation	novel	K26I	0.24
LUAD	chr19	12797053	3'UTR	novel		0.17
LUSC	chr19	12800299	Missense_Mutation	novel	W86C	0.16
LUSC	chr19	12800975	Silent	novel	R66R	0.38
OV	chr19	12797163	Missense_Mutation	novel	C172S	0.11
READ	chr19	12799974	Silent	NA	I132I	0.22
SKCM	chr19	12800894	Intron	novel		0.5
SKCM	chr19	12801159	Missense_Mutation	NA	G35R	0.12
SKCM	chr19	12800276	Missense_Mutation	NA	G94E	0.41
STAD	chr19	12799891	Missense_Mutation	rs201815311	Q160R	0.81
STAD	chr19	12800970	Missense_Mutation	NA	L68P	0.25
STAD	chr19	12797105	Silent	rs761571350	K191K	0.43
STAD	chr19	12800209	Silent	rs201040750	G116G	0.2
UCEC	chr19	12796835	3'UTR	novel		0.47
UCEC	chr19	12797132	Silent	rs759618304	T182T	0.21
UCEC	chr19	12801224	Missense_Mutation	NA	P13L	0.18
UCEC	chr19	12800286	Frame_Shift_Del	novel	*R91Gfs9**	0.59
UCEC	chr19	12797158	Missense_Mutation	rs112697174	A174T	0.19
UCEC	chr19	12800229	Missense_Mutation	rs147563022	R110C	0.42
UCEC	chr19	12800272	Silent	novel	G95G	0.52
UCEC	chr19	12800782	Intron	NA		0.28
UCEC	chr19	12800873	Intron	NA		0.25
UCEC	chr19	12800227	Silent	novel	R110R	0.36
UCEC	chr19	12801063	Missense_Mutation	novel	Y37C	0.41
UCEC	chr19	12799973	Missense_Mutation	rs145076374	D133N	0.24
UCEC	chr19	12800205	Silent	rs774634368	L118L	0.35
UCEC	chr19	12800294	Missense_Mutation	novel	N88S	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1017	0.10492
READ	DEL	0.0848	0.23023
THCA	DEL	0.014	0.10598

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00013	Kaplan-Meier Survival Analysis
MESO	0.015	Kaplan-Meier Survival Analysis
ACC	0.039	Kaplan-Meier Survival Analysis
UCS	0.037	Kaplan-Meier Survival Analysis
LUSC	0.0055	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0024	Kaplan-Meier Survival Analysis
CESC	0.0027	Kaplan-Meier Survival Analysis
GBM	0.034	Kaplan-Meier Survival Analysis
LGG	0.0044	Kaplan-Meier Survival Analysis
CHOL	0.019	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742