EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167862 (Gene tree)
Gene ID: 3396
Gene Symbol: MRPL58
Alias: DS-1|ICT1
Full Name: mitochondrial ribosomal protein L58
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 8,598 bases
Position: chr17:75,012,664-75,021,261
Accession: 5359
RBP type: canonical RBP
Summary: The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000301585	RF-1	PF00472.20	1e-18	1	1
ENSP00000462256	RF-1	PF00472.20	5e-17	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000583772	MRPL58-203	678	-	-	- (aa)	-	-
ENST00000584208	MRPL58-204	593	-	ENSP00000462256	192 (aa)	-	J3KS15
ENST00000580800	MRPL58-202	513	-	ENSP00000464192	71 (aa)	-	J3QRF8
ENST00000301585	MRPL58-201	890	XM_017024574	ENSP00000301585	206 (aa)	XP_016880063	Q14197

Gene Model

Click here to download ENSG00000167862's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167862	Alzheimer Disease	2E-8	26913989
ENSG00000167862	Stroke	2E-8	26913989

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167862's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167862	MRPL58	100	85.437	ENSAMEG00000009104	MRPL58	100	85.437	Ailuropoda_melanoleuca
ENSG00000167862	MRPL58	65	64.662	ENSACIG00000019303	MRPL58	75	64.662	Amphilophus_citrinellus
ENSG00000167862	MRPL58	83	64.912	ENSACAG00000006044	MRPL58	80	64.912	Anolis_carolinensis
ENSG00000167862	MRPL58	100	91.748	ENSANAG00000023857	MRPL58	100	91.748	Aotus_nancymaae
ENSG00000167862	MRPL58	100	80.097	ENSBTAG00000003303	MRPL58	100	80.097	Bos_taurus
ENSG00000167862	MRPL58	100	92.233	ENSCJAG00000047013	MRPL58	100	92.233	Callithrix_jacchus
ENSG00000167862	MRPL58	73	84.211	ENSCAFG00000004699	MRPL58	100	84.211	Canis_familiaris
ENSG00000167862	MRPL58	100	84.466	ENSCAFG00020021889	MRPL58	100	84.466	Canis_lupus_dingo
ENSG00000167862	MRPL58	100	80.583	ENSCHIG00000018213	MRPL58	100	80.583	Capra_hircus
ENSG00000167862	MRPL58	100	75.728	ENSTSYG00000013235	MRPL58	100	75.728	Carlito_syrichta
ENSG00000167862	MRPL58	70	84.722	ENSCAPG00000009003	MRPL58	100	84.722	Cavia_aperea
ENSG00000167862	MRPL58	100	79.126	ENSCPOG00000033171	MRPL58	100	79.126	Cavia_porcellus
ENSG00000167862	MRPL58	100	91.262	ENSCCAG00000035029	MRPL58	100	91.262	Cebus_capucinus
ENSG00000167862	MRPL58	100	91.827	ENSCATG00000039315	MRPL58	100	91.827	Cercocebus_atys
ENSG00000167862	MRPL58	100	82.524	ENSCLAG00000002475	MRPL58	100	82.524	Chinchilla_lanigera
ENSG00000167862	MRPL58	100	95.146	ENSCSAG00000004656	MRPL58	100	95.146	Chlorocebus_sabaeus
ENSG00000167862	MRPL58	100	72.816	ENSCHOG00000003849	-	100	72.816	Choloepus_hoffmanni
ENSG00000167862	MRPL58	99	62.019	ENSCPBG00000028141	MRPL58	99	62.019	Chrysemys_picta_bellii
ENSG00000167862	MRPL58	79	42.105	ENSCING00000022971	-	85	42.105	Ciona_intestinalis
ENSG00000167862	MRPL58	73	43.448	ENSCSAVG00000011462	-	82	40.462	Ciona_savignyi
ENSG00000167862	MRPL58	100	88.835	ENSCANG00000042071	MRPL58	100	88.835	Colobus_angolensis_palliatus
ENSG00000167862	MRPL58	100	82.524	ENSCGRG00001023339	Mrpl58	100	82.524	Cricetulus_griseus_chok1gshd
ENSG00000167862	MRPL58	96	81.818	ENSCGRG00000007240	Mrpl58	99	81.818	Cricetulus_griseus_crigri
ENSG00000167862	MRPL58	72	57.718	ENSCSEG00000020096	-	77	57.718	Cynoglossus_semilaevis
ENSG00000167862	MRPL58	100	84.466	ENSDNOG00000013172	MRPL58	100	84.466	Dasypus_novemcinctus
ENSG00000167862	MRPL58	100	81.068	ENSDORG00000006439	Mrpl58	100	81.068	Dipodomys_ordii
ENSG00000167862	MRPL58	80	42.771	FBgn0032261	CG6094	82	42.771	Drosophila_melanogaster
ENSG00000167862	MRPL58	100	79.227	ENSETEG00000010502	MRPL58	100	79.227	Echinops_telfairi
ENSG00000167862	MRPL58	69	53.147	ENSEBUG00000001979	MRPL58	84	53.147	Eptatretus_burgeri
ENSG00000167862	MRPL58	71	86.301	ENSEASG00005000272	MRPL58	73	67.805	Equus_asinus_asinus
ENSG00000167862	MRPL58	100	86.893	ENSECAG00000013418	MRPL58	100	86.893	Equus_caballus
ENSG00000167862	MRPL58	100	80.097	ENSEEUG00000013113	MRPL58	100	80.097	Erinaceus_europaeus
ENSG00000167862	MRPL58	100	84.951	ENSFCAG00000035293	MRPL58	100	84.951	Felis_catus
ENSG00000167862	MRPL58	100	83.495	ENSFDAG00000005635	MRPL58	100	83.495	Fukomys_damarensis
ENSG00000167862	MRPL58	99	58.252	ENSGALG00000007822	MRPL58	99	58.252	Gallus_gallus
ENSG00000167862	MRPL58	83	56.725	ENSGAFG00000000639	MRPL58	84	56.725	Gambusia_affinis
ENSG00000167862	MRPL58	90	59.887	ENSGAGG00000003969	MRPL58	87	62.353	Gopherus_agassizii
ENSG00000167862	MRPL58	100	92.718	ENSGGOG00000012341	MRPL58	100	92.718	Gorilla_gorilla
ENSG00000167862	MRPL58	100	84.466	ENSHGLG00000007782	ICT1	100	84.466	Heterocephalus_glaber_female
ENSG00000167862	MRPL58	100	84.466	ENSHGLG00100004722	ICT1	100	84.466	Heterocephalus_glaber_male
ENSG00000167862	MRPL58	100	84.466	ENSSTOG00000015149	MRPL58	100	84.466	Ictidomys_tridecemlineatus
ENSG00000167862	MRPL58	100	83.981	ENSJJAG00000000722	Mrpl58	100	83.981	Jaculus_jaculus
ENSG00000167862	MRPL58	100	60.577	ENSLACG00000008356	MRPL58	100	60.577	Latimeria_chalumnae
ENSG00000167862	MRPL58	83	61.494	ENSLOCG00000011474	MRPL58	84	61.494	Lepisosteus_oculatus
ENSG00000167862	MRPL58	100	84.951	ENSLAFG00000000272	MRPL58	100	84.951	Loxodonta_africana
ENSG00000167862	MRPL58	100	93.689	ENSMFAG00000019961	-	100	93.689	Macaca_fascicularis
ENSG00000167862	MRPL58	100	94.660	ENSMFAG00000023313	-	100	94.660	Macaca_fascicularis
ENSG00000167862	MRPL58	100	94.175	ENSMMUG00000011644	MRPL58	100	94.175	Macaca_mulatta
ENSG00000167862	MRPL58	100	94.175	ENSMNEG00000030999	MRPL58	100	94.175	Macaca_nemestrina
ENSG00000167862	MRPL58	96	90.270	ENSMLEG00000026116	-	100	93.820	Mandrillus_leucophaeus
ENSG00000167862	MRPL58	73	94.231	ENSMLEG00000035555	-	93	72.826	Mandrillus_leucophaeus
ENSG00000167862	MRPL58	66	66.912	ENSMGAG00000009312	MRPL58	99	66.912	Meleagris_gallopavo
ENSG00000167862	MRPL58	100	77.184	ENSMAUG00000014528	Mrpl58	100	77.184	Mesocricetus_auratus
ENSG00000167862	MRPL58	100	86.893	ENSMICG00000010640	MRPL58	100	86.893	Microcebus_murinus
ENSG00000167862	MRPL58	100	80.583	ENSMOCG00000015630	Mrpl58	100	80.583	Microtus_ochrogaster
ENSG00000167862	MRPL58	71	61.644	ENSMMOG00000004927	-	78	61.644	Mola_mola
ENSG00000167862	MRPL58	100	70.673	ENSMODG00000007126	MRPL58	100	70.673	Monodelphis_domestica
ENSG00000167862	MRPL58	65	64.662	ENSMALG00000011991	-	69	64.662	Monopterus_albus
ENSG00000167862	MRPL58	100	78.155	MGP_CAROLIEiJ_G0017400	Mrpl58	100	78.155	Mus_caroli
ENSG00000167862	MRPL58	100	79.612	ENSMUSG00000018858	Mrpl58	100	79.612	Mus_musculus
ENSG00000167862	MRPL58	100	78.641	MGP_PahariEiJ_G0018530	Mrpl58	100	78.641	Mus_pahari
ENSG00000167862	MRPL58	100	79.612	MGP_SPRETEiJ_G0018245	Mrpl58	100	79.612	Mus_spretus
ENSG00000167862	MRPL58	100	74.519	ENSMPUG00000014086	MRPL58	100	74.519	Mustela_putorius_furo
ENSG00000167862	MRPL58	70	86.806	ENSMLUG00000006752	MRPL58	80	86.806	Myotis_lucifugus
ENSG00000167862	MRPL58	96	79.798	ENSNGAG00000009226	Mrpl58	98	79.798	Nannospalax_galili
ENSG00000167862	MRPL58	64	62.595	ENSNBRG00000013694	MRPL58	68	62.595	Neolamprologus_brichardi
ENSG00000167862	MRPL58	100	88.835	ENSNLEG00000027867	MRPL58	100	88.835	Nomascus_leucogenys
ENSG00000167862	MRPL58	100	65.865	ENSMEUG00000011411	MRPL58	100	65.865	Notamacropus_eugenii
ENSG00000167862	MRPL58	100	76.214	ENSOPRG00000001655	-	100	76.214	Ochotona_princeps
ENSG00000167862	MRPL58	100	79.126	ENSODEG00000010192	MRPL58	100	79.126	Octodon_degus
ENSG00000167862	MRPL58	72	70.470	ENSOANG00000007032	-	100	70.470	Ornithorhynchus_anatinus
ENSG00000167862	MRPL58	100	80.676	ENSOCUG00000000800	MRPL58	100	80.676	Oryctolagus_cuniculus
ENSG00000167862	MRPL58	100	83.092	ENSOGAG00000003555	MRPL58	100	83.092	Otolemur_garnettii
ENSG00000167862	MRPL58	100	67.619	ENSOARG00000011402	MRPL58	100	67.619	Ovis_aries
ENSG00000167862	MRPL58	100	98.544	ENSPPAG00000032239	MRPL58	100	98.544	Pan_paniscus
ENSG00000167862	MRPL58	100	85.922	ENSPPRG00000008418	MRPL58	100	85.922	Panthera_pardus
ENSG00000167862	MRPL58	100	74.757	ENSPTIG00000014767	MRPL58	100	74.757	Panthera_tigris_altaica
ENSG00000167862	MRPL58	100	99.029	ENSPTRG00000009627	MRPL58	100	99.029	Pan_troglodytes
ENSG00000167862	MRPL58	70	95.139	ENSPANG00000032491	-	100	95.139	Papio_anubis
ENSG00000167862	MRPL58	100	94.660	ENSPANG00000000142	-	100	94.660	Papio_anubis
ENSG00000167862	MRPL58	93	60.938	ENSPSIG00000004736	MRPL58	99	60.190	Pelodiscus_sinensis
ENSG00000167862	MRPL58	100	81.068	ENSPEMG00000003138	Mrpl58	100	81.068	Peromyscus_maniculatus_bairdii
ENSG00000167862	MRPL58	100	71.635	ENSPCIG00000004667	MRPL58	100	71.635	Phascolarctos_cinereus
ENSG00000167862	MRPL58	79	55.215	ENSPFOG00000018595	MRPL58	81	55.215	Poecilia_formosa
ENSG00000167862	MRPL58	79	55.215	ENSPLAG00000016858	MRPL58	80	55.215	Poecilia_latipinna
ENSG00000167862	MRPL58	64	63.359	ENSPMEG00000012976	MRPL58	94	63.359	Poecilia_mexicana
ENSG00000167862	MRPL58	100	96.602	ENSPPYG00000008614	MRPL58	100	96.602	Pongo_abelii
ENSG00000167862	MRPL58	100	83.981	ENSPCAG00000015297	MRPL58	100	83.981	Procavia_capensis
ENSG00000167862	MRPL58	100	87.864	ENSPCOG00000004300	MRPL58	100	87.864	Propithecus_coquereli
ENSG00000167862	MRPL58	100	79.126	ENSPVAG00000016063	MRPL58	100	79.126	Pteropus_vampyrus
ENSG00000167862	MRPL58	64	62.595	ENSPNYG00000007275	MRPL58	68	62.595	Pundamilia_nyererei
ENSG00000167862	MRPL58	100	80.097	ENSRNOG00000032780	Mrpl58	100	80.097	Rattus_norvegicus
ENSG00000167862	MRPL58	100	86.979	ENSRBIG00000033109	MRPL58	93	90.000	Rhinopithecus_bieti
ENSG00000167862	MRPL58	100	94.175	ENSRROG00000006234	-	100	94.175	Rhinopithecus_roxellana
ENSG00000167862	MRPL58	100	94.660	ENSRROG00000010716	-	100	94.660	Rhinopithecus_roxellana
ENSG00000167862	MRPL58	100	89.320	ENSSBOG00000036182	MRPL58	100	89.320	Saimiri_boliviensis_boliviensis
ENSG00000167862	MRPL58	100	74.038	ENSSHAG00000018724	MRPL58	100	74.038	Sarcophilus_harrisii
ENSG00000167862	MRPL58	69	59.859	ENSSMAG00000003640	-	73	59.859	Scophthalmus_maximus
ENSG00000167862	MRPL58	99	60.766	ENSSPUG00000009563	MRPL58	99	60.766	Sphenodon_punctatus
ENSG00000167862	MRPL58	100	81.068	ENSSSCG00000034406	MRPL58	100	81.068	Sus_scrofa
ENSG00000167862	MRPL58	83	63.158	ENSTGUG00000008783	MRPL58	94	63.158	Taeniopygia_guttata
ENSG00000167862	MRPL58	71	58.503	ENSTRUG00000021467	MRPL58	72	58.503	Takifugu_rubripes
ENSG00000167862	MRPL58	100	72.330	ENSTTRG00000002617	MRPL58	100	72.330	Tursiops_truncatus
ENSG00000167862	MRPL58	100	86.408	ENSUAMG00000010472	MRPL58	100	86.408	Ursus_americanus
ENSG00000167862	MRPL58	64	80.153	ENSVPAG00000002667	MRPL58	100	80.153	Vicugna_pacos
ENSG00000167862	MRPL58	100	84.951	ENSVVUG00000011117	MRPL58	100	84.951	Vulpes_vulpes
ENSG00000167862	MRPL58	87	57.459	ENSXETG00000012505	mrpl58	94	57.459	Xenopus_tropicalis
ENSG00000167862	MRPL58	65	61.654	ENSXCOG00000002727	MRPL58	79	61.654	Xiphophorus_couchianus
ENSG00000167862	MRPL58	79	56.442	ENSXMAG00000012414	MRPL58	81	56.442	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004045	aminoacyl-tRNA hydrolase activity	20186120.	IDA	Function
GO:0005739	mitochondrion	20186120.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	20186120.25278503.	IDA	Component
GO:0016150	translation release factor activity, codon nonspecific	20186120.	IDA	Function
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	21873635.	IBA	Process
GO:0070126	mitochondrial translational termination	20186120.	IDA	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process