EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167978 (Gene tree)
Gene ID: 23524
Gene Symbol: SRRM2
Alias: SRm300|SRL300|KIAA0324|Cwc21
Full Name: serine/arginine repetitive matrix 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 20,210 bases
Position: chr16:2,752,329-2,772,538
Accession: 16639
RBP type: canonical RBP
Summary: (Serine/Arginine Repetitive Matrix 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include C2H2 zinc finger domain binding. An important paralog of this gene is MUC12.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000458230	cwf21	PF08312.12	7.1e-11	1	1
ENSP00000461181	cwf21	PF08312.12	1.1e-09	1	1
ENSP00000301740	cwf21	PF08312.12	2.7e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11004489	Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains.	Biochim Biophys Acta	2000 Jun 21	Sawada Y	-
17176074	A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways.	Biochemistry	2006 Dec 26	Mukherji M	-
28919079	Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae.	Cell	2017 Sep 21	Wan R	doi: 10.1016/j.cell.2017.08.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000576674	SRRM2-227	593	-	-	- (aa)	-	-
ENST00000572278	SRRM2-209	711	-	-	- (aa)	-	-
ENST00000572721	SRRM2-210	841	-	-	- (aa)	-	-
ENST00000572883	SRRM2-211	887	-	ENSP00000460642	184 (aa)	-	I3L3Q8
ENST00000576415	SRRM2-226	461	-	ENSP00000458718	94 (aa)	-	I3L1C0
ENST00000576894	SRRM2-229	2210	-	-	- (aa)	-	-
ENST00000571372	SRRM2-207	462	-	-	- (aa)	-	-
ENST00000573692	SRRM2-217	459	-	ENSP00000461535	78 (aa)	-	I3L4U6
ENST00000574340	SRRM2-219	579	-	ENSP00000458230	115 (aa)	-	I3L0N7
ENST00000570705	SRRM2-204	675	-	-	- (aa)	-	-
ENST00000574593	SRRM2-220	1440	-	-	- (aa)	-	-
ENST00000573583	SRRM2-216	543	-	-	- (aa)	-	-
ENST00000571041	SRRM2-206	498	-	-	- (aa)	-	-
ENST00000576878	SRRM2-228	1141	-	-	- (aa)	-	-
ENST00000574866	SRRM2-221	638	-	-	- (aa)	-	-
ENST00000573451	SRRM2-214	441	-	-	- (aa)	-	-
ENST00000301740	SRRM2-201	9353	XM_005255226	ENSP00000301740	2752 (aa)	XP_005255283	Q9UQ35
ENST00000576076	SRRM2-225	914	-	-	- (aa)	-	-
ENST00000571378	SRRM2-208	2870	-	ENSP00000458647	895 (aa)	-	I3L182
ENST00000572952	SRRM2-212	1118	-	-	- (aa)	-	-
ENST00000570971	SRRM2-205	1132	-	ENSP00000484503	251 (aa)	-	A0A087X1W1
ENST00000575870	SRRM2-224	696	-	-	- (aa)	-	-
ENST00000630499	SRRM2-231	1207	-	ENSP00000487247	311 (aa)	-	Q9UQ35
ENST00000573498	SRRM2-215	994	-	-	- (aa)	-	-
ENST00000575701	SRRM2-223	860	-	-	- (aa)	-	-
ENST00000575009	SRRM2-222	1146	-	ENSP00000458870	297 (aa)	-	I3L1I8
ENST00000574331	SRRM2-218	1759	-	-	- (aa)	-	-
ENST00000576924	SRRM2-230	3314	XM_006720874	ENSP00000461181	1018 (aa)	XP_006720937	I3L4D8
ENST00000570655	SRRM2-203	575	-	-	- (aa)	-	-
ENST00000570539	SRRM2-202	431	-	ENSP00000459157	41 (aa)	-	I3L1W5
ENST00000573311	SRRM2-213	732	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000167978's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167978	Platelet Function Tests	2.7502585E-007	-
ENSG00000167978	Platelet Function Tests	9.7922859E-007	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167978's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167978	SRRM2	88	60.194	ENSACIG00000023341	-	92	54.971	Amphilophus_citrinellus
ENSG00000167978	SRRM2	100	100.000	ENSANAG00000034911	SRRM2	100	96.366	Aotus_nancymaae
ENSG00000167978	SRRM2	85	62.000	ENSAMXG00000038994	-	90	51.031	Astyanax_mexicanus
ENSG00000167978	SRRM2	100	100.000	ENSCJAG00000015354	SRRM2	100	96.478	Callithrix_jacchus
ENSG00000167978	SRRM2	100	100.000	ENSCCAG00000031601	SRRM2	100	96.548	Cebus_capucinus
ENSG00000167978	SRRM2	100	100.000	ENSCATG00000038003	SRRM2	100	98.038	Cercocebus_atys
ENSG00000167978	SRRM2	100	100.000	ENSCSAG00000010365	SRRM2	100	98.001	Chlorocebus_sabaeus
ENSG00000167978	SRRM2	100	75.000	ENSCPBG00000005984	-	95	77.731	Chrysemys_picta_bellii
ENSG00000167978	SRRM2	100	100.000	ENSCANG00000029659	SRRM2	100	97.456	Colobus_angolensis_palliatus
ENSG00000167978	SRRM2	89	59.615	ENSCSEG00000009971	-	92	51.531	Cynoglossus_semilaevis
ENSG00000167978	SRRM2	100	99.130	ENSETEG00000019959	SRRM2	50	86.254	Echinops_telfairi
ENSG00000167978	SRRM2	100	71.552	ENSGALG00000047953	-	68	68.000	Gallus_gallus
ENSG00000167978	SRRM2	50	64.912	ENSGACG00000020232	-	92	40.891	Gasterosteus_aculeatus
ENSG00000167978	SRRM2	100	100.000	ENSGGOG00000015296	SRRM2	100	99.491	Gorilla_gorilla
ENSG00000167978	SRRM2	86	53.535	ENSHGLG00100004269	-	82	53.535	Heterocephalus_glaber_male
ENSG00000167978	SRRM2	89	59.615	ENSLBEG00000007729	-	90	55.882	Labrus_bergylta
ENSG00000167978	SRRM2	100	100.000	ENSMFAG00000003406	SRRM2	100	98.147	Macaca_fascicularis
ENSG00000167978	SRRM2	100	100.000	ENSMMUG00000018858	SRRM2	99	97.983	Macaca_mulatta
ENSG00000167978	SRRM2	100	100.000	ENSMNEG00000042677	SRRM2	100	98.074	Macaca_nemestrina
ENSG00000167978	SRRM2	100	100.000	ENSMLEG00000041906	SRRM2	100	97.965	Mandrillus_leucophaeus
ENSG00000167978	SRRM2	100	98.261	MGP_CAROLIEiJ_G0021161	Srrm2	100	97.661	Mus_caroli
ENSG00000167978	SRRM2	100	98.261	ENSMUSG00000039218	Srrm2	100	97.661	Mus_musculus
ENSG00000167978	SRRM2	100	99.130	MGP_PahariEiJ_G0023478	Srrm2	100	98.246	Mus_pahari
ENSG00000167978	SRRM2	100	98.261	MGP_SPRETEiJ_G0022071	Srrm2	100	97.661	Mus_spretus
ENSG00000167978	SRRM2	86	53.535	ENSNGAG00000005825	-	73	53.535	Nannospalax_galili
ENSG00000167978	SRRM2	100	100.000	ENSNLEG00000009466	SRRM2	99	95.820	Nomascus_leucogenys
ENSG00000167978	SRRM2	100	100.000	ENSPPAG00000032551	SRRM2	100	99.382	Pan_paniscus
ENSG00000167978	SRRM2	100	100.000	ENSPTRG00000042918	-	99	96.945	Pan_troglodytes
ENSG00000167978	SRRM2	100	100.000	ENSPTRG00000007662	SRRM2	100	99.491	Pan_troglodytes
ENSG00000167978	SRRM2	100	100.000	ENSPANG00000016966	SRRM2	100	98.001	Papio_anubis
ENSG00000167978	SRRM2	88	63.462	ENSPMGG00000000733	-	92	54.922	Periophthalmus_magnuspinnatus
ENSG00000167978	SRRM2	100	100.000	ENSPPYG00000007012	SRRM2	100	98.910	Pongo_abelii
ENSG00000167978	SRRM2	100	91.304	ENSPCAG00000009687	-	58	83.533	Procavia_capensis
ENSG00000167978	SRRM2	70	43.750	ENSPNYG00000009463	-	88	42.442	Pundamilia_nyererei
ENSG00000167978	SRRM2	85	62.000	ENSPNAG00000018911	-	97	46.460	Pygocentrus_nattereri
ENSG00000167978	SRRM2	100	100.000	ENSRBIG00000033934	SRRM2	98	94.442	Rhinopithecus_bieti
ENSG00000167978	SRRM2	100	100.000	ENSRROG00000030979	SRRM2	100	98.001	Rhinopithecus_roxellana
ENSG00000167978	SRRM2	100	100.000	ENSSBOG00000024771	SRRM2	100	96.439	Saimiri_boliviensis_boliviensis
ENSG00000167978	SRRM2	88	60.194	ENSSLDG00000003595	-	79	53.093	Seriola_lalandi_dorsalis
ENSG00000167978	SRRM2	92	79.245	ENSSPUG00000003428	-	99	74.138	Sphenodon_punctatus
ENSG00000167978	SRRM2	97	89.444	ENSTBEG00000006307	-	56	98.990	Tupaia_belangeri
ENSG00000167978	SRRM2	100	100.000	ENSTTRG00000015432	SRRM2	59	99.415	Tursiops_truncatus
ENSG00000167978	SRRM2	100	100.000	ENSUAMG00000018078	SRRM2	53	98.286	Ursus_americanus
ENSG00000167978	SRRM2	100	100.000	ENSUMAG00000000726	SRRM2	66	85.471	Ursus_maritimus
ENSG00000167978	SRRM2	100	100.000	ENSVVUG00000008770	SRRM2	68	84.890	Vulpes_vulpes
ENSG00000167978	SRRM2	89	59.615	ENSXCOG00000000148	-	92	52.821	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28076346.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	28076346.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0015030	Cajal body	17577209.	IDA	Component
GO:0016607	nuclear speck	17577209.	IDA	Component
GO:0047485	protein N-terminus binding	17577209.	IPI	Function
GO:0070742	C2H2 zinc finger domain binding	17577209.	IDA	Function
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component