EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000167996 (Gene tree)
Gene ID: 2495
Gene Symbol: FTH1
Alias: FTH|PLIF|PIG15|FHC|FTHL6
Full Name: ferritin heavy chain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,943 bases
Position: chr11:61,959,718-61,967,660
Accession: 3976
RBP type: non-canonical RBP
Summary: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14654946	Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.	Int J Oncol	2004 Jan	Grzmil M	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000529191	FTH1-203	530	-	ENSP00000431659	102 (aa)	-	E9PK45
ENST00000533138	FTH1-209	885	-	-	- (aa)	-	-
ENST00000620041	FTH1-212	825	-	ENSP00000484477	183 (aa)	-	P02794
ENST00000529548	FTH1-204	567	-	ENSP00000436947	58 (aa)	-	E9PPQ4
ENST00000526640	FTH1-202	786	-	ENSP00000433321	153 (aa)	-	G3V192
ENST00000532829	FTH1-208	912	-	ENSP00000432223	95 (aa)	-	E9PRK8
ENST00000534180	FTH1-210	983	-	ENSP00000434403	50 (aa)	-	E9PQR3
ENST00000530019	FTH1-206	550	-	ENSP00000433470	114 (aa)	-	E9PKY7
ENST00000534719	FTH1-211	788	-	-	- (aa)	-	-
ENST00000273550	FTH1-201	1229	-	ENSP00000273550	183 (aa)	-	P02794
ENST00000532601	FTH1-207	742	-	ENSP00000435111	113 (aa)	-	G3V1D1
ENST00000529631	FTH1-205	507	-	ENSP00000431575	81 (aa)	-	E9PKM5

Gene Model

Click here to download ENSG00000167996's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04216	Ferroptosis	KEGG
hsa04217	Necroptosis	KEGG
hsa04978	Mineral absorption	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167996	Blood Glucose	4.1970000E-005	-
ENSG00000167996	docosapentaenoic acid	8E-8	21829377

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167996's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004322	ferroxidase activity	21873635.	IBA	Function
GO:0005506	iron ion binding	21873635.	IBA	Function
GO:0005515	protein binding	15607035.16169070.16189514.20133674.20195357.21516116.21573799.21988832.22458338.25277244.25416956.25910212.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006826	iron ion transport	-	IEA	Process
GO:0006879	cellular iron ion homeostasis	-	TAS	Process
GO:0006880	intracellular sequestering of iron ion	21873635.	IBA	Process
GO:0006880	intracellular sequestering of iron ion	9924025.	IDA	Process
GO:0006955	immune response	-	ISS	Process
GO:0008043	intracellular ferritin complex	6589621.	TAS	Component
GO:0008198	ferrous iron binding	21873635.	IBA	Function
GO:0008199	ferric iron binding	21873635.	IBA	Function
GO:0008285	negative regulation of cell proliferation	-	ISS	Process
GO:0042802	identical protein binding	21873635.	IBA	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044754	autolysosome	21873635.	IBA	Component
GO:0044754	autolysosome	25327288.	IDA	Component
GO:0048147	negative regulation of fibroblast proliferation	21873635.	IBA	Process
GO:0048147	negative regulation of fibroblast proliferation	9924025.	IDA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0060547	negative regulation of necrotic cell death	21873635.	IBA	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:1904724	tertiary granule lumen	-	TAS	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24066693	Tumor necrosis factor-α attenuates starvation-induced apoptosis through upregulation of ferritin heavy chain in hepatocellular carcinoma cells.	BMC Cancer	2013 Sep 25	Kou X	doi: 10.1186/1471-2407-13-438.
22426960	Survivin inhibition by an interacting recombinant peptide, derived from the human ferritin heavy chain, impedes tumor cell growth.	J Cancer Res Clin Oncol	2012 Jul	Weiss A	doi: 10.1007/s00432-012-1195-1
28837569	Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value.	PLoS One	2017 Aug 24	Rosager AM	doi: 10.1371/journal.pone.0182954
12435735	Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.	J Biol Chem	2003 Jan 24	Pietsch EC	-
20390345	Role of ferritin alterations in human breast cancer cells.	Breast Cancer Res Treat	2011 Feb	Shpyleva SI	doi: 10.1007/s10549-010-0849-4.
25265351	Significance of ferritin expression in formation of malignant phenotype of human breast cancer cells.	Exp Oncol	2014 Sep	Chekhun SV	-
24742827	Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response.	Mol Cell Proteomics	2014 Jul	Liu NQ	doi: 10.1074/mcp.M113.037176
24446242	Elevation in multiple serum inflammatory biomarkers predicts survival of pancreatic cancer patients with inoperable disease.	J Gastrointest Cancer	2014 Jun	Alkhateeb A	doi: 10.1007/s12029-013-9564-9.
27566559	Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition.	Oncotarget	2016 Sep 20	Lobello N	doi: 10.18632/oncotarget.11495.
30274235	Chemoresistance in H-Ferritin Silenced Cells: The Role of NF-??B.	Int J Mol Sci	2018 Sep 28	Aversa I	doi: 10.3390/ijms19102969.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	61964876	Missense_Mutation	NA	E135K	0.51
BLCA	chr11	61964771	Missense_Mutation	NA	L170V	0.27
BLCA	chr11	61965089	Missense_Mutation	NA	E95D	0.13
BLCA	chr11	61965446	Missense_Mutation	NA	E62Q	0.13
BLCA	chr11	61964893	Splice_Site	novel	X130_splice	0.54
CESC	chr11	61967412	Missense_Mutation	novel	S5F	0.44
COAD	chr11	61965042	Missense_Mutation	novel	V111A	0.11
COAD	chr11	61965498	Silent	rs780322158	R44R	0.14
ESCA	chr11	61967376	Missense_Mutation	novel	S17L	0.31
ESCA	chr11	61967630	5'UTR	novel		0.25
GBM	chr11	61965455	Missense_Mutation	novel	Q59E	0.09
GBM	chr11	61965497	Missense_Mutation	novel	D45N	0.12
GBM	chr11	61965507	Silent	novel	Y41Y	0.08
GBM	chr11	61965421	Missense_Mutation	NA	L70P	0.05
KIRP	chr11	61964775	Missense_Mutation	novel	E168D	0.4
LGG	chr11	61965473	Missense_Mutation	NA	A53P	0.52
LGG	chr11	61967380	Missense_Mutation	novel	D16N	0.52
LUAD	chr11	61964865	Nonsense_Mutation	NA	Y138*	0.16
LUAD	chr11	61964735	Missense_Mutation	novel	E182Q	0.54
LUSC	chr11	61965516	Splice_Site	NA	X39_splice	0.13
LUSC	chr11	61967339	Silent	novel	L29L	0.31
LUSC	chr11	61965106	Missense_Mutation	NA	D90N	0.09
OV	chr11	61964836	Nonsense_Mutation	novel	*E148Vfs3**	0.08
OV	chr11	61964849	Missense_Mutation	NA	K144E	0.18
OV	chr11	61959905	3'Flank	novel		0.24
OV	chr11	61965446	Missense_Mutation	novel	E62K	0.16
OV	chr11	61965503	Missense_Mutation	NA	D43N	0.1
SKCM	chr11	61965392	Nonsense_Mutation	NA	R80*	0.46
SKCM	chr11	61964798	Missense_Mutation	NA	A161T	0.15
STAD	chr11	61965045	Frame_Shift_Del	NA	*N110Mfs2**	0.51
STAD	chr11	61965087	Missense_Mutation	NA	S96I	0.28
STAD	chr11	61964785	Missense_Mutation	novel	G165D	0.47
STAD	chr11	61965512	Missense_Mutation	NA	Y40H	0.28
STAD	chr11	61965421	Missense_Mutation	NA	L70P	0.1
STAD	chr11	61965045	Frame_Shift_Del	NA	*N110Mfs2**	0.26
UCEC	chr11	61959889	3'Flank	novel		0.36
UCEC	chr11	61964795	Missense_Mutation	NA	P162S	0.42
UCEC	chr11	61964779	Missense_Mutation	rs755508306	A167V	0.44
UCEC	chr11	61967417	Silent	novel	T3T	0.43
UCEC	chr11	61964889	Splice_Region	novel	L130L	0.18
UCEC	chr11	61964837	Nonsense_Mutation	novel	E148*	0.5
UCEC	chr11	61965416	Missense_Mutation	novel	K72Q	0.29
UCEC	chr11	61965480	Missense_Mutation	novel	K50N	0.16
UCEC	chr11	61967316	Missense_Mutation	novel	S37F	0.36
UCEC	chr11	61965369	Missense_Mutation	novel	K87N	0.05
UCEC	chr11	61964833	Missense_Mutation	novel	L149S	0.46
UCS	chr11	61964779	In_Frame_Del	novel	G165_A167del	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1685	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0066	Kaplan-Meier Survival Analysis
SARC	0.017	Kaplan-Meier Survival Analysis
HNSC	0.0002	Kaplan-Meier Survival Analysis
KIRP	0.016	Kaplan-Meier Survival Analysis
PAAD	0.025	Kaplan-Meier Survival Analysis
CESC	0.029	Kaplan-Meier Survival Analysis
LAML	0.00015	Kaplan-Meier Survival Analysis
KICH	0.0046	Kaplan-Meier Survival Analysis
LIHC	0.0017	Kaplan-Meier Survival Analysis
DLBC	0.039	Kaplan-Meier Survival Analysis
LGG	0.0026	Kaplan-Meier Survival Analysis
UVM	0.002	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742