EuRBPDB

Description

Ensembl ID: ENSG00000168264 (Gene tree)
Gene ID: 359948
Gene Symbol: IRF2BP2
Alias: IRF-2BP2
Full Name: interferon regulatory factor 2 binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,257 bases
Position: chr1:234,604,269-234,609,525
Accession: 21729
RBP type: non-canonical RBP
Summary: This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19587378	Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.	Blood	2009 Oct 8	Blotta S	doi: 10.1182/blood-2009-04-219436

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491430	IRF2BP2-203	683	-	-	- (aa)	-	-
ENST00000366609	IRF2BP2-201	4663	-	ENSP00000355568	587 (aa)	-	Q7Z5L9
ENST00000366610	IRF2BP2-202	4615	-	ENSP00000355569	571 (aa)	-	Q7Z5L9

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000168264	rs1329125	1	234605134	T	Educational attainment (MTAG)	30038396	[0.007-0.0124] unit decrease	0.0097	EFO_0004784
ENSG00000168264	rs8823	1	234604395	A	Self-reported math ability (MTAG)	30038396	[0.008-0.0158] unit decrease	0.0119	EFO_0004875
ENSG00000168264	rs8823	1	234604395	A	Highest math class taken (MTAG)	30038396	[0.0086-0.016] unit decrease	0.0123	EFO_0004875
ENSG00000168264	rs1329125	1	234605134	T	Educational attainment (years of education)	30038396	[0.0068-0.0126] unit decrease	0.0097	EFO_0004784

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0002327	immature B cell differentiation	27016798.	IDA	Process
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function